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962 results on '"Kaplan, Mariana J."'

1. Mosquito salivary apyrase regulates blood meal hemostasis and facilitates malaria parasite transmission

Author

Pala, Zarna Rajeshkumar, Alves e Silva, Thiago Luiz, Minai, Mahnaz, Crews, Benjamin, Patino-Martinez, Eduardo, Carmona-Rivera, Carmelo, Valenzuela Leon, Paola Carolina, Martin-Martin, Ines, Flores-Garcia, Yevel, Cachau, Raul E., Muslinkina, Liya, Gittis, Apostolos G., Srivastava, Naman, Garboczi, David N., Alves, Derron A., Kaplan, Mariana J., Fischer, Elizabeth, Calvo, Eric, and Vega-Rodriguez, Joel

Published
2024
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2. Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency

Author

Oda, Hirotsugu, Manthiram, Kalpana, Chavan, Pallavi Pimpale, Rieser, Eva, Veli, Önay, Kaya, Öykü, Rauch, Charles, Nakabo, Shuichiro, Kuehn, Hye Sun, Swart, Mariël, Wang, Yanli, Çelik, Nisa Ilgim, Molitor, Anne, Ziaee, Vahid, Movahedi, Nasim, Shahrooei, Mohammad, Parvaneh, Nima, Alipour-olyei, Nasrin, Carapito, Raphael, Xu, Qin, Preite, Silvia, Beck, David B., Chae, Jae Jin, Nehrebecky, Michele, Ombrello, Amanda K., Hoffmann, Patrycja, Romeo, Tina, Deuitch, Natalie T., Matthíasardóttir, Brynja, Mullikin, James, Komarow, Hirsh, Stoddard, Jennifer, Niemela, Julie, Dobbs, Kerry, Sweeney, Colin L., Anderton, Holly, Lawlor, Kate E., Yoshitomi, Hiroyuki, Yang, Dan, Boehm, Manfred, Davis, Jeremy, Mudd, Pamela, Randazzo, Davide, Tsai, Wanxia Li, Gadina, Massimo, Kaplan, Mariana J., Toguchida, Junya, Mayer, Christian T., Rosenzweig, Sergio D., Notarangelo, Luigi D., Iwai, Kazuhiro, Silke, John, Schwartzberg, Pamela L., Boisson, Bertrand, Casanova, Jean-Laurent, Bahram, Seiamak, Rao, Anand Prahalad, Peltzer, Nieves, Walczak, Henning, Lalaoui, Najoua, Aksentijevich, Ivona, and Kastner, Daniel L.

Published
2024
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5. Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19

Author

Wigerblad, Gustaf, Warner, Seth A, Ramos-Benitez, Marcos J, Kardava, Lela, Tian, Xin, Miao, Rui, Reger, Robert, Chakraborty, Mala, Wong, Susan, Kanthi, Yogendra, Suffredini, Anthony F, Dell’Orso, Stefania, Brooks, Stephen, King, Christopher, Shlobin, Oksana, Nathan, Steven D, Cohen, Jonathan, Moir, Susan, Childs, Richard W, Kaplan, Mariana J, Chertow, Daniel S, and Strich, Jeffrey R

Subjects
Biomedical and Clinical Sciences, Immunology, Clinical Research, Clinical Trials and Supportive Activities, Prevention, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Humans, Syk Kinase, COVID-19, Oxazines, HLA-DR Antigens, Homeostasis
Abstract

Spleen tyrosine kinase (SYK) is a previously unidentified therapeutic target that inhibits neutrophil and macrophage activation in coronavirus disease 2019 (COVID-19). Fostamatinib, a SYK inhibitor, was studied in a phase 2 placebo-controlled randomized clinical trial and was associated with improvements in many secondary end points related to efficacy. Here, we used a multiomic approach to evaluate cellular and soluble immune mediator responses of patients enrolled in this trial. We demonstrated that SYK inhibition was associated with reduced neutrophil activation, increased circulation of mature neutrophils (CD10+CD33-), and decreased circulation of low-density granulocytes and polymorphonuclear myeloid-derived suppressor cells (HLA-DR-CD33+CD11b-). SYK inhibition was also associated with normalization of transcriptional activity in circulating monocytes relative to healthy controls, an increase in frequency of circulating nonclassical and HLA-DRhi classical monocyte populations, and restoration of interferon responses. Together, these data suggest that SYK inhibition may mitigate proinflammatory myeloid cellular and soluble mediator responses thought to contribute to immunopathogenesis of severe COVID-19.

