547 results on '"Kar SK"'
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2. COVID19 and Sexuality
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Arafat YSM, Kar SK, and Mishra S R
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COVID-19 ,Sexuality - Abstract
The COVID-19 pandemic has affected almost every aspect of human lives across the globe; sexual life is not an exception to it. However, larger robust studies are warranted to determine the effects of COVID-19 and/or lockdown on human sexuality. In the context of COVID-19, some immediate questions should be addressed regarding the sexual transmission of Coronavirus (Holtmann et al., 2020), safe sexual practice, regular sexual behaviour, pornography, sexual minority group concerns, pregnancy and childbirth during COVID-19 (Kumar, 2020), effective ways of dealing sexual medicine emergencies, domestic violence during the COVID-19 lockdown, effects of COVID-19 on fetus and pregnancy outcome, effect on mar riage and cohabitation, challenges of commercial sex workers and customers etc. Studies reported that during this lockdown as well as postlockdown period, pornography consumption has been substantially increased (Mestre- Bach et al., 2020). Erectile dysfunction can be found in the COVID-19 survivors due to endothelial dysfunction (Sansone et al., 2020) and COVID-19 can also cause male infertility (Vishvkarma and Rajender, 2020). One study from the three countries of South-East Asia (Bangladesh, India, & Nepal) found no major change in sexual habit and increased emotional closeness among heterosexual couples (Arafat et al., 2020). Other studies from Italy revealed a significant reduction of sexual frequency and reduction in Female Sexual Function Index (FSFI)score (Schiavi et al., 2020). COVID-19 affecting the sexual life can be speculated in several ways such as the biology of Coronavirus, risk of transmission, psychological consequences of the pandemic itself as well as the lockdown measures, sudden changes in lifestyle, changes in income, social aspects like social exclusion and isolation which can be in either direction.It has been seen that people with psychiatric disorders (e.g. depression, anxiety disorders, schizophrenia, bipolar affective disorders, etc) also experience sexual dysfunction (due to the nature of the illness and side effects of the medications). It has been seen that during this pandemic there is increase in depression and anxiety (Roy et al., 2020), which is likely to affect the sexual functioning too. Similarly, people many times self-medicate for their mental health issues and encounter several side effects, which might affect the sexual functioning, {"references":["Arafat, S.M.Y., Alradie-Mohamed, A., Kar, S. K., Sharma, P., & Kabir, R. (2020).Does COVID-19 pandemic affect sexual behaviour? A crosssectional, cross-national online survey. Psychiatry Research, 289, 113050.","Holtmann, N., Edimiris, P., Andree, M., Doehmen, C., Baston-Buest, D., Adams, O., Kruessel, J. S., & Bielfeld, A. P. (2020). Assessment of SARS-CoV-2 in human semen-a cohort study.Fertility and sterility, 113, 233-238.","Kumar N. (2020). COVID 19 era: a beginning of upsurge in unwanted pregnancies, unmet need for contraception and other women related issues. The European journal of contraception & reproductive health care, 25, 323-325.","Mestre-Bach, G., Blycker, G. R., & Potenza, M. N. (2020).Pornography use in the setting of the COVID-19 pandemic. Journal of Behavioral Addictions, 9(2), 181-183.","Sansone, A., Mollaioli, D., Ciocca, G., Limoncin, E., Colonnello, E., Vena, W., &Jannini, E. A. (2020).Addressing male sexual and reproductive health in the wake of COVID-19 outbreak. JournalofEndocrinologicalInvestigation.https:/ /doi.org/10.1007/s40618-020-01350-1","Schiavi, M. C., Spina, V., Zullo, M. A., Colagiovanni, V., Luffarelli, P., Rago, R., &Palazzetti, P. (2020). Love in the Time of COVID-19: Sexual Function and Quality of Life Analysis During the Social Distancing Measures in a Group of Italian Reproductive-Age Women. The journal of sexual medicine, 17, 1407-1413.","Roy, D., Tripathy, S., Kar, S.K., Sharma, N., Verma, S.K. and Kaushal, V., 2020. Study of knowledge, attitude, anxiety & perceived mental healthcare need in Indian population during COVID-19 pandemic. Asian Journal of Psychiatry, 51, 102083.","Vishvkarma, R., &Rajender, S. (2020). Could SARS-CoV-2 affect male fertility?.Andrologia, 52, e13712."]}
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- 2020
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3. An Investigation on the Coinfection of Measles and HSV-1 in Hospitalized Acute Encephalitis Syndrome Patients in Eastern India
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Dwibedi, B, primary, Rathore, SK, additional, Pati, SS, additional, Panda, S, additional, Panda, M, additional, Sabat, J, additional, and Kar, SK, additional
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- 2019
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4. A Discussion about Modalities of Smoking Cessation in Perioperative Phase for Addicts: A Review Article
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Kar, SK, primary
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- 2014
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5. Hydrocele fluid: Can it be used for immunodiagnosis of lymphatic filariasis?
