Search

Vonaesch, P., Araújo, J. R., Gody, J. C., Mbecko, J. R., Sanke, H., Andrianonimiadana, L., Naharimanananirina, T., Ningatoloum, S. N., Vondo, S. S., Gondje, P. B., Rodriguez-Pozo, A., Rakotondrainipiana, M., Kandou, K. J. E., Nestoret, A., Kapel, N., Djorie, S. G., Finlay, B. B., Wegener Parfrey, L., Collard, J. M., Randremanana, R. V., Sansonetti, P. J., Afribiota Investigators, Pathogénie microbienne moléculaire, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Swiss Tropical and Public Health Institute [Basel], Université de Lausanne = University of Lausanne (UNIL), University of Basel (Unibas), Centre pédiatrique de Bangui, Institut Pasteur de Bangui, Réseau International des Instituts Pasteur (RIIP), Unité de Bactériologie Expérimentale [Antananarivo, Madagascar] (IPM), Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre Hospitalier Universitaire Joseph Ravoahangy Andrianavalona (CHUJRA), Immunologie Translationnelle - Translational Immunology lab, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of British Columbia (UBC), Collège de France (CdF (institution)), This project was funded by the Total Foundation, the Institut Pasteur, Bill and Melinda Gates Foundation Grant OPP1204689, the Fondation Petram, Nutricia Foundation Grant NRF 2016-10, and a donation from the Odyssey Re-Insurance Company. P.V. was supported by Swiss National Science Foundation Early Postdoctoral Fellowship P2EZP3_152159, Advanced Postdoctoral Fellowship P300PA_177876, and Return Grant P3P3PA_17877, a Roux-Cantarini fellowship (2016), a L’Oréal–UNESCO for Women in Science France fellowship (2017), and an Excellence Scholarship from the University of Basel (Forschungsfonds, 2019). Her group is funded through the NCCR Microbiomes, a National Centre of Competence in Research, funded by the Swiss National Science Foundation (grant number 180575). Work in the group of L.W.P. is funded by Human Frontier Science Program Grant RGY0078/2015. P.J.S. is a Howard Hughes Medical Institute Senior Foreign Scholar and CIFAR scholar in the human microbiome consortium., We thank all children and their families who participated in the Afribiota project. Further, we thank the Afribiota Consortium, the participating hospitals in Bangui and Antananarivo, the Institut Pasteur, the Institut Pasteur de Madagascar, the Institut Pasteur de Bangui, and members of the scientific advisory boards for their continuous support, and we thank the Centre de Recherche Translationelle and the Direction Internationale of the Institut Pasteur (especially Paméla Palvadeau, Jane Lynda Deuve, Cécile Artaud, Nathalie Jolly, Sophie Jarrijon, Mamy Ratsialonina, and Jean-François Damaras) for help in setting up and steering the Afribiota project. We also thank J.-M.C., Pierre-Alain Rubbo, Dieu-Merci Welekoi-Yapondo, L.A., Laurence Arowas, and Marie-Noelle Ungeheuer for managing the biobank, the members of the animal facility at the Institut Pasteur for taking care of the mice, the Centre d’Immunolgoie Humaine of the Institut Pasteur, especially Milena Hasan, Tarshana Stephen, and Esma Karkeni, for help with setting up the LUMINEX assays at their platform, Asmaa Tazi for identification of the bacteria by MALDI-TOF spectroscopy, Estelle Martineau at the Platform Spectrometries Capacités at the University of Nantes for quantification of the fermentation products, Kelsey Huus for critical reading of the manuscript, and Munir Winkel for streamlining of the R code., and Liste of Afribiota Inverstigators : Laurence Barbot-Trystram, Hôpital Pitié-Salpêtrière, Paris, France Robert Barouki, Hôpital Necker- Enfants maladies, Paris, France Alexandra Bastaraud, Institut Pasteur de Madagascar, Antananarivo, Madagascar Jean-Marc Collard, Institut Pasteur de Madagascar, Antananarivo, Madagascar Maria Doria, Institut Pasteur, Paris, France Darragh Duffy, Institut Pasteur, Paris, France B. Brett Finlay, University of British Columbia, Vancouver, Canada Serge Ghislain Djorie, Institut Pasteur de Bangui, Bangui, Central African Republic Tamara Giles-Vernick, Institut Pasteur, Paris, France Bolmbaye Privat Gondje, Complexe Pédiatrique de Bangui, Bangui, Central African Republic Jean-Chrysostome Gody, Complexe