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2. Spirometric pattern and cardiovascular risk: a prospective study of 0.3 million Chinese never-smokers

Author

Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Li, Liming, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Barnard, Maxim, Bennett, Derrick, Boxall, Ruth, Chan, Ka Hung, Chen, Yiping, Clarke, Charlotte, Clarke, Johnathan, Du, Huaidong, Mohamed, Ahmed Edris, Fry, Hannah, Gilbert, Simon, Im, Pek Kei, Iona, Andri, Kakkoura, Maria, Kartsonaki, Christiana, Kolhe, Kshitij, Lam, Hubert, Lin, Kuang, Liu, James, Mazidi, Mohsen, Millwood, Iona, Morris, Sam, Nie, Qunhua, Pozarickij, Alfred, Rahmati, Maryam, Ryder, Paul, Schmidt, Dan, Stevens, Becky, Turnbull, Iain, Wang, Baihan, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Yao, Pang, Han, Xiao, Hou, Can, Xia, Qingmei, Liu, Chao, Pei, Pei, Sun, Dianjianyi, Yu, Canqing, Pan, Lang, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Duan, Haiping, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Sun, Wei, Yan, Shichun, Cui, Xiaoming, Wang, Chi, Wu, Zhenyuan, Li, Yanjie, Kang, Quan, Luo, Huiming, Ou, Tingting, Zheng, Xiangyang, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Lin, Mei, Lu, Zhenzhen, Zhou, Lifang, Xie, Changping, Lan, Jian, Zhu, Tingping, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Chang, Xiaoyu, Yuan, Mingqiang, Wu, Xia, Jiang, Wei, Liu, Jiaqiu, Sun, Qiang, Chen, Faqing, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Kang, Kai, Feng, Shixian, Tian, Huizi, Fan, Lei, Li, XiaoLin, Sun, Huarong, He, Pan, Zhang, Xukui, Yu, Min, Hu, Ruying, Wang, Hao, Zhang, Xiaoyi, Cao, Yuan, Xie, Kaixu, Chen, Lingli, Shen, Dun, Li, Xiaojun, Jin, Donghui, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Xin, Zhang, Hao, Chen, Jianwei, Peng, Yuan, Zhang, Libo, Qu, Chan, Li, Shuya, Qin, Haiqiang, Wang, Yongjun, Chen, Qiling, Wang, Jihua, Sun, Xiaojia, Wang, Lei, Wang, Xun, Zhang, Liming, Zhou, Shanshan, Chen, Hongyuan, Chen, Li, Gou, Haiyan, Wang, Weizhi, Zhu, Yanmei, Zhu, Yulan, Zhang, Ning, Cheng, Xin, Dong, Qiang, Dong, Yi, Fang, Kun, Mao, Yiting, An, Yu, Chen, Peiling, Chen, Yinghua, Liu, Zhihong, Zhang, Lihua, Chen, Xiaohong, Jv, Naixin, Li, Xiaojiu, Liu, Liyang, Lu, Yun, Xing, Xiaona, You, Shihao, Cheng, Xiaoli, Gua, Chaojun, Jiang, Jinping, Liu, Jingyi, Ma, Shumei, Yang, Xuefeng, Du, Xiaomo, Xu, Jian, Yang, Xuecheng, Zhao, Xiaodi, Hao, Zilong, Liu, Ming, Wang, Deren, Li, Xiaoting, Hui, Lili, Liao, Zhanling, Liu, Feng, Feng, Chunning, Ji, Dejiang, Qu, Fengxia, Yuan, Wenwen, Fu, Xin, Ding, Jing, Du, Peng, Jin, Lirong, Mao, Yueshi, Wang, Xin, Ding, Yinqi, and Hu, Jingcen

Published
2025
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3. Associations of long-term nitrogen dioxide exposure with a wide spectrum of diseases: a prospective cohort study of 0·5 million Chinese adults

Author

Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Li, Liming, Lv, Jun, Peto, Richard, Walters, Robin, EdrisMohamed, Ahmed, Pozarickij, Alfred, Iona, Andri, Wang, Baihan, Clarke, Charlotte, Kartsonaki, Christiana, Schmidt, Dan, Avery, Daniel, Bennett, Derrick, Fry, Hannah, Du, Huaidong, Lam, Hubert, Turnbull, Iain, Millwood, Iona, Liu, James, Clarke, Jonathan, Chan, Ka Hung, Kolhe, Kshitij, Lin, Kuang, Wang, Lin, Yang, Ling, Kakkoura, Maria, Rahmati, Maryam, Barnard, Maxim, Mazidi, Mohsen, Wright, Neil, Yao, Pang, Ryder, Paul, Im, Pek Kei, Harish, Prapthi, Nie, Qunhua, Stevens, Rebecca, Boxall, Ruth, Morris, Sam, Gilbert, Simon, Yang, Xiaoming, Chen, Yiping, Han, Xiao, Hou, Can, Xia, Qingmei, Liu, Chao, Pei, Pei, Sun, Dianjianyi, Yu, Canqing, Pan, Lang, Pang, Zengchang, Gao, Ruiqin, Li, Shanpeng, Duan, Haiping, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Sun, Wei, Yan, Shichun, Cui, Xiaoming, Wang, Chi, Wu, Zhenyuan, Li, Yanjie, Kang, Quan, Luo, Huiming, Qu, Tingting, Zheng, Xiangyang, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Lin, Mei, Lu, Zhenzhen, Zhou, Lifang, Xie, Changping, Lan, Jian, Zhu, Tingping, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Qin, Yulu, Wang, Sisi, Wu, Xiangping, Zhang, Ningmei, Chen, Xiaofang, Chang, Xiaoyu, Yuan, Mingqiang, Wu, Xia, Jiang, Wei, Liu, Jiaqiu, Sun, Qiang, Chen, Faqing, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Kang, Kai, Feng, Shixian, Tian, Huizi, Fan, Lei, Li, Xiaolin, Sun, Huarong, He, Pan, Zhang, Xukui, Yu, Min, Hu, Ruying, Wang, Hao, Zhang, Xiaoyi, Cao, Yuan, Xie, Kaixu, Chen, Lingli, Shen, Dun, Li, Xiaojun, Jin, Donghui, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Xin, Zhang, Hao, Chen, Jianwei, Peng, Yuan, Zhang, Libo, Qu, Chan, Xia, Xi, Meng, Xia, Liu, Cong, Guo, Yi, Li, Xinyue, Niu, Yue, Lam, Kin Bong Hubert, Gao, Ruqin, Wu, Shaowei, and Kan, Haidong

Published
2024
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4. One-size-fits-all versus risk-category-based screening interval strategies for cardiovascular disease prevention in Chinese adults: a prospective cohort study

