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343 results on '"Kalff, Victor"'

5. Noninvasive Assessment of Acute Graft-Versus-Host Disease of the Gastrointestinal Tract After Allogeneic Hemopoietic Stem Cell Transplantation Using18F-FDG PET

Author

Cherk, Martin H., primary, Khor, Robert, additional, Barber, Thomas W., additional, Yap, Kenneth S.K., additional, Patil, Sushrut, additional, Walker, Patricia, additional, Avery, Sharon, additional, Roberts, Stuart, additional, Kemp, William, additional, Pham, Alan, additional, Bailey, Michael, additional, and Kalff, Victor, additional

Published
2022
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9. Head‐to‐head comparison of cerebral blood flow single‐photon emission computed tomography and18 F‐fluoro‐2‐deoxyglucose positron emission tomographyin the diagnosis of Alzheimer disease

Author

Nadebaum, David P., primary, Krishnadas, Natasha, additional, Poon, Aurora M. T., additional, Kalff, Victor, additional, Lichtenstein, Meir, additional, Villemagne, Victor L., additional, Jones, Gareth, additional, and Rowe, Christopher C., additional

Published
2021
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40. Positron emission tomography in pulmonary masses where tissue diagnosis is unhelpful or not possible

Author

Pitman, Alex G., Hicks, Rodney J., Kalff, Victor, Binns, David S., Ware, Robert E., McKenzie, Allan F., Ball, David L., and MacManus, Michael P.

Subjects
PET imaging -- Evaluation, Respiratory disease nursing -- Methods, Tomography -- Health aspects, Health
Abstract

An investigation is conducted into the usefulness of positron emission topography (PET) in the diagnosis of lung masses, where tissue diagnosis is not available or useful. It is seen that PET could be used to avoid pen biopsy and contributed to improvements in the management of patients.

Published
2001

41. F-18 fluorodeoxyglucose positron emission tomography staging in radical radiotherapy candidates with nonsmall cell lung carcinoma: powerful correlation with survival and high impact on treatment

Author

Manus, Michael P. Mac, Hicks, Rodney J., Ball, David L., Kalff, Victor, Matthews, Jane P., Salminen, Eeva, Khaw, Pearly, Wirth, Andrew, Rischin, Danny, and McKenzie, Alan

Subjects
Lung cancer, Non-small cell -- Radiotherapy, Tumor staging -- Methods, PET imaging -- Evaluation, Health
Published
2001

42. Utility of 68Ga‐DOTA‐Exendin‐4 positron emission tomography–computed tomography imaging in distinguishing between insulinoma and nesidioblastosis in patients with confirmed endogenous hyperinsulinaemic hypoglycaemia.

Author

Kalff, Victor, Iravani, Amir, Akhurst, Timothy, Pattison, David A., Eu, Peter, Hofman, Michael S., and Hicks, Rodney J.

Subjects
*ISLET cell tumor, *DIFFERENTIAL diagnosis, *RETROSPECTIVE studies, *PANCREATECTOMY, *HYPOGLYCEMIA, *ISLANDS of Langerhans tumors, *DESCRIPTIVE statistics, *EXENATIDE
Abstract

