399 results on '"Kappelhof, Manon"'
Search Results
2. Perceived acceptable uncertainty regarding comparability of endovascular treatment alone versus intravenous thrombolysis plus endovascular treatment
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Kaesmacher, Johannes, Mujanovic, Adnan, Treurniet, Kilian, Kappelhof, Manon, Meinel, Thomas R, Yang, Pengfei, Liu, Jianmin, Zhang, Yongwei, Zi, Wenjie, Yang, Qingwu, Nogueira, Raul G, Kimura, Kazumi, Matsumaru, Yuji, Suzuki, Kentaro, Yan, Bernard, Mitchell, Peter J, Miao, Zhongrong, Roos, Yvo BWEM, Majoie, Charles BLM, Gralla, Jan, Saver, Jeffrey L, and Fischer, Urs
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Clinical Trials and Supportive Activities ,Clinical Research ,Humans ,Brain Ischemia ,Endovascular Procedures ,Fibrinolytic Agents ,Stroke ,Thrombectomy ,Thrombolytic Therapy ,Treatment Outcome ,Uncertainty ,thrombectomy ,thrombolysis ,stroke - Abstract
BackgroundMost trials comparing endovascular treatment (EVT) alone versus intravenous thrombolysis with alteplase (IVT) + EVT in directly admitted patients with a stroke are non-inferiority trials. However, the margin based on the level of uncertainty regarding non-inferiority of the experimental treatment that clinicians are willing to accept to incorporate EVT alone into clinical practice remains unknown.ObjectiveTo characterize what experienced stroke clinicians would consider an acceptable level of uncertainty for hypothetical decisions on whether to administer IVT or not before EVT in patients admitted directly to EVT-capable centers.MethodsA web-based, structured survey was distributed to a cross-section of 600 academic neurologists/neurointerventionalists. For this purpose, a response framework for a hypothetical trial comparing IVT+EVT (standard of care) with EVT alone (experimental arm) was designed. In this trial, a similar proportion of patients in each arm achieved functional independence at 90 days. Invited physicians were asked at what level of certainty they would feel comfortable skipping IVT in clinical practice, considering these hypothetical trial results.ResultsThere were 180 respondents (response rate: 30%) and 165 with complete answers. The median chosen acceptable uncertainty suggesting reasonable comparability between both treatments was an absolute difference in the rate of day 90 functional independence of 3% (mode 5%, IQR 1-5%), with higher chosen margins observed in interventionalists (aOR 2.20, 95% CI 1.06 to 4.67).ConclusionPhysicians would generally feel comfortable skipping IVT before EVT at different certainty thresholds. Most physicians would treat with EVT alone if randomized trial data suggested that the number of patients achieving functional independence at 90 days was similar between the two groups, and one could be sufficiently sure that no more than 3 out of 100 patients would not achieve functional independence at 90 days due to skipping IVT.
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- 2023
3. Collateral-based selection for endovascular treatment of acute ischaemic stroke in the late window (MR CLEAN-LATE): 2-year follow-up of a phase 3, multicentre, open-label, randomised controlled trial in the Netherlands
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van Oostenbrugge, Robert, van Zwam, Wim, Olthuis, Susanne, Pirson, Anne, Hinsenveld, Wouter, Goldhoorn, Robert-Jan, Staals, Julie, Dippel, Diederik, van der Lugt, Aad, van Es, Adriaan, Roozenbeek, Bob, van Doormaal, Pieter-Jan, Roos, Yvo, Majoie, Charles, Coutinho, Jonathan, Emmer, Bart, van der Worp, Bart, Lo, Rob, van Walderveen, Marianne, Wermer, Marieke, van Dijk, Ewoud, Jenniskens, Sjoerd, Boogaarts, Hieronymus, Uyttenboogaart, Maarten, Bokkers, Reinoud, Keizer, Koos, Gons, Rob, Yo, Lonneke, den Hertog, Heleen, van Hasselt, Boudewijn, Schonewille, Wouter, Vos, Jan-Albert, van Tuijl, Julia, Boukrab, Issam, Kortman, Hans, Hofmeijer, Jeannette, Martens, Jasper, van den Wijngaard, Ido, Boiten, Jelis, Lycklama à Nijeholt, Geert, Brouwers, Paul, Sturm, Emiel, Bulut, Tomas, de Laat, Karlijn, van Dijk, Lukas, Remmers, Michel, de Jong, Thijs, Rozeman, Anouk, Elgersma, Otto, Van der Veen, Bas, Sudiono, Davy, Mattle, Heinrich, Fiehler, Jens, van Kuijk, Sander, Nieboer, Daan, Lingsma, Hester, van Nuland, Rick, Roosendaal, Stefan, Krietemeijer, Menno, Postma, Alida, Van den Berg, René, Beenen, Ludo, Hammer, Sebastiaan, Meijer, Anton, van der Hoorn, Anouk, Yoo, Albert, Gerrits, Dick, Jansen, Ben, Truijman, Martine, Manschot, Sanne, Kerkhoff, Henk, Koudstaal, Peter, Chalos, Vicky, Berkhemer, Olvert, Versteeg, Adriaan, Wolff, Lennard, Su, Jiahang, van der Sluijs, Matthijs, van Voorst, Henk, Tolhuisen, Manon, ten Cate, Hugo, de Maat, Moniek, Donse-Donkel, Samantha, van Beusekom, Heleen, Taha, Aladdin, Barakzie, Aarazo, Treurniet, Kilian, van den Berg, Sophie, LeCouffe, Natalie, van de Graaf, Rob, de Ridder, Inger, Pinckaers, Florentina, Ceulemans, Angelique, Knapen, Robrecht, Robbe, Quirien, Sondag, Lotte, Kappelhof, Manon, Reinink, Rik, Silvis, Suzanne, Schreuder, Floris, Uniken Venema, Simone, van Meenen, Laura, Collette, Sabine, van Wijngaarden, Wilma, van der Steen, Wouter, Hoving, Jan, Verheesen, Sabrina, Sterrenberg, Martin, El Ghannouti, Naziha, Sprengers, Rita, van Ahee, Ayla, Zweedijk, Berber, Pellikaan, Wilma, Schonewille, Irati, Blauwendraat, Kitty, Drabbe, Yvonne, Kleine-Kathöfer, Anke, de Meris, Joke, Sandiman, Michelle, Dofferhoff-Vermeulen, Tamara, Simons, Michelle, Bongenaar, Hester, Smallegange, Maylee, van Loon, Anja, Kraus, Karin, Bos-Verheij, Erna, Santegoets, Ester, Kooij, Suze, Slotboom, Annemarie, Ponjee, Eva, Eilander, Rieke, Droste, Hanneke, van Veen, Esther, Visser, Rosalie, Lodico, Jasmijn, de Jong, Marieke, van der Minne, Friedus, Cleophas, Eefje, Muskens, Ernst, Nijst, Amy, Heiligers, Leontien, Martens, Yvonne, Slotboom, Miranda, Hintzen, Rogier, Jacobs, Bart, Huijberts, Ilse, Pinckaers, Florentina M E, Olthuis, Susanne G H, van Kuijk, Sander M J, Postma, Alida A, Boogaarts, Hieronymus D, Roos, Yvo B W E M, Majoie, Charles B L M, Dippel, Diederik W J, van Zwam, Wim H, and van Oostenbrugge, Robert J
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- 2024
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4. Association between computed tomography perfusion and the effect of intravenous alteplase prior to endovascular treatment in acute ischemic stroke
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Hoving, Jan W., van Voorst, Henk, Peerlings, Daan, Daems, Jasper D., Koopman, Miou S., Wouters, Anke, Kappelhof, Manon, LeCouffe, Natalie E., Treurniet, Kilian M., Bruggeman, Agnetha A. E., Rinkel, Leon A., van den Wijngaard, Ido R., Coutinho, Jonathan M., van der Lugt, Aad, Marquering, Henk A., Roos, Yvo B. W. E. M., Majoie, Charles B. L. M., and Emmer, Bart J.
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- 2023
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5. Intravenous Thrombolysis Before Endovascular Treatment in Posterior Circulation Occlusions: A MR CLEAN Registry Study
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Knapen, Robrecht R.M.M., Pirson, F. Anne V., Langezaal, Lucianne C.M., Brouwer, Josje, Majoie, Charles B.L.M., Emmer, Bart J., Vos, Jan-Albert, van Doormaal, Pieter-Jan, Yoo, Albert J., Bruggeman, Agnetha A.E., Lycklama à Nijeholt, Geert J., van der Leij, Chirstiaan, van Oostenbrugge, Robert J., van Zwam, Wim H., Schonewille, Wouter J., Dippel, Diederik W.J., van der Lugt, Aad, Roos, Yvo B.W.E.M., Boiten, Jelis, Jansen, Ivo G.H., Mulder, Maxim J.H.L., Goldhoorn, Robert-Jan B., Compagne, Kars C.J., Kappelhof, Manon, den Hartog, Sanne J., Hinsenveld, Wouter H., Dippel, Diederik W.J., Roozenbeek, Bob, van der Lugt, Aad, Roos, Yvo B.W.E.M., Wermer, Marieke J.H., van Walderveen, Marianne A.A., van Es, Adriaan C.G.M., Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper M., Boiten, Jelis, de Bruijn, Sebastiaan F., van Dijk, Lukas C., Bart van der Worp, H., Lo, Rob H., van Dijk, Ewoud J., Boogaarts, Hieronymus D., de Vries, J., de Kort, Paul L.M., van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P.H., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Yo, Lonneke S.F., den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., van Walderveen, Marianne A.A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., van den Berg, René, Beenen, Ludo F.M., Postma, Alida A., Roosendaal, Stefan D., van der Kallen, Bas F.W., van den Wijngaard, Ido R., van Es, Adriaan C.G.M., Martens, Jasper M., Yo, Lonneke S.F., Bot, Joost, Meijer, Anton, Ghariq, Elyas, Bokkers, Reinoud P.H., van Proosdij, Marc P., Menno Krietemeijer, G., Peluso, Jo P., Boogaarts, Hieronymus D., Lo, Rob, Dinkelaar, Wouter, Appelman, Auke P.A., Hammer, Bas, Pegge, Sjoert, van der Hoorn, Anouk, Vinke, Saman, Cornelissen, Sandra, Brans, Rutger, Dippel, Diederik W.J., van der Lugt, Aad, Roos, Yvo B.W.E.M., Boiten, Jelis, Hofmeijer, Jeannette, Martens, Jasper M., Bart van der Worp, H., Lo, Rob H., Hofmeijer, Jeannette, Zwenneke Flach, H., Lingsma, Hester F., el Ghannouti, Naziha, Sterrenberg, Martin, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, Simons, Michelle, Vossers, Marjolein, de Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, van Vemde, Gina, Simons, Tiny, Messchendorp, Gert, Nicolaij, Nynke, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, Maureen, Verheesen, Sabrina, Jeurrissen, D., Bos, Erna, Drabbe, Yvonne, Sandiman, Michelle, Aaldering, Nicoline, Zweedijk, Berber, Vervoort, Jocova, Ponjee, Eva, Romviel, Sharon, Kanselaar, Karin, Barning, Denn, Venema, Esmee, Chalos, Vicky, Geuskens, Ralph R., van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R.M., Muijres, Daan, de Jong, Anouk, Berkhemer, Olvert A., Boers, Anna M.M., Huguet, J., Groot, P.F.C., Mens, Marieke A., van Kranendonk, Katinka R., Treurniet, Kilian M., Tolhuisen, Manon L., Alves, Heitor, Weterings, Annick J., Kirkels, Eleonora L.F., Voogd, Eva J.H.F., Schupp, Lieve M., Collette, Sabine L., Groot, Adrien E.D., LeCouffe, Natalie E., Konduri, Praneeta R., Prasetya, Haryadi, Arrarte-Terreros, Nerea, Ramos, Lucas A., and Boodt, Nikki
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- 2024
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6. Prediction of Outcome and Endovascular Treatment Benefit
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Venema, Esmee, Roozenbeek, Bob, Mulder, Maxim JHL, Brown, Scott, Majoie, Charles BLM, Steyerberg, Ewout W, Demchuk, Andrew M, Muir, Keith W, Dávalos, Antoni, Mitchell, Peter J, Bracard, Serge, Berkhemer, Olvert A, Lycklama à Nijeholt, Geert J, van Oostenbrugge, Robert J, Roos, Yvo BWEM, van Zwam, Wim H, van der Lugt, Aad, Hill, Michael D, White, Philip, Campbell, Bruce CV, Guillemin, Francis, Saver, Jeffrey L, Jovin, Tudor G, Goyal, Mayank, Dippel, Diederik WJ, Lingsma, Hester F, der Lugt, Aad van, Boiten, Jelis, Vos, Jan Albert, Jansen, Ivo GH, Goldhoorn, Robert-Jan B, Compagne, Kars CJ, Kappelhof, Manon, Brouwer, Josje, den Hartog, Sanne J, Hinsenveld, Wouter H, van Es, Adriaan CGM, Emmer, Bart J, Coutinho, Jonathan M, Schonewille, Wouter J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper M, de Bruijn, Sebastiaan F, van Dijk, Lukas C, van der Worp, H Bart, Lo, Rob H, van Dijk, Ewoud J, Boogaarts, Hieronymus D, Vries, J de, de Kort, Paul LM, van Tuijl, Julia, Peluso, Jo P, Fransen, Puck, van den Berg, Jan SP, van Hasselt, Boudewijn AAM, Aerden, Leo AM, Dallinga, René J, Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud PH, Schreuder, Tobien HCML, Heijboer, Roel JJ, Keizer, Koos, Yo, Lonneke SF, den Hertog, Heleen M, Bulut, Tomas, Brouwers, Paul JAM, Sprengers, Marieke ES, Jenniskens, Sjoerd FM, van den Berg, René, Yoo, Albert J, Beenen, Ludo FM, Postma, Alida A, Roosendaal, Stefan D, van der Kallen, Bas FW, van den Wijngaard, Ido R, Bot, Joost, van Doormaal, Pieter-Jan, Meijer, Anton, Ghariq, Elyas, van Proosdij, Marc P, Krietemeijer, G Menno, Lo, Rob, Gerrits, Dick, Dinkelaar, Wouter, and Appelman, Auke PA
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Clinical Trials and Supportive Activities ,Clinical Research ,Stroke ,Brain Disorders ,Neurosciences ,Aged ,Aged ,80 and over ,Brain Ischemia ,Endovascular Procedures ,Humans ,Ischemic Stroke ,Male ,Middle Aged ,Registries ,Thrombectomy ,Treatment Outcome ,ischemic stroke ,registry ,reperfusion ,thrombectomy ,uncertainty ,HERMES collaborators and MR CLEAN Registry Investigators* ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Neurology & Neurosurgery - Abstract
Background and purposeBenefit of early endovascular treatment (EVT) for ischemic stroke varies considerably among patients. The MR PREDICTS decision tool, derived from MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands), predicts outcome and treatment benefit based on baseline characteristics. Our aim was to externally validate and update MR PREDICTS with data from international trials and daily clinical practice.MethodsWe used individual patient data from 6 randomized controlled trials within the HERMES (Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials) collaboration to validate the original model. Then, we updated the model and performed a second validation with data from the observational MR CLEAN Registry. Primary outcome was functional independence (defined as modified Rankin Scale score 0–2) 3 months after stroke. Treatment benefit was defined as the difference between the probability of functional independence with and without EVT. Discriminative performance was evaluated using a concordance (C) statistic.ResultsWe included 1242 patients from HERMES (633 assigned to EVT, 609 assigned to control) and 3156 patients from the MR CLEAN Registry (all of whom underwent EVT within 6.5 hours). The C-statistic for functional independence was 0.74 (95% CI, 0.72–0.77) in HERMES and, after model updating, 0.80 (0.78–0.82) in the Registry. Median predicted treatment benefit of routinely treated patients (Registry) was 10.3% (interquartile range, 5.8%–14.4%). Patients with low (
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- 2021
7. Desired Qualities of Endovascular Tools and Barriers to Treating Medium Vessel Occlusion MeVO: Insights from the MeVO-FRONTIERS International Survey
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Kashani, Nima, Cimflova, Petra, Ospel, Johanna M., Kappelhof, Manon, Singh, Nishita, McDonough, Rosalie V., Almekhlafi, Mohammed A., Chen, Michael, Sakai, Nobuyuki, Fiehler, Jens, Ahmed, Uzair, Peeling, Lissa, Kelly, Michael, and Goyal, Mayank
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- 2023
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8. Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials
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Zi, Wenjie, Nogueira, Raul, Yang, Qingwu, Liu, Jianmin, Yang, Pengfei, Zhang, Yongwei, Yan, Bernard, Mitchell, Peter, Miao, Zhong Rong, Majoie, Charles B., Roos, Yvo B., Suzuki, Kentaro, Kimura, Kazumi, Matsumaru, Yuji, Fischer, Urs, Gralla, Jan, Cavalcante, Fabiano W., Kappelhof, Manon, Treurniet, Kilian M., Kaesmacher, Johannes, Zhang, Lei, Bush, Steven, Nieboer, Daan, Lingsma, Hester F., Rothwell, Peter, Saver, Jeffrey, Fiehler, Jens, Li, Fengli, Huang, Jiacheng, Song, Jiaxing, Hong, Bo, Chen, Wenhuo, Peng, Ya, Han, Hongxing, Zhang, Liyong, Li, Zifu, Xing, Pengfei, Shen, Hongjian, Zhang, Ping, Zhang, Xiaoxi, Davis, Stephen, Nguyen, Huy-Thang, Donnan, Geoffrey, Huo, Xiaochuan, Nan, Guangxian, Bivard, Andrew, Ma, Henry, Vu, Dang Lu, Campbell, Bruce, Rinkel, Leon A., Emmer, Bart J., Coutinho, Jonathan M., LeCouffe, Natalie E., Dippel, Diederik W., van der Lugt, Aad, van Zwam, Wim H., van Oostenbrugge, Robert J., Uyttenboogaart, Maarten, Costalat, Vincent, Lycklama, Geert, Hofmeijer, Jeannette, van Norden, Anouk, Otsuka, Toshiaki, Takeuchi, Masataka, Morimoto, Masafumi, Kanazawa, Ryuzaburo, Takayama, Yohei, Kamiya, Yuki, Shigeta, Keigo, Okubo, Seiji, Hayakawa, Mikito, Strbian, Daniel, Eker, Omer, Cognard, Christophe, Meinel, Thomas, Dobrocky, Tomas, Jung, Simon, Piechowiak, Eike, Marnat, Gaultier, Sibon, Igor, Bourcier, Romain, de Gaalon, Solene, Papagiannaki, Chrysanthi, Lefebvre, Margaux, Majoie, Charles B, Cavalcante, Fabiano, Treurniet, Kilian M, Miao, Zhongrong, Rinkel, Leon A, Wang, Shouchun, Coutinho, Jonathan M, Emmer, Bart J, LeCouffe, Natalie E, Lingsma, Hester F, Nogueira, Raul G, and Roos, Yvo B
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- 2023
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9. Mathematical modelling of haemorrhagic transformation in the human brain
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Chen, Xi, Wang, Jiayu, van Kranendonk, Katinka R., Józsa, Tamas.I., El-Bouri, Wahbi K., Kappelhof, Manon, van der Sluijs, Matthijs, Dippel, Diederik, Roos, Yvo B.W.M., Marquering, Henk A, Majoie, Charles B.L.M., and Payne, Stephen J.
