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117 results on '"Kao, Chen-Yu"'

5. Using Feature Selection to Improve Performance of Three-Tier Intrusion Detection System

Author

Su, Yi-Jen, Huang, Pei-Yu, Hu, Wu-Chih, Lin, Hsuan-Yu, Kao, Chen-Yu, Hsieh, Shan-Hsiung, Lin, Chun-Li, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Barolli, Leonard, editor, Takizawa, Makoto, editor, Xhafa, Fatos, editor, and Enokido, Tomoya, editor

Published
2019
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24. Using Feature Selection to Improve Performance of Three-Tier Intrusion Detection System

Author

Lin Hsuan-Yu, Yi-Jen Su, Pei-Yu Huang, Hsieh Shan-Hsiung, Chun-Li Lin, Wu-Chih Hu, and Kao Chen-Yu

Subjects
020203 distributed computing, Computer science, Real-time computing, 0202 electrical engineering, electronic engineering, information engineering, Process (computing), 020201 artificial intelligence & image processing, Feature selection, 02 engineering and technology, Intrusion detection system, Flow network, Phase (combat), 5G
Abstract

Social media services have become an essential part of daily life. Once 5G services launch in the near future, the annual network IP flow can be expected to increase significantly. In case of security threats, network attacks will become more various and harder to detect. The intrusion detection system (IDS) in the network defense system is in charge of detecting malicious activities online. The research proposed an intelligent three-tier IDS that can process high-speed network flow and classify attack behaviors into nine kinds of attacks by seven machine learning methods. Based on the operation time, the detection process can be divided into the offline phase, which trains models by machine learning, and the online phase, which enhances the detection rate of network attacks by a three-tier filtering process. In the experiment, UNSW-NB15 was adopted as the dataset, where the accuracy of intrusion detection approached 98%.

Published
2019

28. Correction: Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin

Author

Lee, Shiao-Pieng, primary, Kao, Chen-Yu, additional, Chang, Shun-Cheng, additional, Chiu, Yi-Lin, additional, Chen, Yen-Ju, additional, Chen, Ming-Hsing G., additional, Chang, Chun-Chia, additional, Lin, Yu-Wen, additional, Chiang, Chien-Ping, additional, Wang, Jehng- Kang, additional, Lin, Chen-Yong, additional, and Johnson, Michael D., additional

Published
2018
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30. Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin

Author

Lee, Shiao-Pieng, primary, Kao, Chen-Yu, additional, Chang, Shun-Cheng, additional, Chiu, Yi-Lin, additional, Chen, Yen-Ju, additional, Chen, Ming-Hsing G., additional, Chang, Chun-Chia, additional, Lin, Yu-Wen, additional, Chiang, Chien-Ping, additional, Wang, Jehng-Kang, additional, Lin, Chen-Yong, additional, and Johnson, Michael D., additional

Published
2018
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40. A Liposomal Nanoscale Contrast Agent for Preclinical CT in Mice

Author

Mukundan, Srinivasan, primary, Ghaghada, Ketan B., additional, Badea, Cristian T., additional, Kao, Chen-Yu, additional, Hedlund, Laurence W., additional, Provenzale, James M., additional, Johnson, G. Allan, additional, Chen, Emmanuel, additional, Bellamkonda, Ravi V., additional, and Annapragada, Ananth, additional

Published
2006
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48. Influence of polyvinylpyrrolidone on the hydrophobic properties of partially porous poly(styrene–divinylbenzene) particles for biological applications

Author

Kao, Chen-Yu, Lo, Tzu-Chiang, and Lee, Wen-Chien

Abstract

For the preparation of polymer particles by free radical, stabilizers are usually present in the reaction mixture to maintain the separation of particles from each other. Polyvinylpyrrolidone (PVP) is one the hydrophilic polymers that has been extensively used as the stabilizer in the polymerization system employing a polar solvent or solvent mixture as the continuous phase. As shown in the present study, the presence of PVP in the later steps could significantly influence the hydrophobic property of partially porous poly(styrene–divinylbenzene) (PS–DVB) particles, prepared by the method of multistep swelling and polymerization involving the use of polymeric porogens. The association of PVP molecules on the particle surface reduced the hydrophobicity and consequently the capability of particles for biological applications. For the reversed-phase liquid chromatography of penicillin G and its enzymatic hydrolysis product, particles prepared without PVP led to an enhancement in both retention and resolution, compared with particles resulting from the use of PVP. Results from lipase immobilization on these particles also showed that the presence of PVP could shield the hydrophobic groups on the particle surface and then reduce the efficiency of enzyme immobilization. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 87: 1818–1824, 2003

Published
2003
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49. Photo-Responsive Supramolecular Micelles for Controlled Drug Release and Improved Chemotherapy.

Author

Ilhami, Fasih Bintang, Peng, Kai-Chen, Chang, Yi-Shiuan, Alemayehu, Yihalem Abebe, Tsai, Hsieh-Chih, Lai, Juin-Yih, Chiao, Yu-Hsuan, Kao, Chen-Yu, and Cheng, Chih-Chia

Subjects
CONTROLLED release drugs, DOXORUBICIN, MICELLES, CYTOPROTECTION, ENDOCYTOSIS, REACTIVE oxygen species, CANCER chemotherapy, ANTINEOPLASTIC agents
Abstract

Development of stimuli-responsive supramolecular micelles that enable high levels of well-controlled drug release in cancer cells remains a grand challenge. Here, we encapsulated the antitumor drug doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (5-ALA) within adenine-functionalized supramolecular micelles (A-PPG), in order to achieve effective drug delivery combined with photo-chemotherapy. The resulting DOX/5-ALA-loaded micelles exhibited excellent light and pH-responsive behavior in aqueous solution and high drug-entrapment stability in serum-rich media. A short duration (1–2 min) of laser irradiation with visible light induced the dissociation of the DOX/5-ALA complexes within the micelles, which disrupted micellular stability and resulted in rapid, immediate release of the physically entrapped drug from the micelles. In addition, in vitro assays of cellular reactive oxygen species generation and cellular internalization confirmed the drug-loaded micelles exhibited significantly enhanced cellular uptake after visible light irradiation, and that the light-triggered disassembly of micellar structures rapidly increased the production of reactive oxygen species within the cells. Importantly, flow cytometric analysis demonstrated that laser irradiation of cancer cells incubated with DOX/5-ALA-loaded A-PPG micelles effectively induced apoptotic cell death via endocytosis. Thus, this newly developed supramolecular system may offer a potential route towards improving the efficacy of synergistic chemotherapeutic approaches for cancer. [ABSTRACT FROM AUTHOR]

Published
2021
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