Background: Because management is very different, it is important to differentiate between small focal insulinomas and diffuse pancreatic dysplasia (nesidioblastosis) in patients with confirmed endogenous hyperinsulinaemic hypoglycaemia (EHH). Most insulinomas highly express glucagon‐like peptide‐1 receptors enabling positron emission tomography–computed tomography imaging with its radiolabelled analogue; 68Ga‐DOTA‐Exendin‐4 (Exendin). Aim: To determine: (i) the utility of Exendin in EHH patients in a clinical setting; and (ii) whether the degree of Exendin uptake differentiates non‐insulinoma pancreatogenous hypoglycaemia syndrome (NIPHS) from post‐gastric bypass hypoglycaemia (PGBH). Methods: This retrospective study reviewed the clinical, biochemistry and prior imaging findings in confirmed EHH patients referred for Exendin. Accuracy of Exendin was based on surgical findings and treatment outcomes. Finally, average Exendin uptake (SUVmax) of five PGBH studies was compared with the SUVmax of a key NIPHS case report. Results: Twenty of 25 consecutive patients had confirmed EHH. Exendin located insulinomas in eight of nine patients enabling successful surgical excision with rapid and durable cure. Exendin correctly identified diffuse nesidioblastosis in two of three cases requiring partial pancreatectomy for hypoglycaemia control. All three relapsed within 1.7 years with one needing completion pancreatectomy. Establishing the cause in the remainder relied on other investigations, clinical correlation and response to empirical treatment. Finally, Exendin SUVmax could not distinguish between NIPHS and PGBH. Conclusion: In EHH patients, Exendin accurately identifies the site of insulinoma and thereby differentiates it from nesidioblastosis but negative findings should not be ignored. Exendin is unlikely to differentiate between normal pancreatic uptake, NIPHS and PGBH. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Head‐to‐head comparison of cerebral blood flow single‐photon emission computed tomography and 18F‐fluoro‐2‐deoxyglucose positron emission tomography in the diagnosis of Alzheimer disease.

Author

Nadebaum, David P., Krishnadas, Natasha, Poon, Aurora M. T., Kalff, Victor, Lichtenstein, Meir, Villemagne, Victor L., Jones, Gareth, and Rowe, Christopher C.

Subjects
ALZHEIMER'S disease diagnosis, CONFIDENCE intervals, CEREBRAL circulation, MILD cognitive impairment, COMPARATIVE studies, SINGLE-photon emission computed tomography, RADIOPHARMACEUTICALS, DEMENTIA, DESCRIPTIVE statistics, DEOXY sugars, RECEIVER operating characteristic curves, CEREBRAL cortex
Abstract

Background: Clinical diagnosis of Alzheimer disease (AD) is only 70% accurate. Reduced cerebral blood flow (CBF) and metabolism in parieto‐temporal and posterior cingulate cortex may assist diagnosis. While widely accepted that 18F‐fluoro‐2‐deoxyglucose positron emission tomography (18F‐FDG PET) has superior accuracy to CBF‐SPECT for AD, there are very limited head‐to‐head data from clinically relevant populations and these studies relied on clinical diagnosis as the reference standard. Aims: To compare directly the accuracy of CBF‐SPECT and 18F‐FDG PET in patients referred for diagnostic studies in detecting β‐amyloid PET confirmed AD. Methods: A total of 126 patients, 56% with mild cognitive impairment and 44% with dementia, completed both CBF‐SPECT and 18F‐FDG PET as part of their diagnostic assessment, and subsequently underwent β‐amyloid PET for research purposes. Transaxial slices and Neurostat 3D‐SSP analyses of 18F‐FDG PET and CBF‐SPECT scans were independently reviewed by five nuclear medicine clinicians blinded to all other data. Operators selected the most likely diagnosis and their diagnostic confidence. Accuracy analysis used final diagnosis incorporating β‐amyloid PET as the reference standard. Results: Clinicians reported high diagnostic confidence in 83% of 18F‐FDG PET compared to 67% for CBF‐SPECT (P = 0.001). All reviewers showed individually higher accuracy using 18F‐FDG PET. Based on majority read, the combined area under the receiver operating characteristic curve in diagnosing AD was 0.71 for 18F‐FDG PET and 0.61 for CBF‐SPECT (P = 0.02). The sensitivity of 18F‐FDG PET and CBF‐SPECT was 76% versus 43% (P < 0.001), while specificity was 74% versus 83% (P = 0.45). Conclusions: 18F‐FDG PET is superior to CBF‐SPECT in detecting AD among patients referred for the assessment of cognitive impairment. [ABSTRACT FROM AUTHOR]

Published
2021
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44. Long-Term Follow-up and Outcomes of Retreatment in an Expanded 50-Patient Single-Center Phase II Prospective Trial of 177Lu-PSMA-617 Theranostics in Metastatic Castration-Resistant Prostate Cancer