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Bal, MS, primary, Mishra, S, additional, Achary, KG, additional, Mandal, NN, additional, Tripathy, A, additional, and Kar, SK, additional
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- 2014
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6. Low levels of anti TB drug resistance in Rayagada district of Odisha, India
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Kar, SK, primary, Das, D, additional, and Dwibedi, B, additional
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- 2014
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7. Frequency of Hepatitis B Virus Surface Gene Variant Circulating Among HBsAg Negative Individuals in Coastal Eastern India: A Preliminary Report
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Panigrahi, MK, primary, Kar, SK, additional, Misra, B, additional, Singh, SP, additional, Das, HS, additional, and Panda, C, additional
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- 2011
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8. P44 Arthritis in lymphatic filariasis
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Padhi, N, primary, Achary, KG, additional, Kar, SK, additional, and Mandal, NN, additional
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- 2010
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9. An Outbreak of Cholera Associated with an Unprotected Well in Parbatia, Orissa, Eastern India
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Manickam, P, primary, Das, Amitav, additional, Hutin, Yvan, additional, Pal, BB, additional, Chhotray, GP, additional, Kar, SK, additional, and Gupte, MD, additional
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- 2009
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10. Effect of prophylactic amiodarone in patients with rheumatic valve disease undergoing valve replacement surgery.
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Kar SK, Dasgupta CS, and Goswami A
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- 2011
11. RIVER FLOOD PLAIN INTERACTION AND DISTRIBUTION OF BOUNDARY SHEAR STRESS IN A MEANDER CHANNEL WITH FLOOD PLAIN.
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KAR, SK and GHOSH, JN
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- 1975
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12. RIVER FLOOD PLAIN INTERACTION AND DISTRIBUTION OF BOUNDARY SHEAR STRESS IN A MEANDER CHANNEL WITH FLOOD PLAIN.
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GHOSH, JN, primary and KAR, SK, additional
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- 1975
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13. An outbreak of cholera associated with an unprotected well in Parbatia, Orissa, Eastern India.
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Das A, Manickam P, Hutin Y, Pal BB, Chhotray GP, Kar SK, Gupte MD, Das, Amitav, Manickam, P, Hutin, Yvan, Pal, B B, Chhotray, G P, Kar, S K, and Gupte, M D
- Abstract
In November 2003, an outbreak (41 cases; attack rate-4.3%; no deaths) of severe diarrhoea was reported from a village in Orissa, eastern India. Thirteen of these cases were hospitalized. A matched case-control study was conducted to identify the possible exposure variables. Since all wells were heavily chlorinated immediately after the outbreak, water samples were not tested. The cases were managed symptomatically. Descriptive epidemiology suggested clustering of cases around one public well. Vibrio cholerae El Tor O1, serotype Ogawa was isolated from four of six rectal swabs. The water from the public well was associated with the outbreak (matched odds ratio: 12; 95% confidence interval 1.2-44.1). On the basis of these conclusions, access to the well was barred immediately, and it was protected. This investigation highlighted the broader use of field epidemiology methods to implement public-health actions guided by epidemiologic data to control a cholera epidemic. [ABSTRACT FROM AUTHOR]
