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369 results on '"Kaneko, Keiko"'

1. Development of a new wideband heterodyne receiver system for the Osaka 1.85-m mm-submm telescope -- Corrugated horn & Optics covering 210-375 GHz band

Author

Yamasaki, Yasumasa, Masui, Sho, Ogawa, Hideo, Kondo, Hiroshi, Matsumoto, Takeru, Okawa, Masanari, Yokoyama, Koki, Minami, Taisei, Konishi, Ryotaro, Kawashita, Sana, Konishi, Ayu, Nakao, Yuka, Nishimoto, Shimpei, Yoneyama, Sho, Ueda, Shota, Hasegawa, Yutaka, Fujita, Shinji, Nishimura, Atsushi, Kojima, Takafumi, Kaneko, Keiko, Sakai, Ryo, Gonzalez, Alvaro, Uzawa, Yoshinori, and Onishi, Toshikazu

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The corrugated horn is a high performance feed often used in radio telescopes. There has been a growing demand for wideband optics and corrugated horns in millimeter and submillimeter-wave receivers. It improves the observation efficiency and allows us to observe important emission lines such as CO in multiple excited states simultaneously. However, in the millimeter/submillimeter band, it has been challenging to create a conical corrugated horn with a fractional bandwidth of ~60% because the wavelength is very short, making it difficult to make narrow corrugations. In this study, we designed a conical corrugated horn with good return loss, low cross-polarization, and symmetric beam pattern in the 210-375GHz band (56% fractional bandwidth) by optimizing the dimensions of the corrugations. The corrugated horn was installed on the Osaka 1.85-m mm-submm telescope with the matched frequency-independent optics, and simultaneous observations of 12CO, 13CO, and C18O (J = 2-1, 3-2) were successfully made. In this paper, we describe the new design of the corrugated horn and report the performance evaluation results including the optics., Comment: 22 pages, 15 figures, Accepted for publication in PASJ

Published
2021
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2. Development of a new wideband heterodyne receiver system for the Osaka 1.85-m mm-submm telescope -- Receiver development & the first light of simultaneous observation in 230GHz and 345GHz bands with an SIS-mixer with 4-21GHz IF output

Author

Masui, Sho, Yamasaki, Yasumasa, Ogawa, Hideo, Kondo, Hiroshi, Yokoyama, Koki, Matsumoto, Takeru, Minami, Taisei, Okawa, Masanari, Konishi, Ryotaro, Kawashita, Sana, Konishi, Ayu, Nakao, Yuka, Nishimoto, Shimpei, Yoneyama, Sho, Ueda, Shota, Hasegawa, Yutaka, Fujita, Shinji, Nishimura, Atsushi, Kojima, Takafumi, Uemizu, Kazunori, Kaneko, Keiko, Sakai, Ryo, Gonzalez, Alvaro, Uzawa, Yoshinori, and Onishi, Toshikazu

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We have developed a wideband receiver system for simultaneous observations in CO lines of J = 2-1 and J = 3-2 transitions using the Osaka 1.85-m mm-submm telescope. As a frequency separation system, we developed multiplexers that connect three types of diplexers, each consisting of branch-line couplers and high-pass filters. The radio frequency (RF) signal is eventually distributed into four frequency bands, each of which is fed to a superconductor-insulator-superconductor (SIS) mixer. The RF signal from the horn is divided into two frequency bands by a wideband diplexer with a fractional bandwidth of 56%, and then each frequency band is further divided into two bands by each diplexer. The developed multiplexers were designed, fabricated, and characterized using a vector network analyzer. The measurement results showed good agreement with the simulation. The receiver noise temperature was measured by connecting the SIS-mixers, one of which has a wideband 4-21GHz intermediate frequency (IF) output. The receiver noise temperatures were measured to be ~70K in the 220GHz band, ~100K in the 230GHz band, 110-175K in the 330GHz band, and 150-250K in the 345GHz band. This receiver system has been installed on the 1.85-m telescope at the Nobeyama Radio Observatory. We succeeded in the simultaneous observations of six CO isotopologue lines with the transitions of J = 2-1 and J = 3-2 toward the Orion KL as well as the on-the-fly (OTF) mappings toward the Orion KL and W 51., Comment: 26pages, 20 figures, Accepted for publication in PASJ

