Search

Your search keyword '"Kandel, Christopher E."' showing total 16 results
Start Over Author "Kandel, Christopher E."
16 results on '"Kandel, Christopher E."'

4. Similar duration of viral shedding of the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) delta variant between vaccinated and incompletely vaccinated individuals

Author

Kandel, Christopher E., primary, Banete, Andra, additional, Taylor, Maureen, additional, Llanes, Andrea, additional, McCready, Janine, additional, Crowl, Gloria, additional, Young, Matthew, additional, Li, Angel X., additional, Chien, Emily, additional, Yim, Winfield, additional, Yip, Lily, additional, Kozak, Robert, additional, McGeer, Allison J., additional, Mubareka, Samira, additional, and Powis, Jeff E., additional

Published
2022
Full Text
View/download PDF

5. Sensitivity of Nasopharyngeal Swabs and Saliva for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2

Author

Jamal, Alainna J, Mozafarihashjin, Mohammad, Coomes, Eric, Powis, Jeff, Li, Angel X, Paterson, Aimee, Anceva-Sami, Sofia, Barati, Shiva, Crowl, Gloria, Faheem, Amna, Farooqi, Lubna, Khan, Saman, Prost, Karren, Poutanen, Susan, Taylor, Maureen, Yip, Lily, Zhong, Xi Zoe, McGeer, Allison J, Mubareka, Samira, Coleman, Brenda L, Chen, Danny, Farshait, Nataly, Gold, Wayne, Kandel, Christopher E, Katz, Kevin, Kozak, Robert, Mazzulli, Tony, Muller, Matthew, Opavsky, Anne, Ostrowski, Mario, Plevneshi, Agron, Rau, Neil, Ricciuto, Daniel, Richardson, David, Rose, David, Sales, Valerie, and Walmsley, Sharon

Subjects
0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Saliva, Canada, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 030106 microbiology, Saliva sample, medicine.disease_cause, Real-Time Polymerase Chain Reaction, Gastroenterology, law.invention, 03 medical and health sciences, 0302 clinical medicine, stomatognathic system, law, Internal medicine, Nasopharynx, medicine, Humans, 030212 general & internal medicine, Polymerase chain reaction, Coronavirus, saliva, business.industry, SARS-CoV-2, Brief Report, COVID-19, nasopharyngeal swab, Reverse transcriptase, 3. Good health, Real-time polymerase chain reaction, Infectious Diseases, AcademicSubjects/MED00290, business
Abstract

We enrolled 91 consecutive inpatients with COVID-19 at 6 hospitals in Toronto, Canada, and tested 1 nasopharyngeal swab/saliva sample pair from each patient using real-time RT-PCR for severe acute respiratory syndrome coronavirus 2. Sensitivity was 89% for nasopharyngeal swabs and 72% for saliva (P = .02). Difference in sensitivity was greatest for sample pairs collected later in illness.

Published
2020

7. Detection of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in outpatients: A multicenter comparison of self-collected saline gargle, oral swab, and combined oral–anterior nasal swab to a provider collected nasopharyngeal swab

Author

Kandel, Christopher E., primary, Young, Matthew, additional, Serbanescu, Mihaela Anca, additional, Powis, Jeff E., additional, Bulir, David, additional, Callahan, James, additional, Katz, Kevin, additional, McCready, Janine, additional, Racher, Hilary, additional, Sheldrake, Elena, additional, Quon, Dorothy, additional, Vojdani, Omid Kyle, additional, McGeer, Allison, additional, Goneau, Lee W., additional, and Vermeiren, Christie, additional

Published
2021
Full Text
View/download PDF

9. Similar duration of viral shedding of the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) delta variant between vaccinated and incompletely vaccinated individuals

Author

Kandel, Christopher E., Banete, Andra, Taylor, Maureen, Llanes, Andrea, McCready, Janine, Crowl, Gloria, Young, Matthew, Li, Angel X., Chien, Emily, Yim, Winfield, Yip, Lily, Kozak, Robert, McGeer, Allison J., Mubareka, Samira, and Powis, Jeff E.

Abstract

AbstractAmong outpatients with coronavirus disease 2019 (COVID-19) due to the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) δ (delta) variant who did and did not receive 2 vaccine doses at 7 days after symptom onset, there was no difference in viral shedding (cycle threshold difference 0.59, 95% CI, −4.68 to 3.50; P= .77) with SARS-CoV-2 cultured from 2 (7%) of 28 and 1 (4%) of 26 outpatients, respectively.