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- 2023
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10. Association of thrombus density and endovascular treatment outcomes in patients with acute ischemic stroke due to M1 occlusions
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Bruggeman, Agnetha A. E., Aberson, Nyk, Kappelhof, Manon, Dutra, Bruna G., Hoving, Jan W., Brouwer, Josje, Tolhuisen, Manon L., Terreros, Nerea Arrarte, Konduri, Praneeta R., Boodt, Nikki, Roos, Yvo B. W. E. M., van Zwam, Wim H., Bokkers, Reinoud, Martens, Jasper, Marquering, Henk A., Emmer, Bart J., and Majoie, Charles B. L. M.
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- 2022
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11. Prognostic Value of Thrombus Volume and Interaction With First-Line Endovascular Treatment Device Choice
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van Voorst, Henk, Bruggeman, Agnetha A.E., Andriessen, Jurr, Hoving, Jan W., Konduri, Praneeta R., Yang, Wenjin, Kappelhof, Manon, Arrarte Terreros, Nerea, Roos, Yvo B.W.E.M., van Zwam, Wim H., van der Lugt, Aad, van der Hoorn, Anouk, Boiten, Jelis, Roosendaal, Stefan, Jenniskens, Sjoerd, Caan, Matthan W.A., Marquering, Henk A., Emmer, Bart J., Majoie, Charles B.L.M., Dippel, Diederik W.J., van Oostenbrugge, Robert J., Vos, Jan Albert, Jansen, Ivo G.H., Mulder, Maxim J.H.L., Goldhoorn, Robert- Jan B., Compagne, Kars C.J., Brouwer, Josje, den Hartog, Sanne J., Hinsenveld, Wouter H., Dippel, Diederik W.J., Roozenbeek, Bob, van Es, Adriaan C.G.M., Coutinho, Jonathan M., Schonewille, Wouter J., Vos, Jan Albert, Wermer, Marieke J.H., van Walderveen, Marianne A.A., Staals, Julie, van Oostenbrugge, Robert J., Hofmeijer, Jeannette, Martens, Jasper M., Lycklama à Nijeholt, Geert J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., van der Worp, H. Bart, Lo, Rob H., van Dijk, Ewoud J., Boogaarts, Hieronymus D., de Vries, J., de Kort, Paul L.M., van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P.H., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Yo, Lonneke S.F., den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., Lycklama à Nijeholt, Geert J., van Walderveen, Marianne A.A., Sprengers, Marieke E.S., van den Berg, René, Yoo, Albert J., Beenen, Ludo F.M., Postma, Alida A., van der Kallen, Bas F.W., van den Wijngaard, Ido R., van Es, Adriaan C.G.M., Martens, Jasper M., Yo, Lonneke S.F., Vos, Jan Albert, Bot, Joost, van Doormaal, Pieter-Jan, Meijer, Anton, Ghariq, Elyas, Bokkers, Reinoud P.H., van Proosdij, Marc P., Krietemeijer, G. Menno, Peluso, Jo P., Boogaarts, Hieronymus D., Lo, Rob, Gerrits, Dick, Dinkelaar, Wouter, Appelman, Auke P.A., Hammer, Bas, Pegge, Sjoert, Vinke, Saman, Dippel, Diederik W.J., van Oostenbrugge, Robert J., Lycklama à Nijeholt, Geert J., Vos, Jan Albert, Schonewille, Wouter J., Hofmeijer, Jeannette, Martens, Jasper M., van der Worp, H. Bart, Lo, Rob H., van Oostenbrugge, Robert J., Hofmeijer, Jeannette, Flach, H. Zwenneke, Lingsma, Hester F., el Ghannouti, Naziha, Sterrenberg, Martin, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, Simons, Michelle, Vossers, Marjolein, de Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, van Vemde, Gina, Simons, Tiny, Messchendorp, Gert, Nicolaij, Nynke, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, Maureen, Verheesen, Sabrina, Jeurrissen, D., Bos, Erna, Drabbe, Yvonne, Sandiman, Michelle, Aaldering, Nicoline, Zweedijk, Berber, Vervoort, Jocova, Ponjee, Eva, Romviel, Sharon, Kanselaar, Karin, Barning, Denn, Venema, Esmee, Chalos, Vicky, Geuskens, Ralph R., van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R.M., Muijres, Daan, de Jong, Anouk, Berkhemer, Olvert A., Boers, Anna M.M., Huguet, J., Groot, P.F.C., Mens, Marieke A., van Kranendonk, Katinka R., Treurniet, Kilian M., Tolhuisen, Manon L., Alves, Heitor, Weterings, Annick J., Kirkels, Eleonora L.F., Voogd, Eva J.H.F., Schupp, Lieve M., Collette, Sabine, Groot, Adrien E.D., LeCouffe, Natalie E., Prasetya, Haryadi, and Ramos, Lucas A.
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- 2023
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12. Prehospital transdermal glyceryl trinitrate in patients with presumed acute stroke (MR ASAP): an ambulance-based, multicentre, randomised, open-label, blinded endpoint, phase 3 trial
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van Ahee, Ayla, Visseren, Frank, Halkes, Patricia, van Eijk, Ruben, Simons, Michelle, Pellikaan, Wilma, Van Wijngaarden, Wilma, Ponjee, Eva, Geijtenbeek, Petra, Arts, Ton, Zock, Elles, Oudshoorn, Wilma, Steenwinkel, Frans, Samim, Hamdia, van Zandwijk, Mark, Vrielink, Lisette, Mulder, Peter Jan, Gerritsen, Aico, Ijzermans, Jim, Kooijman, Marjan, Francissen, Oscar, van Nuland, Rick, van Zwam, Wim, Jacobi, Linda, van den Berg, Rene, Beenen, Ludo, van Es, Adriaan, van Doormaal, Pieter-Jan, Lycklama a Nijeholt, Geert, van den Wijngaard, Ido, Yoo, Albert, Yo, Lonneke, Martens, Jasper, Hammer, Bas, Roosendaal, Stefan, Meijer, Anton, Krietemeijer, Menno, Bokkers, Reinoud, van der Hoorn, Anouk, Gerrits, Dick, Coutinho, Jonathan, Jansen, Ben, Manschot, Sanne, Koudstaal, Peter, Keizer, Koos, Chalos, Vicky, Versteeg, Adriaan, Wolff, Lennard, van Voorst, Henk, van der Sluijs, Matthijs, Hoving, Arnolt-Jan, Treurniet, Kilian, LeCouffe, Natalie, van de Graaf, Rob, Goldhoorn, Robert-Jan, Hinseveld, Wouter, Pirson, Anne, Sondag, Lotte, Kappelhof, Manon, Tolhuisen, Manon, Brouwer, Josje, van der Steen, Wouter, Rinkel, Leon, Bruggeman, Agnetha, Sprengers, Rita, Sterrenberg, Martin, Verheesen, Sabrina, Heiligers, Leontien, Martens, Yvonne, El Ghannouti, Naziha, Slotboom, Miranda, van den Berg, Sophie A, Uniken Venema, Simone M, Reinink, Hendrik, Hofmeijer, Jeannette, Schonewille, Wouter J, Miedema, Irene, Fransen, Puck S S, O Pruissen, D Martijn, Raaijmakers, Theodora W M, van Dijk, Gert W, de Leeuw, Frank-Erik, van Vliet, Jorine A, Kwa, Vincent I H, Kerkhoff, Henk, van 't Net, Alex, Boomars, Rene, Siegers, Arjen, Lok, Tycho, Caminada, Klaartje, Esteve Cuevas, Laura M, Visser, Marieke C, Zwetsloot, Casper P, Boomsma, Jooske M F, Schipper, Mirjam H, van Eijkelenburg, Roeland P J, Berkhemer, Olvert A, Nieboer, Daan, Lingsma, Hester F, Emmer, Bart J, van Oostenbrugge, Robert J, van der Lugt, Aad, Roos, Yvo B W E M, Majoie, Charles B L M, Dippel, Diederik W J, Nederkoorn, Paul J, and van der Worp, H Bart
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- 2022
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13. Perceived importance of silent cerebral ischemia following endovascular procedures
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McDonough, Rosalie V., Ganesh, Aravind, Ospel, Johanna M., Kappelhof, Manon, Almekhlafi, Mohammed, and Goyal, Mayank
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- 2022
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14. Cross‐Sectional Imaging Modalities in Correlation to the Thrombolysis in Cerebral Infarction Score: The Next Frontier in Adjunctive Endovascular Stroke Therapy
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Kaesmacher, Johannes, primary, Treurniet, Kilian M., additional, Kappelhof, Manon, additional, Dobrocky, Tomas, additional, Ospel, Johanna, additional, Mujanovic, Adnan, additional, Fiehler, Jens, additional, Yan, Bernard, additional, Goyal, Mayank, additional, Yoo, Albert J., additional, Campbell, Bruce, additional, Zaidat, Osama O., additional, Saver, Jeffrey L., additional, Sanossian, Nerses, additional, Raychev, Radoslav, additional, Roos, Yvo B. W. E. M., additional, Fischer, Urs, additional, Majoie, Charles B. L. M., additional, Gralla, Jan, additional, and Liebeskind, David S., additional
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- 2024
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15. Comparison of NIHSS Within 7-day and 90-day mRS Outcomes in Randomized-controlled Trials of Acute Ischemic Stroke: A Systematic Review and Meta-analysis (P1-5.024)
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Rinkel, Leon, primary, Ospel, Johanna, additional, Kappelhof, Manon, additional, Sehgal, Arshia, additional, McDonough, Rosalie, additional, Tymianski, Michael, additional, Hill, Michael, additional, Goyal, Mayank, additional, and Ganesh, Aravind, additional
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- 2024
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16. Thrombus Imaging Characteristics to Predict Early Recanalization in Anterior Circulation Large Vessel Occlusion Stroke
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Arrarte Terreros, Nerea, primary, Stolp, Jeffrey, additional, Bruggeman, Agnetha A. E., additional, Swijnenburg, Isabella S. J., additional, Lopes, Ricardo R., additional, van Meenen, Laura C. C., additional, Groot, Adrien E. D., additional, Kappelhof, Manon, additional, Coutinho, Jonathan M., additional, Roos, Yvo B. W. E. M., additional, Emmer, Bart J., additional, Beenen, Ludo F. M., additional, Dippel, Diederik W. J., additional, van Zwam, Wim H., additional, van Bavel, Ed, additional, Marquering, Henk A., additional, and Majoie, Charles B. L. M., additional
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- 2024
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17. Associations of thrombus perviousness derived from entire thrombus segmentation with functional outcome in patients with acute ischemic stroke
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Santos, Emilie M.M., Arrarte Terreros, Nerea, Kappelhof, Manon, Borst, Jordi, Boers, Anna M.M., Lingsma, Hester F., Berkhemer, Olvert A., Dippel, Diederik W.J., Majoie, Charles B., Marquering, Henk A., and Niessen, Wiro J.