Published
2021
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3. Experimental Study of a Planar-integrated Dual-Polarization Balanced SIS Mixer

Author

Shan, Wenlei, Ezaki, Shohei, Kaneko, Keiko, Miyachi, Akihira, Kojima, Takafumi, and Uzawa, Yoshinori

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Applied Physics
Abstract

A dual-polarization balanced superconductor-insulator-superconductor mixer operating at 2 mm wavelength is realized in form of a monolithic planar integrated circuit. Planar orthomode transducers and LO couplers are enabled by using silicon membranes that are locally formed on the silicon-on-insulator substrate. The performance of the balanced mixer is experimentally investigated. Over the entire RF band (125-163 GHz), the balanced mixer shows an LO noise rejection ratio about 15 dB, an overall receiver noise about 40 K, and a cross-polarization <-20 dB. The demonstrated compactness and the performance of the integrated circuit indicate that this approach is feasible in developing heterodyne focal plane arrays., Comment: Accepted for publication in IEEE Transactions on Terahertz Science and Technology

Published
2019

5. Small molecule inhibition of non-canonical (TAK1-mediated) BMP signaling results in reduced chondrogenic ossification and heterotopic ossification in a rat model of blast-associated combat-related lower limb trauma

Author

Strong, Amy L., Spreadborough, Philip J., Pagani, Chase A., Haskins, Ryan M., Dey, Devaveena, Grimm, Patrick D., Kaneko, Keiko, Marini, Simone, Huber, Amanda K., Hwang, Charles, Westover, Kenneth, Mishina, Yuji, Bradley, Matthew J., Levi, Benjamin, and Davis, Thomas A.

Published
2020
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7. Liver fibrosis is associated with carotid atherosclerosis in patients with liver biopsy-proven nonalcoholic fatty liver disease

Author

Arai, Taeang, Atsukawa, Masanori, Tsubota, Akihito, Kato, Keizo, Abe, Hiroshi, Ono, Hirotaka, Kawano, Tadamichi, Yoshida, Yuji, Tanabe, Tomohide, Okubo, Tomomi, Hayama, Korenobu, Nakagawa-Iwashita, Ai, Itokawa, Norio, Kondo, Chisa, Kaneko, Keiko, Emoto, Naoya, Nagao, Mototsugu, Inagaki, Kyoko, Fukuda, Izumi, Sugihara, Hitoshi, and Iwakiri, Katsuhiko

Published
2021
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8. ALMA Band 8 version2 receiver upgrade project

Author

Zmuidzinas, Jonas, Gao, Jian-Rong, Kojima, Takafumi, Minamidani, Tetsuhiro, Sakai, Ryo, Imada, Hiroaki, Kaneko, Keiko, Masui, Sho, Uemizu, Kazunori, Makise, Kazumasa, Miyachi, Akihira, Ezaki, Shohei, Tamura, Tomonori, Ishii, Shun, and Hatsukade, Bunyo

Published
2024
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10. Contributors