Published
2023
Full Text
View/download PDF

10. Predictors of Treatment Failure for Hip and Knee Prosthetic Joint Infections in the Setting of 1- and 2-Stage Exchange Arthroplasty: A Multicenter Retrospective Cohort

Author

Kandel, Christopher E, primary, Jenkinson, Richard, additional, Daneman, Nick, additional, Backstein, David, additional, Hansen, Bettina E, additional, Muller, Matthew P, additional, Katz, Kevin C, additional, Widdifield, Jessica, additional, Bogoch, Earl, additional, Ward, Sarah, additional, Sajja, Abhilash, additional, Jeldes, Felipe Garcia, additional, and McGeer, Allison, additional

Published
2019
Full Text
View/download PDF

11. Identification of prosthetic hip and knee joint infections using administrative databases—A validation study

Author

Kandel, Christopher E., Jenkinson, Richard, Widdifield, Jessica, Hansen, Bettina E., Davey, J. Roderick, Muller, Matthew P., Daneman, Nick, and McGeer, Allison

Abstract

AbstractObjective:To determine whether combinations of diagnosis and procedures codes can improve the detection of prosthetic hip and knee joint infections from administrative databases.Design:We performed a validation study of all readmissions from January 1, 2010, until December 31, 2016, following primary arthroplasty comparing the diagnosis and procedure codes obtained from an administrative database based upon the International Classification of Disease, Tenth Revision(ICD-10) to the reference standard of chart review.Setting:Four tertiary-care hospitals in Toronto, Canada, from 2010 to 2016.Participants:Individuals who had a primary arthroplasty were identified using procedure codes.Intervention:Chart review of readmissions identified the presence of a prosthetic joint infection and, if present, the surgical procedure performed.Results:Overall, 27,802 primary arthroplasties were performed. Among 8,844 readmissions over a median follow-up of 669 days (interquartile range, 256–1,249 days), a PJI was responsible for or present in 586 of 8,844 (6.6%). Diagnosis codes alone exhibited a sensitivity of 0.88 (95% CI, 0.85–0.92) and positive predictive value (PPV) of 0.78 (95% CI, 0.74–0.82) for detecting a PJI. Combining a PJI diagnosis code with procedure codes for an arthroplasty and the insertion of a peripherally inserted central catheter improved detection: sensitivity was 0.92 (95% CI, 0.88–0.94) and PPV was 0.78 (95% CI, 0.74–0.82). However, procedure codes were unable to identify the specific surgical approach to PJI treatment.Conclusions:Compared to PJI diagnosis codes, combinations of diagnosis and procedure codes improve the detection of a PJI in administrative databases.

Published
2021
Full Text
View/download PDF

13. Sensitivity of midturbinate versus nasopharyngeal swabs for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Author

Jamal, Alainna J., Mozafarihashjin, Mohammad, Coomes, Eric, Anceva-Sami, Sofia, Barati, Shiva, Crowl, Gloria, Faheem, Amna, Farooqi, Lubna, Kandel, Christopher E., Khan, Saman, Li, Angel X., Mistry, Henna, Paterson, Aimee, Plenderleith, Simon, Prost, Karren, Poutanen, Susan, Powis, Jeff, Schryer, Renée, Taylor, Maureen, Yip, Lily, Zhong, Xi Zoe, McGeer, Allison J., and Mubareka, Samira

Abstract

AbstractTo compare sensitivity of specimens for COVID-19 diagnosis, we tested 151 nasopharyngeal/midturbinate swab pairs from 117 COVID-19 inpatients using reverse-transcriptase polymerase chain reaction (RT-PCR). Sensitivity was 94% for nasopharyngeal and 75% for midturbinate swabs (P= .0001). In 88 nasopharyngeal/midturbinate pairs with matched saliva, sensitivity was 86% for nasopharyngeal swabs and 88% for combined midturbinate swabs/saliva.

Published
2021
Full Text
View/download PDF

16. Elevator buttons as unrecognized sources of bacterial colonization in hospitals.

Author

Kandel CE, Simor AE, and Redelmeier DA

Subjects
Humans, Ontario, Bacteria isolation & purification, Cross Infection etiology, Disease Transmission, Infectious, Elevators and Escalators, Equipment Contamination statistics & numerical data, Hospitals, Urban
Abstract

Background: Elevators are ubiquitous and active inside hospitals, potentially facilitating bacterial transmission. The objective of this study was to estimate the prevalence of bacterial colonization on elevator buttons in large urban teaching hospitals., Methods: A total of 120 elevator buttons and 96 toilet surfaces were swabbed over separate intervals at 3 tertiary care hospitals on weekdays and weekends in Toronto, Ontario. For the elevators, swabs were taken from 2 interior buttons (buttons for the ground floor and one randomly selected upper-level floor) and 2 exterior buttons (the "up" button from the ground floor and the "down" button from the upper-level floor). For the toilet surfaces, swabs were taken from the exterior and interior handles of the entry door, the privacy latch, and the toilet flusher. Samples were obtained using standard bacterial collection techniques, followed by plating, culture, and species identification by a technician blind to sample source., Results: The prevalence of colonization of elevator buttons was 61% (95% confidence interval 52%-70%). No significant differences in colonization prevalence were apparent in relation to location of the buttons, day of the week, or panel position within the elevator. Coagulase-negative staphylococci were the most common organisms cultured, whereas Enterococcus and Pseudomonas species were infrequent. Elevator buttons had a higher prevalence of colonization than toilet surfaces (61% v. 43%, p = 0.008)., Conclusions: Hospital elevator buttons were commonly colonized by bacteria, although most pathogens were not clinically relevant. The risk of pathogen transmission might be reduced by simple countermeasures.

Published
2014

Catalog

Books, media, physical & digital resources
See catalog results