Author

Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Li, Liming, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Barnard, Maxim, Bennett, Derrick, Belbasis, Lazaros, Boxall, Ruth, Chan, Ka Hung, Chen, Yiping, Clarke, Charlotte, Clarke, Johnathan, Du, Huaidong, Mohamed, Ahmed Edris, Fry, Hannah, Gilbert, Simon, Im, Pek Kei, Iona, Andri, Kakkoura, Maria, Kartsonaki, Christiana, Lam, Hubert, Lin, Kuang, Liu, James, Mazidi, Mohsen, Millwood, Iona, Morris, Sam, Nie, Qunhua, Pozarickij, Alfred, Rahmati, Maryanm, Ryder, Paul, Said, Saredo, Schmidt, Dan, Stevens, Becky, Turnbull, Iain, Wang, Baihan, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Yao, Pang, Han, Xiao, Hou, Can, Xia, Qingmei, Liu, Chao, Pei, Pei, Sun, Dianjianyi, Yu, Canqing, Pan, Lang, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Duan, Haiping, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Sun, Wei, Yan, Shichun, Cui, Xiaoming, Wang, Chi, Wu, Zhenyuan, Li, Yanjie, Kang, Quan, Luo, Huiming, Ou, Tingting, Zheng, Xiangyang, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Fang Liu, Jian Su., Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Lin, Mei, Lu, Zhenzhen, Zhou, Lifang, Xie, Changping, Lan, Jian, Zhu, Tingping, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Chang, Xiaoyu, Yuan, Mingqiang, Wu, Xia, Jiang, Wei, Liu, Jiaqiu, Sun, Qiang, Chen, Faqing, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Kang, Kai, Feng, Shixian, Tian, Huizi, Fan, Lei, Li, XiaoLin, Sun, Huarong, He, Pan, Zhang, Xukui, Yu, Min, Hu, Ruying, Wang, Hao, Zhang, Xiaoyi, Cao, Yuan, Xie, Kaixu, Chen, Lingli, Shen, Dun, Li, Xiaojun, Jin, Donghui, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Xin, Zhang, Hao, Chen, Jianwei, Peng, Yuan, Zhang, Libo, Qu, Chan, Sun, Zhijia, Ma, Yu, and Pang, Yuanjie

Published
2024
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6. Association between health insurance cost-sharing and choice of hospital tier for cardiovascular diseases in China: a prospective cohort study

Author

Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Li, Liming, Wang, Chen, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Barnard, Maxim, Bennett, Derrick, Boxall, Ruth, Chan, Kahung, Chen, Yiping, Clarke, Johnathan, Du, Huaidong, Mohamed, Ahmed Edris, Fry, Hannah, Gilbert, Simon, Im, Pek Kei, Iona, Andri, Kakkoura, Maria, Kartsonaki, Christiana, Lam, Hubert, Lin, Kuang, Liu, James, Mazidi, Mohsen, Millwood, Iona, Morris, Sam, Nie, Qunhua, Pozaricki, Alfred, Ryder, Paul, Said, Saredo, Schmidt, Dan, Stevens, Becky, Turnbull, Iain, Wang, Baihan, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Yao, Pang, Han, Xiao, Hou, Can, Xia, Qingmei, Liu, Chao, Pei, Pei, Sun, Dianjianyi, Yu, Canqing, Chen, Naying, Liu, Duo, Tang, Zhenzhu, Chen, Ningyu, Jiang, Qilian, Lan, Jian, Li, Mingqiang, Liu, Yun, Meng, Fanwen, Meng, Jinhuai, Pan, Rong, Qin, Yulu, Wang, Ping, Wang, Sisi, Wei, Liuping, Zhou, Liyuan, Dong, Caixia, Ge, Pengfei, Ren, Xiaolan, Li, Zhongxiao, Mao, Enke, Wang, Tao, Zhang, Hui, Zhang, Xi, Chen, Jinyan, Hu, Ximin, Wang, Xiaohuan, Guo, Zhendong, Li, Huimei, Li, Yilei, Weng, Min, Wu, Shukuan, Yan, Shichun, Zou, Mingyuan, Zhou, Xue, Guo, Ziyan, Kang, Quan, Li, Yanjie, Yu, Bo, Xu, Qinai, Chang, Liang, Fan, Lei, Feng, Shixian, Zhang, Ding, Zhou, Gang, Gao, Yulian, He, Tianyou, He, Pan, Hu, Chen, Sun, Huarong, Zhang, Xukui, Chen, Biyun, Fu, Zhongxi, Huang, Yuelong, Liu, Huilin, Xu, Qiaohua, Yin, Li, Long, Huajun, Xu, Xin, Zhang, Hao, Zhang, Libo, Su, Jian, Tao, Ran, Wu, Ming, Yang, Jie, Zhou, Jinyi, Zhou, Yonglin, Hu, Yihe, Hua, Yujie, Jin, Jianrong, Liu, Fang, Liu, Jingchao, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Jun, Cheng, Liang, Du, Ranran, Gao, Ruqin, Li, Feifei, Li, Shanpeng, Liu, Yongmei, Ning, Feng, Pang, Zengchang, Sun, Xiaohui, Tian, Xiaocao, Wang, Shaojie, Zhai, Yaoming, Zhang, Hua, Hou, Wei, Lv, Silu, Wang, Junzheng, Chen, Xiaofang, Wu, Xianping, Zhang, Ningmei, Chang, Xiaoyu, Li, Jianguo, Liu, Jiaqiu, Luo, Guojin, Sun, Qiang, Zhong, Xunfu, Gong, Weiwei, Hu, Ruying, Wang, Hao, Wang, Meng, Yu, Min, Chen, Lingli, Gu, Qijun, Pan, Dongxia, Wang, Chunmei, Xie, Kaixu, Zhang, Xiaoyi, Chen, Hongyuan, Liu, Liyang, Gou, Haiyan, Wang, Xun, Ding, Jing, Zhang, Ning, Mao, Yueshi, Zhou, Shanshan, Jin, Lirong, Cheng, Xin, Lu, Yun, Chen, Li, Hao, Zilong, Xing, Xiaona, Wang, Lei, Ju, Naixin, Mao, Yiting, Li, Shuya, Du, Peng, Wang, Deren, Sun, Xiaojia, You, Shihao, Wang, Weizhi, Zhu, Yanmei, Li, Xiaojiu, Dong, Yi, Levy, Muriel, Buckell, John, Wu, Nina, Yip, Winnie, and Mihaylova, Borislava

Published
2024
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7. Case study on the formation of a torrential‐rainfall‐producing southwest vortex: Backward trajectory analyses and sensitivity simulations

Author

Kang‐Quan Yang, Di‐Xiang Xiao, Xing‐Wen Jiang, Zi Mai, and Shen‐Ming Fu

Subjects
mesoscale vortex, sensitivity simulation, southwest vortex, torrential rainfall, trajectory analysis, Meteorology. Climatology, QC851-999
Abstract

Abstract The southwest vortices (SWVs) are a unique type of mesoscale vortex that frequently induce torrential rainfall in China. In this study, we focused a long‐lived quasi‐stationary SWV, which was the primary system for producing an extremely heavy rainstorm within/around Sichuan (the maximum hourly precipitation was ~103.8 mm) in Mid July 2021. After reproduced the SWV's formation by using Weather Research and Forecasting model, we conducted trajectory analyses and topography sensitivity simulations to understand the effects of complicated topography on the vortex's formation. It is found that, the regions south and southwest of the SWV acted as the most important source regions for the air clusters that formed the SWV (proportion ≥ 65%), and the air clusters originated from the upper layer contributed the most (≥60%). Of these, the air clusters sourced from the upper layer southwest and south of the SWV played the most important role in the SWV's formation, as their increase in cyclonic vorticity and their contributions to trajectory number and vorticity were all much larger than those of the others. Sensitivity simulations indicated that, detailed topography features around the Sichuan Basin were crucial in determining the structure, intensity and precipitation of the SWV, whereas, the topography features were not a decisive factor for the SWV's formation. In summary, our findings are useful to enrich the current understanding of the SWVs' formation, which would be helpful to improve the related forecasts.

