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Dynamic business environments can cause unexpected disruptions that can force firms to embrace new ways of working. In such situations, salesforce change agility can be a key to success. However, scant research has examined the factors that promote the development of change agility, or the consequences thereof. We address these notable omissions by using a sample of 237 B2B salespeople to explore the effect of idiosyncratic deals on work absorption, change agility, behavioral performance, and sales performance. The findings indicate that a salesperson's idiosyncratic work arrangements (i.e. Flexibility and Development Idiosyncratic Deals) enhance work absorption, which in turn increases salesperson change agility. Moreover, we find that while development idiosyncratic deals are positively related to change agility, flexibility idiosyncratic deals do not impact change agility. Finally, our analysis also shows that change agility is positively related to behavioral performance, with subsequent downstream effects on sales performance. Collectively, these findings offer a glimpse into the importance of agile behaviors as salespeople deal with the changes impacting the sales function. [ABSTRACT FROM AUTHOR]

BackgroundLiposomal drug packaging is well established as an effective means for increasing drug half-life, sustaining drug activity, and increasing drug efficacy, whether administered locally or distally to the site of disease. However, information regarding the relative effectiveness of peripheral (distal) versus local administration of liposomal therapeutics is limited. This issue is of importance with respect to the treatment of central nervous system cancer, for which the blood-brain barrier presents a significant challenge in achieving sufficient drug concentration in tumors to provide treatment benefit for patients.MethodsWe compared the anti-tumor activity and efficacy of a nanoliposomal formulation of irinotecan when delivered peripherally by vascular route with intratumoral administration by convection-enhanced delivery (CED) for treating intracranial glioblastoma xenografts in athymic mice.ResultsOur results show significantly greater anti-tumor activity and survival benefit from CED of nanoliposomal irinotecan. In 2 of 3 efficacy experiments, there were animal subjects that experienced apparent cure of tumor from local administration of therapy, as indicated by a lack of detectable intracranial tumor through bioluminescence imaging and histopathologic analysis. Results from investigating the effectiveness of combination therapy with nanoliposomal irinotecan plus radiation revealed that CED administration of irinotecan plus radiation conferred greater survival benefit than did irinotecan or radiation monotherapy and also when compared with radiation plus vascularly administered irinotecan.ConclusionsOur results indicate that liposomal formulation plus direct intratumoral administration of therapeutic are important for maximizing the anti-tumor effects of irinotecan and support clinical trial evaluation of this therapeutic plus route of administration combination.

While social media has become an integral part of modern‐day life, it is a largely overlooked topic in supply chain business‐to‐business setting. This study utilizes dyadic survey data collected from both supplier account managers and their customers to explore social media's impacts in the digitalized supply chain context. Drawing upon the knowledge‐based view of the firm, the study proposes and tests a conceptual model. Results indicate that supplier account manager's social media use can increase his or her product and competitor knowledge, which can positively influence customer outcome. Further, the moderation test suggests that when perceived customer demandingness is high, the relationship between social media use and knowledge will be stronger. This study draws much‐needed attention to social media as an emerging digital supply chain management too. [ABSTRACT FROM AUTHOR]

Grounded in social capital theory, this study explores the influence of intraorganizational social capital on frontline employees' (FLEs) competitive intelligence activities and the subsequent effects of engaging in competitive intelligence on their information communication behavior and relational customer outcomes. We empirically test the hypothesized relationships using multisource, multi-industry data collected from business-to-business (B2B) FLEs and their customers. The results indicate that bridging social capital directly relates to FLEs' competitive intelligence activities, while bonding social capital functions as a positive moderator of this relationship. Job autonomy also positively moderates the relationship between bridging social capital and competitive intelligence. Results further indicate that FLEs' competitive intelligence directly and positively relates to customers' perception of information communication, which positively influences customer loyalty and engagement behavior. These results indicate that the firms' cultivation of social capital can improve the capability of their FLEs to provide information-based service to industrial customers. [ABSTRACT FROM AUTHOR]