Author

Ahn, Tae In, primary, Akiyama, Takuji, additional, Butturini, Michele, additional, Chintakovid, Watcharra, additional, Chun, Changhoo, additional, Dou, Haijie, additional, Fang, Wei, additional, Fujiwara, Kazuhiro, additional, Fukuda, Kazuhiro, additional, Goto, Eiji, additional, Hara, Hiromichi, additional, Harwood, Ed, additional, He, Dongxian, additional, Hayashi, Eri, additional, Johkan, Masahumi, additional, Kanematsu, Yuichiro, additional, Kikuchi, Yasunori, additional, Kim, Hak Jin, additional, Kozai, Toyoki, additional, Kubota, Chieri, additional, Marcelis, Leo F.M., additional, Maruo, Toru, additional, Mitchell, Cary A., additional, Nguyen, Quynh Thi, additional, Nishida, Yoshikazu, additional, Niu, Genhua, additional, Nunomura, Osamu, additional, Ogura, Toichi, additional, Ohashi-Kaneko, Keiko, additional, Ohshima, Kazutaka, additional, Oshio, Takahiro, additional, Sabeh, Nadia, additional, Sakaguchi, Shunsuke, additional, Sheibani, Fatemeh, additional, Shibuya, Toshio, additional, Shimizu, Hiroshi, additional, Shinohara, Yutaka, additional, Shinozaki, Kimiko, additional, Son, Jung Eek, additional, Supaibulwatana, Kanyaratt, additional, Takagaki, Michiko, additional, Takashima, Miho, additional, Tong, Yuxin, additional, Tsukagoshi, Satoru, additional, Xiao, Yulan, additional, Yamada, Kosuke, additional, Yamaguchi, Toshitaka, additional, Yamori, Wataru, additional, Yang, Qichang, additional, and Zobayed, Sma, additional

Published
2020
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11. Causes and Management of Endoscopic Retrograde Cholangiopancreatography-Related Perforation: A Retrospective Study

Author

Shimizu, Tetsuya, primary, Yoshioka, Masato, additional, Matsushita, Akira, additional, Kaneko, Keiko, additional, Ueda, Junji, additional, Kawashima, Mampei, additional, Irie, Toshiyuki, additional, Ono, Takashi, additional, Furuki, Hiroyasu, additional, Kanda, Tomohiro, additional, Mizuguchi, Yoshiaki, additional, Kawano, Yoichi, additional, Nakamura, Yoshiharu, additional, and Yoshida, Hiroshi, additional

Published
2023
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15. Two cases of impaction of mandibular second molars

Author

KANEKO, KEIKO, UCHIDA, KEIICHI, INOU, TOSHIYUKI, KITAMURA, HIROYUKI, NEZU, HIDEYUKI, TAKAYA, TATSUO, and MORI, HIROSHI

Subjects
埋伏歯, 下顎第二大臼歯
Abstract

Summary An impacted mandibular second molar is rare. Here,we report two cases of such impacted molars.Case 1:A 22–year–old man presented at our university hospital upon referral from his family dental clinic.A panoramic image revealed horizontal impaction of the left mandibular second molar.Since the patient preferred surgical extraction,the left mandibular second molar was extracted. Case 2:A 54–year–old man presented at our health and dental checkup center.Based on the results of a panoramic image,a dentist from oral radiology diagnosed him with impacted bilateral mandibular second molars.He suggested conducting a complete examination;however,these molars were simply observed and no treatment was provided.

Published
2022

18. Development of Receiver Optics for ASTE Band 7+8 Receiver

Author

Lee, Bangwon, Lee, Jung-Won, Gonzalez, Alvaro, Je, Do-Heung, Kaneko, Keiko, and Kojima, Takafumi

Abstract

In this study, we propose an optics design for a submillimeter-wave receiver that combines the Atacama large millimeter/submillimeter array (ALMA) Band 7 and Band 8 frequencies (275–500 GHz). To achieve a fractional bandwidth of over 50%, we applied a profiling technique using a cubic spline pattern for a corrugated feedhorn. With two-mirror optics, the near-field beam patterns were measured at 4K. The quasi-optics system, including the feedhorn, exhibited an aperture efficiency of more than 80% over the RF band.

Published
2024
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26. Practical Aspects of the Design and Fabrication of High-Performance (sub)mm-Wave Dual-Ridged Waveguide Orthomode Transducers, and Application to a 205–280 GHz Design

Author

Gonzalez, Alvaro and Kaneko, Keiko

Abstract

Dual-ridged waveguide orthomode transducers (OMTs) are a well-proven type of high-performance waveguide components used for the separation of orthogonal linear polarizations, and wideband designs have been recently demonstrated at frequencies as high as 500 GHz. In this article, we investigate the limits of performance in a narrower bandwidth, 205–280 GHz, and the practical aspects of design and fabrication. We demonstrate the flexibility of this type of OMT in terms of input waveguide type, circular or square, and position and orientation of output waveguides. In all cases, split-block fabrication is possible by combining traditional direct machining with wire electrodischarge machining and the appropriate use of shim-waveguide transitions.

