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23. Chapter 2 Genetics of the Framingham Heart Study Population

Author

Govindaraju, Diddahally R., Adrienne Cupples, L., Kannel, William B., O'Donnell, Christopher J., Atwood, Larry D., D'Agostino, Ralph B., Sr., Fox, Caroline S., Larson, Marty, Levy, Daniel, Murabito, Joanne, Vasan, Ramachandran S., Lee Splansky, Greta, Wolf, Philip A., and Benjamin, Emelia J.

Published
2008
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26. Pulse pressure and risk of new-onset atrial fibrillation

Author

Mitchell, Gary F., Vasan, Ramachandran S., Keyes, Michelle J., Parise, Helen, Wang, Thomas J., Larson, Martin G., D'Agostino, Ralph B., Sr., Kannel, William B., Levy, Daniel, and Benjamin, Emelia J.

Subjects
Atrial fibrillation -- Risk factors, Atrial fibrillation -- Care and treatment
Abstract

The relationship between pulse pressure and incident atrial fibrillation (AF) is examined. The results have shown that the pulse pressure is an important risk factor for incident AF in a community-based sample.

Published
2007

32. Predictive value for the Chinese population of the Framingham CHD risk assessment tool compared with the Chinese multi-provincial cohort study

Author

Jing Liu, Yuling Hong, D'Agostino, Ralph B., Zhaosu Wu, Wei Wang, Jiayi Sun, Wilson, Peter F.W., Kannel, William B., and Dong Zhao

Subjects
Chinese Americans -- Health aspects, Coronary heart disease -- Care and treatment, Coronary heart disease -- Research
Abstract

A study is undertaken to compare the performance of the Framingham CHD risk factor in a large Chinese population with respect to the performance of the functions derived from the Chinese multi-provincial Cohort study (CMCS). The findings indicate that the original Framingham functions systematically overestimated the absolute CHD risk in the Chinese Multi-provincial Cohort Study (CMCS) cohort.

