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18 results on '"Kanasaki, Ryuichi"'

3. Identification of ten KB425796-A congeners from Paenibacillus sp. 530603 using an antifungal assay against Aspergillus fumigatus in combination with micafungin

Author

Kai, Hirohito, primary, Yamashita, Midori, additional, Takase, Shigehiro, additional, Hashimoto, Michizane, additional, Muramatsu, Hideyuki, additional, Nakamura, Ikuko, additional, Yoshikawa, Koji, additional, Kanasaki, Ryuichi, additional, Ezaki, Masami, additional, Nitta, Kumiko, additional, Watanabe, Masato, additional, Inamura, Noriaki, additional, and Fujie, Akihiko, additional

Published
2013
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4. Anti-herpes virus activity of polyether antibiotic CP-44161 in vivo

Author

Yamagishi, Yukiko, primary, Ueno, Motoi, additional, Ueno, Chihoko, additional, Kato, Akemi, additional, Kanasaki, Ryuichi, additional, Sato, Bunji, additional, Takakura, Koji, additional, Fujie, Akihiko, additional, Nakajima, Hidenori, additional, Fujii, Takashi, additional, Hino, Motohiro, additional, and Tsujii, Eisaku, additional

Published
2009
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7. FR209602 and Related Compounds, Novel Antifungal Lipopeptides from Coleophoma crateriformis No. 738. Part 1. Taxonomy, Fermentation, Isolation and Physico‐Chemical Properties.

Author

Kanasaki, Ryuichi, primary, Sakamoto, Kazutoshi, additional, Hashimoto, Michizane, additional, Takase, Shigehiro, additional, Tsurumi, Yasuhisa, additional, Fujie, Akihiko, additional, Hino, Motohiro, additional, Hashimoto, Seiji, additional, and Hori, Yasuhiro, additional

Published
2006
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15. FR207944, an Antifungal Antibiotic from Chaetomium sp. No. 217 I. Taxonomy, Fermentation, and Biological Properties.

Author

Kobayashi, Motoo, Kanasaki, Ryuichi, Sato, Ikuko, Abe, Fumie, Nitta, Kumiko, Ezaki, Masami, Sakamoto, Kazutoshi, Hashimoto, Michizane, Fujie, Akihiko, Hino, Motohiro, and Hori, Yasuhiro

Subjects
*ANTIBIOTICS, *ANTIFUNGAL agents, *CHAETOMIUM, *FERMENTATION, *ENZYME inhibitors, *BIOLOGICAL classification, *ASPERGILLUS fumigatus
Abstract

Describes the taxonomy and fermentation and discusses the biological properties of FR207944, an antifungal antibiotic from Chaetomium sp. No. 217, compared with those of FR901379, a known 1,3-β-glucan synthase inhibitor, and FR901469. Cultural characteristics on various agar media; Fermentation; In vitro antifungal activity; In vivo antifungal activities of FR207944 against Aspergillus fumigatus in murine infection models.

Published
2005
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16. FR207944, an Antifungal Antibiotic from Chaetomiumsp. No. 217 I. Taxonomy, Fermentation, and Biological Properties

Author

KOBAYASHI, Motoo, KANASAKI, Ryuichi, SATO, Ikuko, ABE, Fumie, NITTA, Kumiko, EZAKI, Masami, SAKAMOTO, Kazutoshi, HASHIMOTO, Michizane, FUJIE, Akihiko, HINO, Motohiro, and HORI, Yasuhiro

Abstract

An antifungal antibiotic, FR207944, was isolated from the culture broth of a fungal strain Chaetomiumsp. no. 217. FR207944 is a triterpene glucoside with antifungal activity against Aspergillus fumigatusand Candida albicans. Specifically, FR207944 exhibits in vitroand in vivoantifungal activity against A. fumigatus. The effects of FR207944 on the morphology of A. fumigatuswere shown to be similar to those of FR901379, a known 1,3-β-glucan synthase inhibitor. The MECs of FR207944 against A. fumigatusFP1305 and C. albicansFP633 in micro-broth dilution test were 0.039 and 1.6 μg/ml respectively. FR207944 showed good potency by subcutaneous injection and oral administration against A. fumigatusin a murine systemic infection model, with ED50s of 5.7 and 17 mg/kg respectively.

Published
2005
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17. FR209602 and related compounds, novel antifungal lipopeptides from Coleophoma crateriformis no.738. I. Taxonomy, fermentation, isolation and physico-chemical properties.

Author

Kanasaki R, Sakamoto K, Hashimoto M, Takase S, Tsurumi Y, Fujie A, Hino M, Hashimoto S, and Hori Y

Subjects
Antifungal Agents chemistry, Fungi metabolism, Lipopeptides, Lipoproteins chemistry, Peptides, Cyclic chemistry, Antifungal Agents isolation & purification, Fermentation, Fungi classification, Lipoproteins isolation & purification, Peptides, Cyclic isolation & purification
Abstract

Novel antifungal lipopeptides, FR209602, FR209603 and FR209604, were isolated from the fermentation broth of a fungal strain No. 738 which was identified as Coleophoma crateriformis from morphological and physiological characteristics. The antibiotics were purified by solvent extraction, HP-20, YMC-ODS and silica gel column chromatography and lyophilization. These compounds were structurally similar to FR901379 previously reported by ourselves which had a sulfate residue in the cyclic peptide portion.

Published
2006
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18. FR227244, a novel antifungal antibiotic from Myrothecium cinctum No. 002 Taxonomy, fermentation, isolation and physico-chemical properties.

Author

Kobayashi M, Kanasaki R, Ezaki M, Sakamoto K, Takase S, Fujie A, Hino M, and Hori Y

Subjects
Antifungal Agents administration & dosage, Ascomycota classification, Ascomycota ultrastructure, Aspergillus fumigatus drug effects, Chromatography, Gel, Microbial Sensitivity Tests, Microscopy, Microscopy, Electron, Antifungal Agents pharmacology, Ascomycota chemistry, Glycosides chemistry, Glycosides isolation & purification, Glycosides pharmacology, Triterpenes chemistry, Triterpenes isolation & purification, Triterpenes pharmacology
Abstract

A novel antifungal antibiotic, FR227244, was isolated from the culture broth of a fungal strain No. 002. The strain was identified as Myrothecium cinctum from morphological and physiological characteristics. This compound was isolated from the culture broth by solvent extraction, HP-20 and YMC ODS gel column chromatographies, and n-hexane precipitation. FR227244 is a white powder which melts at 210 to approximately 211 degrees C and possesses the molecular formula C38H58O11. FR227244 is a novel triterpene glycoside with antifungal activity against Aspergillus fumigatus. The effects of FR227244 on the morphology of A. fumigatus were shown to be similar to those of FR901379 which is a known 1,3-beta-glucan synthase inhibitor.

Published
2004
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