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- 2009
14. Bronchial carcinoid: a neuroendocrine manifestation-presented as bronchospasm and hypertension during resection.
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Majumdar S, Dammalapati PK, Kar SK, Sanki PK, and Dasgupta CS
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Bronchopulmonary carcinoid tumors are rare, slow-growing malignant neuroendocrine tumors. Early diagnosis is pivotal as surgical resection is the main stay of treatment. A 40-year-old female with typical bronchial carcinoid presented with complaints of breathlessness on mild to moderate exertion, intermittent productive cough, low-grade fever, and loss of appetite since 1 year. Right lobectomy was performed with regional lymph node resection; during resection of the tumor, manipulation led to a massive surge and fluctuations in blood pressure which were managed with deepening of the plane of anesthesia and administration of nitroglycerin infusion. She was discharged home in a good condition. Typical carcinoid tumor involves the central airways causing bronchial obstruction; however, in the present case, non-specific symptomatic presentation led to late detection. The outcome of typical carcinoids even with lymph node metastasis is excellent with complete resection; however, close follow-up is recommended due to a high incidence of recurrence., Competing Interests: Conflict of interestNo., (© Indian Association of Cardiovascular-Thoracic Surgeons 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
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- 2024
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15. Crosstalk between ROS-inflammatory gene expression axis in the progression of lung disorders.
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Ashique S, Mishra N, Mantry S, Garg A, Kumar N, Gupta M, Kar SK, Islam A, Mohanto S, and Subramaniyan V
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A significant number of deaths and disabilities worldwide are brought on by inflammatory lung diseases. Many inflammatory lung disorders, including chronic respiratory emphysema, resistant asthma, resistance to steroids, and coronavirus-infected lung infections, have severe variants for which there are no viable treatments; as a result, new treatment alternatives are needed. Here, we emphasize how oxidative imbalance contributes to the emergence of provocative lung problems that are challenging to treat. Endogenic antioxidant systems are not enough to avert free radical-mediated damage due to the induced overproduction of ROS. Pro-inflammatory mediators are then produced due to intracellular signaling events, which can harm the tissue and worsen the inflammatory response. Overproduction of ROS causes oxidative stress, which causes lung damage and various disease conditions. Invasive microorganisms or hazardous substances that are inhaled repeatedly can cause an excessive amount of ROS to be produced. By starting signal transduction pathways, increased ROS generation during inflammation may cause recurrent DNA damage and apoptosis and activate proto-oncogenes. This review provides information about new targets for conducting research in related domains or target factors to prevent, control, or treat such inflammatory oxidative stress-induced inflammatory lung disorders., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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16. Prison mental health in South-East Asia: A narrative review.
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Arafat SMY, Kar SK, Abhayanayake C, Sharma P, and Marthoenis M
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- Humans, Asia, Southeastern epidemiology, Mental Health statistics & numerical data, Nepal epidemiology, Prevalence, Prisoners statistics & numerical data, Prisoners psychology, Mental Disorders epidemiology, Prisons statistics & numerical data, Mental Health Services statistics & numerical data
- Abstract
Background: South-East Asia is a densely populated region with a considerable, however, under-prioritized mental health burden. Little is known about the mental health burden and services status in the prisons of the region., Objectives: We aimed to investigate the individual country-wise prison mental health status in South-East Asian region., Methods: We performed a narrative review based on the evidence available in PubMed, Scopus, PsycINFO, Google, and Google Scholar considering the review objectives. We highlighted country perspectives on total population, prison numbers, prisoner numbers, the prevalence of psychiatric disorders and suicide among prisoners, prison mental health services, current challenges, and ways ahead., Results: We discussed the prison mental health of five countries (Bangladesh, India, Indonesia, Nepal, and Sri Lanka). We found overcrowding (131.4%-215.6%) in the prisons, a high prevalence of psychiatric disorders in the prisons (40%-100%), negligible prison mental health services, and a lack of data on prison suicide with some variations among the five countries. Among the countries, Bangladesh has the highest prevalence (66.4%-100%) of psychiatric morbidity with an absence of a mental health system., Conclusions: Prison mental health in tSouth-East Asia is a neglected domain and warrants attention regarding ensuring adequate mental health services to the prisoners as there are high unmet mental health needs and an absence of poorly supported mental health needs., (© 2024 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.)
