1. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference.
- Author
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Kloske, Courtney, Belloy, Michael, Blue, Elizabeth, Bowman, Gregory, Carrillo, Maria, Chen, Xiaoying, Chiba-Falek, Ornit, Davis, Albert, Paolo, Gilbert, Garretti, Francesca, Gate, David, Golden, Lesley, Heinecke, Jay, Herz, Joachim, Huang, Yadong, Iadecola, Costantino, Johnson, Lance, Kanekiyo, Takahisa, Karch, Celeste, Khvorova, Anastasia, Koppes-den Hertog, Sascha, Lamb, Bruce, Lawler, Paige, Guen, Yann, Litvinchuk, Alexandra, Liu, Chia-Chen, Mahinrad, Simin, Marcora, Edoardo, Marino, Claudia, Michaelson, Danny, Miller, Justin, Morganti, Josh, Narayan, Priyanka, Naslavsky, Michel, Oosthoek, Marlies, Ramachandran, Kapil, Ramakrishnan, Abhirami, Raulin, Ana-Caroline, Robert, Aiko, Saleh, Rasha, Sexton, Claire, Shah, Nilomi, Shue, Francis, Sible, Isabel, Soranno, Andrea, Strickland, Michael, Tcw, Julia, Thierry, Manon, Tsai, Li-Huei, Tuckey, Ryan, Ulrich, Jason, van der Kant, Rik, Wang, Na, Wellington, Cheryl, Weninger, Stacie, Yassine, Hussein, Zhao, Na, Bu, Guojun, Goate, Alison, and Holtzman, David
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APOE ,Alzheimers disease ,apolipoprotein E ,conference proceedings ,dementia ,lipids ,microglia ,neuroinflammation ,risk factor ,therapeutics ,vasculature ,Humans ,Apolipoproteins E ,Alzheimer Disease ,Congresses as Topic ,Animals ,Amyloid beta-Peptides ,Dementia ,Biomedical Research - Abstract
INTRODUCTION: The apolipoprotein E gene (APOE) is an established central player in the pathogenesis of Alzheimers disease (AD), with distinct apoE isoforms exerting diverse effects. apoE influences not only amyloid-beta and tau pathologies but also lipid and energy metabolism, neuroinflammation, cerebral vascular health, and sex-dependent disease manifestations. Furthermore, ancestral background may significantly impact the link between APOE and AD, underscoring the need for more inclusive research. METHODS: In 2023, the Alzheimers Association convened multidisciplinary researchers at the AAIC Advancements: APOE conference to discuss various topics, including apoE isoforms and their roles in AD pathogenesis, progress in apoE-targeted therapeutic strategies, updates on disease models and interventions that modulate apoE expression and function. RESULTS: This manuscript presents highlights from the conference and provides an overview of opportunities for further research in the field. DISCUSSION: Understanding apoEs multifaceted roles in AD pathogenesis will help develop targeted interventions for AD and advance the field of AD precision medicine. HIGHLIGHTS: APOE is a central player in the pathogenesis of Alzheimers disease. APOE exerts a numerous effects throughout the brain on amyloid-beta, tau, and other pathways. The AAIC Advancements: APOE conference encouraged discussions and collaborations on understanding the role of APOE.
- Published
- 2024