Published
2023

7. BTK drives neutrophil activation for sterilizing antifungal immunity

Author

Desai, Jigar V., Zarakas, Marissa A., Wishart, Andrew L., Roschewski, Mark, Aufiero, Mariano A., Donko, Agnes, Wigerblad, Gustaf, Shlezinger, Neta, Plate, Markus, James, Matthew R., Lim, Jean K., Uzel, Gulbu, Bergerson, Jenna R.E., Fuss, Ivan, Cramer, Robert A., Franco, Luis M., Clark, Emily S., Khan, Wasif N., Yamanaka, Daisuke, Chamilos, Georgios, El-Benna, Jamel, Kaplan, Mariana J., Staudt, Louis M., Leto, Thomas L., Holland, Steven M., Wilson, Wyndham H., Hohl, Tobias M., and Lionakis, Michail S.

Subjects
Immune response -- Research, Pharmacology, Experimental, Neutrophils -- Health aspects, Protein tyrosine kinase -- Health aspects, Cellular signal transduction -- Research, Aspergillosis -- Development and progression -- Drug therapy -- Risk factors, Health care industry
Abstract

We describe a previously unappreciated role for Bruton's tyrosine kinase (BTK) in fungal immune surveillance against aspergillosis, an unforeseen complication of BTK inhibitors (BTKi) used for treating B cell lymphoid malignancies. We studied BTK-dependent fungal responses in neutrophils from diverse populations, including healthy donors, patients who were treated with BTKi, and X-linked agammaglobulinemia patients. Upon fungal exposure, BTK was activated in human neutrophils in a TLR2-, Dectin-1-, and Fc[gamma]R-dependent manner, triggering the oxidative burst. BTK inhibition selectively impeded neutrophil-mediated damage to Aspergillus hyphae, primary granule release, and the fungus-induced oxidative burst by abrogating NADPH oxidase subunit [p40.sup.phox] and GTPase RAC2 activation. Moreover, neutrophil-specific Btk deletion in mice enhanced aspergillosis susceptibility by impairing neutrophil function, not recruitment or lifespan. Conversely, GM-CSF partially mitigated these deficits by enhancing [p47.sup.phox] activation. Our findings underline the crucial role of BTK signaling in neutrophils for antifungal immunity and provide a rationale for GM-CSF use to offset these deficits in patients who are susceptible., Introduction Invasive aspergillosis (IA), most often caused by the ubiquitous inhaled mold Aspergillus fumigatus, is an opportunistic fungal infection that exploits numeric or functional neutrophil defects (1-3). IA affects over [...]

Published
2024
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8. Navigating an enigma: the continuing journey of autoimmunity discoveries

Author

Kaplan, Mariana J.

Subjects
Autoantibodies -- Identification and classification -- Health aspects, Autoimmune diseases -- Risk factors -- Development and progression -- Genetic aspects, Health care industry
Abstract

Autoimmune diseases (ADs) constitute about one hundred and fifty conditions that often afflict people in the prime of their life. ADs are strikingly more common in women and affect around [...]

Published
2024
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12. Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome

Author

de Jesus, Adriana A., Chen, Guibin, Yang, Dan, Brdicka, Tomas, Ruth, Natasha M., Bennin, David, Cebecauerova, Dita, Malcova, Hana, Freeman, Helen, Martin, Neil, Svojgr, Karel, Passo, Murray H., Bhuyan, Farzana, Alehashemi, Sara, Rastegar, Andre T., Uss, Katsiaryna, Kardava, Lela, Marrero, Bernadette, Duric, Iris, Omoyinmi, Ebun, Peldova, Petra, Lee, Chyi-Chia Richard, Kleiner, David E., Hadigan, Colleen M., Hewitt, Stephen M., Pittaluga, Stefania, Carmona-Rivera, Carmelo, Calvo, Katherine R., Shah, Nirali, Balascakova, Miroslava, Fink, Danielle L., Kotalova, Radana, Parackova, Zuzana, Peterkova, Lucie, Kuzilkova, Daniela, Campr, Vit, Sramkova, Lucie, Biancotto, Angelique, Brooks, Stephen R., Manes, Cameron, Meffre, Eric, Harper, Rebecca L., Kuehn, Hyesun, Kaplan, Mariana J., Brogan, Paul, Rosenzweig, Sergio D., Merchant, Melinda, Deng, Zuoming, Huttenlocher, Anna, Moir, Susan L., Kuhns, Douglas B., Boehm, Manfred, Skvarova Kramarzova, Karolina, and Goldbach-Mansky, Raphaela

Published
2023
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17. The circadian clock gene BMAL1 modulates autoimmunity features in lupus.

Author

Nakabo, Shuichiro, Sandoval-Heglund, Donavon, Hanata, Norio, Brooks, Stephen, Hoffmann, Victoria, Zhang, Mingzeng, Ambler, William, Manna, Zerai, Poncio, Elaine, Hasni, Sarfaraz, Islam, Shamima, Dell'Orso, Stefania, and Kaplan, Mariana J.

Abstract

Objectives: An important pathogenic role for neutrophils in systemic lupus erythematosus (SLE) has been proposed. Neutrophils that lack brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1 (Bmal1), one of the clock genes, are defective in aging and proinflammatory responses. We assessed the role of Bmal1 in clinical and immunologic manifestations of murine lupus and in human SLE neutrophils. Methods: Myeloid-conditional Bmal1 knockout mice (Bmal1Mye−/−) and wild type (WT) were treated with epicutaneous TLR7/8 agonist (imiquimod; IMQ) for 6 weeks to induce a lupus phenotype. Upon euthanasia, immune responses, autoantibodies and renal manifestations were evaluated. NET formation and gene expression of bone marrow (BM)-derived murine neutrophils were evaluated. BMAL1 expression was quantified in SLE neutrophils and compared with clinical disease. Results: IMQ-treated Bmal1Mye−/− and WT displayed comparable systemic inflammation. While renal function did not differ, serum anti-dsDNA levels and renal immune complex deposition were significantly increased in Bmal1Mye−/−. While no differences were observed in NET formation, expression levels of April in BM neutrophils were significantly higher in Bmal1Mye−/−. Bulk RNA-sequence data showed that BM neutrophils in IMQ-treated Bmal1Mye−/− were relatively immature when compared with IMQ-treated WT. BM showed an enhanced April protein expression in Bmal1Mye−/− mice. BMAL1 levels in human SLE peripheral blood neutrophils correlated positively with serum C3 and negatively with serum anti-dsDNA levels. Conclusion: Bmal1 is associated with lower disease activity in SLE. These results indicate that perturbation in the circadian rhythm of neutrophils can have pathogenic consequences in SLE. [ABSTRACT FROM AUTHOR]

Published
2024
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19. A Multiomic Analysis to Identify Drivers of Subclinical Vascular Disease in Systemic Lupus Erythematosus.

Author

Oliveira, Christopher, Temesgen‐Oyelakin, Yenealem, Naqi, Mohammad, Davis, Michael, Naz, Faiza, Dell'Orso, Stefania, Brooks, Stephen, Kuhn, Skyler, Hill, Tom, Li, Xiaobai, Patel, Nidhi, Parel, Philip, Gadina, Massimo, Gupta, Sarthak, Mehta, Nehal, Hasni, Sarfaraz A., and Kaplan, Mariana J.

