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2. Neuroprotective Effects of N-acetylserotonin and Its Derivative.

Author

Kang, Ji-He, Guo, Xu-Dong, Wang, Yi-Dian, and Kang, Xue-Wen

Subjects
*CEREBRAL anoxia-ischemia, *BRAIN injuries, *NEUROPROTECTIVE agents, *OXIDATIVE stress
Abstract

• NAS and HIOC are neuroprotective agents. • NAS and HIOC are anti-oxidative stress and anti-inflammatory. • NAS and HIOC counteract autophagy dysfunction and apoptosis. • NAS and HIOC may show usefulness in clinical trials. N-acetylserotonin (NAS) is a chemical intermediate in melatonin biosynthesis. NAS and its derivative N-(2-(5-hydroxy-1H-indol-3-yl) ethyl)-2-oxopiperidine-3-carboxamide (HIOC) are potential therapeutic agents for traumatic brain injury, autoimmune encephalomyelitis, hypoxic-ischemic encephalopathy, and other diseases. Evidence shows that NAS and its derivative HIOC have neuroprotective properties, and can exert neuroprotective effects by inhibiting oxidative stress, anti-apoptosis, regulating autophagy dysfunction, and anti-inflammatory. In this review, we discussed the neuroprotective effects and related mechanisms of NAS and its derivative HIOC to provide a reference for follow-up research and applications. [ABSTRACT FROM AUTHOR]

Published
2023
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3. Proanthocyanidins inhibit the apoptosis and aging of nucleus pulposus cells through the PI3K/Akt pathway delaying intervertebral disc degeneration

Author

Chen, Hai-Wei, primary, Liu, Ming-Qiang, additional, Zhang, Guang-Zhi, additional, Zhang, Cang-Yu, additional, Wang, Zhao-Heng, additional, Lin, Ai-Xin, additional, Kang, Ji-He, additional, Liu, Wen-Zhao, additional, Guo, Xu-Dong, additional, Wang, Yi-Dian, additional, and Kang, Xue-Wen, additional

Published
2022
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4. Grape Seed Proanthocyanidins Attenuate LPS-Induced Neuroinflammation Through Microglia Polarization Regulation Via TLR4/MyD88/NF-κB Signaling Pathway in BV2 Cells

Author

Liu, Wenzhao, primary, Ma, Zhan-jun, additional, Liu, Ming-qiang, additional, Kang, Ji-he, additional, Chen, Hai-wei, additional, Lin, Ai-xin, additional, Wang, Zhao-heng, additional, Guo, Xu-dong, additional, Wang, Yi-dian, additional, Liu, Ya-ting, additional, and Kang, Xue-wen, additional

Published
2022
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6. Grape Seed Proanthocyanidins Attenuate LPS-Induced Neuroinflammation Through Microglia Polarization Regulation Via TLR4/MyD88/NF-κB Signaling Pathway in BV2 Cells

Author

Liu, Wenzhao, primary, Ma, Zhan-jun, additional, Liu, Ming-qiang, additional, Kang, Ji-he, additional, Chen, Hai-wei, additional, Lin, Ai-xin, additional, Wang, Zhao-heng, additional, Guo, Xu-dong, additional, Wang, Yi-dian, additional, Liu, Ya-ting, additional, and Kang, Xue-wen, additional

Published
2021
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