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- 2021
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18. Clinical impact of EVT with failed reperfusion in patients with acute ischemic stroke: results from the ESCAPE and ESCAPE-NA1 trials
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Ospel, Johanna M., Hill, Michael D., Demchuk, Andrew, Menon, Bijoy K., Thornton, John, Rempel, Jeremy, Almekhlafi, Mohammed A., Ganesh, Aravind, Kappelhof, Manon, Singh, Nishita, Cimflova, Petra, Kashani, Nima, Bala, Fouzi, Kim, Beom Joon, McTaggart, Ryan, Poppe, Alexandre, Nogueira, Raul G., Tymianski, Michael, and Goyal, Mayank
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- 2021
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19. Balloon guide catheters: use, reject, or randomize?
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Goyal, Mayank, Kappelhof, Manon, Ospel, Johanna M., and Bala, Fouzi
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- 2021
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20. Endovascular treatment of patients with stroke caused by anterior cerebral artery occlusions
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Neurologen, Brain, Circulatory Health, Stroke, Vos, Erik M., Kappelhof, Manon, den Hartog, Sanne J., Coutinho, Jonathan M., Emmer, Bart J., Roozenbeek, Bob, van Zwam, Wim H., van Oostenbrugge, Robert J., van der Worp, H. Bart, Uyttenboogaart, Maarten, van Es, Adriaan C.G.M., Majoie, Charles B.L.M., Dippel, Diederik W.J., Peeters-Scholte, Cacha M.P.C.D., van den Wijngaard, Ido R., Neurologen, Brain, Circulatory Health, Stroke, Vos, Erik M., Kappelhof, Manon, den Hartog, Sanne J., Coutinho, Jonathan M., Emmer, Bart J., Roozenbeek, Bob, van Zwam, Wim H., van Oostenbrugge, Robert J., van der Worp, H. Bart, Uyttenboogaart, Maarten, van Es, Adriaan C.G.M., Majoie, Charles B.L.M., Dippel, Diederik W.J., Peeters-Scholte, Cacha M.P.C.D., and van den Wijngaard, Ido R.
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- 2024
21. Time to Treatment With Intravenous Thrombolysis Before Thrombectomy and Functional Outcomes in Acute Ischemic Stroke: A Meta-Analysis
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Kaesmacher, Johannes, Cavalcante, Fabiano, Kappelhof, Manon, Treurniet, Kilian M, Rinkel, Leon, Liu, Jianmin, Yan, Bernard, Zi, Wenjie, Kimura, Kazumi, Eker, Omer F, Zhang, Yongwei, Piechowiak, Eike I, van Zwam, Wim, Liu, Sheng, Strbian, Daniel, Uyttenboogaart, Maarten, Dobrocky, Tomas, Miao, Zhongrong, Suzuki, Kentaro, Zhang, Lei, van Oostenbrugge, Robert, Meinel, Thomas R, Guo, Changwei, Seiffge, David, Yin, Congguo, Bütikofer, Lukas, Lingsma, Hester, Nieboer, Daan, Yang, Pengfei, Mitchell, Peter, Majoie, Charles, Fischer, Urs, Roos, Yvo, Gralla, Jan, IRIS Collaborators, Kaesmacher, Johannes, Cavalcante, Fabiano, Kappelhof, Manon, Treurniet, Kilian M, Rinkel, Leon, Liu, Jianmin, Yan, Bernard, Zi, Wenjie, Kimura, Kazumi, Eker, Omer F, Zhang, Yongwei, Piechowiak, Eike I, van Zwam, Wim, Liu, Sheng, Strbian, Daniel, Uyttenboogaart, Maarten, Dobrocky, Tomas, Miao, Zhongrong, Suzuki, Kentaro, Zhang, Lei, van Oostenbrugge, Robert, Meinel, Thomas R, Guo, Changwei, Seiffge, David, Yin, Congguo, Bütikofer, Lukas, Lingsma, Hester, Nieboer, Daan, Yang, Pengfei, Mitchell, Peter, Majoie, Charles, Fischer, Urs, Roos, Yvo, Gralla, Jan, and IRIS Collaborators
- Abstract
IMPORTANCE: The benefit of intravenous thrombolysis (IVT) for acute ischemic stroke declines with longer time from symptom onset, but it is not known whether a similar time dependency exists for IVT followed by thrombectomy. OBJECTIVE: To determine whether the benefit associated with IVT plus thrombectomy vs thrombectomy alone decreases with treatment time from symptom onset. DESIGN, SETTING, AND PARTICIPANTS: Individual participant data meta-analysis from 6 randomized clinical trials comparing IVT plus thrombectomy vs thrombectomy alone. Enrollment was between January 2017 and July 2021 at 190 sites in 15 countries. All participants were eligible for IVT and thrombectomy and presented directly at thrombectomy-capable stroke centers (n?=?2334). For this meta-analysis, only patients with an anterior circulation large-vessel occlusion were included (n?=?2313). EXPOSURE: Interval from stroke symptom onset to expected administration of IVT and treatment with IVT plus thrombectomy vs thrombectomy alone. MAIN OUTCOMES AND MEASURES: The primary outcome analysis tested whether the association between the allocated treatment (IVT plus thrombectomy vs thrombectomy alone) and disability at 90 days (7-level modified Rankin Scale [mRS] score range, 0 [no symptoms] to 6 [death]; minimal clinically important difference for the rates of mRS scores of 0-2: 1.3%) varied with times from symptom onset to expected administration of IVT. RESULTS: In 2313 participants (1160 in IVT plus thrombectomy group vs 1153 in thrombectomy alone group; median age, 71 [IQR, 62 to 78] years; 44.3% were female), the median time from symptom onset to expected administration of IVT was 2 hours 28 minutes (IQR, 1 hour 46 minutes to 3 hours 17 minutes). There was a statistically significant interaction between the time from symptom onset to expected administration of IVT and the association of allocated treatment with functional outcomes (ratio of adjusted common odds ratio [OR] per 1-hour delay, 0.84 [95%
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- 2024
22. Thrombus Imaging Characteristics to Predict Early Recanalization in Anterior Circulation Large Vessel Occlusion Stroke
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Arrarte Terreros, Nerea, Stolp, Jeffrey, Bruggeman, Agnetha A.E., Swijnenburg, Isabella S.J., Lopes, Ricardo R., van Meenen, Laura C.C., Groot, Adrien E.D., Kappelhof, Manon, Coutinho, Jonathan M., Roos, Yvo B.W.E.M., Emmer, Bart J., Beenen, Ludo F.M., Dippel, Diederik W.J., van Zwam, Wim H., van Bavel, Ed, Marquering, Henk A., Majoie, Charles B.L.M., Arrarte Terreros, Nerea, Stolp, Jeffrey, Bruggeman, Agnetha A.E., Swijnenburg, Isabella S.J., Lopes, Ricardo R., van Meenen, Laura C.C., Groot, Adrien E.D., Kappelhof, Manon, Coutinho, Jonathan M., Roos, Yvo B.W.E.M., Emmer, Bart J., Beenen, Ludo F.M., Dippel, Diederik W.J., van Zwam, Wim H., van Bavel, Ed, Marquering, Henk A., and Majoie, Charles B.L.M.
- Abstract
The early management of transferred patients with a large vessel occlusion (LVO) stroke could be improved by identifying patients who are likely to recanalize early. We aim to predict early recanalization based on patient clinical and thrombus imaging characteristics. We included 81 transferred anterior-circulation LVO patients with an early recanalization, defined as the resolution of the LVO or the migration to a distal location not reachable with endovascular treatment upon repeated radiological imaging. We compared their clinical and imaging characteristics with all (322) transferred patients with a persistent LVO in the MR CLEAN Registry. We measured distance from carotid terminus to thrombus (DT), thrombus length, density, and perviousness on baseline CT images. We built logistic regression models to predict early recanalization. We validated the predictive ability by computing the median area-under-the-curve (AUC) of the receiver operating characteristics curve for 100 5-fold cross-validations. The administration of intravenous thrombolysis (IVT), longer transfer times, more distal occlusions, and shorter, pervious, less dense thrombi were characteristic of early recanalization. After backward elimination, IVT administration, DT and thrombus density remained in the multivariable model, with an AUC of 0.77 (IQR 0.72–0.83). Baseline thrombus imaging characteristics are valuable in predicting early recanalization and can potentially be used to optimize repeated imaging workflow.
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- 2024
23. Value of Automatically Derived Full Thrombus Characteristics:An Explorative Study of Their Associations with Outcomes in Ischemic Stroke Patients
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Mojtahedi, Mahsa, Bruggeman, Agnetha E., van Voorst, Henk, Ponomareva, Elena, Kappelhof, Manon, van der Lugt, Aad, Hoving, Jan W., Dutra, Bruna G., Dippel, Diederik, Cavalcante, Fabiano, Yo, Lonneke, Coutinho, Jonathan, Brouwer, Josje, Treurniet, Kilian, Tolhuisen, Manon L., LeCouffe, Natalie, Arrarte Terreros, Nerea, Konduri, Praneeta R., van Zwam, Wim, Roos, Yvo, Majoie, Charles B.L.M., Emmer, Bart J., Marquering, Henk A., Mojtahedi, Mahsa, Bruggeman, Agnetha E., van Voorst, Henk, Ponomareva, Elena, Kappelhof, Manon, van der Lugt, Aad, Hoving, Jan W., Dutra, Bruna G., Dippel, Diederik, Cavalcante, Fabiano, Yo, Lonneke, Coutinho, Jonathan, Brouwer, Josje, Treurniet, Kilian, Tolhuisen, Manon L., LeCouffe, Natalie, Arrarte Terreros, Nerea, Konduri, Praneeta R., van Zwam, Wim, Roos, Yvo, Majoie, Charles B.L.M., Emmer, Bart J., and Marquering, Henk A.
- Abstract
(1) Background: For acute ischemic strokes caused by large vessel occlusion, manually assessed thrombus volume and perviousness have been associated with treatment outcomes. However, the manual assessment of these characteristics is time-consuming and subject to inter-observer bias. Alternatively, a recently introduced fully automated deep learning-based algorithm can be used to consistently estimate full thrombus characteristics. Here, we exploratively assess the value of these novel biomarkers in terms of their association with stroke outcomes. (2) Methods: We studied two applications of automated full thrombus characterization as follows: one in a randomized trial, MR CLEAN-NO IV (n = 314), and another in a Dutch nationwide registry, MR CLEAN Registry (n = 1839). We used an automatic pipeline to determine the thrombus volume, perviousness, density, and heterogeneity. We assessed their relationship with the functional outcome defined as the modified Rankin Scale (mRS) at 90 days and two technical success measures as follows: successful final reperfusion, which is defined as an eTICI score of 2b-3, and successful first-pass reperfusion (FPS). (3) Results: Higher perviousness was significantly related to a better mRS in both MR CLEAN-NO IV and the MR CLEAN Registry. A lower thrombus volume and lower heterogeneity were only significantly related to better mRS scores in the MR CLEAN Registry. Only lower thrombus heterogeneity was significantly related to technical success; it was significantly related to a higher chance of FPS in the MR CLEAN-NO IV trial (OR = 0.55, 95% CI: 0.31–0.98) and successful reperfusion in the MR CLEAN Registry (OR = 0.88, 95% CI: 0.78–0.99). (4) Conclusions: Thrombus characteristics derived from automatic entire thrombus segmentations are significantly related to stroke outcomes.
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- 2024
24. Effect of incomplete reperfusion patterns on clinical outcome: insights from the ESCAPE-NA1 trial.
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Cimflova, Petra, Singh, Nishita, Kappelhof, Manon, Ospel, Johanna M., Sehgal, Arshia, Kashani, Nima, Almekhlafi, Mohammed A., Demchuk, Andrew M., Berrouschot, Joerg, Dorn, Franziska, Kelly, Michael E., Buck, Brian H., Field, Thalia S., Dowlatshahi, Dariush, Tymianski, Michael, Hill, Michael D., and Goya, Mayank
- Subjects
MYOCARDIAL infarction ,ACUTE diseases ,ISCHEMIA ,THROMBOLYTIC therapy ,RESEARCH funding ,STATISTICAL sampling ,TREATMENT effectiveness ,RANDOMIZED controlled trials ,ANGIOGRAPHY ,DESCRIPTIVE statistics ,LONGITUDINAL method ,ODDS ratio ,ISCHEMIC stroke ,RESEARCH ,REPERFUSION ,THROMBECTOMY ,CEREBRAL infarction ,COMPARATIVE studies ,CONFIDENCE intervals ,DISEASE incidence - Abstract
Background Incomplete reperfusion (IR) after mechanical thrombectomy (MT) can be a consequence of residual occlusion, no-reflow phenomenon, or collateral counterpressure. Data on the impact of these phenomena on clinical outcome are limited. Methods Patients from the ESCAPE-NA1 trial with IR (expanded Thrombolysis In Cerebral Infarction (eTICI) 2b) were compared with those with complete or near-complete reperfusion (eTICI 2c-3) on the final angiography run. Final runs were assessed for (a) an MT-accessible occlusion, or (b) a non-MT-accessible occlusion pattern. The primary clinical outcome was modified Rankin Scale (mRS) 0--2 at 90 days. Our imaging outcome was infarction in IR territory on follow-up imaging. Unadjusted and adjusted incidence rate ratios (aIRR) with 95% confidence intervals (95% CI) were obtained. Results Of 1105 patients, 443 (40.1%) with IR and 506 (46.1%) with complete or near-complete reperfusion were included. An MT-accessible occlusion was identified in 147/443 patients (33.2%) and a non-MT-accessible occlusion in 296/443 (66.8%). As compared with patients with near-complete/complete reperfusion, patients with IR had significantly lower chances of achieving mRS 0--2 at 90 days (aIRR 0.82, 95% CI 0.74 to 0.91). Rates of mRS 0--2 were lower in the MT-accessible occlusion group as compared with the non-MT-accessible occlusion pattern group (aIRR 0.71, 95% CI 0.60 to 0.83, and aIRR 0.89, 95% CI 0.81 to 0.98, respectively). More patients with MT-accessible occlusion patterns developed infarcts in the non-reperfused territory as compared with patients with non-MT occlusion patterns (68.7% vs 46.3%). Conclusion IR was associated with worse clinical outcomes than near-complete/complete reperfusion. Two-thirds of our patients with IR had non-MT-accessible occlusion patterns which were associated with better clinical and imaging outcomes compared with those with MT-accessible occlusion patterns. [ABSTRACT FROM AUTHOR]
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- 2024
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25. Outcome of patients with multivessel occlusion stroke after endovascular treatment.