Subjects
RISK assessment, PROTEINS, RESEARCH funding, RADIOPHARMACEUTICALS, MULTIOMICS, DEOXY sugars, SYSTEMIC lupus erythematosus, DESCRIPTIVE statistics, CARDIOVASCULAR disease diagnosis, PROTEOMICS, EMISSION-computed tomography, VASCULAR diseases, DISEASE progression, BIOMARKERS, SEQUENCE analysis, INTERLEUKINS, TUMOR necrosis factors, EVALUATION, DISEASE risk factors
Abstract

Objective: Systemic lupus erythematosus (SLE) increases cardiovascular disease (CVD) risk, and this is not explained by traditional risk factors. Characterization of blood immunologic signatures that associate with subclinical CVD and predict its progression has been challenging and may help identify subgroups at risk. Methods: Patients with SLE (n = 77) and healthy controls (HCs) (n = 27) underwent assessments of arterial stiffness, vascular wall inflammation, and coronary atherosclerosis burden with cardio‐ankle vascular index (CAVI); fluorodeoxyglucose–positron emission tomography/computed tomography (CT) (target‐to‐background ratio [TBR]); and coronary CT angiography. Whole blood bulk RNA sequencing was performed in a subset of study participants (HC n = 10, SLE n = 20). In a partially overlapping subset (HC n = 24, SLE n = 64), serum inflammatory protein biomarkers were quantified with an Olink platform. Results: CAVI, TBR, and noncalcified coronary plaque burden (NCB) were increased in patients with SLE compared to HCs. When comparing patients with SLE with high CAVI scores to those with low CAVI scores or to HCs, there was a down‐regulation of genes in pathways involved in the cell cycle and differentially regulated pathways related to metabolism. Distinct serum proteins associated with increased CAVI (CCL23, colony‐stimulating factor 1, latency‐activating peptide transforming growth factor β1, interleukin 33 [IL‐33], CD8A, and IL‐12B), NCB (monocyte chemotactic protein 4 and FMS‐like tyrosine kinase 3 ligand [Flt3L]), and TBR (CD5, IL‐1α, AXIN1, cystatin D [CST5], and tumor necrosis factor receptor superfamily 9; P < 0.05). Conclusion: Blood gene expression patterns and serum proteins that associate with worse vascular phenotypes suggest dysregulated immune and metabolic pathways linked to premature CVD. Cytokines and chemokines identified in associations with arterial stiffness, inflammation, and NCB in SLE may allow for characterization of new CVD biomarkers in lupus. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism

Author

Gupta, Sarthak, Nakabo, Shuichiro, Blanco, Luz P., O’Neil, Liam J., Wigerblad, Gustaf, Goel, Rishi R., Mistry, Pragnesh, Jiang, Kan, Carmona-Rivera, Carmelo, Chan, Diana W., Wang, Xinghao, Pedersen, Hege L., Gadkari, Manasi, Howe, Katherine N., Naz, Faiza, Dell’Orso, Stefania, Hasni, Sarfaraz A., Dempsey, Caeden, Buscetta, Ashley, Frischmeyer-Guerrerio, Pamela A., Kruszka, Paul, Muenke, Maximilian, Franco, Luis M., Sun, Hong-Wei, and Kaplan, Mariana J.

Published
2020

23. Immunity to commensal skin fungi promotes psoriasiform skin inflammation

Author

Hurabielle, Charlotte, Link, Verena M., Bouladoux, Nicolas, Han, Seong-Ji, Merrill, Eric Dean, Lightfoot, Yaima L., Seto, Nickie, Bleck, Christopher K. E., Smelkinson, Margery, Harrison, Oliver J., Linehan, Jonathan L., Tamoutounour, Samira, Lionakis, Michail S., Kaplan, Mariana J., Nakajima, Saeko, and Belkaid, Yasmine

Published
2020

24. Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis

Author

Jing, Chenzhi, Castro-Dopico, Tomas, Richoz, Nathan, Tuong, Zewen K., Ferdinand, John R., Lok, Laurence S. C., Loudon, Kevin W., Banham, Gemma D., Mathews, Rebeccah J., Cader, Zaeem, Fitzpatrick, Susan, Bashant, Kathleen R., Kaplan, Mariana J., Kaser, Arthur, Johnson, Randall S., Murphy, Michael P., Siegel, Richard M., and Clatworthy, Menna R.