Author

Violet, John, primary, Sandhu, Shahneen, additional, Iravani, Amir, additional, Ferdinandus, Justin, additional, Thang, Sue-Ping, additional, Kong, Grace, additional, Kumar, Aravind Ravi, additional, Akhurst, Tim, additional, Pattison, David, additional, Beaulieu, Alexis, additional, Mooi, Jennifer, additional, Tran, Ben, additional, Guo, Christina, additional, Kalff, Victor, additional, Murphy, Declan G, additional, Jackson, Price, additional, Eu, Peter, additional, Scalzo, Mark, additional, Williams, Scott, additional, Hicks, Rodney J., additional, and Hofman, Michael S., additional

Published
2019
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47. Validation of a new cardiac image fusion software for three-dimensional integration of myocardial perfusion SPECT and stand-alone 64-slice CT angiography

Author

Gaemperli, Oliver, Schepis, Tiziano, Kalff, Victor, Namdar, Mehdi, Valenta, Ines, Stefani, Laurent, Desbiolles, Lotus, Leschka, Sebastian, Husmann, Lars, Alkadhi, Hatem, Kaufmann, Philipp, Gaemperli, Oliver, Schepis, Tiziano, Kalff, Victor, Namdar, Mehdi, Valenta, Ines, Stefani, Laurent, Desbiolles, Lotus, Leschka, Sebastian, Husmann, Lars, Alkadhi, Hatem, and Kaufmann, Philipp

Abstract

Purpose: Combining the functional information of SPECT myocardial perfusion imaging (SPECT-MPI) and the morphological information of coronary CT angiography (CTA) may allow easier evaluation of the spatial relationship between coronary stenoses and perfusion defects. The aim of the present study was the validation of a novel software solution for three-dimensional (3D) image fusion of SPECT-MPI and CTA. Methods: SPECT-MPI with adenosine stress/rest 99mTc-tetrofosmin was fused with 64-slice CTA in 15 consecutive patients with a single perfusion defect and a single significant coronary artery stenosis (≥50% diameter stenosis). 3D fused SPECT/CT images were analysed by two independent observers with regard to superposition of the stenosed vessel onto the myocardial perfusion defect. Interobserver variability was assessed by recording the X, Y, Z coordinates for the origin of the stenosed coronary artery and the centre of the perfusion defect and measuring the distance between the two landmarks. Results: SPECT-MPI revealed a fixed defect in seven patients, a reversible defect in five patients and a mixed defect in three patients and CTA documented a significant stenosis in the respective subtending coronary artery. 3D fused SPECT/CT images showed a match of coronary lesion and perfusion defect in each patient and the fusion process took less than 15min. Interobserver variability was excellent for landmark detection (r = 1.00 and r = 0.99, p < 0.0001) and very good for the 3D distance between the two landmarks (r = 0.94, p < 0.001). Conclusion: 3D SPECT/CT image fusion is feasible, reproducible and allows correct superposition of SPECT segments onto cardiac CT anatomy

Published
2018

49. Long term follow-up and outcomes of re-treatment in an expanded 50 patient single-center phase II prospective trial of Lutetium-177 (177Lu) PSMA-617 theranostics in metastatic castrate-resistant prostate cancer.

Author

Violet, John, Sandhu, Shahneen, Iravani, Amir, Ferdinandus, Justin, Thang, Sue-Ping, Kong, Grace, Kumar, Aravind Ravi, Akhurst, Tim, Pattison, David, Beaulieu, Alexis, Mooi, Jennifer, Tran, Ben, Guo, Christina, Kalff, Victor, Murphy, Declan G, Jackson, Price, Eu, Peter, Scalzo, Mark, Williams, Scott, and Hicks, Rodney J.

Published
2019
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50. A prospective reassessment of the utility of the Wells score in identifying pulmonary embolism

Author

Yap, Kenneth S.K., Kalff, Victor, Turlakow, Alla, and Kelly, Michael J.

Subjects
Diagnostic imaging -- Evaluation, Pulmonary embolism -- Diagnosis, Health
Abstract

A study is done to evaluate whether a cumulative clinical risk score (Wells score) can optimize imaging strategies in patients with suspected pulmonary embolism (PE). Results show patients with Wells score of greater than 2 warrant imaging assessment for PE however further imaging will be problematic for scores with less than 2.

Published
2007

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