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LeCouffe, Natalie E, Treurniet, Kilian M, Kappelhof, Manon, Jansen, Ivo GH, Boers, Merel, Marquering, Henk A, Beenen, Ludo FM, Boiten, Jelis, van Zwam, Wim H, Yo, Lonneke SF, Majoie, Charles BLM, Roos, Yvo BWEM, Emmer, Bart J, and Coutinho, Jonathan M
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- 2024
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26. Improvements in Endovascular Treatment for Acute Ischemic Stroke: A Longitudinal Study in the MR CLEAN Registry
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Compagne, Kars C.J., Kappelhof, Manon, Hinsenveld, Wouter H., Brouwer, Josje, Goldhoorn, Robert-Jan B., Uyttenboogaart, Maarten, Bokkers, Reinoud P.H., Schonewille, Wouter J., Martens, Jasper M., Hofmeijer, Jeannette, van der Worp, H. Bart, Lo, Rob T.H., Keizer, Koos, Yo, Lonneke S.F., Lycklama à Nijeholt, Geert J., den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., van Walderveen, Marianne A.A., Wermer, Marieke J.H., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Boogaarts, Hieronymus D., van Dijk, Ewout J., van Tuijl, Julia H., Peluso, Jo P.P., de Kort, Paul L.M., van Hasselt, Boudewijn A.A.M., Fransen, Puck S., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Jenniskens, Sjoerd F.M., Sprengers, Marieke E.S., Ghariq, Elias, van den Wijngaard, Ido R., Roosendaal, Stefan D., Meijer, Anton F.J.A., Beenen, Ludo F.M., Postma, Alida A., van den Berg, René, Yoo, Albert J., van Doormaal, Pieter Jan, van Proosdij, Marc P., Krietemeijer, Menno G.M., Gerrits, Dick G., Hammer, Sebastiaan, Vos, Jan Albert, Boiten, Jelis, Coutinho, Jonathan M., Emmer, Bart J., van Es, Ad C.G.M., Roozenbeek, Bob, Roos, Yvo B.W.E.M., van Zwam, Wim H., van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., and van der Lugt, Aad
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- 2022
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27. Role of Intravenous Thrombolytics Prior to Endovascular Thrombectomy
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Campbell, Bruce C.V., Kappelhof, Manon, and Fischer, Urs
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- 2022
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28. Value of Automatically Derived Full Thrombus Characteristics: An Explorative Study of Their Associations with Outcomes in Ischemic Stroke Patients
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Mojtahedi, Mahsa, primary, Bruggeman, Agnetha E., additional, van Voorst, Henk, additional, Ponomareva, Elena, additional, Kappelhof, Manon, additional, van der Lugt, Aad, additional, Hoving, Jan W., additional, Dutra, Bruna G., additional, Dippel, Diederik, additional, Cavalcante, Fabiano, additional, Yo, Lonneke, additional, Coutinho, Jonathan, additional, Brouwer, Josje, additional, Treurniet, Kilian, additional, Tolhuisen, Manon L., additional, LeCouffe, Natalie, additional, Arrarte Terreros, Nerea, additional, Konduri, Praneeta R., additional, van Zwam, Wim, additional, Roos, Yvo, additional, Majoie, Charles B. L. M., additional, Emmer, Bart J., additional, and Marquering, Henk A., additional
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- 2024
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29. Abstract 22: Time to Treatment and the Effect of Intravenous Thrombolysis Before Thrombectomy: An Individual Participant Data Meta-Analysis
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Kaesmacher, Johannes, primary, Cavalcante, Fabiano, additional, Kappelhof, Manon, additional, Treurniet, Kilian, additional, Rinkel, Leon A, additional, Liu, Jianmin, additional, Yan, Bernard, additional, Zi, Wenjie, additional, Kimura, Kazumi, additional, Eker, Omer, additional, Zhang, Yongwei, additional, Piechowiak, Eike, additional, van Zwam, Wim, additional, Liu, Sheng, additional, Strbian, Daniel, additional, Uyttenboogaart, Maarten, additional, Dobrocky, Tomas, additional, Zhongrong, Miao, additional, Suzuki, Kentaro, additional, Lei, Zhang, additional, Oostenbrugge, Robert Van V, additional, Meinel, Thomas, additional, Guo, Changwei, additional, Seiffge, David, additional, Ying, Congguo, additional, Bütikofer, Lukas, additional, Lingsma, Hester, additional, Mitchell, Peter J, additional, Yang, Pengfei, additional, Majoie, Charles B, additional, Roos, Yvo, additional, Fischer, Urs M, additional, and Gralla, Jan, additional
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- 2024
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30. Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data
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Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, Wright, MR, Kamal, NR, Andersen, L, Randhawa, PA, Stewart, T, Patil, S, Minhas, P, Almekhlafi, M, Mishra, S, Clement, F, Sajobi, T, Shuaib, A, Montanera, WJ, Roy, D, Silver, FL, Jovin, TG, Frei, DF, Sapkota, B, Rempel, JL, Thornton, J, Williams, D, Tampieri, D, Poppe, AY, Dowlatshahi, D, Wong, JH, Mitha, AP, Subramaniam, S, Hull, G, Lowerison, MW, Salluzzi, M, Maxwell, M, Lacusta, S, Drupals, E, Armitage, K, Barber, PA, Smith, EE, Morrish, WF, Coutts, SB, Derdeyn, C, Demaerschalk, B, Yavagal, D, Martin, R, Brant, R, Yu, Y, Willinsky, RA, Weill, A, Kenney, C, Aram, H, Stys, PK, Watson, TW, Klein, G, Pearson, D, Couillard, P, Trivedi, A, Singh, D, Klourfeld, E, Imoukhuede, O, Nikneshan, D, Blayney, S, Reddy, R, Choi, P, Horton, M, Musuka, T, Dubuc, V, Field, TS, Desai, J, Adatia, S, Alseraya, A, Nambiar, V, van Dijk, R, Newcommon, NJ, Schwindt, B, Butcher, KS, Jeerakathil, T, Buck, B, Khan, K, Naik, SS, Emery, DJ, Owen, RJ, Kotylak, TB, Ashforth, RA, Yeo, TA, McNally, D, Siddiqui, M, Saqqur, M, Hussain, D, Kalashyan, H, Manosalva, A, Kate, M, Gioia, L, Hasan, S, Mohammad, A, Muratoglu, M, Cullen, A, Brennan, P, O'Hare, A, Looby, S, Hyland, D, Duff, S, McCusker, M, Hallinan, B, Lee, S, McCormack, J, Moore, A, O'Connor, M, Donegan, C, Brewer, L, Martin, A, Murphy, S, O'Rourke, K, Smyth, S, Kelly, P, Lynch, T, Daly, T, O'Brien, P, O'Driscoll, A, Martin, M, Collins, R, Coughlan, T, McCabe, D, O'Neill, D, Mulroy, M, Lynch, O, Walsh, T, O'Donnell, M, Galvin, T, Harbison, J, McElwaine, P, Mulpeter, K, McLoughlin, C, Reardon, M, Harkin, E, Dolan, E, Watts, M, Cunningham, N, Fallon, C, Gallagher, S, Cotter, P, Crowe, M, Doyle, R, Noone, I, Lapierre, M, Coté, VA, Lanthier, S, Odier, C, Durocher, A, Raymond, J, Daneault, N, Deschaintre, Y, Jankowitz, B, Baxendell, L, Massaro, L, Jackson-Graves, C, Decesare, S, Porter, P, Armbruster, K, Adams, A, Billigan, J, Oakley, J, Ducruet, A, Jadhav, A, Giurgiutiu, D-V, Aghaebrahim, A, Reddy, V, Hammer, M, Starr, M, Totoraitis, V, 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A, Amaro, S, Llull, L, Codas, J, Balasa, M, Navarro, J, Ariño, H, Aceituno, A, Rudilosso, S, Renu, A, Macho, JM, San Roman, L, Blasco, J, López, A, Macías, N, Cardona, P, Quesada, H, Rubio, F, Cano, L, Lara, B, de Miquel, MA, Aja, L, Serena, J, Cobo, E, Albers, Gregory W, Lees, Kennedy R, Arenillas, J, Roberts, R, Al-Ajlan, F, Zimmel, L, Patel, S, Martí-Fàbregas, J, Salvat-Plana, M, Bracard, S, Ducrocq, Xavier, Anxionnat, René, Baillot, Pierre-Alexandre, Barbier, Charlotte, Derelle, Anne-Laure, Lacour, Jean-Christophe, Richard, Sébastien, Samson, Yves, Sourour, Nader, Baronnet-Chauvet, Flore, Clarencon, Frédéric, Crozier, Sophie, Deltour, Sandrine, Di Maria, Federico, Le Bouc, Raphael, Leger, Anne, Mutlu, Gurkan, Rosso, Charlotte, Szatmary, Zoltan, Yger, Marion, Zavanone, Chiara, Bakchine, Serge, Pierot, Laurent, Caucheteux, Nathalie, Estrade, Laurent, Kadziolka, Krzysztof, Leautaud, Alexandre, Renkes, Céline, Serre, Isabelle, Desal, Hubert, Guillon, Benoît, Boutoleau-Bretonniere, Claire, Daumas-Duport, Benjamin, De Gaalon, Solène, Derkinderen, Pascal, Evain, Sarah, Herisson, Fanny, Laplaud, David-Axel, Lebouvier, Thibaud, Lintia-Gaultier, Alina, Pouclet-Courtemanche, Hélène, Rouaud, Tiphaine, Rouaud Jaffrenou, Violaine, Schunck, Aurélia, Sevin-Allouet, Mathieu, Toulgoat, Frederique, Wiertlewski, Sandrine, Gauvrit, Jean-Yves, Ronziere, Thomas, Cahagne, Vincent, Ferre, Jean-Christophe, Pinel, Jean-François, Raoult, Hélène, Mas, Jean-Louis, Meder, Jean-François, Al Najjar-Carpentier, Amen-Adam, Birchenall, Julia, Bodiguel, Eric, Calvet, David, Domigo, Valérie, Godon-Hardy, Sylvie, Guiraud, Vincent, Lamy, Catherine, Majhadi, Loubna, Morin, Ludovic, Naggara, Olivier, Trystram, Denis, Turc, Guillaume, Berge, Jérôme, Sibon, Igor, Menegon, Patrice, Barreau, Xavier, Rouanet, François, Debruxelles, Sabrina, Kazadi, Annabelle, Renou, Pauline, Fleury, Olivier, Pasco-Papon, Anne, Dubas, Frédéric, Caroff, Jildaz, Godard Ducceschi, Sophie, Hamon, Marie-Aurélie, Lecluse, Alderic, Marc, Guillaume, Giroud, Maurice, Ricolfi, Frédéric, Bejot, Yannick, Chavent, Adrien, Gentil, Arnaud, Kazemi, Apolline, Osseby, Guy-Victor, Voguet, Charlotte, Mahagne, Marie-Hélène, Sedat, Jacques, Chau, Yves, Suissa, Laurent, Lachaud, Sylvain, Houdart, Emmanuel, Stapf, Christian, Buffon Porcher, Frédérique, Chabriat, Hugues, Guedin, Pierre, Herve, Dominique, Jouvent, Eric, Mawet, Jérôme, Saint-Maurice, Jean-Pierre, Schneble, Hans-Martin, Nighoghossian, Norbert, Berhoune, Nadia-Nawel, Bouhour, Françoise, Cho, Tae-Hee, Derex, Laurent, Felix, Sandra, Gervais-Bernard, Hélène, Gory, Benjamin, Manera, Luis, Mechtouff, Laura, Ritzenthaler, Thomas, Riva, Roberto, Salaris Silvio, Fabrizio, Tilikete, Caroline, Blanc, Raphael, Obadia, Michaël, Bartolini, Mario Bruno, Gueguen, Antoine, Piotin, Michel, Pistocchi, Silvia, Redjem, Hocine, Drouineau, Jacques, Neau, Jean-Philippe, Godeneche, Gaelle, Lamy, Matthias, Marsac, Emilia, Velasco, Stephane, Clavelou, Pierre, Chabert, Emmanuel, 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Medeiros, Elisabeth, Vuillier, Fabrice, Courtheoux, Patrick, Viader, Fausto, Apoil-Brissard, Marion, Bataille, Mathieu, Bonnet, Anne-Laure, Cogez, Julien, Touze, Emmanuel, Leclerc, Xavier, Leys, Didier, Aggour, Mohamed, Aguettaz, Pierre, Bodenant, Marie, Cordonnier, Charlotte, Deplanque, Dominique, Girot, Marie, Henon, Hilde, Kalsoum, Erwah, Lucas, Christian, Pruvo, Jean-Pierre, Zuniga, Paolo, Arquizan, Caroline, Costalat, Vincent, Machi, Paolo, Mourand, Isabelle, Riquelme, Carlos, Bounolleau, Pierre, Arteaga, Charles, Faivre, Anthony, Bintner, Marc, Tournebize, Patrice, Charlin, Cyril, Darcel, Françoise, Gauthier-Lasalarie, Pascale, Jeremenko, Marcia, Mouton, Servane, Zerlauth, Jean-Baptiste, Lamy, Chantal, Hervé, Deramond, Hassan, Hosseini, Gaston, André, Barral, Francis-Guy, Garnier, Pierre, Beaujeux, Rémy, Wolff, Valérie, Herbreteau, Denis, Debiais, Séverine, Murray, Alicia, Ford, Gary, Muir, Keith W, White, Philip, Clifton, Andy, Freeman, Janet, Ford, Ian, Markus, Hugh, Wardlaw, Joanna, Molyneux, Andy, Robinson, Thompson, Lewis, Steff, Norrie, John, Robertson, Fergus, Perry, Richard, Dixit, Anand, Cloud, Geoffrey, Clifton, Andrew, Madigan, Jeremy, Roffe, Christine, Nayak, Sanjeev, Lobotesis, Kyriakos, Smith, Craig, Herwadkar, Amit, Kandasamy, Naga, Goddard, Tony, Bamford, John, Subramanian, Ganesh, Lenthall, Rob, Littleton, Edward, Lamin, Sal, Storey, Kelley, Ghatala, Rita, Banaras, Azra, Aeron-Thomas, John, Hazel, Bath, Maguire, Holly, Veraque, Emelda, Harrison, Louise, Keshvara, Rekha, Cunningham, James, Campbell, Bruce C V, Majoie, Charles B L M, Menon, Bijoy K, van Zwam, Wim H, van Oostenbrugge, Robert J, Demchuk, Andrew M, Guillemin, Francis, Dávalos, Antoni, Butcher, Kenneth S, Cherifi, Aboubaker, Marquering, Henk A, Macho Fernández, Juan M, Oppenheim, Catherine, Roos, Yvo B W E M, Shankar, Jai, Lingsma, Hester, Hernández-Pérez, María, Bharatha, Aditya, Levy, Elad I, Soudant, Marc, Aja, Lucia, Krings, Timo, Tisserand, Marie, San Román, Luis, Tomasello, Alejandro, Brown, Scott, Liebeskind, David S, Bracard, Serge, Dippel, Diederik W J, Jovin, Tudor G, and Hill, Michael D
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- 2019
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31. Symptomatic non-stenotic carotid disease: current challenges and opportunities for diagnosis and treatment.