Pédiatrique de Bangui, Bangui, Central African Republic Milena Hasan, Institut Pasteur, France Francis Allen Hunald, Service de Chirurgie pédiatrique, Centre Hospitalier Universitaire Joseph Ravoahangy Andrianavalona (CHU-JRA), Antananarivo, Madagascar Nathalie Kapel, Hôpital Pitié-Salpêtrière, Paris, France Jean-Pierre Lombart, Institut Pasteur de Bangui, Bangui, Central African Republic Alexandre Manirakiza, Institut Pasteur de Bangui, Bangui, Central African Republic Synthia Nazita Nigatoloum, Complexe Pédiatrique de Bangui, Bangui, Central African Republic Laura Wegener Parfrey, University of British Columbia, Vancouver, Canada Lisette Raharimalala, Centre de Santé Materno-Infantile, Tsaralalana, Antananarivo, Madagascar Maheninasy Rakotondrainipiana, Institut Pasteur de Madagascar, Antananarivo, Madagascar Rindra Vatosoa Randremanana, Institut Pasteur de Madagascar, Antananarivo, Madagascar Harifetra Mamy Richard Randriamizao, Centre Hospitalier Universitaire Joseph Ravoahangy Andrianavalona (CHU-JRA), Antananarivo, Madagascar Frédérique Randrianirina, Institut Pasteur de Madagascar, Antananarivo, Madagascar Annick Robinson, Centre Hospitalier Universitaire Mère Enfant de Tsaralalana, Antananarivo, Madagascar Pierre-Alain Rubbo, Institut Pasteur de Bangui, Bangui, République Centrafricaine Philippe Sansonetti, Institut Pasteur, Paris, France Laura Schaeffer, Institut Pasteur, Paris, France Ionela Gouandjika-Vassilache, Institut Pasteur de Bangui, Bangui, République Centrafricaine Pascale Vonaesch, Institut Pasteur, Paris, France Sonia Sandrine Vondo, Complexe Pédiatrique de Bangui, Bangui, Central African Republic Inès Vigan-Womas, Institut Pasteur de Madagascar, Antananarivo, Madagasca

Vonaesch, P., Winkel, M., Kapel, N., Nestoret, A., Barbot-Trystram, L., Pontoizeau, C., Barouki, R., Rakotondrainipiana, M., Kandou, K., Andriamanantena, Z., Andrianonimiadana, L., Habib, A., Rodriguez-Pozo, A., Hasan, M., Vigan-Womas, I., Collard, J. M., Gody, J. C., Djorie, S., Sansonetti, P. J., Randremanana, R. V., On Behalf Of The Afribiota Investigators, Pathogénie microbienne moléculaire, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lausanne = University of Lausanne (UNIL), Swiss Tropical and Public Health Institute [Basel], University of Basel (Unibas), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP), Institut Pasteur de Bangui, Cytometrie et Biomarqueurs – Cytometry and Biomarkers (UTechS CB), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Centre National Hospitalier Universitaire [Bangui] (CNHUB), This project was funded by the Total Foundation, Institut Pasteur, the Bill and Melinda Gates Foundation (OPP1204689), the Fondation Petram and a donation by the Odyssey Re-Insurance company. PV was supported by an Early Postdoctoral Fellowship (P2EZP3_152159), an Advanced Postdoctoral Fellowship (P300PA_177876) as well as a Return Grant (P3P3PA_17877) from the Swiss National Science Foundation, a Roux-Cantarini Fellowship (award year: 2016), a L’Oréal-UNESCO for Women in Science France Fellowship (award year: 2017) and an Excellence Scholarship from the University of Basel (Forschungsfonds, award year: 2019)., and We wish to thank all implicated children and their families, the AFRIBIOTA Consortium, the participating hospitals in Bangui and Antananarivo, Institut Pasteur, Institut Pasteur de Madagascar and Institut Pasteur de Bangui and members of the scientific advisory board for their continuous support. Furthermore, we wish to thank the Centre de Recherche Translationelle and the Direction Internationale of the Institut Pasteur, and especially Paméla Palvadeau, Jane Lynda Deuve, Cécile Artaud, Nathalie Jolly, Sophie Jarrijon, Mamy Ratsialonina, and Jean-François Damaras for precious help in setting-up and steering the AFRIBIOTA project. We would also like to thank Jean-Marc Collard, Pierre-Alain Rubbo, Dieu-Merci Welekoi-Yapondo, Lova Andrianonimiadana, Laurence Arowas and Marie-Noelle Ungeheuer for managing the AFRIBIOTA biobank. Furthermore, we would like to thank the Centre d’Immunologie Humaine of the Institut Pasteur, especially Tarshana Stephen and Esma Karkeni for help with setting-up the LUMINEX assays at their platform.

