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9 results on '"Kaou, Mohamed"'

3. Fhit Delocalizes Annexin A4 from Plasma Membrane to Cytosol and Sensitizes Lung Cancer Cells to Paclitaxel

Author

Gaudio, Eugenio, primary, Paduano, Francesco, additional, Spizzo, Riccardo, additional, Ngankeu, Apollinaire, additional, Zanesi, Nicola, additional, Gaspari, Marco, additional, Ortuso, Francesco, additional, Lovat, Francesca, additional, Rock, Jonathan, additional, Hill, Grace A., additional, Kaou, Mohamed, additional, Cuda, Giovanni, additional, Aqeilan, Rami I., additional, Alcaro, Stefano, additional, Croce, Carlo M., additional, and Trapasso, Francesco, additional

Published
2013
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4. AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia

Author

Motiwala, Tasneem, primary, Zanesi, Nicola, additional, Datta, Jharna, additional, Roy, Satavisha, additional, Kutay, Huban, additional, Checovich, Allyn M., additional, Kaou, Mohamed, additional, Zhong, Yiming, additional, Johnson, Amy J., additional, Lucas, David M., additional, Heerema, Nyla A., additional, Hagan, John, additional, Mo, Xiaokui, additional, Jarjoura, David, additional, Byrd, John C., additional, Croce, Carlo M., additional, and Jacob, Samson T., additional

Published
2011
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5. Abstract 276: Role of AP1 elements and TCL1 protein in regulation of the gene encoding PTPROt (protein tyrosine phosphatase receptor-type O) in chronic lymphocytic leukemia

Author

Motiwala, Tasneem, primary, Datta, Jharna, additional, Kutay, Huban, additional, Roy, Satavisha, additional, Checovich, Allyn, additional, Zanesi, Nicola, additional, Kaou, Mohamed, additional, Johnson, Amy, additional, Hagan, John, additional, Byrd, John C., additional, Croce, Carlo M., additional, and Jacob, Samson T., additional

Published
2011
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6. Effect of Rapamycin on Mouse Chronic Lymphocytic Leukemia and the Development of Nonhematopoietic Malignancies in Eμ-TCL1 Transgenic Mice

Author

Zanesi, Nicola, primary, Aqeilan, Rami, additional, Drusco, Alessandra, additional, Kaou, Mohamed, additional, Sevignani, Cinzia, additional, Costinean, Stefan, additional, Bortesi, Laura, additional, La Rocca, Gaspare, additional, Koldovsky, Pavel, additional, Volinia, Stefano, additional, Mancini, Rita, additional, Calin, George, additional, Scott, Charles P., additional, Pekarsky, Yuri, additional, and Croce, Carlo M., additional

Published
2006
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9. Tcl1 interacts with Atm and enhances NF-?B activation in hematologic malignancies

Author

Gaudio, Eugenio, Spizzo, Riccardo, Paduano, Francesco, Luo, Zhenghua, Efanov, Alexey, Palamarchuk, Alexey, Leber, Amanda S., Kaou, Mohamed, Zanesi, Nicola, Bottoni, Arianna, Costinean, Stefan, Rassenti, Laura Z., Nakamura, Tatsuya, Kipps, Thomas J., Aqeilan, Rami I., Pekarsky, Yuri, Trapasso, Francesco, and Croce, Carlo M.

Abstract

The T-cell leukemia/lymphoma 1 (TCL1) oncogene is a target of chromosomal translocations and inversions at 14q31.2, and its rearrangement in T cells causes T-cell prolymphocytic leukemias. TCL1 dysregulation in B cells is responsible for the development of an aggressive form of chronic lymphocytic leukemia (CLL), the most common human leukemia. We have investigated the mechanisms underlying the oncogenic functions of Tcl1 protein using a mass spectrometry approach and have identified Atm (ataxia-telangiectasia mutated) as a candidate Tcl1-interacting protein. The Tcl1-Atm complex formation was validated by coimmunoprecipitation experiments. Importantly, we show that the association of Atm with Tcl1 leads to enhanced I?Ba phosphorylation and ubiquitination and subsequent activation of the NF-?B pathway. Our findings reveal functional cross-talk between Atm and Tcl1 and provide evidence for a novel pathway that could be targeted in leukemias and lymphomas.

Published
2012
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