Published
2004

35. Contributors

Author

Abe, Takato, primary, Adams, Harold P., additional, Adeoye, Opeolu, additional, Agarwal, Sachin, additional, Aguilar, Maria I., additional, Al-Khoury, Lama, additional, Arboix, Adrià, additional, Auer, Roland N., additional, Awad, Issam A., additional, Baird, Alison E., additional, Baltan, Selva, additional, Barnett, Henry J.M., additional, Batjer, H. Hunt, additional, Benavente, Oscar R., additional, Bendok, Bernard R., additional, Bershad, Eric M., additional, Binder, Jeffrey R., additional, Boulos, Alan S., additional, Bousser, Marie-Germaine, additional, Bova, Frank J., additional, Brainin, Michael, additional, Brisman, Jonathan L., additional, Brown, Wendy, additional, Brust, John C.M., additional, Canhão, Patrícia, additional, Caplan, Louis R., additional, Castellanos, Mar, additional, Chabriat, Hugues, additional, Chamorro, Angel, additional, Choi, Jae H., additional, Chopp, Michael, additional, Connolly, E. Sander, additional, Coull, Bruce M., additional, Cucchiara, Brett L., additional, Dalkara, Turgay, additional, Dani, Krishna A., additional, Dannenbaum, Mark J., additional, Dashti, Shervin R., additional, Davis, Patricia H., additional, Dawson, Ted M., additional, Dawson, Valina L., additional, Day, Arthur L., additional, De Leo, Michael J., additional, del Zoppo, Gregory J., additional, Diedler, Jennifer, additional, Diener, Hans-Christoph, additional, Di Tullio, Marco R., additional, Dobkin, Bruce H., additional, Drake, Kendra, additional, Du, Rose, additional, Ducros, Anne, additional, Dzialowski, Imanuel, additional, Eddleman, Christopher S., additional, Elhammady, Mohamed Samy, additional, Elkind, Mitchell S.V., additional, Elliott, J. Paul, additional, Ferro, José M., additional, Findlay, J. Max, additional, Friedman, William A., additional, Furie, Karen L., additional, Furlan, Anthony J., additional, Geibprasert, Sasikhan, additional, Gobin, Y. Pierre, additional, Goldberg, Mark P., additional, Goldstein, Larry B., additional, Gonzales, Nicole R., additional, Gounis, Matthew J., additional, Greenberg, Steven M., additional, Greer, David M., additional, Grotta, James C., additional, Hacke, Werner, additional, Hallenbeck, John, additional, Hamann, Gerhard F., additional, Hartmann, Andreas, additional, Hennerici, Michael, additional, Heros, Roberto C., additional, Higashida, Randall, additional, Homma, Shunichi, additional, Hongo, Kazuhiro, additional, Hopkins, L. Nelson, additional, Horiuchi, Tetsuyoshi, additional, Howard, George, additional, Howard, Virginia J., additional, Huddle, Daniel, additional, Iadecola, Costantino, additional, Joutel, Anne, additional, Jüttler, Eric, additional, Kakarla, Udaya K., additional, Kalafut, Mary A., additional, Kannel, William B., additional, Kase, Carlos S., additional, Kasner, Scott E., additional, Kaste, Markku, additional, Khaw, Alexander, additional, Kidwell, Chelsea S., additional, Kim, Helen, additional, Kim, Louis J., additional, Kim, Stanley H., additional, Klijn, Catharina J.M. (Karin), additional, Kobayashi, Shigeaki, additional, Komotar, Ricardo J., additional, Krings, Timo, additional, Kunz, Alexander, additional, Kurth, Tobias, additional, Lamy, Catherine, additional, Lazar, Ronald M., additional, Levy, Elad I., additional, Liebeskind, David S., additional, Lyden, Patrick D., additional, Markham, Joanne, additional, Marshall, Randolph S., additional, Martí-Vilalta, J.L., additional, Mas, Jean-Louis, additional, Mast, Henning, additional, Masuda, Junichi, additional, Mathers, Colin D., additional, Mayberg, Marc R., additional, Meairs, Stephen, additional, Mendelow, Alexander David, additional, Meschia, James F., additional, Miller, Alyson A., additional, Miyawaki, Takahiro, additional, Mocco, J, additional, Mohr, J.P., additional, Morcos, Jacques J., additional, Morgenstern, Lewis B., additional, Moskowitz, Michael A., additional, Nahed, Brian V., additional, Newell, David W., additional, Ofengeim, Dimitry, additional, Ogata, Jun, additional, Ogilvy, Christopher S., additional, Palesch, Yuko Y., additional, Pancioli, Arthur, additional, Park, Min S., additional, Pawlikowska, Ludmila, additional, Pile-Spellman, John, additional, Powers, William J., additional, Puetz, Volker, additional, Ransom, Bruce R., additional, Roine, Risto O., additional, Ruigrok, Ynte M., additional, Rundek, Tatjana, additional, Sacco, Ralph L., additional, Sattenberg, Ronald J., additional, Saver, Jeffrey L., additional, Savitz, Sean I., additional, Seshadri, Sudha, additional, Sharma, Jitendra, additional, Silverboard, Gerald, additional, Singhal, Aneesh B., additional, Sobey, Christopher G., additional, Spetzler, Robert F., additional, Stapf, Christian, additional, Starke, Robert M., additional, Stiefel, Michael F., additional, Strong, Kathleen, additional, Suarez, José I., additional, Sykora, Marek, additional, Tafreshi, Gilda, additional, Brugge, Karel ter, additional, Tilley, Barbara C., additional, Toni, Danilo, additional, Tournier-Lasserve, Elisabeth, additional, Vilela, Marcelo D., additional, von Kummer, Rüdiger, additional, Wakhloo, Ajay K., additional, Warach, Steven, additional, Weksler, Babette B., additional, Willey, Joshua Z., additional, Wintermark, Max, additional, Wolf, Philip A., additional, Woo, Daniel, additional, Yamaguchi, Takenori, additional, Yasaka, Masahiro, additional, Young, William L., additional, Zahuranec, Darin B., additional, Zazulia, Allyson R., additional, Zhang, Zheng Gang, additional, Zukin, R. Suzanne, additional, and Zweifler, Richard M., additional

Published
2011
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36. A risk score for predicting stroke or death in individuals with new-onset atrial fibrillation in the community: the Framingham Heart Study

Author

Wang, Thomas J., Massaro, Joseph M., Levy, Daniel, Vasan, Ramachandran S., Wolf, Philip A., D'Agostino, Ralph B., Larson, Martin G., Kannel, William B., and Benjamin, Emelia J.