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Ospel, Johanna Maria, Kappelhof, Manon, Ganesh, Aravind, Kallmes, David F., Brinjikji, Waleed, and Goyal, Mayank
- Subjects
ATHEROSCLEROSIS complications ,CAROTID artery ,RISK assessment ,NEUROSURGERY ,STENOSIS ,CAROTID artery stenosis ,STROKE ,STROKE patients ,PSYCHOSOCIAL factors ,DISEASE risk factors ,DISEASE complications - Abstract
Symptomatic non-stenotic carotid plaques (SyNC) are an under-researched and under-recognized source of stroke. Various imaging markers of non-stenotic carotid plaques that are associated with stroke risk have been identified, but these causal relationships need to be confirmed in additional prospective studies. Currently, there exists neither a standardized SyNC definition nor a dedicated set of imaging protocols, although researchers have started to address these shortcomings. Moreover, many neuroradiologists are still unaware of the condition, and hence do not comment on high-risk plaque features other than stenosis in their reports. Regarding SyNC treatment, scant data exist as to whether and to what extent medical, interventional and surgical treatments could influence the course of the disease; the relative lack of data on the 'natural' history of untreated SyNC makes treatment comparisons difficult. In our opinion, endovascular SyNC treatment represents the most promising treatment option for SyNC, since it allows for targeted elimination of the embolic source, with few systemic side effects and without the need for general anesthesia. However, currently available carotid devices are designed to treat stenotic lesions, and thus are not optimally designed for SyNC. Developing a device specifically tailored to SyNC could be an important step towards establishing endovascular SyNC treatment in clinical practice. In this review, we provide an overview of the current state of evidence with regard to epidemiological, clinical and imaging features of SyNC, propose a SyNC definition based on imaging and clinical features, and outline a possible pathway towards evidence-based SyNC therapies, with a special focus on endovascular SyNC treatment. [ABSTRACT FROM AUTHOR]
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- 2024
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32. Young Professionals in Neuroradiology: Opportunities, Challenges, and Future Directions.
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Trofimova, Anna V., Yi Li, Mazaheri, Parisa, Krishnan, Arun, Payabvash, Seyedmehdi, Kappelhof, Manon, and Gadde, Judith A.
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- 2024
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33. No Sex Differences in Mechanical Thrombectomy Time Metrics and Outcomes in Saskatchewan
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Ospel, Johanna M., primary, Kashani, Nima, additional, Singh, Nishita, additional, Zhou, Amy, additional, Cimflova, Petra, additional, Kappelhof, Manon, additional, Liu, Eva, additional, Pendleton, Nicole, additional, Marciniuk, Kristen, additional, Toyota, Patrick, additional, Newton, Braedon, additional, Persad, Amit, additional, Holodinsky, Jessalyn, additional, Yang, Lotus, additional, Perlau, Michaela, additional, Abdalrahman, Sarah, additional, Gardner, Aaron, additional, Cooley, Regan, additional, Wasyliw, Sanchea, additional, Graham, Brett R., additional, Ganesh, Aravind, additional, Hunter, Gary, additional, Whelan, Ruth, additional, Ahmed, Uzair, additional, Kelly, Michael E., additional, and Peeling, Lissa, additional
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- 2023
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34. Catching Up With Time: Endovascular Treatment Beyond 24 Hours
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Kappelhof, Manon, primary and Kaesmacher, Johannes, additional
- Published
- 2023
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35. Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials
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Majoie, Charles B, primary, Cavalcante, Fabiano, additional, Gralla, Jan, additional, Yang, Pengfei, additional, Kaesmacher, Johannes, additional, Treurniet, Kilian M, additional, Kappelhof, Manon, additional, Yan, Bernard, additional, Suzuki, Kentaro, additional, Zhang, Yongwei, additional, Li, Fengli, additional, Morimoto, Masafumi, additional, Zhang, Lei, additional, Miao, Zhongrong, additional, Rinkel, Leon A, additional, Huang, Jiacheng, additional, Otsuka, Toshiaki, additional, Wang, Shouchun, additional, Davis, Stephen, additional, Cognard, Christophe, additional, Hong, Bo, additional, Coutinho, Jonathan M, additional, Song, Jiaxing, additional, Chen, Wenhuo, additional, Emmer, Bart J, additional, Eker, Omer, additional, Zhang, Liyong, additional, Dobrocky, Tomas, additional, Nguyen, Huy-Thang, additional, Bush, Steven, additional, Peng, Ya, additional, LeCouffe, Natalie E, additional, Takeuchi, Masataka, additional, Han, Hongxing, additional, Matsumaru, Yuji, additional, Strbian, Daniel, additional, Lingsma, Hester F, additional, Nieboer, Daan, additional, Yang, Qingwu, additional, Meinel, Thomas, additional, Mitchell, Peter, additional, Kimura, Kazumi, additional, Zi, Wenjie, additional, Nogueira, Raul G, additional, Liu, Jianmin, additional, Roos, Yvo B, additional, Fischer, Urs, additional, Nogueira, Raul, additional, Miao, Zhong Rong, additional, Majoie, Charles B., additional, Roos, Yvo B., additional, Cavalcante, Fabiano W., additional, Treurniet, Kilian M., additional, Lingsma, Hester F., additional, Rothwell, Peter, additional, Saver, Jeffrey, additional, Fiehler, Jens, additional, Li, Zifu, additional, Xing, Pengfei, additional, Shen, Hongjian, additional, Zhang, Ping, additional, Zhang, Xiaoxi, additional, Donnan, Geoffrey, additional, Huo, Xiaochuan, additional, Nan, Guangxian, additional, Bivard, Andrew, additional, Ma, Henry, additional, Vu, Dang Lu, additional, Campbell, Bruce, additional, Rinkel, Leon A., additional, Emmer, Bart J., additional, Coutinho, Jonathan M., additional, LeCouffe, Natalie E., additional, Dippel, Diederik W., additional, van der Lugt, Aad, additional, van Zwam, Wim H., additional, van Oostenbrugge, Robert J., additional, Uyttenboogaart, Maarten, additional, Costalat, Vincent, additional, Lycklama, Geert, additional, Hofmeijer, Jeannette, additional, van Norden, Anouk, additional, Kanazawa, Ryuzaburo, additional, Takayama, Yohei, additional, Kamiya, Yuki, additional, Shigeta, Keigo, additional, Okubo, Seiji, additional, Hayakawa, Mikito, additional, Jung, Simon, additional, Piechowiak, Eike, additional, Marnat, Gaultier, additional, Sibon, Igor, additional, Bourcier, Romain, additional, de Gaalon, Solene, additional, Papagiannaki, Chrysanthi, additional, and Lefebvre, Margaux, additional
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- 2023
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36. Association between thrombus composition and stroke etiology in the MR CLEAN Registry biobank
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Hund, Hajo M., Boodt, Nikki, Hansen, Daniel, Haffmans, Willem A., Lycklama à Nijeholt, Geert J., Hofmeijer, Jeannette, Dippel, Diederik W. J., van der Lugt, Aad, van Es, Adriaan C. G. M., van Beusekom, Heleen M. M., Majoie, Charles B. L. M., Roos, Yvo B. W. E. M., van Oostenbrugge, Robert J., van Zwam, Wim H., Boiten, Jelis, Vos, Jan Albert, Jansen, Ivo G. H., Mulder, Maxim J. H. L., Goldhoorn, Robert- Jan B., Compagne, Kars C. J., Kappelhof, Manon, Brouwer, Josje, den Hartog, Sanne J., Hinsenveld, Wouter H., Roozenbeek, Bob, Emmer, Bart J., Coutinho, Jonathan M., Schonewille, Wouter J., Wermer, Marieke J. H., van Walderveen, Marianne A. A., Staals, Julie, Martens, Jasper M., de Bruijn, Sebastiaan F., van Dijk, Lukas C., van der Worp, H. Bart, Lo, Rob H., van Dijk, Ewoud J., Boogaarts, Hieronymus D., de Vries, J., de Kort, Paul L. M., van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, van den Berg, Jan S. P., van Hasselt, Boudewijn A. A. M., Aerden, Leo A. M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P. H., Schreuder, Tobien H. C. M. L., Heijboer, Roel J. J., Keizer, Koos, Yo, Lonneke S. F., den Hertog, Heleen M., Bulut, Tomas, Brouwers, Paul J. A. M., Sprengers, Marieke E. S., Jenniskens, Sjoerd F. M., van den Berg, René, Yoo, Albert J., Beenen, Ludo F. M., Postma, Alida A., Roosendaal, Stefan D., van der Kallen, Bas F. W., van den Wijngaard, Ido R., Bot, Joost, van Doormaal, Pieter-Jan, Meijer, Anton, Ghariq, Elyas, van Proosdij, Marc P., Krietemeijer, G. Menno, Dinkelaar, Wouter, Appelman, Auke P. A., Hammer, Bas, Pegge, Sjoert, van der Hoorn, Anouk, Vinke, Saman, Flach, H. Zwenneke, Lingsma, Hester F., el Ghannouti, Naziha, Sterrenberg, Martin, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, Simons, Michelle, Vossers, Marjolein, de Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, van Vemde, Gina, Simons, Tiny, Messchendorp, Gert, Nicolaij, Nynke, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, Maureen, Verheesen, Sabrina, Jeurrissen, D., Bos, Erna, Drabbe, Yvonne, Sandiman, Michelle, Aaldering, Nicoline, Zweedijk, Berber, Vervoort, Jocova, Ponjee, Eva, Romviel, Sharon, Kanselaar, Karin, Barning, Denn, Venema, Esmee, Chalos, Vicky, Geuskens, Ralph R., van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R. M., Muijres, Daan, de Jong, Anouk, Berkhemer, Olvert A., Boers, Anna M. M., Huguet, J., Groot, P. F. C., Mens, Marieke A., van Kranendonk, Katinka R., Treurniet, Kilian M., Tolhuisen, Manon L., Alves, Heitor, Weterings, Annick J., Kirkels, Eleonora L.F., Voogd, Eva J. H. F., Schupp, Lieve M., Collette, Sabine L., Groot, Adrien E. D., LeCouffe, Natalie E., Konduri, Praneeta R., Prasetya, Haryadi, Arrarte-Terreros, Nerea, Ramos, Lucas A., Radiology and Nuclear Medicine, ACS - Microcirculation, ANS - Neurovascular Disorders, Neurology, ACS - Atherosclerosis & ischemic syndromes, ANS - Cellular & Molecular Mechanisms, ANS - Compulsivity, Impulsivity & Attention, Graduate School, Biomedical Engineering and Physics, AMS - Amsterdam Movement Sciences, ANS - Brain Imaging, Adult Psychiatry, APH - Methodology, Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Cardiology, Radiology & Nuclear Medicine, Radiology and nuclear medicine, Internal medicine, Pediatrics, Amsterdam Neuroscience - Neurovascular Disorders, and CCA - Imaging and biomarkers
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Microscopy ,Ischemic stroke ,Radiology, Nuclear Medicine and imaging ,Endovascular treatment ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,Mechanical thrombectomy ,Stent-retriever ,Thrombus - Abstract
Purpose The composition of thrombi retrieved during endovascular thrombectomy (EVT) in acute ischemic stroke (AIS) due to large vessel occlusion (LVO) may differ depending on their origin. In this study, we investigated the association between thrombus composition and stroke etiology in a large population of patients from the Dutch MR CLEAN Registry treated with EVT in daily clinical practice. Methods The thrombi of 332 patients with AIS were histologically analyzed for red blood cells (RBC), fibrin/platelets (F/P), and white blood cells (leukocytes) using a machine learning algorithm. Stroke etiology was assessed using the Trial of Org 10,172 in acute stroke treatment (TOAST) classification. Results The thrombi of cardioembolic origin contained less RBC and more F/P than those of non-cardioembolic origin (25.8% vs 41.2% RBC [p = 0.003] and 67.1% vs 54.5% F/P [p = 0.004]). The likelihood of a non-cardioembolic source of stroke increased with increasing thrombus RBC content (OR 1.02; [95% CI 1.00–1.06] for each percent increase) and decreased with a higher F/P content (OR 1.02; [95% CI 1.00–1.06]). Thrombus composition in patients with a cardioembolic origin and undetermined origin was similar. Conclusion Thrombus composition is significantly associated with stroke etiology, with an increase in RBC and a decrease in F/P raising the odds for a non-cardioembolic cause. No difference between composition of cardioembolic thrombi and of undetermined origin was seen. This emphasizes the need for more extensive monitoring for arrhythmias and/or extended cardiac analysis in case of an undetermined origin.