Published
2024
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8. Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population

Author

Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li, Liming, Lv, Jun, Peto, Richard, Walter, Robin, Avery, Daniel, Bennett, Derrick, Boxall, Ruth, Burgess, Sue, Chan, Ka Hung, Chang, Yumei, Chen, Yiping, Clarke, Johnathan, Du, Huaidong, Mohamed, Ahmed Edris, Fairhurst-Hunter, Zammy, Fry, Hannah, Hill, Mike, Holmes, Michael, Im, Pek Kei, Iona, Andri, Kakkoura, Maria, Kartsonaki, Christiana, Kerosi, Rene, Lin, Kuang, Mazidi, Mohsen, Millwood, Iona, Morris, Sam, Nie, Qunhua, Pozarickij, Alfred, Ryder, Paul, Said, Saredo, Schmidt, Dan, Sherliker, Paul, Stevens, Becky, Turnbull, Iain, Walters, Robin, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Yao, Pang, Han, Xiao, Hou, Can, Pei, Pei, Liu, Chao, Yu, Canqing, Xia, Qingmei, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Duan, Haiping, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Sun, Wei, Yan, Shichun, Cui, Xiaoming, Wang, Chi, Wu, Zhenyuan, Li, Yanjie, Kang, Quan, Luo, Huiming, Ou, Tingting, Zheng, Xiangyang, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Lin, Mei, Lu, Zhenzhen, Zhou, Lifang, Xie, Changping, Lan, Jian, Zhu, Tingping, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Chang, Xiaoyu, Yuan, Mingqiang, Wu, Xia, Jiang, Wei, Liu, Jiaqiu, Sun, Qiang, Chen, Faqing, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, zhang, Xi, Kang, Kai, Feng, Shixian, Tian, Huizi, Fan, Lei, Li, XiaoLin, Sun, Huarong, He, Pan, Zhang, Xukui, Yu, Min, Hu, Ruying, Wang, Hao, Zhang, Xiaoyi, Cao, Yuan, Xie, Kaixu, Chen, Lingli, Shen, Dun, Li, Xiaojun, Jin, Donghui, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Xin, Zhang, Hao, Chen, Jianwei, Peng, Yuan, Zhang, Libo, Qu, Chan, Zhu, Yunqing, Zhuang, Zhenhuang, Sun, Dianjianyi, Millwood, Iona Y., and Walters, Robin G.

Published
2024
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9. A wide landscape of morbidity and mortality risk associated with marital status in 0.5 million Chinese men and women: a prospective cohort study

Author

Chen, Junshi, Chen (PI, Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li (PI, Liming, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Bennett, Derrick, Boxall, Ruth, Burgess, Sue, Chan, Ka Hung, Chang, Yumei, Chen, Yiping, Chen, Zhengming, Clarke, Johnathan, Du, Huaidong, Mohamed, Ahmed Edris, Fairhurst-Hunter, Zammy, Fry, Hannah, Hill, Mike, Holmes, Michael, Im, Pek Kei, Iona, Andri, Kakkoura, Maria, Kartsonaki, Christiana, Kerosi, Rene, Lin, Kuang, Mazidi, Mohsen, Millwood, Iona, Morris, Sam, Nie, Qunhua, Pozarickij, Alfred, Ryder, Paul, Said, Saredo, Schmidt, Dan, Sherliker, Paul, Stevens, Becky, Turnbull, Iain, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Yao, Pang, Han, Xiao, Hou, Can, Pei, Pei, Liu, Chao, Yu, Canqing, Xia, Qingmei, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Duan, Haiping, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Sun, Wei, Yan, Shichun, Cui, Xiaoming, Wang, Chi, Wu, Zhenyuan, Li, Yanjie, Kang, Quan, Luo, Huiming, Ou, Tingting, Zheng, Xiangyang, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Lin, Mei, Lu, Zhenzhen, Zhou, Lifang, Xie, Changping, Lan, Jian, Zhu, Tingping, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Chang, Xiaoyu, Yuan, Mingqiang, Wu, Xia, Jiang, Wei, Liu, Jiaqiu, Sun, Qiang, Chen, Faqing, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, zhang, Xi, Kang, Kai, Feng, Shixian, Tian, Huizi, Fan, Lei, Li, XiaoLin, Sun, Huarong, He, Pan, Zhang, Xukui, Yu, Min, Hu, Ruying, Wang, Hao, Zhang, Xiaoyi, Cao, Yuan, Xie, Kaixu, Chen, Lingli, Shen, Dun, Li, Xiaojun, Jin, Donghui, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Xin, Zhang, Hao, Chen, Jianwei, Peng, Yuan, Zhang, Libo, Qu, Chan, Xiao, Meng, Li, Aolin, Wang, Yueqing, Pang, Yuanjie, Li, Liming, and Sun, Dianjianyi

Published
2024
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11. Long-Term Exposure to Fine Particulate Matter and Incidence of Esophageal Cancer: A Prospective Study of 0.5 Million Chinese Adults

Author

Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li, Liming, Peto, Richard, Walters, Robin, Avery, Daniel, Bennett, Derrick, Boxall, Ruth, Burgess, Sue, Chan, Ka Hung, Chang, Yumei, Chen, Yiping, Clarke, Johnathan, Du, Huaidong, Mohamed, Ahmed Edris, Fairhurst-Hunter, Zammy, Fry, Hannah, Gilbert, Simon, Hacker, Alex, Hill, Mike, Holmes, Michael, Im, Pek Kei, Iona, Andri, Kakkoura, Maria, Kartsonaki, Christiana, Kerosi, Rene, Lin, Kuang, Mazidi, Mohsen, Millwood, Iona, Morris, Sam, Nie, Qunhua, Pozarickij, Alfred, Ryder, Paul, Said, Saredo, Sansome, Sam, Schmidt, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Yao, Pang, Han, Xiao, Hou, Can, Lv, Jun, Pei, Pei, Liu, Chao, Yu, Canqing, Xia, Qingmei, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Duan, Haiping, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Sun, Wei, Yan, Shichun, Cui, Xiaoming, Wang, Chi, Wu, Zhenyuan, Li, Yanjie, Kang, Quan, Luo, Huiming, Ou, Tingting, Zheng, Xiangyang, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Lin, Mei, Lu, Zhenzhen, Zhou, Lifang, Xie, Changping, Lan, Jian, Zhu, Tingping, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Chang, Xiaoyu, Yuan, Mingqiang, Wu, Xia, Jiang, Wei, Liu, Jiaqiu, Sun, Qiang, Chen, Faqing, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Kang, Kai, Feng, Shixian, Tian, Huizi, Fan, Lei, Li, XiaoLin, Sun, Huarong, He, Pan, Zhang, Xukui, Yu, Min, Hu, Ruying, Wang, Hao, Zhang, Xiaoyi, Cao, Yuan, Xie, Kaixu, Chen, Lingli, Shen, Dun, Li, Xiaojun, Jin, Donghui, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Xin, Zhang, Hao, Chen, Jianwei, Peng, Yuan, Zhang, Libo, Qu, Chan, Sun, Dong, Liu, Cong, Zhu, Yunqing, Sun, Dianjianyi, Pang, Yuanjie, Meng, Xia, Liu, Yang, and Kan, Haidong