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- 2024
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17. Analysis of preoperative and postoperative blood gas indices and airflow dynamics with tracheal stenosis undergoing tracheal reconstruction.
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Ghosh K, Kar SK, and Dammalapati PK
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Prolonged ventilation remains the most common cause of tracheal stenosis. Tracheal reconstruction is the gold standard treatment in these cases. The success of surgery is based on results of the pulmonary function test (PFT) which relies on patients' performance and their cooperation. The objective of the study was to investigate the impact of tracheal reconstruction in cases of tracheal stenosis on blood gas indices as well as airflow indices and whether arterial blood gas (ABG) can be a better surrogate of adequacy of tracheal reconstruction. This was a retrospective observational study of 61 patients with tracheal stenosis between the ages of 21 and 65 years who underwent tracheal reconstruction. The preoperative and postoperative values of various blood gas indices like partial pressure of oxygen (pO
2 ), partial pressure of carbon dioxide (pCO2 ), and potential of hydrogen (pH) and airflow indices like forced expiratory volume in 1 s (FEV1) and peak expiratory flow (PEF) were evaluated and found that all the parameters showed significant improvement after tracheal reconstruction with P < 0.0001. Tracheal reconstruction resulted in improvement of oxygenation and airflow parameters which led to relief of symptoms. Hence, ABG can be used as a surrogate marker for denoting the success of the surgery., Competing Interests: Conflict of interestNone declared., (© Indian Association of Cardiovascular-Thoracic Surgeons 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)- Published
- 2024
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18. Diet-induced changes in the jejunal microbiota of developing broilers reduce the abundance of Enterococcus hirae and Enterococcus faecium.
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Stege PB, Schokker D, Harders F, Kar SK, Stockhofe N, Perricone V, Rebel JMJ, de Jong IC, and Bossers A
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- Animals, Diet veterinary, Metagenomics methods, Dietary Supplements, Chickens microbiology, Chickens growth & development, Enterococcus faecium genetics, Gastrointestinal Microbiome drug effects, Jejunum microbiology, Enterococcus hirae, Animal Feed
- Abstract
Modern broiler breeds allow for high feed efficiency and rapid growth, which come at a cost of increased susceptibility to pathogens and disease. Broiler growth rate, feed efficiency, and health are affected by the composition of the gut microbiota, which in turn is influenced by diet. In this study, we therefore assessed how diet composition can affect the broiler jejunal gut microbiota. A total of 96 broiler chickens were divided into four diet groups: control, coated butyrate supplementation, medium-chain fatty acid supplementation, or a high-fibre low-protein content. Diet groups were sub-divided into age groups (4, 12 and 33 days of age) resulting in groups of 8 broilers per diet per age. The jejunum content was used for metagenomic shotgun sequencing to determine the microbiota taxonomic composition at species level. The composed diets resulted in a total of 104 differentially abundant bacterial species. Most notably were the butyrate-induced changes in the jejunal microbiota of broilers 4 days post-hatch, resulting in the reduced relative abundance of mainly Enterococcus faecium (-1.8 l2fc, P
adj = 9.9E-05) and the opportunistic pathogen Enterococcus hirae (-2.9 l2fc, Padj = 2.7E-08), when compared to the control diet. This effect takes place during early broiler development, which is critical for broiler health, thus exemplifying the importance of how diet can influence the microbiota composition in relation to broiler health. Future studies should therefore elucidate how diet can be used to promote a beneficial microbiota in the early stages of broiler development., (© 2024. The Author(s).)- Published
- 2024
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19. Transcranial direct current stimulation as early augmentation in adolescent obsessive compulsive disorder: A pilot proof-of-concept randomized control trial.
