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357 results on '"Kannan, Palanisamy"'

44. Multifunctional Sensors for Successive Detection of Endogenous ONOO–and Mitochondrial Viscosity: Discriminating Normal to Cancer Models

Author

Shen, Jian, Rajalakshmi, Kanagaraj, Muthusamy, Selvaraj, Ahn, Dae-Hwan, Song, Jong-Won, Choi, Ki Young, Xi, Chunyan, Dai, Jindong, Zhou, Zhipeng, Kannan, Palanisamy, Nam, Yun-Sik, and Zhu, Dongwei

Abstract

Diagnosing cancer in its early stages can play an important role in prolonging the lifespan of patients, which demands the use of powerful tools to detect biomarkers accurately. However, since most fluorescent probes described for cancer diagnosis are limited to recognizing a single molecule, achieving the high accuracy criteria remains difficult. Here, sensor 1is constructed for the sequential detection of D, ONOO–, and viscosity. Initially, sensor 1detected Dand underwent an intramolecular charge transfer mechanism, resulting in the formation of 2and fluorescence quenching at 587 nm. Subsequently, the intermediate (2) monitored ONOO–and reproduced sensor 1reversibly with fluorescence enhancement at 496 nm, showing concentration-related quantitative analysis. Similar sensing processes were observed in monitoring ONOO–and viscosity by synthetically developed sensor 2. The proposed mechanisms of sensors 1and 2are verified through various characterizations (1H NMR, HR-MS, and HPLC) and DFT calculations. Investigations on endogenous ONOO–and mitochondrial viscosity in cancer (HeLa) and normal (NCM460) cells were conducted to distinguish cancerous cells from normal cells. We anticipated that sensor 2could effectively serve as a reliable bioanalytical reagent for cancer diagnosis at an earlier stage through sequential detection of two cancer markers, ONOO–and mitochondrial viscosity, in living cells. Importantly, sensor 2has been employed for imaging ONOO–in normal and liver injury mouse models and tissues, achieving outstanding results.

Published
2024
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47. Ionic Polymers with Phenolic Hydroxyl Groups as Hydrogen Bond Donors Toward Enhanced Catalytic Performance for CO2 Conversion.

Author

Zhu, Lihua, Huang, Ziying, Ge, Tianhao, Jiang, Chaoqi, Zhong, Wei, and Kannan, Palanisamy

Subjects
CONDUCTING polymers, ATMOSPHERIC carbon dioxide, IONIC bonds, CATALYTIC activity, LEWIS bases
Abstract

In this study, imidazolium‐based multifunctional ionic polymer (IP 1–IP 3) series, co‐incorporated with phenolic hydroxyl groups as hydrogen bond donors (HBDs) and Cl− as nucleophiles, are synthesized by a facile quaternization method. The physicochemical characterizations of these IPs are systematically examined by using FTIR, XPS, BET, TGA, CO2‐TPD, SEM with elemental mapping and TEM methods. Their catalytic activities are evaluated toward the conversion of carbon dioxide (CO2) and epoxides into cyclic carbonates under solvent‐ and additive‐free environments. Apart from the synergy effect between HBDs and Cl−, it is found that the types of the spacer linking the two imidazole units in the diimidazole precursors (L1–L3) also play an important role in the catalytic activity. And IP 2, with a pyridine spacer as a Lewis base site, exhibits the best catalytic performance under solvent‐free mild conditions i. e., atmospheric pressure CO2, 80 °C, and 5 h. Notably, the catalyst demonstrates a good substrate applicability. Furthermore, IP 2 exhibited good reusability, stability, and it can be recycled for ten successive runs with stable and potential catalytic activity. This study provides an alternative route to construct IPs with efficient activity for CO2 catalytic conversion and fixation under mild‐conditions. [ABSTRACT FROM AUTHOR]

Published
2024
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