Published
2023
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12. Tobacco smoking and risks of more than 470 diseases in China: a prospective cohort study

Author

Avery, Daniel, Bennett, Derrick, Boxall, Ruth, Burgess, Sushila, Chan, Peter Ka Hung, Chen, Yiping, Chen, Zhengming, Clarke, Johnathan, Clarke, Robert, Du, Huaidong, Mohamed, Ahmed Edris, Fry, Hannah, Gilbert, Simon, Hill, Mike, Im, Becky Pek Kei, Iona, Andri, Kakkoura, Maria, Kartsonaki, Christiana, Lam, Hubert, Lin, Kuang, Mazidi, Mohsen, Millwood, Iona Y, Morris, Sam, Nie, Qunhua, Pozarickij, Alfred, Ryder, Paul, Said, Saredo, Schmidt, Dan, Sherliker, Paul, Stevens, Rebecca, Turnbull, Iain, Walters, Robin, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Yao, Pang, Guo, Yu, Han, Xiao, Hou, Can, Xia, Qingmei, Liu, Chao, Lv, Jun, Pei, Pei, Yu, Canqing, Chen, Junshi, Collins, Rory, Li, Liming, Wang, Chen, Peto, Richard, Chen, Naying, Liu, Duo, Tang, Zhenzhu, Chen, Ningyu, Jiang, Qilian, Lan, Jian, Li, Mingqiang, Liu, Yun, Meng, Fanwen, Meng, Jinhuai, Pan, Rong, Qin, Yulu, Wang, Ping, Wang, Sisi, Wei, Liuping, Zhou, Liyuan, Dong, Caixia, Ge, Pengfei, Ren, Xiaolan, Li, Zhongxiao, Mao, Enke, Wang, Tao, Zhang, Hui, Zhang, Xi, Chen, Jinyan, Hu, Ximin, Wang, Xiaohuan, Guo, Zhendong, Li, Huimei, Li, Yilei, Weng, Min, Wu, Shukuan, Yan, Shichun, Zou, Mingyuan, Zhou, Xue, Guo, Ziyan, Kang, Quan, Li, Yanjie, Yu, Bo, Xu, Qinai, Chang, Liang, Fan, Lei, Feng, Shixian, Zhang, Ding, Zhou, Gang, Gao, Yulian, He, Tianyou, He, Pan, Hu, Chen, Sun, Huarong, Zhang, Xukui, Chen, Biyun, Fu, Zhongxi, Huang, Yuelong, Liu, Huilin, Xu, Qiaohua, Yin, Li, Long, Huajun, Xu, Xin, Zhang, Hao, Zhang, Libo, Su, Jian, Tao, Ran, Wu, Ming, Yang, Jie, Zhou, Jinyi, Zhou, Yonglin, Hu, Yihe, Hua, Yujie, Jin, Jianrong, Liu, Fang, Liu, Jingchao, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Jun, Cheng, Liang, Du, Ranran, Gao, Ruqin, Li, Feifei, Li, Shanpeng, Liu, Yongmei, Ning, Feng, Pang, Zengchang, Sun, Xiaohui, Tian, Xiaocao, Wang, Shaojie, Zhai, Yaoming, Zhang, Hua, Hou, Wei, Lv, Silu, Wang, Junzheng, Chen, Xiaofang, Wu, Xianping, Zhang, Ningmei, Zhou, Weiwei, Li, Jianguo, Liu, Jiaqiu, Luo, Guojin, Sun, Qiang, Zhong, Xunfu, Gong, Weiwei, Hu, Ruying, Wang, Hao, Wang, Meng, Yu, Min, Chen, Lingli, Gu, Qijun, Pan, Dongxia, Wang, Chunmei, Xie, Kaixu, Zhang, Xiaoyi, Chan, Ka Hung, and Xiao, Dan

Published
2022
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16. Association of heart rate and diabetes among 0.5 million adults in the China Kadoorie biobank: Results from observational and Mendelian randomization analyses

Author

Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li, Liming, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Boxall, Ruth, Bennett, Derrick, Chang, Yumei, Chen, Yiping, Du, Huaidong, Gilbert, Simon, Hacker, Alex, Hill, Mike, Holmes, Michael, Iona, Andri, Kartsonaki, Christiana, Kerosi, Rene, Kong, Ling, Kurmi, Om, Lancaster, Garry, Lewington, Sarah, Lin, Kuang, McDonnell, John, Millwood, Iona, Nie, Qunhua, Radhakrishnan, Jayakrishnan, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Jenny, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Bian, Zheng, Han, Xiao, Hou, Can, Pei, Pei, Liu, Chao, Tan, Yunlong, Yu, Canqing, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Zeng, Mingyuan, Jiang, Ge, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Xu, Qinai, Kang, Quan, Guo, Ziyan, Wang, Dan, Hu, Ximin, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Weng, Min, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Fu, Zhifang, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Lan, Jian, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Ping Wang, Ningyu Chen, Meng, Fanwen, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Zhou, Weiwei, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, zhang, Xi, Zhang, Ding, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Zhang, Xukui, Wu, Huifang, Yu, Min, Hu, Ruying, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixu, Chen, Lingli, Zhang, Yidan, Pan, Dongxia, Gu, Qijun, Huang, Yuelong, Chen, Biyun, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Long, Huajun, Li, Xianzhi, Zhang, Libo, Qiu, Zhe, Wang, Wenxiu, Wang, Jingjia, Shao, Chunli, Tang, Yida, Millwood, Iona Y., Walters, Robin G., and Huang, Tao

Published
2021
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17. Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype

Author

Chisaka Kuehnemann, Kang-Quan Hu, Kayla Butera, Sandip K. Patel, Joanna Bons, Birgit Schilling, Cristina Aguayo-Mazzucato, and Christopher D. Wiley

Subjects
senescence, cellular senescence, NAMPT, eNAMPT, SASP, NAD, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Cellular senescence is a stress or damage response by which a cell adopts of state of essentially permanent proliferative arrest, coupled to the secretion of a number of biologically active molecules. This senescence-associated secretory phenotype (SASP) underlies many of the degenerative and regenerative aspects of cellular senescence - including promoting wound healing and development, but also driving diabetes and multiple age-associated diseases. We find that nicotinamide phosphoribosyltransferase (NAMPT), which catalyzes the rate-limiting step in nicotinamide adenine dinucleotide (NAD) biosynthesis, is elevated in senescent cells without a commensurate increase in NAD levels. This elevation is distinct from the acute DNA damage response, in which NAD is depleted, and recovery of NAD by NAMPT elevation is AMPK-activated protein kinase (AMPK)-dependent. Instead, we find that senescent cells release extracellular NAMPT (eNAMPT) as part of the SASP. eNAMPT has been reported to be released as a catalytically active extracellular vesicle-contained dimer that promotes NAD increases in other cells and extends lifespan, and also as free monomer that acts as a damage-associated molecular pattern and promotes conditions such as diabetes and fibrosis. Senescent cells released eNAMPT as dimer, but surprisingly eNAMPT appeared in the soluble secretome while being depleted from exosomes. Finally, diabetic mice showed elevated levels of eNAMPT, and this was lowered by treatment with the senolytic drug, ABT-263. Together, these data reveal a new SASP factor with implications for NAD metabolism.