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Agrawal A, Agarwal V, Kar SK, and Arya A
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Background: Transcranial direct current stimulation (tDCS) is proven to be safe in treating various neurological conditions in children and adolescents. It is also an effective method in the treatment of OCD in adults., Aim: To assess the safety and efficacy of tDCS as an add-on therapy in drug-naive adolescents with OCD., Methods: We studied drug-naïve adolescents with OCD, using a Children's Yale-Brown obsessive-compulsive scale (CY-BOCS) scale to assess their condition. Both active and sham groups were given fluoxetine, and we applied cathode and anode over the supplementary motor area and deltoid for 20 min in 10 sessions. Reassessment occurred at 2, 6, and 12 wk using CY-BOCS., Results: Eighteen adolescents completed the study (10-active, 8-sham group). CY-BOCS scores from baseline to 12 wk reduced significantly in both groups but change at baseline to 2 wk was significant in the active group only. The mean change at 2 wk was more in the active group (11.8 ± 7.77 vs 5.25 ± 2.22, P = 0.056). Adverse effects between the groups were comparable., Conclusion: tDCS is safe and well tolerated for the treatment of OCD in adolescents. However, there is a need for further studies with a larger sample population to confirm the effectiveness of tDCS as early augmentation in OCD in this population., Competing Interests: Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article., (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)
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- 2024
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20. Reply to Comments on "The digital health dilemma: Exploring cyberchondria, well-being, and smartphone addiction in medical and non-medical undergraduates".
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Agrawal V, Khulbe Y, Singh A, and Kar SK
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Competing Interests: There are no conflicts of interest.
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- 2024
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21. Not reinventing the wheel: Nesting suicide prevention and awareness activities within existing health programs.
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Gnanadhas J, Cherian AV, Kar SK, and Menon V
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- Humans, Health Knowledge, Attitudes, Practice, Suicide Prevention
- Abstract
Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest relevant to the contents of the manuscript.
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- 2024
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22. Psychometric properties and factor structure of the suicidal narrative inventory in major depression: A multicentric evaluation.
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Menon V, Balasubramanian I, Rogers ML, Grover S, Lakdawala B, Ranjan R, Sarkhel S, Nebhinani N, Kallivayalil RA, Raghavan V, Mishra KK, Aneja J, Abhivant N, Deep R, Singh LK, De Sousa A, Nongpiur A, Subramanyam AA, Mohapatra D, Kar SK, Dhiman V, Kumar PS, Shreekantiah U, Bhandari SS, Ransing R, Ramasubramanian V, and Praharaj SK
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- Humans, Female, Male, Adult, Middle Aged, Reproducibility of Results, Cross-Sectional Studies, India, Psychiatric Status Rating Scales standards, Self Report standards, Factor Analysis, Statistical, Young Adult, Depressive Disorder, Major diagnosis, Psychometrics standards, Psychometrics instrumentation, Suicidal Ideation
- Abstract
Background: The Suicidal Narrative Inventory (SNI) is a 38-item self-report measure developed to assess elements of the suicidal narrative, a subacute, predominantly cognitive, presuicidal construct. Our objectives were to assess the factor structure, validity, and reliability of the SNI-38 among adults with major depressive disorder (MDD)., Methods: Using a cross-sectional design, we administered the Hindi version of the SNI along with other self-report measures to adults with MDD, recruited from 24 tertiary care hospitals across India. Confirmatory factor analysis (CFA) was performed to assess the factor structure of SNI-38. Reliability (internal consistency) was assessed using Cronbach's alpha (α). Convergent, discriminant, and criterion validity of the SNI-38 were tested by comparing it against other appropriate measures., Results: We collected usable responses from 654 Hindi-speaking participants (Mean age = 36.9 ± 11.9 years, 50.2% female). The eight-factor solution of the SNI showed good model fit indices (χ2[637] = 3345.58, p <.001, CFI =.98, and RMSEA =.08). Internal consistencies for the SNI subscale scores were good to excellent, α ranging from .73 to.92. While most subscales significantly converged with other measures, associations were comparatively weaker and inconsistent for the 'thwarted belongingness' and 'goal reengagement' subscales., Conclusion: Consistent with prior data, our study confirmed an eight-factor solution and demonstrated adequate psychometric properties for the Hindi version of the SNI-38 in our sample. These findings provide empirical support for the use of SNI to assess the suicidal narrative among Indian adults with MDD., Competing Interests: Declaration of Competing Interest The authors have no conflicts to declare with regard to the contents of this manuscript., (Copyright © 2024 Elsevier B.V. All rights reserved.)
