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Your search keyword '"Kalaitzopoulos, Dimitrios R."' showing total 11 results
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11 results on '"Kalaitzopoulos, Dimitrios R."'

5. Double vitrification and warming does not compromise the chance of live birth after single unbiopsied blastocyst transfer

Author

Makieva, Sofia; https://orcid.org/0000-0001-6143-3553, Sachs, M K, Xie, M, Velasco, A, El-Hadad, Samia; https://orcid.org/0000-0001-8844-6709, Kalaitzopoulos, Dimitrios R; https://orcid.org/0000-0002-8053-1308, Dedes, Ioannis, Stiller, Ruth, Leeners, Brigitte; https://orcid.org/0000-0003-4027-6151, Makieva, Sofia; https://orcid.org/0000-0001-6143-3553, Sachs, M K, Xie, M, Velasco, A, El-Hadad, Samia; https://orcid.org/0000-0001-8844-6709, Kalaitzopoulos, Dimitrios R; https://orcid.org/0000-0002-8053-1308, Dedes, Ioannis, Stiller, Ruth, and Leeners, Brigitte; https://orcid.org/0000-0003-4027-6151

Abstract

STUDY QUESTION: Does double vitrification and thawing of an embryo compromise the chance of live birth after a single blastocyst transfer? SUMMARY ANSWER: The live birth rate (LBR) obtained after double vitrification was comparable to that obtained after single vitrification. WHAT IS KNOWN ALREADY: Double vitrification-warming (DVW) is commonly practiced to accommodate surplus viable embryos suitable for transfer, to allow retesting of inconclusively diagnosed blastocysts in preimplantation genetic testing (PGT), and to circumvent limitations associated with national policies on embryo culture in certain countries. Despite its popularity, the evidence concerning the impact of DVW practice on ART outcomes is limited and lacking credibility. This is the first thorough investigation of clinical pregnancy and LBR following DVW in the case where the first round of vitrification occurred at the zygote stage and the second round occurred at the blastocyst stage in the absence of biopsy. STUDY DESIGN, SIZE, DURATION: This is a retrospective observational analysis of n = 407 single blastocyst transfers whereby embryos created by IVF/ICSI were vitrified-warmed once (single vitrification-warming (SVW) n = 310) or twice (DVW, n = 97) between January 2017 and December 2021. PARTICIPANTS/MATERIALS, SETTING, METHODS: In the SVW group, blastocysts were vitrified on Day 5/6 and warmed on the day of embryo transfer (ET). In the DVW group, two pronuclear (2PN) zygotes were first vitrified-warmed and then re-vitrified on Day 5/6 and warmed on the day of ET. Exclusion criteria were ETs from PGT and vitrified-warmed oocyte cycles. All of the ETs were single blastocyst transfers performed at the University Hospital Zurich in Switzerland following natural or artificial endometrial preparation. MAIN RESULTS AND THE ROLE OF CHANCE: The biochemical pregnancy rate, clinical pregnancy rate (CPR), and LBR were all comparable between the DVW and SVW groups. The CPR for DVW was 44.3% and for SVW i

Published
2023

7. Fertility, pregnancy and neonatal outcomes of patients with adenomyosis: a systematic review and meta-analysis

Author

Nirgianakis, Konstantinos, Kalaitzopoulos, Dimitrios R, Kohl Schwartz, Alexandra Sabrina, Spaanderman, Marc, Kramer, Boris W, Mueller, Michael D, Mueller, Martin, University of Zurich, and Nirgianakis, Konstantinos

Subjects
1309 Developmental Biology, Reproductive Medicine, 610 Medicine & health, 2729 Obstetrics and Gynecology, 2743 Reproductive Medicine, 10174 Clinic for Gynecology, Developmental Biology
Abstract

This study aimed to investigate the association of adenomyosis with fertility, pregnancy and neonatal outcomes. An electronic search was conducted using the MEDLINE, PubMed and Cochrane databases up to April 2020. Seventeen observational studies were included. Adenomyosis was significantly associated with a lower clinical pregnancy rate (odds ratio [OR] 0.69; 95% confidence interval [CI] 0.51-0.94) and higher miscarriage rate (OR 2.17; 95% CI 1.25-3.79) after treatment with assisted reproductive technology (ART). The lower clinical pregnancy rate was more significant in the subgroup of patients with short down-regulation protocols. Similar associations were recorded after age adjustment. Adenomyosis was also significantly associated with an increased risk of pre-eclampsia, preterm delivery, Caesarean section, fetal malpresentation, small for gestational age infancy and post-partum haemorrhage, which was confirmed after correction for age and mode of conception. In conclusion, adenomyosis is associated with negative effects on fertility after ART. The potentially protective role of the ultra-long down-regulation protocols needs further evaluation in randomized controlled studies. Adenomyosis is also associated (independently of the mode of conception) with adverse pregnancy and neonatal outcomes. Proper counselling prior to ART and close monitoring of pregnancy in patients with adenomyosis should be recommended.

Published
2021
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11. Diagnosis of Endometriosis by Transvaginal Ultrasound: An Online Survey of Gynecologists Practising in Greece.

Author

Grigoriadis G, Roman H, Kalaitzopoulos DR, Christoforidis N, Pados G, and Daniilidis A

Abstract

Accurate diagnosis and assessment of endometriosis by transvaginal ultrasound scan (TVS) can be challenging. We performed an online survey of specialist gynecologists who perform TVS on a regular basis regarding their views as well as clinical experience on the use of TVS in the diagnosis of endometrioma and deep endometriosis (DE). We collected 64 responses. Sixty-one participants (95.31%) answered that they can confidently diagnose endometrioma by TVS "always" or "most of the time". With the exception of DE of the recto-vaginal septum/posterior vaginal vault, for all other DE locations, more than 50% of participants felt that they can "rarely" or "never" diagnose it by TVS in their own clinical practice. Forty-two participants (65.6%) stated that additional, specialized training is required for the diagnosis of endometrioma. When asked about a diagnosis of DE, 58 participants (90.6%) felt that the same is required. The only statistically significant association was between the number of TVSs performed per year and the clinician's ability to diagnose bowel DE in their practice. The answers to all other questions did not differ significantly based on professional status, years of experience post-residency, or number of TVSs per year. Our results demonstrate the delayed adoption of novel diagnostic approaches in endometriosis and confirm the urgent need for specialized ultrasound training., Competing Interests: The authors have declared financial relationships, which are detailed in the next section., (Copyright © 2023, Grigoriadis et al.)

Published
2023
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