Illouz, Frédéric, Wang, Daniel Y, Ye, Fei, Zhao, Shilin, Johnson, Douglas B, Gupta, A., De Felice, K. M., Loftus, E. V., Khanna, S., Beck, Kimberly E., Blansfield, Joseph A., Tran, Khoi Q., Feldman, Andrew L., Hughes, Marybeth S., Royal, Richard E., Kammula, Udai S., Topalian, Suzanne L., Sherry, Richard M., Kleiner, David, Quezado, Martha, Lowy, Israel, Yellin, Michael, Rosenberg, Steven A., Yang, James C., Michot, J. M., Bigenwald, C., Champiat, S., Collins, M., Carbonnel, Franck, Postel-Vinay, S., Berdelou, A., Varga, A., Bahleda, R., Hollebecque, A., Massard, C., Fuerea, A., Ribrag, V., Gazzah, A., Armand, J. P., Amellal, N., Angevin, E., Noel, N., Boutros, C., Mateus, C., Robert, C., Soria, J. C., Marabelle, A., Lambotte, O., Gonzalez, Raul S., Salaria, Safia N., Bohannon, Caitlin D., Huber, Aaron R., Feely, Michael M., Shi, Chanjuan, Marthey, L., Mussini, C., Nachury, M., Nancey, S., Grange, F., Zallot, C., Peyrin-Biroulet, L., Rahier, J. F., de Beauregard, M. Bourdier, Mortier, L., Coutzac, C., Soularue, E., Lanoy, E., Kapel, N., Planchard, D., Chaput, N., Benson, Al B., Ajani, Jaffer A., Catalano, Robert B., Engelking, Constance, Kornblau, Steven M., Martenson, James A., McCallum, Richard, Mitchell, Edith P., O'Dorisio, Thomas M., Vokes, Everett E., Wadler, Scott, Haanen, J B A G, Kerr, K M, Peters, S, Larkin, J, Jordan, K, Bergqvist, Viktoria, Hertervig, Erik, Gedeon, Peter, Kopljar, Marija, Griph, Håkan, Kinhult, Sara, Carneiro, Ana, Marsal, Jan, Hsieh, Amy Hsin Chieh, Ferman, Mutaz, Brown, Michael P., Andrews, Jane M., Trainer, Harris, Hulse, Paul, Higham, Claire E, Trainer, Peter, Lorigan, Paul, Hughes, Jing, Vudattu, Nalini, Sznol, Mario, Gettinger, Scott, Kluger, Harriet, Lupsa, Beatrice, and Herold, Kevan C

Abdul Mutalib, Nur Elina, de Almeida-Pittito, Bianca, Matoso Montuori de Andrade, Ana Clara, Alves, José Luiz de Brito, Antunes, L. Caetano M., Arias-Tellez, M.J., Arturo, Panduro, Awais, R., Balarini, Camille de Moura, Banerjee, Dibyajyoti, Bartelli, Thais Fernanda, Basso, Paulo José, Bekri, Soumeya, Bhattacharyya, Rajasri, Birg, Aleksandr, Alvarenga Borges, Natália, Braga, Valdir de Andrade, Buys, Nicholas, Câmara, Niels Olsen Saraiva, Carvalho, Agostinho, Castro, Maria Dolores Luque de, Vaz Coelho, Luiz Gonzaga, Cohen, Nathaniel Aviv, Conlon, Kevin C., Cortez, Ramon V., Couto, Cláudia A., Cruz, Josiane de