Published
2020

26. Patients with COVID-19: in the dark-NETs of neutrophils

Author

Ackermann, Maximilian, Anders, Hans-Joachim, Bilyy, Rostyslav, Bowlin, Gary L., Daniel, Christoph, De Lorenzo, Rebecca, Egeblad, Mikala, Henneck, Timo, Hidalgo, Andrés, Hoffmann, Markus, Hohberger, Bettina, Kanthi, Yogendra, Kaplan, Mariana J., Knight, Jason S., Knopf, Jasmin, Kolaczkowska, Elzbieta, Kubes, Paul, Leppkes, Moritz, Mahajan, Aparna, Manfredi, Angelo A., Maueröder, Christian, Maugeri, Norma, Mitroulis, Ioannis, Muñoz, Luis E., Narasaraju, Teluguakula, Naschberger, Elisabeth, Neeli, Indira, Ng, Lai Guan, Radic, Marko Z., Ritis, Konstantinos, Rovere-Querini, Patrizia, Schapher, Mirco, Schauer, Christine, Simon, Hans-Uwe, Singh, Jeeshan, Skendros, Panagiotis, Stark, Konstantin, Stürzl, Michael, van der Vlag, Johan, Vandenabeele, Peter, Vitkov, Ljubomir, von Köckritz-Blickwede, Maren, Yanginlar, Cansu, Yousefi, Shida, Zarbock, Alexander, Schett, Georg, and Herrmann, Martin

Published
2021
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31. Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögren's disease.

Author

Gupta, Sarthak, Yamada, Eiko, Nakamura, Hiroyuki, Perez, Paola, Pranzatelli, Thomas J. F., Dominick, Kalie, Shyh-Ing Jang, Abed, Mehdi, Martin, Daniel, Burbelo, Peter, ChangYu Zheng, French, Ben, Alevizos, Ilias, Khavandgar, Zohreh, Beach, Margaret, Pelayo, Eileen, Walitt, Brian, Hasni, Sarfaraz, Kaplan, Mariana J., and Tandon, Mayank

Published
2024
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32. Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells

Author

Kolev, Martin, West, Erin E., Kunz, Natalia, Chauss, Daniel, Moseman, E. Ashley, Rahman, Jubayer, Freiwald, Tilo, Balmer, Maria L., Lötscher, Jonas, Dimeloe, Sarah, Rosser, Elizabeth C., Wedderburn, Lucy R., Mayer-Barber, Katrin D., Bohrer, Andrea, Lavender, Paul, Cope, Andrew, Wang, Luopin, Kaplan, Mariana J., Moutsopoulos, Niki M., McGavern, Dorian, Holland, Steven M., Hess, Christoph, Kazemian, Majid, Afzali, Behdad, and Kemper, Claudia

Published
2020
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36. Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus

Author

Hasni, Sarfaraz A., Gupta, Sarthak, Davis, Michael, Poncio, Elaine, Temesgen-Oyelakin, Yenealem, Carlucci, Philip M., Wang, Xinghao, Naqi, Mohammad, Playford, Martin P., Goel, Rishi R., Li, Xiaobai, Biehl, Ann J., Ochoa-Navas, Isabel, Manna, Zerai, Shi, Yinghui, Thomas, Donald, Chen, Jinguo, Biancotto, Angélique, Apps, Richard, Cheung, Foo, Kotliarov, Yuri, Babyak, Ashley L., Zhou, Huizhi, Shi, Rongye, Stagliano, Katie, Tsai, Wanxia Li, Vian, Laura, Gazaniga, Nathalia, Giudice, Valentina, Lu, Shajia, Brooks, Stephen R., MacKay, Meggan, Gregersen, Peter, Mehta, Nehal N., Remaley, Alan T., Diamond, Betty, O’Shea, John J., Gadina, Massimo, and Kaplan, Mariana J.