Published
2023
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27. Antifibrotic effect and long‐term outcome of SGLT 2 inhibitors in patients with NAFLD complicated by diabetes mellitus

Author

Arai, Taeang, primary, Atsukawa, Masanori, additional, Tsubota, Akihito, additional, Mikami, Shigeru, additional, Haruki, Uojima, additional, Yoshikata, Keiichiro, additional, Ono, Hiroki, additional, Kawano, Tadamichi, additional, Yoshida, Yuji, additional, Tanabe, Tomohide, additional, Okubo, Tomomi, additional, Hayama, Korenobu, additional, Nakagawa‐Iwashita, Ai, additional, Itokawa, Norio, additional, Kondo, Chisa, additional, Kaneko, Keiko, additional, Nagao, Mototsugu, additional, Inagaki, Kyoko, additional, Fukuda, Izumi, additional, Sugihara, Hitoshi, additional, and Iwakiri, Katsuhiko, additional

Published
2022
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29. Contributors

Author

Ahn, Tae In, primary, Akiyama, Takuji, additional, Cheng, Ruifeng, additional, Chun, Changhoo, additional, Fang, Wei, additional, Fujiwara, Kazuhiro, additional, Fukuda, Kazuhiro, additional, Goto, Eiji, additional, Hagiya, Kozo, additional, Hara, Hiromichi, additional, He, Dongxian, additional, Inada, Shinji, additional, Johkan, Masahumi, additional, Kikuchi, Yasunori, additional, Kim, Hak Jin, additional, Kitagawa, Katsuyuki, additional, Kozai, Toyoki, additional, Kubota, Chieri, additional, Lu, Chungui, additional, Maruo, Toru, additional, Nguyen, Quynh Thi, additional, Nishida, Yoshikazu, additional, Niu, Genhua, additional, Nunomura, Osamu, additional, Ogura, Toichi, additional, Ohashi-Kaneko, Keiko, additional, Ohshima, Kazutaka, additional, Oshio, Takahiro, additional, Sasaki, Yasuhito, additional, Sabeh, Nadia, additional, Sakaguchi, Shunsuke, additional, Shibuya, Toshio, additional, Shinozaki, Kimiko, additional, Shimamura, Shigeharu, additional, Shimizu, Hiroshi, additional, Shinohara, Yutaka, additional, Son, Jung Eek, additional, Takagaki, Michiko, additional, Takashima, Miho, additional, Tong, Yuxin, additional, Tsukagoshi, Satoru, additional, Watanabe, Hiroyuki, additional, Xiao, Yulan, additional, Yang, Chan-suk, additional, Yamada, Kosuke, additional, Yamaguchi, Kazuhiko, additional, Yamaguchi, Toshitaka, additional, Yamori, Wataru, additional, Yang, Qichang, additional, and Zobayed, Sma, additional

Published
2016
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33. A Case Report of Kissing Molars Class III

Author

Kaneko, Keiko, primary, Uchida, Keiichi, additional, Inou, Toshiyuki, additional, Nezu, Hideyuki, additional, Mori, Hiroshi, additional, Kitamura, Hiroyuki, additional, Takaya, Tatsuo, additional, Yoko, Yukiko, additional, and Okafuji, Norimasa, additional

Published
2022
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35. State of anxiety may be associated with exocrine pancreatic insufficiency in functional dyspepsia patients with pancreatic enzyme abnormalities

Author

Agawa, Shuhei, primary, Futagami, Seiji, additional, Yamawaki, Hiroshi, additional, Gudis, Katya, additional, Higuchi, Kazutoshi, additional, Kaneko, Keiko, additional, Habiro, Mayu, additional, Kodaka, Yasuhiro, additional, Ueki, Nobue, additional, Watanabe, Yoshiyuki, additional, Motoda, Norio, additional, Ohashi, Ryuji, additional, and Iwakiri, Katsuhiko, additional

