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11 results on '"Kaltenbach, Tanja"'

1. Fettleber und Cholezystopathie

Author

Kaltenbach, Tanja, Kratzer, Wolfgang, Wabitsch, Martin, editor, Hebebrand, Johannes, editor, Kiess, Wieland, editor, Reinehr, Thomas, editor, and Wiegand, Susanna, editor

Published
2022
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5. Albendazole increases the inflammatory response and the amount of Em2-positive small particles of Echinococcus multilocularis (spems) in human hepatic alveolar echinococcosis lesions

Author

Ricken, Franz J., primary, Nell, Juliane, additional, Grüner, Beate, additional, Schmidberger, Julian, additional, Kaltenbach, Tanja, additional, Kratzer, Wolfgang, additional, Hillenbrand, Andreas, additional, Henne-Bruns, Doris, additional, Deplazes, Peter, additional, Moller, Peter, additional, Kern, Peter, additional, and Barth, Thomas F. E., additional

Published
2017
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6. Albendazole increases the inflammatory response and the amount of Em2-positive small particles of Echinococcus multilocularis (spems) in human hepatic alveolar echinococcosis lesions

Author

Ricken, Franz J, Nell, Juliane, Grüner, Beate, Schmidberger, Julian, Kaltenbach, Tanja, Kratzer, Wolfgang, Hillenbrand, Andreas, Henne-Bruns, Doris, Deplazes, Peter, Moller, Peter, Kern, Peter, Barth, Thomas F E; https://orcid.org/0000-0002-3379-6311, Ricken, Franz J, Nell, Juliane, Grüner, Beate, Schmidberger, Julian, Kaltenbach, Tanja, Kratzer, Wolfgang, Hillenbrand, Andreas, Henne-Bruns, Doris, Deplazes, Peter, Moller, Peter, Kern, Peter, and Barth, Thomas F E; https://orcid.org/0000-0002-3379-6311

Abstract

BACKGROUND: Alveolar echinococcosis (AE) is caused by the metacestode stage of Echinococcus multilocularis. The inflammatory response to this infection is influenced by the interaction of the parasite with the host. We aimed to analyze human liver lesions infected with Echinococcus multilocularis and the changes of the cellular infiltrates during albendazole (ABZ) treatment. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed liver tissue samples from 8 untreated patients, 5 patients treated with two daily doses of 400 mg ABZ for up to two months and 7 patients treated for more than two months with the same ABZ therapy. A broad panel of monoclonal antibodies was used to characterize the lesion by immunohistochemistry. A change in the cellular infiltrate was observed between the different chemotherapy times. During the initial phases of treatment an increase in CD15+ granulocytes and CD68+ histocytes as well as in small particles of Echinococcus multilocularis (spems) was observed in the tissue surrounding the metacestode. Furthermore, we observed an increase in CD4+ T cells, CD20+ B cells and CD38+ plasma cells during a longer duration of treatment. CONCLUSIONS/SIGNIFICANCE: ABZ treatment of AE leads to morphological changes characterized by an initial, predominantly acute, inflammatory response which is gradually replaced by a response of the adaptive immune system.

Published
2017

7. Vergleich von Kontrastmittelsonographie (SonoVue®) und weiteren Ultraschallmodalitäten (B-Bild, Dopplersonografie, Acoustic Structure Quantification) mit F-18-FDG-PET-CT bei Patienten mit alveolärer Echinokokkose

Author

Kaltenbach, Tanja Eva-Maria

Subjects
Kontrastultraschall, ASQ, Alveoläre Echinokokkose, Echinococcosis, hepatic, ddc:610, Ultraschall, FDG-PET-CT, DDC 610 / Medicine & health, Ultrasonography
Abstract