Subjects
Health risk assessment -- Methods, Stroke (Disease) -- Risk factors, Atrial fibrillation -- Complications
Abstract

The risk of stroke in patients with atrial fibrillation depends on their age, blood pressure, history of diabetes, heart disease or a previous stroke, and whether they smoke. Doctors can assign points to all of these values and then determine an individual patient's risk of having a stroke. Patients with a high risk can take anticoagulant drugs if necessary.

Published
2003

38. Obesity and the risk of heart failure

Author

Kenchaiah, Satish, Evans, Jane C., Levy, Daniel, Wilson, Peter W.F., Benjamin, Emelia J., Larson, Martin G., Kannel, William B., and Vasan, Ramachandran S.

Subjects
Heart failure -- Risk factors, Obesity -- Health aspects
Abstract

People who are obese have twice the risk of developing heart failure as people with normal weight. Obesity is technically defined as a body-mass index of 30 or greater. Even people who are overweight but not obese have a higher than normal risk of developing heart failure.

Published
2002

39. Residual Lifetime Risk for Developing Hypertension in Middle-aged Women and Men: The Framingham Heart Study. (Original Contribution)

Author

Vasan, Ramachandran S., Beiser, Alexa, Seshadri, Sudha, Larson, Martin G., Kannel, William B., D'Agostino, Ralph B., and Levy, Daniel

Subjects
Hypertension -- Risk factors, Aging -- Health aspects
Abstract

The lifetime risk of developing high blood pressure in middle and old age is about 90%, according to a study of 1,298 people participating in the Framingham Heart Study. However, the lifetime risk of developing severe hypertension is much lower, most likely due to effective treatments., Context The long-term risk for developing hypertension is best described by the lifetime risk statistic. The lifetime risk for hypertension and trends in this risk over time are unknown. Objectives To estimate the residual lifetime risk for hypertension in older US adults and to evaluate temporal trends in this risk. Design, Setting, and Participants Community-based prospective cohort study of 1298 participants from the Framingham Heart Study who were aged 55 to 65 years and free of hypertension at baseline (1976-1998). Main Outcome Measures Residual lifetime risk (lifetime cumulative incidence not adjusted for competing causes of mortality) for hypertension, defined as blood pressure of 140/90 mm Hg or greater or use of antihypertensive medications. Results The residual lifetime risks for developing hypertension and stage 1 high blood pressure or higher ([greater than or equal to]140/90 mm Hg regardless of treatment) were 90% in both 55-and 65-year-old participants. The lifetime probability of receiving antihypertensive medication was 60%. The risk for hypertension remained unchanged for women, but it was approximately 60% higher for men in the contemporary 1976-1998 period compared with an earlier 1952-1975 period. In contrast, the residual lifetime risk for stage 2 high blood pressure or higher ([greater than or equal to]160/100 mm Hg regardless of treatment) was considerably lower in both sexes in the recent period (35%-57% in 1952-1975 vs 35%-44% in 1976-1998), likely due to a marked increase in treatment of individuals with substantially elevated blood pressure. Conclusion The residual lifetime risk for hypertension for middle-aged and elderly individuals is 90%, indicating a huge public health burden. Although the decline in lifetime risk for stage 2 high blood pressure or higher represents a major achievement, efforts should be directed at the primary prevention of hypertension.

Published
2002

43. Impact of high-normal blood pressure on the risk of cardiovascular disease

Author

Vasan, Ramachandran S., Larson, Martin G., Leip, Eric P., Evans, Jane C., O'Donnell, Christopher J., Kannel, William B., and Levy, Daniel

Subjects
Blood pressure -- Health aspects, Cardiovascular diseases -- Risk factors
Abstract

People whose blood pressure is at the high end of the normal range have a higher than normal risk of developing cardiovascular disease, according to a 10-year follow-up of the 6,859 people participating in the Framingham Heart Study. The high end of the normal blood pressure range is a systolic, or top number between 130 and 139, and a diastolic, or bottom number between 85 and 89.