Published
2022
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36. Development of Receiver Optics Components using Additive Manufacturing Technology

Author

KANEKO, Keiko

Subjects
Addutive Manufacturing, Radio Astronomy
Abstract

National Astronomical Observatory of Japan is performing R&D studies related to additive manufacturing (AM) technologies based on metal 3D printing. This technology is evolving day by day in the world, both instruments and methods, and is used for diverse industries, e.g., aerospace, medical, automotive, ISS. Benefits of AM are rapid prototyping, design optimization with topology methods, cost and lead time reductions. We have focused this research on the development of receiver optics component, especially the ALMA Band1 corrugated horn. Through these studies, we have also learned some practical disadvantages of additive manufacturing, which need to be compensated by other existing technologies. In addition, the material/physical properties of components produced by AM should be checked carefully because they may change during the manufacturing process and through aging. We will present the current status of this research and would like to discuss the usefulness of AM for the development of future receivers.

Published
2021
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37. Development of Band 7+8 Cartridge Receiver

Author

Lee, Jung-Won, Kojima, Takafumi, Gonzalez, Alvaro, Lee, Bang-Won, Kaneko, Keiko, Je, Do-Heung, and Seungrae, Kim

Abstract

We will present the design and performance of a cartridge receiver which covers both ALMA band 7 and band 8 frequency ranges (275-500 GHz).The receiver has dual-linear polarization and sideband-separation capabilities providing four IF outputs of 4-8 GHz IF frequency. Wideband components such as a splined horn, an OMT, high-jc AlN barrier SIS mixers, RF hybrids, and LO diplexers have been developedmeeting requirements and assembled into a standard ALMA cartridge. &nbsp

Published
2021
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38. Development of seven-beam optics using dielectric lenses for a new 72–116 GHz receiver in the Nobeyama 45 m telescope

Author

Yamasaki, Yasumasa, Hasegawa, Yutaka, Yoneyama, Sho, Kawashita, Sana, Chinen, Tsubasa, Masui, Sho, Nosohara, Chiaki, Sun, Heyang, Dakie, Shuto, Kameyama, Akira, Fujitomo, Ikko, Nishikawa, Yuma, Ogawa, Hideo, Tatematsu, Ken’ichi, Nishimura, Atsushi, Miyazawa, Chieko, Takahashi, Toshikazu, Maekawa, Jun, Gonzalez, Alvaro, Kojima, Takafumi, Imada, Hiroaki, Kaneko, Keiko, Sakai, Ryo, Sakai, Takeshi, and Onishi, Toshikazu

Abstract

We developed a new seven-beam heterodyne receiver “7BEE” in the 72–116 GHz band for the Nobeyama 45 m telescope to investigate the early stage of star formation by deriving the deuterium fraction of dense cores. The optics for the receiver employs wideband corrugated horns covering the 72–116 GHz band and dielectric lenses to couple the incoming radiation from the antenna on to the feeds. One of the important aspects in the lens design is the anti-reflection (AR) structure to mitigate the reflections on the lens surfaces. Triangular grooves, which gradually change the effective refractive index from air to dielectric, were adopted as a basic AR design since the return loss can be in the order of 20 dB or better. The main goal of this study is to compare the radio frequency (RF) characteristics of the lenses with different patterns and sizes of AR grooving structures. We confirmed that concentric grooves degraded beam symmetry, cross-polarization characteristics, and aperture efficiency due to the birefringence of the grooves, which gave rise to wavefront distortions. Straight grooves of two different gap widths, 1.2 mm and 1.7 mm, were compared and showed similar good performance in terms of beam patterns and noise contribution. However, the latter showed a few percent higher aperture efficiency. Therefore, the straight grooves with 1.7 mm gap width were adopted as the AR structure of our lens.

Published
2023
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39. Antifibrotic effect and long‐term outcome of SGLT2 inhibitors in patients with NAFLD complicated by diabetes mellitus.