Published
2022
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18. Mortality and recurrent vascular events after first incident stroke: a 9-year community-based study of 0·5 million Chinese adults

Author

Chen, Yiping, Wright, Neil, Guo, Yu, Turnbull, Iain, Kartsonaki, Christiana, Yang, Ling, Bian, Zheng, Pei, Pei, Pan, Dongxia, Zhang, Yidan, Qin, Haiqiang, Wang, Yilong, Lv, Jun, Liu, Ming, Hao, Zilong, Wang, Yongjun, Yu, Canqing, Peto, Richard, Collins, Rory, Li, Liming, Clarke, Robert, Chen, Zhengming, Chen, Junshi, Walters, Robin, Avery, Daniel, Bennett, Derrick, Boxall, Ruth, Bragg, Fiona, Chang, Yumei, Du, Huaidong, Gilbert, Simon, Hacker, Alex, Holmes, Michael, Kerosi, Rene, Lancaster, Garry, Lin, Kuang, McDonnell, John, Millwood, Iona, Nie, Qunhua, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sohoni, Rajani, Wang, Jenny, Wang, Lin, Yang, Xiaoming, Han, Xiao, Hou, Can, Jing, Biao, Liu, Chao, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Zeng, Mingyuan, Jiang, Ge, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Xu, Qinai, Kang, Quan, Guo, Ziyan, Wang, Dan, Hu, Ximin, Wang, Hongmei, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Weng, Min, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Fu, Zhifang, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Lan, Jian, Liu, Yun, Wei, Liuping, Chen, Ningyu, Wang, Ping, Meng, Fanwen, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Zhou, Weiwei, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhang, Ding, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Zhang, Xukui, Wu, Huifang, Yu, Min, Hu, Ruying, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixu, Chen, Lingli, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Long, Huajun, Li, Xianzhi, Zhang, Libo, and Qiu, Zhe

Published
2020
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19. Association between health insurance cost-sharing and choice of hospital tier for cardiovascular diseases in China: a prospective cohort study

Author

Levy, Muriel, primary, Buckell, John, additional, Clarke, Robert, additional, Wu, Nina, additional, Pei, Pei, additional, Sun, Dianjianyi, additional, Avery, Daniel, additional, Zhang, Hua, additional, Lv, Jun, additional, Yu, Canqing, additional, Li, Liming, additional, Chen, Zhengming, additional, Yip, Winnie, additional, Chen, Yiping, additional, Mihaylova, Borislava, additional, Chen, Junshi, additional, Collins, Rory, additional, Wang, Chen, additional, Peto, Richard, additional, Walters, Robin, additional, Barnard, Maxim, additional, Bennett, Derrick, additional, Boxall, Ruth, additional, Chan, Kahung, additional, Clarke, Johnathan, additional, Du, Huaidong, additional, Mohamed, Ahmed Edris, additional, Fry, Hannah, additional, Gilbert, Simon, additional, Im, Pek Kei, additional, Iona, Andri, additional, Kakkoura, Maria, additional, Kartsonaki, Christiana, additional, Lam, Hubert, additional, Lin, Kuang, additional, Liu, James, additional, Mazidi, Mohsen, additional, Millwood, Iona, additional, Morris, Sam, additional, Nie, Qunhua, additional, Pozaricki, Alfred, additional, Ryder, Paul, additional, Said, Saredo, additional, Schmidt, Dan, additional, Stevens, Becky, additional, Turnbull, Iain, additional, Wang, Baihan, additional, Wang, Lin, additional, Wright, Neil, additional, Yang, Ling, additional, Yang, Xiaoming, additional, Yao, Pang, additional, Han, Xiao, additional, Hou, Can, additional, Xia, Qingmei, additional, Liu, Chao, additional, Chen, Naying, additional, Liu, Duo, additional, Tang, Zhenzhu, additional, Chen, Ningyu, additional, Jiang, Qilian, additional, Lan, Jian, additional, Li, Mingqiang, additional, Liu, Yun, additional, Meng, Fanwen, additional, Meng, Jinhuai, additional, Pan, Rong, additional, Qin, Yulu, additional, Wang, Ping, additional, Wang, Sisi, additional, Wei, Liuping, additional, Zhou, Liyuan, additional, Dong, Caixia, additional, Ge, Pengfei, additional, Ren, Xiaolan, additional, Li, Zhongxiao, additional, Mao, Enke, additional, Wang, Tao, additional, Zhang, Hui, additional, Zhang, Xi, additional, Chen, Jinyan, additional, Hu, Ximin, additional, Wang, Xiaohuan, additional, Guo, Zhendong, additional, Li, Huimei, additional, Li, Yilei, additional, Weng, Min, additional, Wu, Shukuan, additional, Yan, Shichun, additional, Zou, Mingyuan, additional, Zhou, Xue, additional, Guo, Ziyan, additional, Kang, Quan, additional, Li, Yanjie, additional, Yu, Bo, additional, Xu, Qinai, additional, Chang, Liang, additional, Fan, Lei, additional, Feng, Shixian, additional, Zhang, Ding, additional, Zhou, Gang, additional, Gao, Yulian, additional, He, Tianyou, additional, He, Pan, additional, Hu, Chen, additional, Sun, Huarong, additional, Zhang, Xukui, additional, Chen, Biyun, additional, Fu, Zhongxi, additional, Huang, Yuelong, additional, Liu, Huilin, additional, Xu, Qiaohua, additional, Yin, Li, additional, Long, Huajun, additional, Xu, Xin, additional, Zhang, Hao, additional, Zhang, Libo, additional, Su, Jian, additional, Tao, Ran, additional, Wu, Ming, additional, Yang, Jie, additional, Zhou, Jinyi, additional, Zhou, Yonglin, additional, Hu, Yihe, additional, Hua, Yujie, additional, Jin, Jianrong, additional, Liu, Fang, additional, Liu, Jingchao, additional, Lu, Yan, additional, Ma, Liangcai, additional, Tang, Aiyu, additional, Zhang, Jun, additional, Cheng, Liang, additional, Du, Ranran, additional, Gao, Ruqin, additional, Li, Feifei, additional, Li, Shanpeng, additional, Liu, Yongmei, additional, Ning, Feng, additional, Pang, Zengchang, additional, Sun, Xiaohui, additional, Tian, Xiaocao, additional, Wang, Shaojie, additional, Zhai, Yaoming, additional, Hou, Wei, additional, Lv, Silu, additional, Wang, Junzheng, additional, Chen, Xiaofang, additional, Wu, Xianping, additional, Zhang, Ningmei, additional, Chang, Xiaoyu, additional, Li, Jianguo, additional, Liu, Jiaqiu, additional, Luo, Guojin, additional, Sun, Qiang, additional, Zhong, Xunfu, additional, Gong, Weiwei, additional, Hu, Ruying, additional, Wang, Hao, additional, Wang, Meng, additional, Yu, Min, additional, Chen, Lingli, additional, Gu, Qijun, additional, Pan, Dongxia, additional, Wang, Chunmei, additional, Xie, Kaixu, additional, Zhang, Xiaoyi, additional, Chen, Hongyuan, additional, Liu, Liyang, additional, Gou, Haiyan, additional, Wang, Xun, additional, Ding, Jing, additional, Zhang, Ning, additional, Mao, Yueshi, additional, Zhou, Shanshan, additional, Jin, Lirong, additional, Cheng, Xin, additional, Lu, Yun, additional, Chen, Li, additional, Hao, Zilong, additional, Xing, Xiaona, additional, Wang, Lei, additional, Ju, Naixin, additional, Mao, Yiting, additional, Li, Shuya, additional, Du, Peng, additional, Wang, Deren, additional, Sun, Xiaojia, additional, You, Shihao, additional, Wang, Weizhi, additional, Zhu, Yanmei, additional, Li, Xiaojiu, additional, and Dong, Yi, additional

