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19 results on '"Kalpakidou, Anastasia"'

7. Cerebellar Growth and Behavioural & Neuropsychological Outcome in Preterm Adolescents

Author

Parker, Jennifer, Mitchell, Ann, and Kalpakidou, Anastasia

Abstract

Adolescence is a time of social and cognitive development associated with changes in brain structure and function. These developmental changes may show an altered path in individuals born before 33 weeks' gestation (very preterm; VPT). The cerebellum is affected by VPT birth, but no studies have yet assessed the adolescent development of this structure, or whether developmental changes in cerebellar structure are associated with cognitive and behavioural outcome. We measured cerebellar volumes on structural magnetic resonance images in 65 adolescents who were born before 33 weeks' gestation (VPT) and 34 term-born adolescents (mean age VPT = 15.09, SD = 1.43/mean age term-born = 15.43, SD = 0.56) and again in adulthood (mean age VPT = 18.61, SD = 1.02/mean age term-born = 19.17, SD = 0.95). Participants also underwent neuropsychological tests; the Wechsler Abbreviated Scale of Intelligence and the Controlled Oral Word Association Test and completed the General Health Questionnaire-12. Repeated measures ANOVA showed a main effect of time-point (F = 4.59, df = 1, P = 0.035) and a time-point by group interaction (F = 8.03, df = 1, P = 0.006) on cerebellar growth. By adulthood, cerebellar volumes were 3.11% smaller in the preterm group than they had been in early adolescence (P = 0.000). Cerebellar volume did not change significantly in the control group (P = 0.612). There were significant negative correlations between change in cerebellar volume and GHQ-12 in the VPT group; total score (r = -0.324 P = 0.028) and several subscales; concentration (r = -0.378 P = 0.010), feeling useful (r = -0.311 P = 0.035), decision-making capability (r = -0.348 P = 0.018), overcoming difficulties (r = -0.331 P = 0.025), feeling confident (r = -0.309 P = 0.037) and feeling worthless (r = -0.329 P = 0.026). In the VPT group there were positive correlations between cerebellar volume and full-scale IQ (adolescence; r = 0.471, P = 0.002/adulthood; r = 0.309, P = 0.047), performance IQ (adolescence; r = 0.434, P = 0.004/adulthood; r = 0.345, P = 0.025) and verbal IQ (adolescence; r = 0.401, P = 0.008) which were not maintained after controlling for white matter volume. We have demonstrated a reduction in cerebellar volume between adolescence and young adulthood in VPT individuals, which is correlated with reduced self-reported well being.

Published
2008
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9. Study recruitment factors in advanced cancer: the Prognosis in Palliative care Study II (PiPS2) - a multicentre, prospective, observational cohort project

Author

Kalpakidou, Anastasia K, primary, Todd, Chris, additional, Omar, Rumana Z, additional, Keeley, Vaughan, additional, Griffiths, Jane, additional, Spencer, Karen, additional, Vickerstaff, Victoria, additional, Christidoulides, Karolina, additional, Perry, Rachel, additional, Katsampa, Dafni, additional, and Stone, Patrick, additional

Published
2021
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19. 26 The prognosis in palliative care ii (PIPS2): recruitment data collected during the first year of a multi-centre, prospective, observational cohort study

Author

Kalpakidou, Anastasia K, Todd, Chris, Omar, Rumana Z, Keeley, Vaughan, Griffiths, Jane, Vickerstaff, Victoria, and Stone, Patrick

Abstract

IntroductionMore accurate methods of prognostication are likely to lead to improvements in the quality of care of patients approaching the ends of their lives. The Prognosis in Palliative care Scales (PiPS) predict survival in terms of ‘days’, ‘weeks’ or ‘months’ and have been shown to perform as well as, or better than Clinician Estimates of Survival (CES).1Aimsa) To validate PiPS in a new cohort of patients and b) to evaluate the accuracy of other prognostic tools.2,3MethodsThis is a national, multi-centre, prospective, observational cohort study, aiming to recruit 1780 patients via palliative care services (PCS). Eligible patients have advanced, incurable cancer who have recently been referred to PCS. Patients with or without capacity are included in the study.The primary outcome is the accuracy of PiPS predictions and the difference in accuracy between these predictions and the CES. The secondary outcomes include the accuracy of predictions by the Palliative Prognostic Score, Palliative Prognostic Index, Palliative Performance Scale, and the Feliu Prognostic Nomogram compared with actual patient survival and CES.ResultsWithin 10 months of recruitment, 5699 patients were screened across 27 recruiting sites. Of those, 1608 were approached to participate in the study and 940 were recruited (812 patients with and 128 patients without capacity). Updated recruitment figures and a breakdown of the reasons for ineligibility, inability to approach patients and refusal to consent will be presented.ConclusionThis study demonstrates the feasibility of recruiting large numbers of participants to a prospective palliative care study.References. Gwilliam B, Keeley V, Todd C, Roberts C, Gittins M, Kelly L, Barclay S, Stone P. Prognosticating in patients with advanced cancer-observational study comparing the accuracy of clinicians’ and patients‘ estimates of survival. Ann Oncol2013;24(2):482–488available from: PM:23028038.. Kim ES, Lee JK, Kim MH, Noh HM, Jin YH.Validation of the prognosis in palliative care study predictor models in terminal cancer patients. Korean J Fam Med2014;35(6):283–294available from: PM:25426276. Stone PC, Lund S. Predicting prognosis in patients with advanced cancer. AnnOncol2007;18(6):971–976available from: PM:17043092

Published
2017
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