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- 2023
37. Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data
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Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, Wright, MR, Kamal, NR, Andersen, L, Randhawa, PA, Stewart, T, Patil, S, Minhas, P, Almekhlafi, M, Mishra, S, Clement, F, Sajobi, T, Shuaib, A, Montanera, WJ, Roy, D, Silver, FL, Jovin, TG, Frei, DF, Sapkota, B, Rempel, JL, Thornton, J, Williams, D, Tampieri, D, Poppe, AY, Dowlatshahi, D, Wong, JH, Mitha, AP, Subramaniam, S, Hull, G, Lowerison, MW, Salluzzi, M, Maxwell, M, Lacusta, S, Drupals, E, Armitage, K, Barber, PA, Smith, EE, Morrish, WF, Coutts, SB, Derdeyn, C, Demaerschalk, B, Yavagal, D, Martin, R, Brant, R, Yu, Y, Willinsky, RA, Weill, A, Kenney, C, Aram, H, Stys, PK, Watson, TW, Klein, G, Pearson, D, Couillard, P, Trivedi, A, Singh, D, Klourfeld, E, Imoukhuede, O, Nikneshan, D, Blayney, S, Reddy, R, Choi, P, Horton, M, Musuka, T, Dubuc, V, Field, TS, Desai, J, Adatia, S, Alseraya, A, Nambiar, V, van Dijk, R, Newcommon, NJ, Schwindt, B, Butcher, KS, Jeerakathil, T, Buck, B, Khan, K, Naik, SS, Emery, DJ, Owen, RJ, Kotylak, TB, Ashforth, RA, Yeo, TA, McNally, D, Siddiqui, M, Saqqur, M, Hussain, D, Kalashyan, H, Manosalva, A, Kate, M, Gioia, L, Hasan, S, Mohammad, A, Muratoglu, M, Cullen, A, Brennan, P, O'Hare, A, Looby, S, Hyland, D, Duff, S, McCusker, M, Hallinan, B, Lee, S, McCormack, J, Moore, A, O'Connor, M, Donegan, C, Brewer, L, Martin, A, Murphy, S, O'Rourke, K, Smyth, S, Kelly, P, Lynch, T, Daly, T, O'Brien, P, O'Driscoll, A, Martin, M, Collins, R, Coughlan, T, McCabe, D, O'Neill, D, Mulroy, M, Lynch, O, Walsh, T, O'Donnell, M, Galvin, T, Harbison, J, McElwaine, P, Mulpeter, K, McLoughlin, C, Reardon, M, Harkin, E, Dolan, E, Watts, M, Cunningham, N, Fallon, C, Gallagher, S, Cotter, P, Crowe, M, Doyle, R, Noone, I, Lapierre, M, Coté, VA, Lanthier, S, Odier, C, Durocher, A, Raymond, J, Daneault, N, Deschaintre, Y, Jankowitz, B, Baxendell, L, Massaro, L, Jackson-Graves, C, Decesare, S, Porter, P, Armbruster, K, Adams, A, Billigan, J, Oakley, J, Ducruet, A, Jadhav, A, Giurgiutiu, D-V, Aghaebrahim, A, Reddy, V, Hammer, M, Starr, M, Totoraitis, V, Wechsler, L, Streib, S, Rangaraju, S, Campbell, D, Rocha, M, Gulati, D, Krings, T, Kalman, L, Cayley, A, Williams, J, Wiegner, R, Casaubon, LK, Jaigobin, C, del Campo, JM, Elamin, E, Schaafsma, JD, Agid, R, Farb, R, ter Brugge, K, Sapkoda, BL, Baxter, BW, Barton, K, Knox, A, Porter, A, Sirelkhatim, A, Devlin, T, Dellinger, C, Pitiyanuvath, N, Patterson, J, Nichols, J, Quarfordt, S, Calvert, J, Hawk, H, Fanale, C, Bitner, A, Novak, A, Huddle, D, Bellon, R, Loy, D, Wagner, J, Chang, I, Lampe, E, Spencer, B, Pratt, R, Bartt, R, Shine, S, Dooley, G, Nguyen, T, Whaley, M, McCarthy, K, Teitelbaum, J, Poon, W, Campbell, N, Cortes, M, Lum, C, Shamloul, R, Robert, S, Stotts, G, Shamy, M, Steffenhagen, N, Blacquiere, D, Hogan, M, AlHazzaa, M, Basir, G, Lesiuk, H, Iancu, D, Santos, M, Choe, H, Weisman, DC, Jonczak, K, Blue-Schaller, A, Shah, Q, MacKenzie, L, Klein, B, Kulandaivel, K, Kozak, O, Gzesh, DJ, Harris, LJ, Khoury, JS, Mandzia, J, Pelz, D, Crann, S, Fleming, L, Hesser, K, Beauchamp, B, Amato-Marzialli, B, Boulton, M, Lopez-Ojeda, P, Sharma, M, Lownie, S, Chan, R, Swartz, R, Howard, P, Golob, D, Gladstone, D, Boyle, K, Boulos, M, Hopyan, J, Yang, V, Da Costa, L, Holmstedt, CA, Turk, AS, Navarro, R, Jauch, E, Ozark, S, Turner, R, Phillips, S, Shankar, J, Jarrett, J, Gubitz, G, Maloney, W, Vandorpe, R, Schmidt, M, Heidenreich, J, Hunter, G, Kelly, M, Whelan, R, Peeling, L, Burns, PA, Hunter, A, Wiggam, I, Kerr, E, Watt, M, Fulton, A, Gordon, P, Rennie, I, Flynn, P, Smyth, G, O'Leary, S, Gentile, N, Linares, G, McNelis, P, Erkmen, K, Katz, P, Azizi, A, Weaver, M, Jungreis, C, Faro, S, Shah, P, Reimer, H, Kalugdan, V, Saposnik, G, Bharatha, A, Li, Y, Kostyrko, P, Marotta, T, Montanera, W, Sarma, D, Selchen, D, Spears, J, Heo, JH, Jeong, K, Kim, DJ, Kim, BM, Kim, YD, Song, D, Lee, K-J, Yoo, J, Bang, OY, Rho, S, Lee, J, Jeon, P, Kim, KH, Cha, J, Kim, SJ, Ryoo, S, Lee, MJ, Sohn, S-I, Kim, C-H, Ryu, H-G, Hong, J-H, Chang, H-W, Lee, C-Y, Rha, J, Davis, Stephen M, Donnan, Geoffrey A, Campbell, Bruce CV, Mitchell, Peter J, Churilov, Leonid, Yan, Bernard, Dowling, Richard, Yassi, Nawaf, Oxley, Thomas J, Wu, Teddy Y, Silver, Gabriel, McDonald, Amy, McCoy, Rachael, Kleinig, Timothy J, Scroop, Rebecca, Dewey, Helen M, Simpson, Marion, Brooks, Mark, Coulton, Bronwyn, Krause, Martin, Harrington, Timothy J, Steinfort, Brendan, Faulder, Kenneth, Priglinger, Miriam, Day, Susan, Phan, Thanh, Chong, Winston, Holt, Michael, Chandra, Ronil V, Ma, Henry, Young, Dennis, Wong, Kitty, Wijeratne, Tissa, Tu, Hans, Mackay, Elizabeth, Celestino, Sherisse, Bladin, Christopher F, Loh, Poh Sien, Gilligan, Amanda, Ross, Zofia, Coote, Skye, Frost, Tanya, Parsons, Mark W, Miteff, Ferdinand, Levi, Christopher R, Ang, Timothy, Spratt, Neil, Kaauwai, Lara, Badve, Monica, Rice, Henry, de Villiers, Laetitia, Barber, P. Alan, McGuinness, Ben, Hope, Ayton, Moriarty, Maurice, Bennett, Patricia, Wong, Andrew, Coulthard, Alan, Lee, Andrew, Jannes, Jim, Field, Deborah, Sharma, Gagan, Salinas, Simon, Cowley, Elise, Snow, Barry, Kolbe, John, Stark, Richard, King, John, Macdonnell, Richard, Attia, John, D'Este, Cate, Saver, Jeffrey L, Goyal, Mayank, Diener, Hans-Christoph, Levy, Elad I., Bonafé, Alain, Mendes Pereira, Vitor, Jahan, Reza, Albers, Gregory W., Cognard, Christophe, Cohen, David J., Hacke, Werner, Jansen, Olav, Jovin, Tudor G., Mattle, Heinrich P., Nogueira, Raul G., Siddiqui, Adnan H., Yavagal, Dileep R., von Kummer, Rüdiger, Smith, Wade, Turjman, Francis, Hamilton, Scott, Chiacchierini, Richard, Amar, Arun, Sanossian, Nerses, Loh, Yince, Baxter, B, Reddy, VK, Horev, A, Star, M, Siddiqui, A, Hopkins, LN, Snyder, K, Sawyer, R, Hall, S, Costalat, V, Riquelme, C, Machi, P, Omer, E, Arquizan, C, Mourand, I, Charif, M, Ayrignac, X, Menjot de Champfleur, N, Leboucq, N, Gascou, G, Moynier, M, du Mesnil de Rochemont, R, Singer, O, Berkefeld, J, Foerch, C, Lorenz, M, Pfeilschifer, W, Hattingen, E, Wagner, M, You, SJ, Lescher, S, Braun, H, Dehkharghani, S, Belagaje, SR, Anderson, A, Lima, A, Obideen, M, Haussen, D, Dharia, R, Frankel, M, Patel, V, Owada, K, Saad, A, Amerson, L, Horn, C, Doppelheuer, S, Schindler, K, Lopes, DK, Chen, M, Moftakhar, R, Anton, C, Smreczak, M, Carpenter, JS, Boo, S, Rai, A, Roberts, T, Tarabishy, A, Gutmann, L, Brooks, C, Brick, J, Domico, J, Reimann, G, Hinrichs, K, Becker, M, Heiss, E, Selle, C, Witteler, A, Al-Boutros, S, Danch, M-J, Ranft, A, Rohde, S, Burg, K, Weimar, C, Zegarac, V, Hartmann, C, Schlamann, M, Göricke, S, Ringlestein, A, Wanke, I, Mönninghoff, C, Dietzold, M, Budzik, R, Davis, T, Eubank, G, Hicks, WJ, Pema, P, Vora, N, Mejilla, J, Taylor, M, Clark, W, Rontal, A, Fields, J, Peterson, B, Nesbit, G, Lutsep, H, Bozorgchami, H, Priest, R, Ologuntoye, O, Barnwell, S, Dogan, A, Herrick, K, Takahasi, C, Beadell, N, Brown, B, Jamieson, S, Hussain, MS, Russman, A, Hui, F, Wisco, D, Uchino, K, Khawaja, Z, Katzan, I, Toth, G, Cheng-Ching, E, Bain, M, Man, S, Farrag, A, George, P, John, S, Shankar, L, Drofa, A, Dahlgren, R, Bauer, A, Itreat, A, Taqui, A, Cerejo, R, Richmond, A, Ringleb, P, Bendszus, M, Möhlenbruch, M, Reiff, T, Amiri, H, Purrucker, J, Herweh, C, Pham, M, Menn, O, Ludwig, I, Acosta, I, Villar, C, Morgan, W, Sombutmai, C, Hellinger, F, Allen, E, Bellew, M, Gandhi, R, Bonwit, E, Aly, J, Ecker, RD, Seder, D, Morris, J, Skaletsky, M, Belden, J, Baker, C, Connolly, LS, Papanagiotou, P, Roth, C, Kastrup, A, Politi, M, Brunner, F, Alexandrou, M, Merdivan, H, Ramsey, C, Given II, C, Renfrow, S, Deshmukh, V, Sasadeusz, K, Vincent, F, Thiesing, JT, Putnam, J, Bhatt, A, Kansara, A, Caceves, D, Lowenkopf, T, Yanase, L, Zurasky, J, Dancer, S, Freeman, B, Scheibe-Mirek, T, Robison, J, Roll, J, Clark, D, Rodriguez, M, Fitzsimmons, B-FM, Zaidat, O, Lynch, JR, Lazzaro, M, Larson, T, Padmore, L, Das, E, Farrow-Schmidt, A, 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Ajlan, Fahad S, Reddy, Vivek, Dowlatshahi, Dar, Sourour, Nader-Antoine, Oppenheim, Catherine, Mitha, Alim P, Weimar, Christian, van Oostenbrugge, Robert J, Cobo, Erik, Demchuk, Andrew M, Boers, Anna M M, Ford, Gary A, Brown, B Scott, Jovin, Tudor, van Zwam, Wim H, Hill, Michael D, White, Phil, and Bracard, Serge
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38. Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data
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Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, 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de Rochemont, R, Singer, O, Berkefeld, J, Foerch, C, Lorenz, M, Pfeilschifer, W, Hattingen, E, Wagner, M, You, SJ, Lescher, S, Braun, H, Dehkharghani, S, Belagaje, SR, Anderson, A, Lima, A, Obideen, M, Haussen, D, Dharia, R, Frankel, M, Patel, V, Owada, K, Saad, A, Amerson, L, Horn, C, Doppelheuer, S, Schindler, K, Lopes, DK, Chen, M, Moftakhar, R, Anton, C, Smreczak, M, Carpenter, JS, Boo, S, Rai, A, Roberts, T, Tarabishy, A, Gutmann, L, Brooks, C, Brick, J, Domico, J, Reimann, G, Hinrichs, K, Becker, M, Heiss, E, Selle, C, Witteler, A, Al-Boutros, S, Danch, M-J, Ranft, A, Rohde, S, Burg, K, Weimar, C, Zegarac, V, Hartmann, C, Schlamann, M, Göricke, S, Ringlestein, A, Wanke, I, Mönninghoff, C, Dietzold, M, Budzik, R, Davis, T, Eubank, G, Hicks, WJ, Pema, P, Vora, N, Mejilla, J, Taylor, M, Clark, W, Rontal, A, Fields, J, Peterson, B, Nesbit, G, Lutsep, H, Bozorgchami, H, Priest, R, Ologuntoye, O, Barnwell, S, Dogan, A, Herrick, K, Takahasi, C, Beadell, N, Brown, B, Jamieson, S, 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Hassan, A, Tekle, W, Cate, C, Jansen, O, Cnyrim, C, Wodarg, F, Wiese, C, Binder, A, Riedel, C, Rohr, A, Lang, N, Laufs, H, Krieter, S, Remonda, L, Diepers, M, Añon, J, Nedeltchev, K, Kahles, T, Biethahn, S, Lindner, M, Chang, V, Gächter, C, Esperon, C, Guglielmetti, M, Arenillas Lara, JF, Martínez Galdámez, M, Calleja Sanz, AI, Cortijo Garcia, E, Garcia Bermejo, P, Perez, S, Mulero Carrillo, P, Crespo Vallejo, E, Ruiz Piñero, M, Lopez Mesonero, L, Reyes Muñoz, FJ, Brekenfeld, C, Buhk, J-H, Krützelmann, A, Thomalla, G, Cheng, B, Beck, C, Hoppe, J, Goebell, E, Holst, B, Grzyska, U, Wortmann, G, Starkman, S, Duckwiler, G, Jahan, R, Rao, N, Sheth, S, Ng, K, Noorian, A, Szeder, V, Nour, M, McManus, M, Huang, J, Tarpley, J, Tateshima, S, Gonzalez, N, Ali, L, Liebeskind, D, Hinman, J, Calderon-Arnulphi, M, Liang, C, Guzy, J, Koch, S, DeSousa, K, Gordon-Perue, G, Elhammady, M, Peterson, E, Pandey, V, Dharmadhikari, S, Khandelwal, P, Malik, A, Pafford, R, Gonzalez, P, Ramdas, K, Andersen, G, Damgaard, D, Von Weitzel-Mudersbach, P, Simonsen, C, Ruiz de Morales Ayudarte, N, Poulsen, M, Sørensen, L, Karabegovich, S, Hjørringgaard, M, Hjort, N, Harbo, T, Sørensen, K, Deshaies, E, Padalino, D, Swarnkar, A, Latorre, JG, Elnour, E, El-Zammar, Z, Villwock, M, Farid, H, Balgude, A, Cross, L, Hansen, K, Holtmannspötter, M, Kondziella, D, Hoejgaard, J, Taudorf, S, Soendergaard, H, Wagner, A, Cronquist, M, Stavngaard, T, Cortsen, M, Krarup, LH, Hyldal, T, Haring, H-P, Guggenberger, S, Hamberger, M, Trenkler, J, Sonnberger, M, Nussbaumer, K, Dominger, C, Bach, E, Jagadeesan, BD, Taylor, R, Kim, J, Shea, K, Tummala, R, Zacharatos, H, Sandhu, D, Ezzeddine, M, Grande, A, Hildebrandt, D, Miller, K, Scherber, J, Hendrickson, A, Jumaa, M, Zaidi, S, Hendrickson, T, Snyder, V, Killer-Oberpfalzer, M, Mutzenbach, J, Weymayr, F, Broussalis, E, Stadler, K, Jedlitschka, A, Malek, A, Mueller-Kronast, N, Beck, P, Martin, C, Summers, D, Day, J, Bettinger, I, Holloway, W, Olds, K, Arkin, S, Akhtar, N, Boutwell, C, Crandall, S, Schwartzman, M, Weinstein, C, Brion, B, Prothmann, S, Kleine, J, Kreiser, K, Boeckh-Behrens, T, Poppert, H, Wunderlich, S, Koch, ML, Biberacher, V, Huberle, A, Gora-Stahlberg, G, Knier, B, Meindl, T, Utpadel-Fischler, D, Zech, M, Kowarik, M, Seifert, C, Schwaiger, B, Puri, A, Hou, S, Wakhloo, A, Moonis, M, Henninger, N, Goddeau, R, Massari, F, Minaeian, A, Lozano, JD, Ramzan, M, Stout, C, Patel, A, Tunguturi, A, Onteddu, S, Carandang, R, Howk, M, Ribó, M, Sanjuan, E, Rubiera, M, Pagola, J, Flores, A, Muchada, M, Meler, P, Huerga, E, Gelabert, S, Coscojuela, P, Tomasello, A, Rodriguez, D, Santamarina, E, Maisterra, O, Boned, S, Seró, L, Rovira, A, Molina, CA, Millán, M, Muñoz, L, Pérez