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10 results on '"Kanehara, Keigo"'

6. Abstract 25: Identifying new inhibitors of ABCG2 by high-throughput screening

Author

Kokubo, Shoji, primary, Ohnuma, Shinobu, additional, Karasawa, Hideaki, additional, Yamamura, Akihiro, additional, Suzuki, Hideyuki, additional, Murakami, Megumi, additional, Sugisawa, Norihiko, additional, Kanehara, Keigo, additional, Sato, Keisuke, additional, Ishida, Takanori, additional, Kamei, Takashi, additional, Naitoh, Takeshi, additional, and Unno, Michiaki, additional

Published
2019
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8. Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance–Linked ATP-Binding Cassette Transporter ABCG2

Author

Murakami, Megumi, primary, Ohnuma, Shinobu, additional, Fukuda, Michihiro, additional, Chufan, Eduardo E., additional, Kudoh, Katsuyoshi, additional, Kanehara, Keigo, additional, Sugisawa, Norihiko, additional, Ishida, Masaharu, additional, Naitoh, Takeshi, additional, Shibata, Hiroyuki, additional, Iwabuchi, Yoshiharu, additional, Ambudkar, Suresh V., additional, and Unno, Michiaki, additional

Published
2017
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10. [Two Cases of Locally Recurrent Rectal Cancer Successfully Treated by Carbon Ion Radiotherapy].

Author

Kanehara K, Ohnuma S, Suzuki H, Yamamura A, Karasawa H, Kohyama A, Aoki T, Watanabe K, Tanaka N, Musha H, Motoi F, Kamei T, Naitoh T, and Unno M

Subjects
Chemoradiotherapy, Female, Humans, Middle Aged, Neoplasm Recurrence, Local, Positron Emission Tomography Computed Tomography, Heavy Ion Radiotherapy, Rectal Neoplasms diagnostic imaging, Rectal Neoplasms radiotherapy
Abstract

Case 1: A female patient in her 60s underwent laparoscopic intersphincteric resection for rectal cancer. After 42 months, the serum level of carcinoembryonic antigen(CEA)was elevated, and PET-CT showed a locally recurrent rectal cancer that increased FDG-uptake. Carbon ion radiotherapy(CIRT)(73.6 GyE/16 Fr)was performed. Serum CEA level and FDG-uptake were normalized. No regrowth of tumor has been found for 12 months. Case 2: A female patient in her 60s underwent abdominoperineal resection for rectal cancer. After 42 months, the serum level of CEA was elevated, and CT revealed a local recurrence of rectal cancer. Subsequently, the tumor was resected; however, resection margin was microscopically positive. Therefore, chemoradiotherapy(S-1, 60 Gy)was performed. At 31 months after local resection, a re-recurrent tumor was noted in her left ischium. Therefore, CIRT(70.4 GyE/16 Fr)was performed. Serum CEA level and FDG-uptake were normalized. No regrowth of tumor has been found for 24 months. CIRT is an effective therapy for locally recurrent rectal cancer.

Published
2018

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