Objective of our study is qualitative and quantitative comparison of contrast enhanced ultrasound (CEUS) and F-18-FDG-PET-CT examination in the follow-up of hepatic alveolar echinococcosis (HAE). Parasitic lesions are to be examined regarding number, size, morphology, calcification, vascularization (CEUS) and metabolic activity (F-18-FDG-PET-CT). We aim to answer the question whether delineation and measurement of liver lesions in HAE can be improved by ASQ and we want to explore how ASQ parameters in HAE lesions develop. 36 patients with proven, medically-treated HAE have been included in this study. Abdominal ultrasound, ASQ and CEUS have been carried out. As part of the monitoring, patients were examined by F-18 FDG PET-CT. F-18-FDG uptake in parasitic lesions has been diagnosed by F-18-FDG-PET-CT in 32 of 36 patients. Vascularization of liver lesions has been detected by CEUS in 22 of 32 FDG-positive patients with sensitivity of 69 % and specificity of 100 %. Mean maximum diameter of the lesions was 69.5 mm in CEUS and 63.7mm in B-scan ultrasound. Parasitic tumors appearvmore prominent in color-coded ASQ imaging, but size of lesions measured in ASQ mode does not differ from size measurements in B-mode. Statistical comparison of ASQ parameters shows significant results. Compared with F-18 FDG PET-CT as a gold standard in determining metabolic activities of liver lesions in HAE, CEUS represents vascularization of active lesions with high specificity and sensitivity. The dimensions of parasitic lesions are displayed more precisely through CEUS than in B-scan. ASQ is a promising sonographic method for examination and quantification of structural changes of liver parenchyma in HAE lesions.

Published
2015
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10. Correction to: Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century.

Author

Baumann, Sven, Shi, Rong, Liu, Wenya, Bao, Haihua, Schmidberger, Julian, Kratzer, Wolfgang, Li, Weixia, the interdisciplinary Echinococcosis Working Group Ulm, Barth, Thomas F. E., Bloehdorn, Johannes, Fischer, Iris, Graeter, Tilmann, Graf, Natalja, Gruener, Beate, Henne-Bruns, Doris, Hillenbrand, Andreas, Kaltenbach, Tanja, Kern, Peter, Kern, Petra, and Klein, Katharina

Abstract

A correction for the article "Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty‑first century" is presented, which is published in the October 11, 2021 issue of the periodical.

Published
2022
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11. Proposal of an ultrasonographic classification for hepatic alveolar echinococcosis: Echinococcosis multilocularis Ulm classification-ultrasound.

Author

Kratzer W, Gruener B, Kaltenbach TE, Ansari-Bitzenberger S, Kern P, Fuchs M, Mason RA, Barth TF, Haenle MM, Hillenbrand A, Oeztuerk S, and Graeter T

Subjects
Adult, Aged, Animals, Echinococcosis, Hepatic classification, Echinococcosis, Hepatic parasitology, Female, Humans, Liver parasitology, Male, Middle Aged, Predictive Value of Tests, Prognosis, Retrospective Studies, Echinococcosis, Hepatic diagnostic imaging, Echinococcus multilocularis isolation & purification, Liver diagnostic imaging, Terminology as Topic, Ultrasonography, Doppler, Color
Abstract

Aim: To establish an ultrasonographic classification based on a large sample of patients with confirmed hepatic alveolar echinococcosis (AE)., Methods: Clinical data and ultrasonography (US) findings of 185 patients (100 males; 85 females; mean age at diagnosis: 51.4 ± 17.6 years; mean age at time of US examination: 58.7 ± 18.2 years) were retrospectively reviewed with respect to the US morphology of hepatic AE lesions. The sonomorphological findings were grouped according to a five-part classification scheme., Results: Application of the new classification resulted in the following distribution of sonomorphological patterns among the patients examined: hailstorm (54.1%); pseudocystic (13.5%); ossification (13.0%); hemangioma-like (8.1%); and metastasis-like (6.5%). Only 4.9% of lesions could not be assigned to a sonomorphological pattern., Conclusion: The sonomorphological classification proposed in the present study facilitates the diagnosis, interpretation and comparison of hepatic alveolar echinococcosis in routine practice and in the context of scientific studies.

Published
2015
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