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1. Fosinopril/hydrochlorothiazide: single dose and steady-state pharmacokinetics and pharmacodynamics

Author

Kan-Fat Yee, Padraig O’Grady, Robert Lins, and Bernhard Mangold

Subjects
Pharmacology, medicine.medical_specialty, biology, business.industry, Kidney metabolism, Angiotensin-converting enzyme, Hydrochlorothiazide, Endocrinology, Pharmacokinetics, Internal medicine, Fosinopril, Pharmacodynamics, ACE inhibitor, Fosinoprilat, biology.protein, Medicine, Pharmacology (medical), business, medicine.drug
Abstract

Aims Fosinoprilat, the active product of fosinopril, is eliminated by an hepatic pathway in addition to the renal pathway shared by other angiotensin converting enzyme inhibitors (ACEIs). This study aimed to determine whether impaired renal function affects the pharmacokinetics and pharmacodynamics of a combination of fosinopril and hydrochlorothiazide (HCTZ).

Published
1999
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