Published
2024
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20. Cooking fuels and risk of all-cause and cardiopulmonary mortality in urban China: a prospective cohort study

Author

Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li, Liming, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Boxall, Ruth, Chang, Yumei, Chen, Yiping, Du, Huaidong, Gilbert, Simon, Hacker, Alex, Hill, Mike, Holmes, Michael, Iona, Andri, Kartsonaki, Christiana, Kerosi, Rene, Kong, Ling, Kurmi, Om, Lancaster, Garry, Lewington, Sarah, Lin, Kuang, McDonnell, John, Millwood, Iona, Nie, Qunhua, Radhakrishnan, Jayakrishnan, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Jenny, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Bian, Zheng, Han, Xiao, Hou, Can, Pei, Pei, Liu, Chao, Tan, Yunlong, Yu, Canqing, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Zeng, Mingyuan, Jiang, Ge, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Xu, Qinai, Kang, Quan, Guo, Ziyan, Wang, Dan, Hu, Ximin, Wang, Hongmei, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Weng, Min, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Fu, Zhifang, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Lan, Jian, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Wang, Ping, Meng, Fanwen, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Zhou, Weiwei, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhang, Ding, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Zhang, Xukui, Wu, Huifang, Yu, Min, Hu, Ruying, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixu, Chen, Lingli, Zhang, Yidan, Pan, Dongxia, Gu, Qijun, Huang, Yuelong, Chen, Biyun, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Long, Huajun, Li, Xianzhi, Zhang, Libo, Qiu, Zhe, Yu, Kuai, Qiu, Gaokun, Wang, Chaolong, Pan, An, Liang, Liming, Hu, Frank B, and Wu, Tangchun

Published
2020
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21. β-Cryptoxanthin Attenuates Cigarette-Smoke-Induced Lung Lesions in the Absence of Carotenoid Cleavage Enzymes (BCO1/BCO2) in Mice

Author

Rachel A. Chiaverelli, Kang-Quan Hu, Chun Liu, Ji Ye Lim, Michael S. Daniels, Hui Xia, Jonathan Mein, Johannes von Lintig, and Xiang-Dong Wang

Subjects
β-cryptoxanthin, vitamin A, lung inflammation, cigarette smoke exposure, carotenoid cleavage enzymes, Organic chemistry, QD241-441
Abstract

High dietary intake of β-cryptoxanthin (BCX, an oxygenated provitamin A carotenoid) is associated with a lower risk of lung disease in smokers. BCX can be cleaved by β-carotene-15,15′-oxygenase (BCO1) and β-carotene-9′,10′-oxygenase (BCO2) to produce retinol and apo-10′-carotenoids. We investigated whether BCX has protective effects against cigarette smoke (CS)-induced lung injury, dependent or independent of BCO1/BCO2 and their metabolites. Both BCO1−/−/BCO2−/− double knockout mice (DKO) and wild type (WT) littermates were supplemented with BCX 14 days and then exposed to CS for an additional 14 days. CS exposure significantly induced macrophage and neutrophil infiltration in the lung tissues of mice, regardless of genotypes, compared to the non-exposed littermates. BCX treatment significantly inhibited CS-induced inflammatory cell infiltration, hyperplasia in the bronchial epithelium, and enlarged alveolar airspaces in both WT and DKO mice, regardless of sex. The protective effects of BCX were associated with lower expression of IL-6, TNF-α, and matrix metalloproteinases-2 and -9. BCX treatment led to a significant increase in hepatic BCX levels in DKO mice, but not in WT mice, which had significant increase in hepatic retinol concentration. No apo-10′-carotenoids were detected in any of the groups. In vitro BCX, at comparable doses of 3-OH-β-apo-10′-carotenal, was effective at inhibiting the lipopolysaccharide-induced inflammatory response in a human bronchial epithelial cell line. These data indicate that BCX can serve as an effective protective agent against CS-induced lung lesions in the absence of carotenoid cleavage enzymes.

Published
2023
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22. Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins (BMPs) in lineage commitment and differentiation of mesenchymal stem cells (MSCs)

Author

Zhang, Linghuan, Luo, Qing, Shu, Yi, Zeng, Zongyue, Huang, Bo, Feng, Yixiao, Zhang, Bo, Wang, Xi, Lei, Yan, Ye, Zhenyu, Zhao, Ling, Cao, Daigui, Yang, Lijuan, Chen, Xian, Liu, Bin, Wagstaff, William, Reid, Russell R., Luu, Hue H., Haydon, Rex C., Lee, Michael J., Wolf, Jennifer Moriatis, Fu, Zhou, He, Tong-Chuan, and Kang, Quan

Published
2019
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25. Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population

