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1. Mid-term outcome of catheter ablation of idiopathic non-outflow tract ventricular arrhythmias

Author

Dian Cheng, Jinbo Yu, Kanghui Chen, Xiaorong Li, Fengxiang Zhang, Weizhu Ju, Hongwu Chen, Gang Yang, Mingfang Li, Kai Gu, Xuecheng Wang, Xin Xie, Yizhang Wu, Jian Zhou, Xiaoqian Zhou, Pipin Kojodjojo, Bing Yang, and Minglong Chen

Subjects
Catheter ablation, Non-outflow tract, Ventricular arrhythmias, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Catheter ablation is recommended in patients with frequent and symptomatic ventricular arrhythmias (VAs) in an otherwise normal heart. Right or left outflow tract (OT) are the most common origins, and catheter ablation is highly effective with low complication rates. However, outcome of catheter ablation of VAs other than the OT (non-OTVAs) is limited. The aim of this single-center study was to assess the safety and mid-term outcome of catheter ablation for non-OTVAs. Method and Results From 2013 to 2018, 251 patients who underwent catheter ablation for idiopathic non-OTVAs were enrolled and grouped according to the origins including His-Purkinje system (HPS, n = 108), papillary muscle / moderator band (PM/MB, n = 47), tricuspid annulus (TA, n = 70), and mitral annulus (MA, n = 26), 244 (97.2%) had acute elimination of VAs. The time of VAs recurrence of the single procedure was 1.69 (0.12,9.72) months, with 66% occurring within the first 3 months. The recurrence rate was significantly higher in the PM/MB group than in the TA (p = 0.025) and MA groups (p = 0.023). The single procedure success rate in all patients was 70.1%, in which 66.7%, 59.6%, 80%, and 76.9% were achieved in the HPS, PM/MB, TA, and MA groups, respectively (p = 0.284). After multiple procedures, the total success rate was 76.5% at the follow-up of 4.38 ± 2.42 years. The rate was significantly lower in the PM/MB group than in the TA group (p = 0.035). In subgroup analysis, no significant difference was observed in the recurrence rate of single procedure in patients with different VA origins within the PM/MB (log-rank test, p = 0.546). Conclusion Despite a certain percentage of recurrences observed in the mid-term follow-up, catheter ablation remained feasible and effective for idiopathic non-OTVAs.

Published
2024
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3. V

Author

Dian, Cheng, Weizhu, Ju, Lili, Zhu, Kanghui, Chen, Fengxiang, Zhang, Hongwu, Chen, Gang, Yang, Xiaorong, Li, Mingfang, Li, Kai, Gu, Bing, Han, Jie, Fan, Yazhou, Lin, Kejiang, Cao, Pipin, Kojodjojo, Bing, Yang, and Minglong, Chen

Subjects
Male, Electrocardiography, Treatment Outcome, Predictive Value of Tests, Heart Ventricles, Catheter Ablation, Tachycardia, Ventricular, Humans, Female, Prospective Studies, Middle Aged, Algorithms
Abstract

Several algorithms have been proposed to predict the origin of outflow tract (OT) ventricular arrhythmias (VAs) using standard 12-lead ECG. However, the additive value of right precordial and posterior leads is unknown.Standard 12-lead ECG, right precordial leads ECG (VOne hundred ninety-one patients were recruited, of which 94 formed the validation cohort (mean age of 45.7±15.6, 39% male, 79% RVOT foci). During OT-VAs, a QS pattern in lead VThe V

Published
2018

4. V 3 R/V 7 Index

Author

Kejiang Cao, Mingfang Li, Fengxiang Zhang, Xiaorong Li, Gang Yang, Bing Yang, Hongwu Chen, Lili Zhu, Kai Gu, Dian Cheng, Weizhu Ju, Bing Han, Yazhou Lin, Minglong Chen, Jie Fan, Pipin Kojodjojo, and Kanghui Chen

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Catheter ablation, 030204 cardiovascular system & hematology, Ventricular premature contractions, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Internal medicine, medicine, Cardiology, Outflow, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business, Electrocardiography
Abstract

Background: Several algorithms have been proposed to predict the origin of outflow tract (OT) ventricular arrhythmias (VAs) using standard 12-lead ECG. However, the additive value of right precordial and posterior leads is unknown. Methods: Standard 12-lead ECG, right precordial leads ECG (V 3 R, V 4 R, V 5 R) and posterior leads ECG (V 7 , V 8 , V 9 ) were recorded and analyzed in a development cohort of consecutive patients undergoing OT-VAs ablation at a single center. These findings informed the development of a novel algorithm incorporating right precordial and posterior leads to discriminate between left ventricular OT (LVOT) and right ventricular OT (RVOT) foci. The performance of this novel algorithm which includes the V 3 R/V 7 index was prospectively tested in a validation cohort of consecutive patients undergoing OT-VA ablation at 4 centers and compared with published algorithms. The location of the foci was determined by the successful ablation site. Results: One hundred ninety-one patients were recruited, of which 94 formed the validation cohort (mean age of 45.7±15.6, 39% male, 79% RVOT foci). During OT-VAs, a QS pattern in lead V 3 R and an S wave in lead V 7 were exclusively recorded in RVOT and LVOT foci, respectively. The V 3 R/V 7 index of LVOT origin was significantly greater than that of RVOT (1.05±0.83 versus 0.28±0.23, P 3 R/V 7 index ≥0.85 predicted an LVOT origin with 87% sensitivity and 96% specificity. In the prospective evaluation, when the V 3 R/V 7 index ≥0.85, an RVOT origin could be excluded with 98.6% accuracy. The area under the curve of V 3 R/V 7 index (0.954) was larger than that of previously reported ECG criteria, including V 2 S/V 3 R (0.896), V 2 transition ratio (0.792), and transition zone index (0.666). This novel index was also accurate in both patients without obvious LVOT or RVOT origins and subgroups with cardiac rotation or lead V 3 R/S transition. Conclusions: The V 3 R/V 7 index is a novel and accurate ECG criterion that predicts OT-VAs origin.

Published
2018

5. How Status Diversity Fosters Team Innovation? The Role Of Behavior Integration And Empowering Leader.

Author

YUPING XU, YANYI HUANG, Yuqi Huang, KangHui Chen, and Kong Zhou

Abstract

Although status diversity has emerged as an important concept, it is still relatively understudied in organizational behavior research, especially in team innovation research. By taking a behavior integration perspective, we propose that team status diversity has a curvilinear relationship with team members' behavior integration that promotes team innovation. Furthermore, we argue that the relationship between status diversity and behavior integration is moderated by empowering leadership, i.e., team members tend to achieve a higher level of behavior integration and team innovation at slightly low and medium level of status diversity when empowering leadership is high. Results from a multisource field study support all of our hypotheses. The findings provide new insights into the team innovation research. [ABSTRACT FROM AUTHOR]

Published
2021
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