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1,485 results on '"Kang, Sang-Wook"'

35. Artificial Vasa‐Vasorum Serves as an On‐Site Regenerative Promoter of Cell‐Free Vascular Grafting.

Author

Ha, Hyun‐su, Baek, Sewoom, Lee, Kyubae, Cho, Sungwoo, Cho, Min Jeong, Chung, Seyong, Choi, Hyeongyun, Lee, Chan Hee, Kim, Min Seok, Kim, Si Yeong, Kim, Dae‐Hyun, Kang, Sang‐Wook, and Sung, Hak‐Joon

Subjects
VASCULAR grafts, EXTERIOR walls, MUSCLE cells, SMOOTH muscle, ARTERIES
Abstract

The control paradigm of small vessel pathophysiology has changed to focus on the vascular out‐wall rather than the lumen‐intimal factors. As an emerging controller of the external wall, the microvasculature ("vasa vasorum") provides interactional routes between the in‐and out‐sides of the vascular wall. Despite numerous approaches to developing small‐diameter vascular grafts, engineering artificial vasa vasorum (AVV) has not been projected as a multi‐functional solution to address long‐standing issues such as thrombotic and immune controls for wall regeneration. Here, the AVV is engineered using a microchannel network hydrogel after a multi‐study validation of implantation functions and then used to wrap the external wall of the cell‐free vessel post‐decellularization while preserving its mechanical properties. Upon inter‐positional and bypass grafting to rabbit arteries, the AVV graft facilitates the recruitment of vascular cells into the cell‐free wall by promoting invasion of angiogenic and vasculogenic cells through the microchannel‐mediated M2 polarization of macrophages. This function results in the efficient restoration of smooth muscle cells, and the revitalized vascular elasticity helps to maintain long‐term patency. The AVV, therefore, serves as an effective catalyst for vascular wall regeneration, offering a solution to clinically successful small‐diameter vascular grafting. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Effect of intra‐alveolar delivery of Frondoside A on inflammatory response of delayed tooth replantation.

Author

Herr, Lar, Ye, Ju Ri, Kang, Sang Wook, Ro, Sang Tae, Chae, Yong Kwon, Lee, Ko Eun, Kim, Mi Sun, Jih, Myeong Kwan, Lee, Chunui, Choi, Sung Chul, and Nam, Ok Hyung

Subjects
TOOTH replantation, ROOT resorption (Teeth), INFLAMMATION, TOOTH eruption, PERIODONTAL ligament, SEA cucumbers, SPRAGUE Dawley rats
Abstract

Background/Aim: Frondoside A is a sea cucumber extract which is well known for its anti‐inflammatory and immunomodulatory properties. The purpose of this study was to evaluate the effect of Frondoside A application in the alveolar socket on inflammatory responses after delayed replantation in rat teeth. Materials and Methods: Human periodontal ligament cells were cultured and exposed to Frondoside A. Cell‐counting kit‐8 assay was performed to evaluate the cell viability and nitric oxide assay was performed to assess the anti‐inflammatory effect of Frondoside A. Molars were extracted from 32 Sprague–Dawley rats and randomly divided into control and Frondoside A groups. After 30 min of extra‐oral dry time, molars were replanted. In the Frondoside A group, Frondoside A solution was applied in the alveolar socket before replantation. The animals were sacrificed after 28 days and histologically and immunohistochemically evaluated. Results: 0.5 μM Frondoside A showed higher cellular viability at 6 h and lower production of nitric oxide compared with other Frondoside A solutions (p <.05). The Frondoside A group demonstrated lower inflammatory resorption scores in both middle 1/3 and apical 1/3 of root compared to the control group (p <.05). The Frondoside A group showed lower levels of expression in both cathepsin K and CD45 compared with the control group (p <.05). Conclusions: Within the limits of this study, intra‐alveolar delivery of Frondoside A alleviates inflammatory root resorption in delayed replantation of rat teeth. [ABSTRACT FROM AUTHOR]

Published
2024
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