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- 2024
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23. Editorial: Assessing and evaluating the psychosocial impact of the Covid-19 pandemic on anxiety and stress: perspectives from the Indian sub-continent.
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Arafat SMY, Kar SK, Singh R, and Kabir R
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Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
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- 2024
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24. Prevalence and Pattern of Morbidity, Febrile Illness, and Treatment-Seeking Behavior in a Tribal-Dominated District in Odisha, India: An Observational Study.
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Dwibedi B, Sahu P, Somalkar N, Kerketta AS, Khuntia HK, and Kar SK
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Background Tribal populations constitute a major portion of India's total population, especially in the eastern and northeastern states. We lack comprehensive information on the community burden of general morbidity and febrile illness in tribal population-dominated areas, which is quite essential for the microplanning of healthcare expenditure and implementation. This study aimed to provide evidence on the prevalence and pattern of general morbidity and febrile illness at the community level as well as the treatment-seeking behaviour in a tribal-dominated area. Methods The study was undertaken as an observational study in the community setting; looking into seasonal cross-sectional evidence on period prevalence (two weeks) of morbidity and qualitative/semiquantitative information on treatment-seeking behaviour of the selected community during 2012 and 2013. Result This study involved 5541, 5482, and 5638 individuals during the rainy season 2012, winter 2012-13, and rainy season 2013 seasons, respectively, from 25 tribal villages of Odisha, India. A period prevalence (two weeks) of overall morbidities was shown to be 27.28% and 28.9% during the rainy seasons of 2012 and 2013, respectively, of which 13% and 11.5%, respectively, were febrile, with low prevalence (6.44% overall morbidity and 1.81% febrile illness) in the winter of 2012-13. It indicated inadequacy in skills of the village-level health staff, monitoring of supplies/logistics, and population awareness for early reporting of fever to healthcare providers at the community level. Conclusion The evidence provided by the study would be helpful in making public health plans in tribal settings and also highlighted the opportunity to improve tribal health status through community awareness, especially in areas and populations with limited health access., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Dwibedi et al.)
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- 2024
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25. Psychiatric Co-Morbidities and Profile of Patients with Irritable Bowel Syndrome in Northern India.
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Saroj A, Tripathi A, Rungta S, and Kar SK
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Objectives: To study sociodemographic and clinical variables, including psychiatric co-morbidities, in patients with irritable bowel syndrome., Methods: A total of 158 patients attending a medical gastroenterology clinic in a tertiary care center in Northern India were screened, from whom 100 were selected for the study. Rome IV criteria were used to diagnose IBS, and the severity of symptoms was assessed by the Irritable Bowel Syndrome Symptom Severity Scale (IBS-SSS). Psychiatric co-morbidities were screened via clinical evaluation, and if present, a diagnosis was made as per DSM-5. The Depression, Anxiety, and Stress Scale-21 (DASS-21) and Somatic Symptom Scale-8 (SSS-8) were used to assess depression, anxiety, stress, and somatic symptoms., Result: The mean age of cases was 35.6 years' old, and the majority of cases (i.e., 38.0%) were between 18 and 29 years' old. Males comprised 62.0% of the sample and females 38.0%. Moderate IBS was present in 61.0% of the cases. Evaluation via DASS-21 revealed that 53.0% were in the moderate category of depression, 43.0% had moderate anxiety, and 36.0% had moderate stress. The somatic symptom scale revealed that 48.0% patients were in the high category. Psychiatric co-morbidities were present in 29.0% of cases. Depressive disorders were the most common psychiatric co-morbidity., Conclusions: Patients with IBS presenting to a tertiary care center in Northern India were primarily young males living in semi-urban areas who belonged to the Hindu religion, were married, and had a nuclear family. Patients with IBS commonly have associated psychiatric disorders; anxiety disorders and depression are most common.