de la Ossa, N, Gomis, M, Dorado, L, López-Cancio, E, Palomeras, E, Munuera, J, García Bermejo, P, Remollo, S, Castaño, C, García-Sort, R, Cuadras, P, Puyalto, P, Hernández-Pérez, M, Jiménez, M, Martínez-Piñeiro, A, Lucente, G, Dávalos, A, Chamorro, A, Urra, X, Obach, V, Cervera, A, Amaro, S, Llull, L, Codas, J, Balasa, M, Navarro, J, Ariño, H, Aceituno, A, Rudilosso, S, Renu, A, Macho, JM, San Roman, L, Blasco, J, López, A, Macías, N, Cardona, P, Quesada, H, Rubio, F, Cano, L, Lara, B, de Miquel, MA, Aja, L, Serena, J, Cobo, E, Albers, Gregory W, Lees, Kennedy R, Arenillas, J, Roberts, R, Al-Ajlan, F, Zimmel, L, Patel, S, Martí-Fàbregas, J, Salvat-Plana, M, Bracard, S, Ducrocq, Xavier, Anxionnat, René, Baillot, Pierre-Alexandre, Barbier, Charlotte, Derelle, Anne-Laure, Lacour, Jean-Christophe, Richard, Sébastien, Samson, Yves, Sourour, Nader, Baronnet-Chauvet, Flore, Clarencon, Frédéric, Crozier, Sophie, Deltour, Sandrine, Di Maria, Federico, Le Bouc, Raphael, Leger, Anne, Mutlu, Gurkan, Rosso, Charlotte, Szatmary, Zoltan, Yger, Marion, Zavanone, Chiara, Bakchine, Serge, Pierot, Laurent, Caucheteux, Nathalie, Estrade, Laurent, Kadziolka, Krzysztof, Leautaud, Alexandre, Renkes, Céline, Serre, Isabelle, Desal, Hubert, Guillon, Benoît, Boutoleau-Bretonniere, Claire, Daumas-Duport, Benjamin, De Gaalon, Solène, Derkinderen, Pascal, Evain, Sarah, Herisson, Fanny, Laplaud, David-Axel, Lebouvier, Thibaud, Lintia-Gaultier, Alina, Pouclet-Courtemanche, Hélène, Rouaud, Tiphaine, Rouaud Jaffrenou, Violaine, Schunck, Aurélia, Sevin-Allouet, Mathieu, Toulgoat, Frederique, Wiertlewski, Sandrine, Gauvrit, Jean-Yves, Ronziere, Thomas, Cahagne, Vincent, Ferre, Jean-Christophe, Pinel, Jean-François, Raoult, Hélène, Mas, Jean-Louis, Meder, Jean-François, Al Najjar-Carpentier, Amen-Adam, Birchenall, Julia, Bodiguel, Eric, Calvet, David, Domigo, Valérie, Godon-Hardy, Sylvie, Guiraud, Vincent, Lamy, Catherine, Majhadi, Loubna, Morin, Ludovic, Naggara, Olivier, Trystram, Denis, Turc, Guillaume, Berge, Jérôme, Sibon, Igor, Menegon, Patrice, Barreau, Xavier, Rouanet, François, Debruxelles, Sabrina, Kazadi, Annabelle, Renou, Pauline, Fleury, Olivier, Pasco-Papon, Anne, Dubas, Frédéric, Caroff, Jildaz, Godard Ducceschi, Sophie, Hamon, Marie-Aurélie, Lecluse, Alderic, Marc, Guillaume, Giroud, Maurice, Ricolfi, Frédéric, Bejot, Yannick, Chavent, Adrien, Gentil, Arnaud, Kazemi, Apolline, Osseby, Guy-Victor, Voguet, Charlotte, Mahagne, Marie-Hélène, Sedat, Jacques, Chau, Yves, Suissa, Laurent, Lachaud, Sylvain, Houdart, Emmanuel, Stapf, Christian, Buffon Porcher, Frédérique, Chabriat, Hugues, Guedin, Pierre, Herve, Dominique, Jouvent, Eric, Mawet, Jérôme, Saint-Maurice, Jean-Pierre, Schneble, Hans-Martin, Nighoghossian, Norbert, Berhoune, Nadia-Nawel, Bouhour, Françoise, Cho, Tae-Hee, Derex, Laurent, Felix, Sandra, Gervais-Bernard, Hélène, Gory, Benjamin, Manera, Luis, Mechtouff, Laura, Ritzenthaler, Thomas, Riva, Roberto, Salaris Silvio, Fabrizio, Tilikete, Caroline, Blanc, Raphael, Obadia, Michaël, Bartolini, Mario Bruno, Gueguen, Antoine, Piotin, Michel, Pistocchi, Silvia, Redjem, Hocine, Drouineau, Jacques, Neau, Jean-Philippe, Godeneche, Gaelle, Lamy, Matthias, Marsac, Emilia, Velasco, Stephane, Clavelou, Pierre, Chabert, Emmanuel, Bourgois, Nathalie, Cornut-Chauvinc, Catherine, Ferrier, Anna, Gabrillargues, Jean, Jean, Betty, Marques, Anna-Raquel, Vitello, Nicolas, Detante, Olivier, Barbieux, Marianne, Boubagra, Kamel, Favre Wiki, Isabelle, Garambois, Katia, Tahon, Florence, Ashok, Vasdev, Coskun, Oguzhan, Rodesch, Georges, Lapergue, Bertrand, Bourdain, Frédéric, Evrard, Serge, Graveleau, Philippe, Decroix, Jean Pierre, Wang, Adrien, Sellal, François, Ahle, Guido, Carelli, Gabriela, Dugay, Marie-Hélène, Gaultier, Claude, Lebedinsky, Ariel Pablo, Lita, Lavinia, Musacchio, Raul Mariano, Renglewicz-Destuynder, Catherine, Tournade, Alain, Vuillemet, Françis, Montoro, Francisco Macian, Mounayer, Charbel, Faugeras, Frederic, Gimenez, Laetitia, Labach, Catherine, Lautrette, Géraldine, Denier, Christian, Saliou, Guillaume, Chassin, Olivier, Dussaule, Claire, Melki, Elsa, Ozanne, Augustin, Puccinelli, Francesco, Sachet, Marina, Sarov, Mariana, Bonneville, Jean-François, Moulin, Thierry, Biondi, Alessandra, De Bustos Medeiros, Elisabeth, Vuillier, Fabrice, Courtheoux, Patrick, Viader, Fausto, Apoil-Brissard, Marion, Bataille, Mathieu, Bonnet, Anne-Laure, Cogez, Julien, Touze, Emmanuel, Leclerc, Xavier, Leys, Didier, Aggour, Mohamed, Aguettaz, Pierre, Bodenant, Marie, Cordonnier, Charlotte, Deplanque, Dominique, Girot, Marie, Henon, Hilde, Kalsoum, Erwah, Lucas, Christian, Pruvo, Jean-Pierre, Zuniga, Paolo, Arquizan, Caroline, Costalat, Vincent, Machi, Paolo, Mourand, Isabelle, Riquelme, Carlos, Bounolleau, Pierre, Arteaga, Charles, Faivre, Anthony, Bintner, Marc, Tournebize, Patrice, Charlin, Cyril, Darcel, Françoise, Gauthier-Lasalarie, Pascale, Jeremenko, Marcia, Mouton, Servane, Zerlauth, Jean-Baptiste, Lamy, Chantal, Hervé, Deramond, Hassan, Hosseini, Gaston, André, Barral, Francis-Guy, Garnier, Pierre, Beaujeux, Rémy, Wolff, Valérie, Herbreteau, Denis, Debiais, Séverine, Murray, Alicia, Ford, Gary, Muir, Keith W, White, Philip, Brown, Martin M, Clifton, Andy, Freeman, Janet, Ford, Ian, Markus, Hugh, Wardlaw, Joanna, Molyneux, Andy, Robinson, Thompson, Lewis, Steff, Norrie, John, Robertson, Fergus, Perry, Richard, Dixit, Anand, Cloud, Geoffrey, Clifton, Andrew, Madigan, Jeremy, Roffe, Christine, Nayak, Sanjeev, Lobotesis, Kyriakos, Smith, Craig, Herwadkar, Amit, Kandasamy, Naga, Goddard, Tony, Bamford, John, Subramanian, Ganesh, Lenthall, Rob, Littleton, Edward, Lamin, Sal, Storey, Kelley, Ghatala, Rita, Banaras, Azra, Aeron-Thomas, John, Hazel, Bath, Maguire, Holly, Veraque, Emelda, Harrison, Louise, Keshvara, Rekha, Cunningham, James, Campbell, Bruce C V, van Zwam, Wim H, Menon, Bijoy K, Dippel, Diederik W J, Demchuk, Andrew M, Bracard, Serge, Dávalos, Antoni, Majoie, Charles B L M, Ford, Gary A, de la Ossa, Natalia Pérez, Kelly, Michael, Bourcier, Romain, Roos, Yvo B W E M, Bang, Oh Young, Nogueira, Raul G, Devlin, Thomas G, Clarençon, Frédéric, Burns, Paul, Carpenter, Jeffrey, Yavagal, Dileep R, Pereira, Vitor Mendes, Quesada, Helena, Epstein, Jonathan, Rubiera, Marta, Urra, Xabier, Micard, Emilien, Brown, Scott, Guillemin, Francis, van Oostenbrugge, Robert J, Jovin, Tudor G, and Hill, Michael D
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- 2018
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39. Combined Effect of Age and Baseline Alberta Stroke Program Early Computed Tomography Score on Post-Thrombectomy Clinical Outcomes in the MR CLEAN Registry
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Ospel, Johanna, Kappelhof, Manon, Groot, Adrien E., LeCouffe, Natalie E., Coutinho, Jonathan M., Yoo, Albert J., Yo, Lonneke S.F., Beenen, Ludo F.M., van Zwam, Wim H., van der Lugt, Aad, Postma, Alida A., Roos, Yvo B.W.E.M., Goyal, Mayank, and Majoie, Charles B.L.M.
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- 2020
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40. Stroke Etiology and Thrombus Computed Tomography Characteristics in Patients With Acute Ischemic Stroke: A MR CLEAN Registry Substudy
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Boodt, Nikki, Compagne, Kars C.J., Dutra, Bruna G., Samuels, Noor, Tolhuisen, Manon L., Alves, Heitor C.B.R., Kappelhof, Manon, Lycklama à Nijeholt, Geert J., Marquering, Henk. A., Majoie, Charles B.L.M., Lingsma, Hester F., Dippel, Diederik W.J., and van der Lugt, Aad
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- 2020
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41. Distal Embolization in Relation to Radiological Thrombus Characteristics, Treatment Details, and Functional Outcome
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Bala, Fouzi, Kappelhof, Manon, Ospel, Johanna M., Cimflova, Petra, Qiu, Wu, Singh, Nishita, Zhu, Kairan, Kim, Beom Joon, Wadhwa, Ankur, Almekhlafi, Mohammed A., Menon, Bijoy K., Arrarte Terreros, Nerea, Marquering, Henk, Majoie, Charles, Hill, Michael D., Goyal, Mayank, Radiology and Nuclear Medicine, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, ANS - Cellular & Molecular Mechanisms, ANS - Compulsivity, Impulsivity & Attention, ANS - Neurovascular Disorders, Biomedical Engineering and Physics, ANS - Brain Imaging, and Radiology and nuclear medicine
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catheters ,Advanced and Specialized Nursing ,thrombectomy ,ischemic stroke ,angiography ,Neurology (clinical) ,tomography ,Cardiology and Cardiovascular Medicine - Abstract
Background: Distal embolization (DE) is a common complication of endovascular treatment (EVT). We investigated the association of radiological thrombus characteristics and treatment details with DE. Methods: Patients with thin-slice (≤2.5 mm) baseline noncontrast computed tomography and computed tomography angiography from the ESCAPE-NA1 trial (Efficacy and Safety of Nerinetide for the Treatment of Acute Ischemic Stroke) were included. Thrombus annotation was performed manually on coregistered scans by experienced readers. We assessed thrombus location, distance from internal carotid artery terminus, length, perviousness, absolute attenuation, and hyperdense artery sign. In addition, we evaluated balloon guide catheter use during EVT, first-line EVT approach, the number of thrombectomy passes, and prior intravenous thrombolysis administration. DE was defined as the occurrence of emboli distal to the target artery or in new territories during EVT. The association between thrombus characteristics, treatment details, and DE was evaluated using descriptive statistics and multivariable mixed-effects logistic regression, resulting in adjusted odds ratios (aOR) with 95% CI. Interaction between IVT and radiological thrombus characteristics was assessed by adding interaction terms in separate models. Results: In total, 496 out of 1105 (44.9%) ESCAPE-NA1 patients were included. DE was detected in 251 out of 496 patients (50.6%). Patients with DE had longer thrombi (median, 28.5 [interquartile range, 20.8–42.3] mm versus 24.4 [interquartile range, 17.1–32.4] mm; P P for interaction=0.04. Conclusions: DE was associated with longer thrombi, no balloon guide catheter use, and more EVT passes. IVT was associated with a reduced risk of DE in patients with hyperdense artery sign. These findings may support treatment decisions on IVT and EVT approaches.
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- 2023
42. 2B, 2C, or 3: What Should Be the Angiographic Target for Endovascular Treatment in Ischemic Stroke?
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LeCouffe, Natalie E., Kappelhof, Manon, Treurniet, Kilian M., Lingsma, Hester F., Zhang, Guang, van den Wijngaard, Ido R., van Es, Adriaan C.G.M., Emmer, Bart J., Majoie, Charles B.L.M., Roos, Yvo B.W.E.M., and Coutinho, Jonathan M.