Author

Zhu, Yunqing, primary, Zhuang, Zhenhuang, additional, Lv, Jun, additional, Sun, Dianjianyi, additional, Pei, Pei, additional, Yang, Ling, additional, Millwood, Iona Y., additional, Walters, Robin G., additional, Chen, Yiping, additional, Du, Huaidong, additional, Wu, Xianping, additional, Schmidt, Dan, additional, Avery, Daniel, additional, Chen, Junshi, additional, Chen, Zhengming, additional, Li, Liming, additional, Yu, Canqing, additional, Clarke, Robert, additional, Collins, Rory, additional, Guo, Yu, additional, Peto, Richard, additional, Walter, Robin, additional, Bennett, Derrick, additional, Boxall, Ruth, additional, Burgess, Sue, additional, Chan, Ka Hung, additional, Chang, Yumei, additional, Clarke, Johnathan, additional, Mohamed, Ahmed Edris, additional, Fairhurst-Hunter, Zammy, additional, Fry, Hannah, additional, Hill, Mike, additional, Holmes, Michael, additional, Im, Pek Kei, additional, Iona, Andri, additional, Kakkoura, Maria, additional, Kartsonaki, Christiana, additional, Kerosi, Rene, additional, Lin, Kuang, additional, Mazidi, Mohsen, additional, Millwood, Iona, additional, Morris, Sam, additional, Nie, Qunhua, additional, Pozarickij, Alfred, additional, Ryder, Paul, additional, Said, Saredo, additional, Sherliker, Paul, additional, Stevens, Becky, additional, Turnbull, Iain, additional, Walters, Robin, additional, Wang, Lin, additional, Wright, Neil, additional, Yang, Xiaoming, additional, Yao, Pang, additional, Han, Xiao, additional, Hou, Can, additional, Liu, Chao, additional, Xia, Qingmei, additional, Pang, Zengchang, additional, Gao, Ruqin, additional, Li, Shanpeng, additional, Duan, Haiping, additional, Wang, Shaojie, additional, Liu, Yongmei, additional, Du, Ranran, additional, Zang, Yajing, additional, Cheng, Liang, additional, Tian, Xiaocao, additional, Zhang, Hua, additional, Zhai, Yaoming, additional, Ning, Feng, additional, Sun, Xiaohui, additional, Li, Feifei, additional, Lv, Silu, additional, Wang, Junzheng, additional, Hou, Wei, additional, Sun, Wei, additional, Yan, Shichun, additional, Cui, Xiaoming, additional, Wang, Chi, additional, Wu, Zhenyuan, additional, Li, Yanjie, additional, Kang, Quan, additional, Luo, Huiming, additional, Ou, Tingting, additional, Zheng, Xiangyang, additional, Guo, Zhendong, additional, Wu, Shukuan, additional, Li, Yilei, additional, Li, Huimei, additional, Wu, Ming, additional, Zhou, Yonglin, additional, Zhou, Jinyi, additional, Tao, Ran, additional, Yang, Jie, additional, Su, Jian, additional, Liu, Fang, additional, Zhang, Jun, additional, Hu, Yihe, additional, Lu, Yan, additional, Ma, Liangcai, additional, Tang, Aiyu, additional, Zhang, Shuo, additional, Jin, Jianrong, additional, Liu, Jingchao, additional, Lin, Mei, additional, Lu, Zhenzhen, additional, Zhou, Lifang, additional, Xie, Changping, additional, Lan, Jian, additional, Zhu, Tingping, additional, Liu, Yun, additional, Wei, Liuping, additional, Zhou, Liyuan, additional, Chen, Ningyu, additional, Qin, Yulu, additional, Wang, Sisi, additional, Zhang, Ningmei, additional, Chen, Xiaofang, additional, Chang, Xiaoyu, additional, Yuan, Mingqiang, additional, Wu, Xia, additional, Jiang, Wei, additional, Liu, Jiaqiu, additional, Sun, Qiang, additional, Chen, Faqing, additional, Ren, Xiaolan, additional, Dong, Caixia, additional, Zhang, Hui, additional, Mao, Enke, additional, Wang, Xiaoping, additional, Wang, Tao, additional, zhang, Xi, additional, Kang, Kai, additional, Feng, Shixian, additional, Tian, Huizi, additional, Fan, Lei, additional, Li, XiaoLin, additional, Sun, Huarong, additional, He, Pan, additional, Zhang, Xukui, additional, Yu, Min, additional, Hu, Ruying, additional, Wang, Hao, additional, Zhang, Xiaoyi, additional, Cao, Yuan, additional, Xie, Kaixu, additional, Chen, Lingli, additional, Shen, Dun, additional, Li, Xiaojun, additional, Jin, Donghui, additional, Yin, Li, additional, Liu, Huilin, additional, Fu, Zhongxi, additional, Xu, Xin, additional, Zhang, Hao, additional, Chen, Jianwei, additional, Peng, Yuan, additional, Zhang, Libo, additional, and Qu, Chan, additional

Published
2024
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30. Case study on the formation of a torrential‐rainfall‐producing southwest vortex: Backward trajectory analyses and sensitivity simulations.

Author

Yang, Kang‐Quan, Xiao, Di‐Xiang, Jiang, Xing‐Wen, Mai, Zi, and Fu, Shen‐Ming

Subjects
RAINSTORMS, METEOROLOGICAL research, SENSITIVITY analysis, WEATHER forecasting, VORTEX motion, TOPOGRAPHY
Abstract

The southwest vortices (SWVs) are a unique type of mesoscale vortex that frequently induce torrential rainfall in China. In this study, we focused a long‐lived quasi‐stationary SWV, which was the primary system for producing an extremely heavy rainstorm within/around Sichuan (the maximum hourly precipitation was ~103.8 mm) in Mid July 2021. After reproduced the SWV's formation by using Weather Research and Forecasting model, we conducted trajectory analyses and topography sensitivity simulations to understand the effects of complicated topography on the vortex's formation. It is found that, the regions south and southwest of the SWV acted as the most important source regions for the air clusters that formed the SWV (proportion ≥ 65%), and the air clusters originated from the upper layer contributed the most (≥60%). Of these, the air clusters sourced from the upper layer southwest and south of the SWV played the most important role in the SWV's formation, as their increase in cyclonic vorticity and their contributions to trajectory number and vorticity were all much larger than those of the others. Sensitivity simulations indicated that, detailed topography features around the Sichuan Basin were crucial in determining the structure, intensity and precipitation of the SWV, whereas, the topography features were not a decisive factor for the SWV's formation. In summary, our findings are useful to enrich the current understanding of the SWVs' formation, which would be helpful to improve the related forecasts. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Long-Term Exposure to Fine Particulate Matter and Incidence of Esophageal Cancer: A Prospective Study of 0.5 Million Chinese Adults