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- 2024
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26. Coping and emotions of global higher education students to the Ukraine war worldwide.
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Raccanello D, Burro R, Aristovnik A, Ravšelj D, Umek L, Vicentini G, Hall R, Buizza C, Buzdar MA, Chatterjee S, Cucari N, Dobrowolska B, Ferreira-Oliveira AT, França T, Ghilardi A, Inasius F, Kar SK, Karampelas K, Kuzyshyn A, Lazăr F, Machin-Mastromatteo JD, Malliarou M, Marques BP, Méndez-Prado SM, Mollica C, Obadić A, Olaniyan OF, Rodrigues AS, Sbravati G, Vasić A, Zamfir AM, and Tomaževič N
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- Female, Humans, Ukraine, Coping Skills, Students, Emotions, Anxiety
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Trauma scientists have raised the alarm about the devastating consequences of the Ukraine war on mental health. We examined how higher education students-as indirect victims-coped with this conflict and how they emotionally reacted during 2022. We involved 2314 students from 16 countries through an online survey. A structural equation model indicated significant relations between war-related worry about military and macroeconomics domains and two coping strategies (opposition, support giving), in turn significantly linked with six emotions. The model was strongly invariant across gender, study field, and geographic area. The most frequent emotions were anger and anxiety, followed by two future-centred emotions (hopelessness and hope). Emotions were more frequent for females and students of the countries geographically close to the war region. Our findings call for evidence-based policy recommendations to be implemented by institutions to combat the negative short and long-term psychological sequelae of being witnesses of armed conflicts., (© 2024. The Author(s).)
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- 2024
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27. Activation of ERK/NF-kB Pathways Contributes to the Inflammatory Response in Epithelial Cells and Macrophages Following Manganese Exposure.
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Gandhi D, Bhandari S, Maity S, Mahapatra SK, and Rajasekaran S
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Different types of metals, including manganese (Mn), are constantly encountered in various environmental matrices due to natural and anthropogenic activities. They induce a sustained inflammatory response in various organs, which is considered to be an important priming event in the pathogenesis of several diseases. Mn-induced neuroinflammation and subsequent neurodegeneration are well recognized. However, emerging data suggest that occupationally and environmentally relevant levels may affect various organs, including the lungs. Therefore, the present study was carried out to investigate the effects of Mn (as Mn
2+ ) exposure on the inflammatory response in human normal bronchial (BEAS-2B) and adenocarcinoma alveolar basal (A549) epithelial cells, as well as in murine macrophages (J774). Mn2+ exposure significantly induced mRNA and protein expression of various pro-inflammatory mediators (cytokines and chemokines) in all cells compared to corresponding vehicle controls. Furthermore, Mn2+ treatment also led to increased phosphorylation of extracellular-signal-regulated kinase (ERK)1/2 and nuclear factor-kappa B (NF-kB) p65 in both epithelial cells and macrophages. As expected, cells treated with inhibitors of ERK1/2 (PD98059) and NF-kB p65 (IMD0354) effectively mitigated the expression of various pro-inflammatory mediators induced by Mn2+ , suggesting that ERK/NF-kB pathways have a critical role in the Mn2+ -induced inflammatory response. Further, in vivo studies are required to confirm these in vitro findings to support clinical translation., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)- Published
- 2024
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28. The Efficacy of Transcranial Magnetic Stimulation in the Treatment of Obsessive-Compulsive Disorder: An Umbrella Review of Meta-Analyses.