Author

Arai, Taeang, Atsukawa, Masanori, Tsubota, Akihito, Mikami, Shigeru, Haruki, Uojima, Yoshikata, Keiichiro, Ono, Hiroki, Kawano, Tadamichi, Yoshida, Yuji, Tanabe, Tomohide, Okubo, Tomomi, Hayama, Korenobu, Nakagawa‐Iwashita, Ai, Itokawa, Norio, Kondo, Chisa, Kaneko, Keiko, Nagao, Mototsugu, Inagaki, Kyoko, Fukuda, Izumi, and Sugihara, Hitoshi

Subjects
SODIUM-glucose cotransporter 2 inhibitors, NON-alcoholic fatty liver disease, DIABETES, HEPATIC fibrosis, TYPE 2 diabetes, SODIUM-glucose cotransporters, CANAGLIFLOZIN
Abstract

The aim of this retrospective multicenter study was to clarify the antifibrotic effect and long‐term outcome of sodium glucose cotransporter 2 inhibitors (SGLT2‐Is) in patients with nonalcoholic fatty liver disease (NAFLD) complicated by type 2 diabetes mellitus (T2DM). Of the 1262 consecutive patients with T2DM who recently received SGLT2‐Is, 202 patients with NAFLD had been receiving SGLT2‐Is for more than 48 weeks and were subjected to this analysis. Furthermore, 109 patients who had been on SGLT2‐I therapy for more than 3 years at the time of analysis were assessed for the long‐term effects of SGLT2‐Is. Significant decreases in body weight, liver transaminases, plasma glucose, hemoglobin A1c, and Fibrosis‐4 (FIB‐4) index were found at week 48. Overall, the median value of FIB‐4 index decreased from 1.42 at baseline to 1.25 at week 48 (p < 0.001). In the low‐risk group (FIB‐4 index < 1.3), there was no significant change in the FIB‐4 index. In the intermediate‐risk (≥1.3 and <2.67) and high‐risk (≥2.67) groups, the median levels significantly decreased from 1.77 and 3.33 at baseline to 1.58 and 2.75 at week 48, respectively (p < 0.001 for both). Improvements in body weight, glucose control, liver transaminases, and FIB‐4 index were found at 3 years of SGLT2‐I treatment. In the intermediate‐risk and high‐risk groups (≥1.3 FIB‐4 index), the FIB‐4 index maintained a significant reduction from baseline throughout the 3 years of treatment. Conclusion: This study showed that SGLT2‐Is offered a favorable effect on improvement in FIB‐4 index as a surrogate marker of liver fibrosis in patient with NAFLD complicated by T2DM, especially those with intermediate and high risks of advanced fibrosis, and this antifibrotic effect is sustained for the long term. [ABSTRACT FROM AUTHOR]

Published
2022
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42. A Wideband Millimeter-Wave Corrugated Horn at 30–50 GHz Taking Advantage of All-Metal 3-D Printing Fabrication

Author

Kang, Haoran, Kaneko, Keiko, Sakai, Ryo, and Gonzalez, Alvaro

Abstract

The development of commercial all-metal 3-D printing technology provides a new fabrication method for wideband millimeter-wave corrugated horns up to 50 GHz. Compared with conventional fabrication techniques, such as direct machining, electroforming, or recently developed methods relying on the assembly of platelets, all-metal 3-D printing has advantages of low cost, fast delivery, possibility of mass production, flexibility in fabrication of complicated geometries, and good mechanical robustness. In this letter, we report the development of a wideband millimeter-wave corrugated horn at 30–50 GHz (50% fractional bandwidth) based on commercial all-metal 3-D printing technology. Measurement results reported in this letter show good performance in terms of both return loss and cross polarization.