Published
2021
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37. Contributors

Author

Agmon-Levin, Nancy, primary, Alarcón, Graciela S., additional, Amengual, Olga, additional, Ardoin, Stacy P., additional, Arora, Swati, additional, Atisha-Fregoso, Yemil, additional, Atkinson, John P., additional, Atsumi, Tatsuya, additional, Ayoub, Isabelle, additional, Barilla-LaBarca, Maria-Louise, additional, Bermas, Bonnie L., additional, Bernatsky, Sasha, additional, Bertsias, George, additional, Bichile, Tanmayee, additional, Blanco, Patrick, additional, Bohgaki, Miyuki, additional, Bonsmann, Gisela, additional, Borghi, Maria Orietta, additional, Boumpas, Dimitrios T., additional, Bourn, Rebecka, additional, Buyon, Jill P., additional, Caricchio, Roberto, additional, Chan, Edward K.L., additional, Chang, Christopher, additional, Charrier, Manon, additional, Chighizola, Cecilia Beatrice, additional, Clarke, Ann E., additional, Crispín, José C., additional, Cuneo, Bettina, additional, Dörner, Thomas, additional, Damato, Erika M., additional, Denniston, Alastair K.O., additional, Devlin, Amy, additional, Diamond, Betty, additional, Ernandez, T., additional, Falasinnu, Titilola, additional, Fernandez-Ruiz, Ruth, additional, Fitzpatrick, Brianna, additional, Forbess, Lindsy, additional, Frangou, Eleni A., additional, Fritzler, Marvin J., additional, Fu, Shu Man, additional, Furie, Richard, additional, Gaskin, Felicia, additional, Gladman, Dafna, additional, Gordon, Caroline, additional, Grammer, Amrie C., additional, Greidinger, Eric L., additional, Greiling, Teri M., additional, Han, Shuhong, additional, Hansen, James E., additional, Hasni, Sarfaraz A., additional, Hassan, Fadi, additional, Hedrich, Christian M., additional, Hiromura, Keiju, additional, Horowitz, Diane, additional, Huang, Xin, additional, Hunt, David, additional, Izmirly, Peter M., additional, James, Judith A., additional, Jarjour, Wael N., additional, Jefferies, Caroline A., additional, Jefferies, Caroline, additional, Jiang, Xiaoyue, additional, Kaplan, Mariana J., additional, Katsuyama, Takayuki, additional, Khamashta, Munther, additional, Kingsmore, Kathryn M., additional, Koike, Takao, additional, Kono, Dwight H., additional, Kriegel, Martin A., additional, Kuhn, Annegret, additional, Kyttaris, Vasileios C, additional, La Cava, Antonio, additional, Ladouceur, Alexandra, additional, Lahita, Robert G., additional, Landmann, Aysche, additional, Lazaro, Estibaliz, additional, Lennard Richard, Mara L., additional, Lino, Andreia C., additional, Lipsky, Peter E., additional, Liszewski, M. Kathryn, additional, Lo, Mindy S., additional, Lu, Qianjin, additional, Mahieu, Mary, additional, Malkiel, Susan, additional, Manzi, Susan, additional, Marder, Galina, additional, Mayadas, T.N., additional, Meroni, Pier Luigi, additional, Merrill, Joan T., additional, Mohan, Chandra, additional, Mok, Chi Chiu, additional, Moulton, Vaishali R., additional, Murray, Philip I., additional, Naffaa, Mohammad E., additional, Nangaku, Masaomi, additional, Niewold, Timothy, additional, Okubo, K., additional, Olsen, Nancy J., additional, Pal, Trina, additional, Paz, Ziv, additional, Perl, Andras, additional, Pons-Estel, Guillermo J., additional, Qu, Bo, additional, Rahman, Anisur, additional, Raman, Ziaur S.M., additional, Ramsey-Goldman, Rosalind, additional, Reeves, Westley H., additional, Richez, Christophe, additional, Rosetti, Florencia, additional, Rovin, Brad H., additional, Rubin, Robert L., additional, Saeli, Stephanie, additional, Saggu, G., additional, Sammaritano, Lisa R., additional, Satoh, Minoru, additional, Sawalha, Amr H., additional, Saxena, Amit, additional, Sciascia, Savino, additional, Shaharir, Syahrul Sazliyana, additional, Sharabi, Amir, additional, Shen, Nan, additional, Shmerling, Robert H., additional, Simard, Julia F., additional, Sisirak, Vanja, additional, Slight-Webb, Samantha, additional, Stillman, Isaac Ely, additional, Sung, Sun-Sang J., additional, Thakkar, Payal, additional, Theofilopoulos, Argyrios N., additional, Thomas, Jr, Donald E., additional, Tissera, Hiromi, additional, Touma, Zahi, additional, Tsao, Betty P., additional, Ugarte-Gil, Manuel F., additional, Urowitz, Murray B., additional, Vieira, Silvio Manfredo, additional, Wainwright, Benjamin, additional, Wallace, Daniel J., additional, Wang, Hongyang, additional, Wu, Haijing, additional, Yahia, Soad Haj, additional, Yu, C. Yung, additional, Zhao, Zhenhuan, additional, and Zhuang, Haoyang, additional