Campos, Cunha, Cristina, D'Amelio, P., Dahiya, Dinesh Kumar, Dangi, Arun Kumar, Dias-Neto, Emmanuel, Duarte-Oliveira, Cláudio, Duggan, Sinead N., Escalona, Alex, Faintuch, Joel, Faintuch, Jacob J., Faintuch, Salomao, Faria, Luciana Costa, Fernández-Reynoso, Carla, Ferolla, Silvia M., Ferrari, Maria de Lourdes A., Ferrari, Teresa C.A., Ferreira, Nicole V., Ferreira, Sandra Roberta G., Ferreira, Rosana B.R., Ferrer, Manuel, Fiamoncini, Jarlei, Foo, Hooi Ling, Gajurel, Damodar, Garrido, Daniel, Gil, A., Giri, Shailendra, Glatthardt, Thaís, Gonçalves, Samuel M., Grill, Alexandra, Hendrix, Emily K., Ignacio, Aline, Íñiguez, M., Jorba, Rosa, Kapel, N., Kirby, Trevor O., Koulaouzidis, Anastasios, Kumar, Deepak, Lauretani, Fulvio, Lin, Henry C., Linhares, Iara M., Loh, Teck Chwen, Loniewski, Igor, Eustáquio Moura Lopes, Mateus, Mafra, Denise, Magnani, Marciane, Maharshak, Nitsan, Malik, Danish J., Mangalam, Ashutosh, Maniar, Kunal, Marlicz, Wojciech, Martínez-Cuesta, M.Carmen., Memba, Robert, Meschi, Tiziana, Milani, Christian, Minis, Evelyn, Moideen, Amal, F. Moraes, Ana Carolina, Moreira, Luana N., Moscoso, Carlos G., Nascimento, Marcelle M., Nelson, Andrew, Neumann, E., Newman, Krista M., Nicoli, J.R., Nouvenne, Antonio, Ochoa-Repáraz, Javier, Ojeda-Granados, Claudia, de Oliveira, Gislane Lellis Vilela, Oteo, J.A., Pace, L.R., Pallares-Méndez, Rigoberto, Parker, R.D., Patel, Kalpesh G., Pauer, Heidi, Payen, Mathilde, Peláez, Carmen., Pereira, Murilo, Perez-Gordo, Marina, Pérez-Matute, P., Plaza-Diaz, J., Priego-Capote, F., Puniya, Anil Kumar, Pyrsopoulos, Nikolaos T., Raczkowska, Beata Anna, Rahim, Raha Abdul, Reinhardt, Christoph, Renuka, Requena, Teresa, Reygner, J., Ritz, Nathaniel L., Rivera-Iñiguez, Ingrid, Robial, Renata, Rojo, David, Roman, Sonia, Rousseau, Clotilde, Ruiz-Ojeda, F.J., Saez-Lara, M.J., Martins dos Santos, Liliane, Sassi, F., Shandilya, Umesh K., Shrestha, P., Shukla, Pratyoosh, Singh, Vandana, Skonieczna-Żydecka, Karolina, Solar, Camila, Solis-Urra, P., Souza, Evandro Leite de, Stefanaki, Charikleia, Stewart, Christopher J., Sun, Jing, Taddei, Carla R., Tana, Claudio, Tebani, Abdellah, Terra, Fernanda Fernandes, Ticinesi, Andrea, Vaughn, Byron P., Ventura, Marco, Vidal, Hubert, Vieira, L.Q., Villanueva-Millán, M.J., Watanabe, Ingrid Kazue Mizuno, Wells, C.M., Witkin, Steven S., Wong, T.Y., Yin, Chenghong, and Zubeldia-Varela, Elisa