Search

Cancer is one of the most dreaded diseases of the 20th century and spreading further with continuance and increasing incidence in the 21st century. The situation is so alarming that every fourth person is having a lifetime risk of cancer. India registers more than 11 lakh new cases of cancer Every year, whereas, this figure is above 14 million worldwide. Is cancer curable? The short answer to this question is “Yes.” In fact, all cancers Are curable if they are caught early enough. Cancer cells continue to grow unless one of four things occur: (1) The cancerous mass is removed Surgically; (2) using chemotherapy or another type of cancer‑specific medication, such as hormonal therapy; (3) using radiation therapy; (4) The Cancer cells shrink and disappear on their own.

The present investigation entitled, “Effect of Organic and Inorganic Fertilizer on Vegetative Growth Parameter of Lilium (Lilium Longiflorum) cv. Pavia Under Shade Net Condition” was under taken in the Department of Horticulture, Naini Agricultural Institute, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, (Allahabad). During winter season of 2020-2021, 2021-2022 and Pooled. The experiment was layout in Randomized Block Design (RBD) with 13 treatments and each treatment replicated thrice. The treatments consist of different combinations of inorganic fertilizers (N, P and K) and organic fertilizers (FYM, Vermicompost and Poultry Manure) and control (No fertilizers and manures). The treatment T5 50% RDF + FYM 14 t ha-1 was found the statistically significant compared to other treatment combination, which recorded highest plant height (23.68, 57.11 and 76.41 cm), spread area (8.19 cm2, 15.54 cm2 and 18.47 cm2), Number of leaves (36.63, 57.11 and 76.41), Leaf area (15.03 cm2, 15.63 cm2 and 15.33 cm2), Chlorophyll content (66.11 mg, 65.60 mg and 65.86 mg), followed by T9 25% RDF + Vermicompost 6.9 t ha-1 and lowest yield was obtained from T0 (control).

Epigenetics play important roles during development progress of tumor. The histone modifications are the most important constitutedfield. Recently, accumulating research focused on exploring the roles of those modifications in regulating tumorigenesis. Moreover, the dysregulation of histone modifications is supposed to have vital clinical significance. Numerous histone modifications have the potential to be prognostic biomarkers, monitoring response of therapy, early diagnostic markers. Herein, we review the recent advances of histone modifications involving development of gastric cancer.Gastric cancer (GC) is one of the most frequent tumors in the world. Stomach adenocarcinoma is a heterogeneous tumor, turning the prognosisprediction and patients’ clinical management difficult. Some diagnosis tests for GC are been development using knowledge based in polymorphisms, somatic copy number alteration (SCNA) and aberrant histone methylation. This last event, a posttranslational modification that occurs at the chromatin level, is an important epigenetic alteration seen in several tumors including stomach adenocarcinoma. Histone methyltransferases (HMT) are the proteins responsible for the methylation in specific amino acids residues of histones tails. Here, were presented several HMTs that could be relating to GC process.

The experiment was performed at Maharajpur Farm under the Department of Horticulture, College of Agriculture, J.N.K.V.V., Jabalpur (M.P.) during the Kharif season 2019-2022 and planted in Randomized Complete Block Design (RCBD) with three replications. The characterization of thirty genotype for thirty-five qualitative traits articulated no variability for trait i.e., the monomorphic trait was non-enveloping fruit calyx cover, two descriptors were found to be moderately diverse, which were with medium fruit intensity of the red colour (at the mature unripe stage) and the narrow triangular shape of fruit with the Shannon-Weaver diversity index H'=0.46 & H'=0.50, both of these are fruit related traits. The descriptor intensity of pubescence (hairiness) of the stem had the highest diversity index of 1.82. The studies highlighted some of the genotypes with the distinctness, MPKC-1(Katni collection) addressed unique features with green with purple tinge leaf colour, purple petal colour, upright fruit orientation, absence of fruit curvature, purple fruit colour at ripening maturity, ovate leaf and erect plant habit, depicting it like a wild relative of capsicum and could be utilized as the morphological descriptor.

Aim of the study was to compare the surgical outcome of endoscopic with microscopic Type 1 tympanoplasty in dry, mucosal type of chronic otitis media with respect to graft uptake rate, hearing gain and duration of surgery. This randomized controlled trial of 3 years was carried out at Tertiary Care Hospital of Central India. Total 80 cases of mucosal type of chronic otitis media posted for Type I tympanoplasty were included in the study. They were randomly divided into two groups viz. Endoscopic tympanoplasty and microscopic tympanoplasty with 40 patients in each group. Chi–square test was used to compare the qualitative results and student’s t–test was used to compare quantitative results with a level of significance of p ≤ 0.05. Intraoperatively, widening of external auditory canal and auxiliary incision were required in 45% and 47.5% patients of microscopic group respectively. Mean operative time for endoscopic tympanoplasty (62.5 ±14.94 mins) was less as compared to microscopic tympanoplasty (74.88 ± 15.83 mins). Graft uptake rate was 95% and 92.5% in endoscopic and microscopic tympanoplasty groups respectively with statistically insignificant difference (p = 0.32). The preoperative mean air bone gap in both the groups was improved significantly 6 months postoperatively. Air bone gap closure was of 13.21± 4.37 dB in endoscopic group and 12.54 ± 4.14 dB in microscopic group with statistically insignificant difference. Endoscope provides superior visualization of hidden areas of middle ear cavity and has shorter operative time than microscopic tympanoplasty with comparable surgical and functional outcomes. hence endoscopic tympanoplasty can be a good option to microscopic surgery.

Introduction Hoarseness is a symptom with a varied etiology ranging from inflammatory condition, benign lesions to malignant lesions. Benign conditions are more common than malignant. Proper knowledge of clinical profile and evaluation is necessary to treat the cause. Objective It was conducted with the aim to study the clinical profile of patients with hoarseness of voice. Materials and Methods It was a descriptive cross-sectional study of 2 years conducted at Department of ENT at Tertiary Health Care Hospital, India. Patients aged above 10 years presenting with hoarseness of voice were included in the study. After detailed history related to sociodemographic particulars, clinical examinations including Hopkin’s rod examination in all patients and direct laryngoscopy, and radiological and histopathological examination were performed whenever indicated. Results Out of total 100 patients, maximum patients (32%) were in the age group of 21 to 30 years. There was slight male preponderance with male:female ratio of 1.17:1. Laborer (29%) was the major group affected in terms of occupation. Most common predisposing factor was smoking (35%). Commonest etiology for hoarseness of voice was chronic laryngitis (20%). Conclusion Hoarseness of voice as a symptom should never be ignored as its etiology may range from simple infection to malignancy. At our tertiary care center majority of patients come from rural area. Most of the etiological factors found in our study were treatable medically or surgically. Early diagnosis is the key to improve the outcome of treatment.