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- 2020
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43. Admission blood pressure and clinical outcomes in patients with acute ischaemic stroke treated with intravenous alteplase and endovascular treatment versus endovascular treatment alone: A MR CLEAN-NO IV substudy
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van den Berg, Sophie A, primary, Uniken Venema, Simone M, additional, LeCouffe, Natalie E, additional, Postma, Alida A, additional, Lycklama à Nijeholt, Geert J, additional, Rinkel, Leon A, additional, Treurniet, Kilian M, additional, Kappelhof, Manon, additional, Bruggeman, Agnetha E, additional, van Kranendonk, Katinka R, additional, Majoie, Charles BLM, additional, Dippel, Diederik WJ, additional, van der Worp, H Bart, additional, Coutinho, Jonathan M, additional, Nederkoorn, Paul J, additional, and Roos, Yvo BWEM, additional
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- 2023
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44. Symptomatic non-stenotic carotid disease: current challenges and opportunities for diagnosis and treatment
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Ospel, Johanna Maria, primary, Kappelhof, Manon, additional, Ganesh, Aravind, additional, Kallmes, David F, additional, Brinjikji, Waleed, additional, and Goyal, Mayank, additional
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- 2023
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45. Validity of Early Outcomes as Indicators for Comparing Hospitals on Quality of Stroke Care
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Amini, Marzyeh, primary, Eijkenaar, Frank, additional, Lingsma, Hester F., additional, den Hartog, Sanne J., additional, Olthuis, Susanne G. H., additional, Martens, Jasper, additional, van der Worp, Bart, additional, van Zwam, Wim, additional, van der Hoorn, Anouk, additional, Roosendaal, Stefan D., additional, Roozenbeek, Bob, additional, Dippel, Diederik, additional, van Leeuwen, Nikki, additional, Dippel, Diederik W. J., additional, van der Lugt, Aad, additional, Majoie, Charles B. L. M., additional, Roos, Yvo B. W. E. M., additional, van Oostenbrugge, Robert J., additional, van Zwam, Wim H., additional, Boiten, Jelis, additional, Vos, Jan Albert, additional, Brouwer, Josje, additional, Hinsenveld, Wouter H., additional, Kappelhof, Manon, additional, Compagne, Kars C. J., additional, Goldhoorn, Robert‐Jan B., additional, Mulder, Maxim J. H. L., additional, Jansen, Ivo G. H., additional, van Es, Adriaan C. G. M., additional, Emmer, Bart J., additional, Coutinho, Jonathan M., additional, Schonewille, Wouter J., additional, Wermer, Marieke J. H., additional, van Walderveen, Marianne A. A., additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, Martens, Jasper M., additional, Lycklama à Nijeholt, Geert J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, van der Worp, H. Bart, additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Vries, J., additional, de Kort, Paul L. M., additional, van Tuijl, Julia, additional, Peluso, Jo Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S. P., additional, van Hasselt, Boudewijn A. A. M., additional, Aerden, Leo A. M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Bokkers, Reinoud P. H., additional, Schreuder, Tobien H. C. M. L., additional, Heijboer, Roel J. J., additional, Keizer, Koos, additional, Yo, Lonneke S. F., additional, den Hertog, Heleen M., additional, Sturm, Emiel J. C., additional, Brouwers, Paul, additional, Sprengers, Marieke E. S., additional, Jenniskens, Sjoerd F. M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F. M., additional, Postma, Alida A., additional, van der Kallen, Bas F. W., additional, van den Wijngaard, Ido R., additional, Bot, Joost, additional, van Doormaal, Pieter‐Jan, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Krietemeijer, G. Menno, additional, Peluso, Jo P., additional, Lo, Rob, additional, Dinkelaar, Wouter, additional, Appelman, Auke P. A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, Vinke, Saman, additional, Flach, H. Zwenneke, additional, el Ghannouti, Naziha, additional, Sterrenberg, Martin, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, van Rijswijk, Cathelijn, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Khalilzada, Mostafa, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R. M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M. M., additional, Huguet, J., additional, Groot, P. F. C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L. F., additional, Voogd, Eva J. H. F., additional, Schupp, Lieve M., additional, Collette, Sabine, additional, Groot, Adrien E. D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte‐Terreros, Nerea, additional, and Ramos, Lucas A., additional
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- 2023
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46. Association des caractéristiques radiologiques du thrombus et des détails du traitement avec le risque de fragmentation et d'embolisation distale du thrombus au cours des thrombectomie mécaniques
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Bala, Fouzi, primary, Kappelhof, Manon, additional, Ospel, Johanna, additional, Hill, Michael, additional, Almekhlafi, Mohammed, additional, Menon, Bijoy, additional, and Goyal, Mayank, additional
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- 2023
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47. Bifurcation occlusions and endovascular treatment outcome in acute ischemic stroke
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UMC Utrecht Holding, Neurologen, Brain, Circulatory Health, Stroke, Arrarte Terreros, Nerea, Bruggeman, Agnetha A.E., Van Voorst, Henk, Konduri, Praneeta R., Jansen, Ivo G.H., Kappelhof, Manon, Tolhuisen, Manon L., Boodt, Nikki, Dippel, Diederik W.J., Van Der Lugt, Aad, Van Zwam, Wim H., Van Oostenbrugge, Robert J., Van Der Worp, H. Bart, Emmer, Bart J., Meijer, Frederick J.A., Roos, Yvo B.W.E.M., Van Bavel, Ed, Marquering, Henk A., Majoie, Charles B.L.M., UMC Utrecht Holding, Neurologen, Brain, Circulatory Health, Stroke, Arrarte Terreros, Nerea, Bruggeman, Agnetha A.E., Van Voorst, Henk, Konduri, Praneeta R., Jansen, Ivo G.H., Kappelhof, Manon, Tolhuisen, Manon L., Boodt, Nikki, Dippel, Diederik W.J., Van Der Lugt, Aad, Van Zwam, Wim H., Van Oostenbrugge, Robert J., Van Der Worp, H. Bart, Emmer, Bart J., Meijer, Frederick J.A., Roos, Yvo B.W.E.M., Van Bavel, Ed, Marquering, Henk A., and Majoie, Charles B.L.M.
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- 2023
48. Endovascular treatment for isolated posterior cerebral artery occlusion stroke in the MR CLEAN registry
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Brouwer, Josje, Ergezen, Saliha, Mulder, Maxim Johan Heymen Laurence, Nijeholt, Geert J.Lycklama A., Van Es, Adriaan C.G.M., Van Der Lugt, Aad, Dippel, Diederik W.J., Majoie, Charles B.L.M., Roos, Yvo B.W.E.M., Coutinho, J. M., Emmer, Bart J., Van Oostenbrugge, Robert J., Van Zwam, Wim H., Boiten, Jelis, Vos, Jan Albert, Jansen, Ivo G.H., Goldhoorn, Robert Jan B., Compagne, Kars C.J., Kappelhof, Manon, Den Hartog, Sanne J., Hinsenveld, Wouter H., Roozenbeek, Bob, Schonewille, Wouter J., Wermer, Marieke J.H., Van Walderveen, Marianne A.A., Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper M., De Bruijn, Sebastiaan F., Van Dijk, Lukas C., Van Der Worp, H. Bart, Lo, Rob H., Van Dijk, Ewoud J., Boogaarts, Hieronymus D., De Vries, J., De Kort, Paul L.M., Van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, Van Den Berg, Jan S.P., Van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P.H., Schreuder, Tobien H.C.M.L., Postma, Alida A., Van Der Leij, Christiaan, Brans, Rutger, Pirson, Anne-France, MR CLEAN Registry Investigators, Brouwer, Josje, Ergezen, Saliha, Mulder, Maxim Johan Heymen Laurence, Nijeholt, Geert J.Lycklama A., Van Es, Adriaan C.G.M., Van Der Lugt, Aad, Dippel, Diederik W.J., Majoie, Charles B.L.M., Roos, Yvo B.W.E.M., Coutinho, J. M., Emmer, Bart J., Van Oostenbrugge, Robert J., Van Zwam, Wim H., Boiten, Jelis, Vos, Jan Albert, Jansen, Ivo G.H., Goldhoorn, Robert Jan B., Compagne, Kars C.J., Kappelhof, Manon, Den Hartog, Sanne J., Hinsenveld, Wouter H., Roozenbeek, Bob, Schonewille, Wouter J., Wermer, Marieke J.H., Van Walderveen, Marianne A.A., Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper M., De Bruijn, Sebastiaan F., Van Dijk, Lukas C., Van Der Worp, H. Bart, Lo, Rob H., Van Dijk, Ewoud J., Boogaarts, Hieronymus D., De Vries, J., De Kort, Paul L.M., Van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, Van Den Berg, Jan S.P., Van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P.H., Schreuder, Tobien H.C.M.L., Postma, Alida A., Van Der Leij, Christiaan, Brans, Rutger, Pirson, Anne-France, and MR CLEAN Registry Investigators
- Abstract
Background Endovascular treatment (EVT) is standard of care in anterior circulation large vessel occlusions. In posterior circulation occlusions, data on EVT in isolated posterior cerebral artery (PCA) occlusions are limited, although PCA occlusions can cause severe neurological deficit. Objective To describe in a prospective study the clinical manifestations, outcomes, and safety of EVT in isolated PCA occlusions. Methods We used data (2014-2017) from the MR CLEAN Registry, a nationwide, prospective cohort of EVT-treated patients in the Netherlands. We included patients with acute ischemic stroke (AIS) due to an isolated PCA occlusion on CT angiography. Patients with concurrent occlusion of the basilar artery were excluded. Outcomes included change in National Institutes of Health Stroke Scale (?NIHSS) score, modified Rankin Scale (mRS) score 0-3 after 90 days, mortality, expanded Thrombolysis in Cerebral Infarction (eTICI), and periprocedural complications. Results Twenty (12%) of 162 patients with posterior circulation occlusions had an isolated PCA occlusion. Median age was 72 years; 13 (65%) were women. Median baseline NIHSS score was 13 (IQR 5-21). Six (30%) patients were comatose. Twelve patients (60%) received IVT. Median ?NIHSS was -4 (IQR -11-+1). At follow-up, nine patients (45%) had mRS score 0-3. Seven (35%) died. eTICI 2b-3 was achieved in 13 patients (65%). Nine patients (45%) had periprocedural complications. No symptomatic intracranial hemorrhages (sICH) occurred. Conclusions EVT should be considered in selected patients with AIS with an isolated PCA occlusion, presenting with moderate-severe neurological deficits, as EVT was technically feasible in most of our patients and about half had good clinical outcome. In case of lower NIHSS score, a more conservative approach seems warranted, since periprocedural complications are not uncommon. Nonetheless, EVT seems reasonably safe considering the absence of sICH in our study.
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- 2023
49. Hemorrhage rates in patients with acute ischemic stroke treated with intravenous alteplase and thrombectomy versus thrombectomy alone
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van Kranendonk, Katinka R, Kappelhof, Manon, Bruggeman, Agnetha A E, Rinkel, Leon A, Treurniet, Kilian M, LeCouffe, Natalie, Emmer, Bart J, Coutinho, Jonathan M, Wolff, Lennard, van Zwam, Wim H, van Oostenbrugge, Robert J, van der Lugt, Aad, Dippel, Diederik W J, Roos, Yvo B W E M, Marquering, Henk A, Majoie, Charles B L M, MR CLEAN-NO IV Investigators, van Kranendonk, Katinka R, Kappelhof, Manon, Bruggeman, Agnetha A E, Rinkel, Leon A, Treurniet, Kilian M, LeCouffe, Natalie, Emmer, Bart J, Coutinho, Jonathan M, Wolff, Lennard, van Zwam, Wim H, van Oostenbrugge, Robert J, van der Lugt, Aad, Dippel, Diederik W J, Roos, Yvo B W E M, Marquering, Henk A, Majoie, Charles B L M, and MR CLEAN-NO IV Investigators
- Abstract
BACKGROUND: Intravenous alteplase treatment (IVT) for acute ischemic stroke carries a risk of intracranial hemorrhage (ICH). However, reperfusion of an occluded vessel itself may contribute to the risk of ICH. We determined whether IVT and reperfusion are associated with ICH or its volume in the Multicenter Randomized Clinical trial of Endovascular treatment for Acute ischemic stroke in the Netherlands (MR CLEAN)-NO IV trial.METHODS: The MR CLEAN-NO IV trial randomized patients with acute ischemic stroke due to large vessel occlusion to receive either IVT followed by endovascular treatment (EVT) or EVT alone. ICH was classified according to the Heidelberg bleeding classification on follow-up MRI or CT approximately 8 hours-7 days after stroke. Hemorrhage volume was measured with ITK-snap. Successful reperfusion was defined as extended Thrombolysis In Cerebral Infarction (eTICI) score of 2b-3. Multinomial and binary adjusted logistic regression were used to determine the association of IVT and reperfusion with ICH subtypes.RESULTS: Of 539 included patients, 173 (32%) developed ICH and 30 suffered from symptomatic ICH (sICH) (6%). Of the patients with ICH, 102 had hemorrhagic infarction, 47 had parenchymal hematoma, 44 had SAH, and six had other ICH. Reperfusion was associated with a decreased risk of SAH, and IVT was not associated with SAH (eTICI 2b-3: adjusted OR 0.45, 95% CI 0.21 to 0.97; EVT without IVT: OR 1.6, 95% CI 0.91 to 2.8). Reperfusion status and IVT were not associated with overall ICH, hemorrhage volume, and sICH (sICH: EVT without IVT, OR 0.96, 95% CI 0.41 to 2.25; eTICI 2b-3, OR 0.49, 95% CI 0.23 to 1.05).CONCLUSION: Neither IVT administration before EVT nor successful reperfusion after EVT were associated with ICH, hemorrhage volume, and sICH. SAH occurred more often in patients for whom successful reperfusion was not achieved.
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- 2023
50. Influence of time metrics on the treatment effect of intravenous alteplase prior to endovascular treatment in MR CLEAN-NO IV
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Rinkel, Leon A, Treurniet, Kilian Maurizio, Kappelhof, Manon, LeCouffe, Natalie E, Bruggeman, Agnetha A E, Nieboer, Daan, van Zwam, Wim H, Uyttenboogaart, Maarten, Dippel, Diederik W J, Emmer, Bart J, Roos, Yvo B W E M, Majoie, Charles B L M, Coutinho, J M, MR CLEAN-NO IV Investigators, Rinkel, Leon A, Treurniet, Kilian Maurizio, Kappelhof, Manon, LeCouffe, Natalie E, Bruggeman, Agnetha A E, Nieboer, Daan, van Zwam, Wim H, Uyttenboogaart, Maarten, Dippel, Diederik W J, Emmer, Bart J, Roos, Yvo B W E M, Majoie, Charles B L M, Coutinho, J M, and MR CLEAN-NO IV Investigators
- Abstract
BACKGROUND: We assessed whether the treatment effect of intravenous alteplase (IVT) prior to endovascular treatment (EVT) on functional outcome is modified by time metrics.METHODS: We used data from all patients included in MR CLEAN-NO IV, a randomized trial of IVT followed by EVT versus EVT alone in patients who presented directly to EVT-capable hospitals. The primary outcome was the modified Rankin Scale score at 90 days. We used ordinal regression with a multiplicative interaction term to assess if the effect of IVT is modified by onset-to-randomization (OTR), onset-to-IV-needle (OTN), door-to-groin (DTG) or needle-to-groin (NTG) times. Secondary outcomes included successful reperfusion (extended Thrombolysis In Cerebral Infarction Scale 2b-3) and symptomatic intracranial hemorrhage (sICH).RESULTS: In 539 included patients (266 allocated to IVT+EVT and 273 to EVT alone), median workflow times were OTR: 93 (IQR 71-145) min; OTN: 98 (IQR 75-156) min; DTG: 64 (IQR 51-78) min; and NTG: 28 (IQR 20-41) min. There was a significant association between worse outcomes and longer time intervals for all metrics except NTG. We found no interaction between any of the time metrics and IVT for the effect on functional outcome (p values for interaction: OTR=0.40, OTN=0.39, DTG=0.61, NTG=0.56). We also did not observe any significant interaction for successful reperfusion or sICH.CONCLUSION: In MR CLEAN-NO IV, the effect of IVT prior to EVT was not modified by OTR, OTN, DTG or NTG times. Our results do not support the use of these metrics to guide IVT treatment decisions prior to EVT in comprehensive stroke centres.TRIAL REGISTRATION NUMBER: ISRCTN80619088.
- Published
- 2023
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