Published
2001

44. Validation of an Atrial Fibrillation Risk Algorithm in Whites and African Americans

Author

Schnabel, Renate B., Aspelund, Thor, Li, Guo, Sullivan, Lisa M., Suchy-Dicey, Astrid, Harris, Tamara B., Pencina, Michael J., D’Agostino, Ralph B., Sr, Levy, Daniel, Kannel, William B., Wang, Thomas J., Kronmal, Richard A., Wolf, Philip A., Burke, Gregory L., Launer, Lenore J., Vasan, Ramachandran S., Psaty, Bruce M., Benjamin, Emelia J., Gudnason, Vilmundur, and Heckbert, Susan R.

Published
2010
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48. CONTRIBUTORS

Author

AlMahameed, Amjad, primary, Ansell, Jack E., additional, Aquino, Melinda, additional, Aruny, John, additional, Ayerdi, Juan, additional, Beckman, Joshua A., additional, Belch, Jill J.F., additional, Belkin, Michael, additional, Berk, Bradford C., additional, Blei, Francine, additional, Blume, Peter, additional, Brass, Eric P., additional, Burke, Allen P., additional, Caplan, Louis R., additional, Cid, Maria C., additional, Coffman, Jay D., additional, Cooke, John P., additional, Creager, Mark A., additional, Criqui, Michael H., additional, Cronenwett, Jack L., additional, Davis, Mark D.P., additional, del Zoppo, Gregory J., additional, Donaldson, Magruder C., additional, Eagleton, Matthew J., additional, Edwards, Matthew S., additional, Fisher, Jonathan E.E., additional, Flohr, Thomas G., additional, Freedman, Jane E., additional, Freischlag, Julie A., additional, Fulton, David R., additional, Gerhard-Herman, Marie, additional, Giswold, Mary E., additional, Goldhaber, Samuel Z., additional, Goldstein, Irwin, additional, Gornik, Heather L., additional, Gram, Christopher H., additional, Gravereaux, Edwin C., additional, Halperin, Jonathan L., additional, Hansen, Kimberley J., additional, Hanzel, George, additional, Hiatt, William R., additional, Hobson, Robert W., additional, Hoffman, Gary S., additional, Iyer, Sriram S., additional, Kane, Laura B., additional, Kang, Andrew, additional, Kannel, William B., additional, Karamlou, Tara, additional, Kim, Noel N., additional, Klings, Elizabeth S., additional, Kronzon, Itzhak, additional, Kucher, Nils, additional, Lam, Everett Y., additional, Landry, Gregory J., additional, LeMaire, Scott A., additional, Lerman, Lilach O., additional, Libby, Peter, additional, Lipton, Martin J., additional, Loscalzo, Joseph, additional, Machleder, Herbert I., additional, Maksimowicz-McKinnon, Kathleen, additional, Mandel, Jess, additional, Menard, Matthew T., additional, Menzoian, James O., additional, Merkel, Peter A., additional, Miller, Virginia M., additional, Moneta, Gregory L., additional, Munarriz, Ricardo, additional, Newburger, Jane W., additional, Ninomiya, John, additional, O'Gara, Patrick, additional, Olin, Jeffrey W., additional, O'Rourke, Stephen T., additional, Ouriel, Kenneth, additional, Paszkowiak, Jacek, additional, Patterson, Dean, additional, Raffetto, Joseph D., additional, Raghow, Rajendra, additional, Rigberg, David A., additional, Rockson, Stanley G., additional, Rooke, Thom W., additional, Roubin, Gary S., additional, Ruberg, Frederick L., additional, Rzucidlo, Eva M., additional, Safian, Robert D., additional, Schoepf, U. Joseph, additional, Seyer, Jerome, additional, Sobieszczyk, Piotr, additional, Srivastava, Sunita D., additional, Stanton-Hicks, Michael, additional, Sumpio, Bauer E., additional, Taylor, Allen J., additional, Taylor, Lloyd M., additional, Textor, Stephen C., additional, Thompson, Robert W., additional, Topper, James N., additional, Traish, Abdul M., additional, Tunick, Paul A., additional, Upchurch, Gilbert R., additional, Valentine, R. James, additional, Vanhoutte, Paul M., additional, Virmani, Renu, additional, Vitek, Jiri J., additional, Wasserman, Scott M., additional, Weisz, Giora, additional, Welborn, M. Burress, additional, White, Christopher J., additional, Wilson, David B., additional, Wolf, Philip A., additional, and Yucel, E. Kent, additional

Published
2006
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