Published
2021
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38. Contributors

Author

Ahearn, Joseph M., primary, Alarcón-Riquelme, Marta E., additional, Almaani, Salem J., additional, Anolik, Jennifer H., additional, Aranow, Cynthia, additional, Bacalao, Maria A., additional, Barilla-LaBarca, Maria-Louise, additional, Barnas, Jennifer L., additional, Barturen, Guillermo, additional, Bermas, Bonnie L., additional, Bernatsky, Sasha, additional, Bruce, I.N., additional, Bucala, Richard, additional, Buyon, Jill P., additional, Carnero-Montoro, Elena, additional, Clarke, Ann E., additional, Clowse, Megan E.B., additional, Concha, Josef Symon S., additional, Dellaripa, Paul, additional, Diamond, Betty, additional, Doyle, Tracy J., additional, Fernando, Michelle M.A., additional, Fisk, John D., additional, Furie, Richard, additional, Gordon, Caroline, additional, Greiling, Teri M., additional, Han, Shuhong, additional, Hanly, John G., additional, Hile, Grace A., additional, Horowitz, Diane, additional, Isenberg, David, additional, Izmirly, Peter, additional, Jacobs, Barbara, additional, James, Judith A., additional, Kahlenberg, J. Michelle, additional, Kalunian, Kenneth C., additional, Kang, Insoo, additional, Kaplan, Mariana J., additional, Khamashta, Munther A., additional, Kim, Mimi, additional, Knight, Jason S., additional, Koumpouras, Fotios, additional, Kriegel, Martin A., additional, La Cava, Antonio, additional, Ladouceur, Alexandra, additional, Lahita, Robert G., additional, Lee, Iris Jung-Won, additional, Lessard, Christopher J., additional, Lewandowski, Laura B., additional, Liang, Yun, additional, Liu, Chau-Ching, additional, Mackay, Meggan, additional, Madaio, Michael P., additional, Marder, Galina, additional, Matteson, Eric L., additional, McCoy, Sara, additional, McMahon, Maureen, additional, Meffre, Eric, additional, Mejia-Vilet, Juan, additional, Merrill, Joan, additional, Morand, Eric F., additional, Moreira Pinto, Sara, additional, Nakabo, Shuichiro, additional, Northcott, Melissa, additional, Omisade, Antonina, additional, Ortel, Thomas L., additional, Perl, Andras, additional, Ramsey-Goldman, Rosalind, additional, Reeves, Westley H., additional, Reyes-Thomas, Joyce, additional, Reynolds, J.A., additional, Richardson, Bruce, additional, Rodriguez, Juan Vicente, additional, Rovin, Brad H., additional, Rudinskaya, Alla, additional, Ruiz-Irastorza, Guillermo, additional, Saxena, Amit, additional, Schanberg, Laura E., additional, Sharma, Tarun S., additional, Skaggs, Brian, additional, Somers, Emily C., additional, Stohl, William, additional, Talabi, Mehret Birru, additional, Tessneer, Kandice L., additional, Tsao, Betty P., additional, Ugarte, Amaia, additional, Volpe, Bruce T., additional, Vyse, Timothy J., additional, Wainwright, Benjamin J., additional, Ward, Michael M., additional, Wasko, Mary Chester M., additional, Werth, Victoria P., additional, Wise, Leanna, additional, Zhuang, Haoyang, additional, and Zuo, Yu, additional