Published
2023
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44. Development of a new wideband heterodyne receiver system for the Osaka 1.85 m mm–submm telescope: Corrugated horn and optics covering the 210–375 GHz band

Author

Yamasaki, Yasumasa, primary, Masui, Sho, additional, Ogawa, Hideo, additional, Kondo, Hiroshi, additional, Matsumoto, Takeru, additional, Okawa, Masanari, additional, Yokoyama, Koki, additional, Minami, Taisei, additional, Konishi, Ryotaro, additional, Kawashita, Sana, additional, Konishi, Ayu, additional, Nakao, Yuka, additional, Nishimoto, Shimpei, additional, Yoneyama, Sho, additional, Ueda, Shota, additional, Hasegawa, Yutaka, additional, Fujita, Shinji, additional, Nishimura, Atsushi, additional, Kojima, Takafumi, additional, Kaneko, Keiko, additional, Sakai, Ryo, additional, Gonzalez, Alvaro, additional, Uzawa, Yoshinori, additional, and Onishi, Toshikazu, additional

Published
2021
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45. Development of a new wideband heterodyne receiver system for the Osaka 1.85 m mm–submm telescope: Receiver development and the first light of simultaneous observations in 230 GHz and 345 GHz bands with an SIS-mixer with 4–21 GHz IF output

Author

Masui, Sho, primary, Yamasaki, Yasumasa, additional, Ogawa, Hideo, additional, Kondo, Hiroshi, additional, Yokoyama, Koki, additional, Matsumoto, Takeru, additional, Minami, Taisei, additional, Okawa, Masanari, additional, Konishi, Ryotaro, additional, Kawashita, Sana, additional, Konishi, Ayu, additional, Nakao, Yuka, additional, Nishimoto, Shimpei, additional, Yoneyama, Sho, additional, Ueda, Shota, additional, Hasegawa, Yutaka, additional, Fujita, Shinji, additional, Nishimura, Atsushi, additional, Kojima, Takafumi, additional, Uemizu, Kazunori, additional, Kaneko, Keiko, additional, Sakai, Ryo, additional, Gonzalez, Alvaro, additional, Uzawa, Yoshinori, additional, and Onishi, Toshikazu, additional

Published
2021
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46. Effect of Vitamin D Supplementation on Skeletal Muscle Volume and Strength in Patients with Decompensated Liver Cirrhosis Undergoing Branched Chain Amino Acids Supplementation: A Prospective, Randomized, Controlled Pilot Trial

Author

Okubo, Tomomi, primary, Atsukawa, Masanori, additional, Tsubota, Akihito, additional, Ono, Hiroki, additional, Kawano, Tadamichi, additional, Yoshida, Yuji, additional, Arai, Taeang, additional, Hayama, Korenobu, additional, Itokawa, Norio, additional, Kondo, Chisa, additional, Kaneko, Keiko, additional, and Iwakiri, Katsuhiko, additional

Published
2021
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48. Readministration of Cancer Drugs in a Patient with Chemorefractory Metastatic Colorectal Cancer

Author

Kawagoe, Tetsuro, Ikeda, Go, Oshiro, Yu, Maruki, Yuta, Kaneko, Keiko, and Iwakiri, Katsuhiko

Subjects
Article Subject
Abstract

A 63-year-old woman was admitted to our institution for severe pain in her right lower abdomen caused by the perforation of cecal cancer. She underwent emergency surgery, from which she was diagnosed with cecal carcinoma with liver, lung, and lymph node metastases. As she was taking aspirin to prevent cerebral infarction, anti-vascular endothelial growth factor (receptor) antibody and regorafenib therapy were not used. Thus, we started a modified FOLFOX 6+cetuximab regimen. This first-line treatment initially achieved a partial response (PR), but she then developed progressive disease (PD) after 14 months. We changed the regimen to FOLFIRI, followed by trifluridine/tipiracil, but her progression-free survival periods were 2.7 months and 1 month, respectively. Although we cycled through the available array of standard cancer drugs, the patient showed a good performance status, and some benefit from treatment still seemed plausible. We readministered the 5-fluorouracil oral preparation S-1, which maintained stable disease (SD) for 7 months. After PD emerged, we readministered the anti-epidermal growth factor receptor (EGFR) antibody panitumumab for 7.5 months of SD. Finally, 39 months after her diagnosis, she died from rapidly progressing disease. However, her relatively long survival implies that readministering drugs similar to those used in previous regimens might benefit patients with metastatic colorectal cancer.

Published
2020
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