Author

Sun, Dong, primary, Liu, Cong, additional, Zhu, Yunqing, additional, Yu, Canqing, additional, Guo, Yu, additional, Sun, Dianjianyi, additional, Pang, Yuanjie, additional, Pei, Pei, additional, Du, Huaidong, additional, Yang, Ling, additional, Chen, Yiping, additional, Meng, Xia, additional, Liu, Yang, additional, Zhang, Jun, additional, Schmidt, Dan, additional, Avery, Daniel, additional, Chen, Junshi, additional, Chen, Zhengming, additional, Lv, Jun, additional, Kan, Haidong, additional, Li, Liming, additional, Clarke, Robert, additional, Collins, Rory, additional, Peto, Richard, additional, Walters, Robin, additional, Bennett, Derrick, additional, Boxall, Ruth, additional, Burgess, Sue, additional, Chan, Ka Hung, additional, Chang, Yumei, additional, Clarke, Johnathan, additional, Mohamed, Ahmed Edris, additional, Fairhurst-Hunter, Zammy, additional, Fry, Hannah, additional, Gilbert, Simon, additional, Hacker, Alex, additional, Hill, Mike, additional, Holmes, Michael, additional, Im, Pek Kei, additional, Iona, Andri, additional, Kakkoura, Maria, additional, Kartsonaki, Christiana, additional, Kerosi, Rene, additional, Lin, Kuang, additional, Mazidi, Mohsen, additional, Millwood, Iona, additional, Morris, Sam, additional, Nie, Qunhua, additional, Pozarickij, Alfred, additional, Ryder, Paul, additional, Said, Saredo, additional, Sansome, Sam, additional, Sherliker, Paul, additional, Sohoni, Rajani, additional, Stevens, Becky, additional, Turnbull, Iain, additional, Wang, Lin, additional, Wright, Neil, additional, Yang, Xiaoming, additional, Yao, Pang, additional, Han, Xiao, additional, Hou, Can, additional, Liu, Chao, additional, Xia, Qingmei, additional, Pang, Zengchang, additional, Gao, Ruqin, additional, Li, Shanpeng, additional, Duan, Haiping, additional, Wang, Shaojie, additional, Liu, Yongmei, additional, Du, Ranran, additional, Zang, Yajing, additional, Cheng, Liang, additional, Tian, Xiaocao, additional, Zhang, Hua, additional, Zhai, Yaoming, additional, Ning, Feng, additional, Sun, Xiaohui, additional, Li, Feifei, additional, Lv, Silu, additional, Wang, Junzheng, additional, Hou, Wei, additional, Sun, Wei, additional, Yan, Shichun, additional, Cui, Xiaoming, additional, Wang, Chi, additional, Wu, Zhenyuan, additional, Li, Yanjie, additional, Kang, Quan, additional, Luo, Huiming, additional, Ou, Tingting, additional, Zheng, Xiangyang, additional, Guo, Zhendong, additional, Wu, Shukuan, additional, Li, Yilei, additional, Li, Huimei, additional, Wu, Ming, additional, Zhou, Yonglin, additional, Zhou, Jinyi, additional, Tao, Ran, additional, Yang, Jie, additional, Su, Jian, additional, Liu, Fang, additional, Hu, Yihe, additional, Lu, Yan, additional, Ma, Liangcai, additional, Tang, Aiyu, additional, Zhang, Shuo, additional, Jin, Jianrong, additional, Liu, Jingchao, additional, Lin, Mei, additional, Lu, Zhenzhen, additional, Zhou, Lifang, additional, Xie, Changping, additional, Lan, Jian, additional, Zhu, Tingping, additional, Liu, Yun, additional, Wei, Liuping, additional, Zhou, Liyuan, additional, Chen, Ningyu, additional, Qin, Yulu, additional, Wang, Sisi, additional, Wu, Xianping, additional, Zhang, Ningmei, additional, Chen, Xiaofang, additional, Chang, Xiaoyu, additional, Yuan, Mingqiang, additional, Wu, Xia, additional, Jiang, Wei, additional, Liu, Jiaqiu, additional, Sun, Qiang, additional, Chen, Faqing, additional, Ren, Xiaolan, additional, Dong, Caixia, additional, Zhang, Hui, additional, Mao, Enke, additional, Wang, Xiaoping, additional, Wang, Tao, additional, Zhang, Xi, additional, Kang, Kai, additional, Feng, Shixian, additional, Tian, Huizi, additional, Fan, Lei, additional, Li, XiaoLin, additional, Sun, Huarong, additional, He, Pan, additional, Zhang, Xukui, additional, Yu, Min, additional, Hu, Ruying, additional, Wang, Hao, additional, Zhang, Xiaoyi, additional, Cao, Yuan, additional, Xie, Kaixu, additional, Chen, Lingli, additional, Shen, Dun, additional, Li, Xiaojun, additional, Jin, Donghui, additional, Yin, Li, additional, Liu, Huilin, additional, Fu, Zhongxi, additional, Xu, Xin, additional, Zhang, Hao, additional, Chen, Jianwei, additional, Peng, Yuan, additional, Zhang, Libo, additional, and Qu, Chan, additional

Published
2023
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46. Mechanisms Governing the Formation and Long-Term Sustainment of a Northeastward Moving Southwest Vortex

Author

Fu, Kang-Quan Yang, Di-Xiang Xiao, Xing-Wen Jiang, Zi-Rui Li, and Shen-Ming

Subjects
mesoscale vortex, southwest vortex, heavy rainfall, vorticity budget
Abstract

From 10 July to 12 July 2021, a long-lived (~66 h) southwest vortex (SWV), moved from Southwest China to Northeast China and caused a series of heavy rainfall events. This SWV case was rarely seen, as its lifespan was much longer than the SWVs’ mean lifespan, and the vast majority of SWVs showed a quasi-stationary behavior. It was found that the SWV formed and sustained in favorable background environments, which were characterized by a strong upper-level divergence (related to the South Asia High), a notable middle-tropospheric warm advection (related to a shortwave trough), and a vigorous low-level jet. The SWV showed remarkable interactions with a middle-tropospheric mesoscale vortex. The strong southwesterly wind in the eastern section of a deep shortwave trough east of the Tibetan Plateau acted as the steering flow for the northeastward movement of both vortices. Vorticity budget showed that the convergence-related vertical stretching dominated the SWV’s formation and development; the convection-related upward transport of cyclonic vorticity was the most favorable factor for the SWV’s sustainment, whereas, during the decaying stage, the SWV dissipated mainly due to the tilting effects and the net export transport of cyclonic vorticity. Backward trajectory analyses showed that most of the air particles that formed the SWV (at its formation time) were sourced from the lower troposphere. These air particles mainly ascended and experienced a rapid increase in cyclonic vorticity during the SWV’s formation stage. The topography of the Yunnan–Guizhou Plateau was crucial for the SWV’s formation, as around a half of the air particles (that formed the SWV) came from this region. Most of these air particles enhanced in their cyclonic vorticity and convergence when they descended along the topography of the plateau.

Published
2023
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47. PFFNET: A Fast Progressive Feature Fusion Network for Detecting Drones in Infrared Images

Author

Qiang Zi Han, Cong Zhang, Zhen Heng Feng, Kai Ming Yue, and Nan Kang Quan

Abstract

The rampant misuse of drones poses a serious threat to national security and human life. Currently, the CNN method has been widely used in drone detection. However, there is a challenge that traditional CNN cannot cope with, which is small drone targets often have reduced amplitude or even lost features in infrared images. This paper proposes a Progressive Feature Fusion Network (PFFNet) that gradually increases the response amplitude of the target in the deep network. The Feature Selection Model (FSM) is designed to improve the utilisation of the output coding graph and enhance the feature representation of the target in the network. A lightweight segmentation head is also designed to achieve progressive feature fusion with multi-layer outputs. Experimental results show that the proposed algorithm can achieve low duration and high accuracy in drone target detection. On the public dataset, the IoU is improved by 2.53% and the detection time is reduced by 81.03%.

Published
2023
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49. Supplementary Figure 2 from Lycopene Metabolite, Apo-10′-Lycopenoic Acid, Inhibits Diethylnitrosamine-Initiated, High Fat Diet–Promoted Hepatic Inflammation and Tumorigenesis in Mice

Author

Xiang-Dong Wang, Lynne M. Ausman, Martin S. Obin, Donald E. Smith, Chun Liu, Kang-Quan Hu, and Blanche C. Ip

Abstract

PDF file - 61K, Supplementary Figure S2. Inhibition of carcinogen-initiated (DEN), HFD-promoted glucose intolerance by APO10LA. Glucose tolerance test was conducted on 6-8 mice/group and calculated for AUC.

Published
2023
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