Published
2021
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44. Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis

Author

Teague, Heather L., Varghese, Nevin J., Tsoi, Lam C., Dey, Amit K., Garshick, Michael S., Silverman, Joanna I., Baumer, Yvonne, Harrington, Charlotte L., Stempinski, Erin, Elnabawi, Youssef A., Dagur, Pradeep K., Cui, Kairong, Tunc, Ilker, Seifuddin, Fayaz, Joshi, Aditya A., Stansky, Elena, Purmalek, Monica M., Rodante, Justin A., Keel, Andrew, Aridi, Tarek Z., Carmona-Rivera, Carmelo, Sanda, Gregory E., Chen, Marcus Y., Pirooznia, Mehdi, McCoy, J. Philip, Jr., Gelfand, Joel M., Zhao, Keji, Gudjonsson, Johann E., Playford, Martin P., Kaplan, Mariana J., Berger, Jeffrey S., and Mehta, Nehal N.

Published
2019
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46. "Rounding Third Base and Heading Home": Arthritis & Rheumatology in 2024.

Author

Solomon, Daniel H., Kaplan, Mariana J., Nigrovic, Peter A., and Bucala, Richard

Subjects
*SERIAL publications, *SOCIAL media, *ARTIFICIAL intelligence, *ARTHRITIS, *STREAMING media, *RHEUMATOLOGY, *ORGANIZATIONAL goals, *COVID-19 pandemic, *RHEUMATISM, *OPEN access publishing
Abstract

The article presents the discussion on editorial leadership at Arthritis & Rheumatology, highlighting the challenges and developments encountered, particularly during the COVID-19 pandemic. Topics include increase in manuscript submissions related to COVID-19, the importance of expert opinions in delivering quality care, and the introduction of new article types such as Expert Perspectives on Clinical Challenges and Notes From the Field.

Published
2024
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49. Equity and diversity in academic medicine: a perspective from the JCI editors

Author

Resar, Linda M.S., Jaffee, Elizabeth M., Armamos, Mary, Jackson, Sarah, Azad, Nilofer S., Horton, Maureen R., Kaplan, Mariana J., Laiho, Marikki, Maus, Marcela V., Sumner, Charlotte J., Wheelan, Sarah J., and Wills-Karp, Marsha

Subjects
United States. National Institutes of Health -- Training, Sexual harassment, Harassment, Women, Health care industry, Johns Hopkins University. School of Medicine -- Training
Abstract

#MeToo in academia The #MeToo movement has taken on sexual harassment in the workplace and served to inform the world that these unacceptable and illegal acts have become commonplace, including [...]

Published
2019
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50. To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps

Author

Boeltz, Sebastian, Amini, Poorya, Anders, Hans-Joachim, Andrade, Felipe, Bilyy, Rostyslav, Chatfield, Simon, Cichon, Iwona, Clancy, Danielle M., Desai, Jyaysi, Dumych, Tetiana, Dwivedi, Nishant, Gordon, Rachael Ann, Hahn, Jonas, Hidalgo, Andrés, Hoffmann, Markus H., Kaplan, Mariana J., Knight, Jason S., Kolaczkowska, Elzbieta, Kubes, Paul, Leppkes, Moritz, Manfredi, Angelo A., Martin, Seamus J., Maueröder, Christian, Maugeri, Norma, Mitroulis, Ioannis, Munoz, Luis E., Nakazawa, Daigo, Neeli, Indira, Nizet, Victor, Pieterse, Elmar, Radic, Marko Z, Reinwald, Christiane, Ritis, Konstantinos, Rovere-Querini, Patrizia, Santocki, Michal, Schauer, Christine, Schett, Georg, Shlomchik, Mark Jay, Simon, Hans-Uwe, Skendros, Panagiotis, Stojkov, Darko, Vandenabeele, Peter, Berghe, Tom Vanden, van der Vlag, Johan, Vitkov, Ljubomir, von Köckritz-Blickwede, Maren, Yousefi, Shida, Zarbock, Alexander, and Herrmann, Martin

Published
2019
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