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Kar SK, Agrawal A, Silva-Dos-Santos A, Gupta Y, and Deng ZD
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- Humans, Prefrontal Cortex, Transcranial Magnetic Stimulation methods, Treatment Outcome, Meta-Analysis as Topic, Motor Cortex, Obsessive-Compulsive Disorder therapy
- Abstract
Background: Repetitive transcranial magnetic stimulation (rTMS) has been increasingly used for treating obsessive-compulsive disorder (OCD). Although several meta-analyses have explored its effectiveness and safety, there is no umbrella review specifically focused on rTMS for OCD. This umbrella review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and analyzed relevant meta-analyses on rTMS for OCD., Methods: Twenty-three articles were identified from PubMed, and after screening, 12 meta-analyses were included in the review. The studies analyzed in the meta-analyses ranged from 10 to 27, with total participants ranging from 282 to 791. The most commonly studied regions were the dorsolateral prefrontal cortex (DLPFC), supplementary motor area (SMA), and orbito-frontal cortex (OFC)., Result: The majority of the meta-analyses consistently supported the effectiveness of rTMS in reducing OCD symptoms when applied to the DLPFC and SMA. Encouraging results were also observed when targeting the medial prefrontal cortex (mPFC) and anterior cingulate cortex (ACC) through deep transcranial magnetic stimulation (dTMS). However, there was a high level of heterogeneity in the findings of nine out of 12 meta-analyses., Conclusion: In conclusion, existing evidence suggests that rTMS targeting the DLPFC and SMA consistently reduces OCD symptoms, but targeting the mPFC and ACC through dTMS shows variable results. However, the high heterogeneity in the study findings indicates a need for further research and standardization in the field.
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- 2024
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29. The spectrum of psychiatric manifestations in subacute sclerosing panencephalitis: A systematic review of published case reports and case series.
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Garg RK, Kar SK, Malhotra HS, Pandey S, Jain A, Rizvi I, Uniyal R, and Kumar N
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- Humans, Catatonia etiology, Catatonia diagnosis, Adolescent, Schizophrenia, Subacute Sclerosing Panencephalitis complications
- Abstract
Data related to psychiatric manifestations in subacute sclerosing panencephalitis (SSPE) is currently available only in the form of isolated case reports. In this systematic review, we evaluated the spectrum of psychiatric manifestations and their impact on the course and outcome of SSPE. Data were obtained from 4 databases (PubMed, Embase, Scopus, and Google Scholar), with the most recent search conducted on March 27, 2023. The PRISMA guidelines were followed, and the PROSPERO registration number for the protocol is CRD42023408227. SSPE was diagnosed using Dyken's criteria. Extracted data were recorded in an Excel spreadsheet. To evaluate the quality of the data, the Joanna Briggs Institute Critical Appraisal tool was employed. Our search resulted in 30 published reports of 32 patients. The mean age was 17.9 years. Schizophrenia, catatonia, and poorly characterized psychotic illnesses were the 3 most common psychiatric presentations that were seen in 63% (20/32) of cases. Catatonia was seen in 4 patients. Affective disorders, mania, and depression were reported among 22% (7/32) cases. In approximately 81% (26/32) cases, the course of SSPE was acute fulminant. Treatment with antipsychotic drugs had poor or no response. Out of 17 patients, who received antipsychotic drugs, 6 patients noted severe extrapyramidal adverse effects. SSPE often masquerades as a psychiatric disorder. Unresponsive psychiatric symptoms, early extrapyramidal signs, and progressive encephalopathy indicate SSPE.
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- 2024
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30. Electroconvulsive therapy: a last resort for lorazepam-resistant catatonia in patient with large arachnoid cyst.
- Author
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Parasher G, Yadav BK, and Kar SK
- Subjects
- Humans, Lorazepam therapeutic use, Combined Modality Therapy, Catatonia complications, Catatonia drug therapy, Electroconvulsive Therapy, Cysts
- Published
- 2024
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31. Accelerated Continuous Theta Burst Stimulation in the Treatment of Trichotillomania: A Comprehensive Case Study From Acute Intervention to Maintenance Phase.
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Chaudhary P and Kar SK
- Abstract
Competing Interests: The authors have no conflicts of interest or financial disclosures to report.
- Published
- 2024
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32. Transcranial Random Noise Stimulation in the Management of Cognitive and Behavioral Symptoms in a Suicidal Hanging Survivor: A Case Study.
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Kar SK, Prajapati R, Bharti V, Bhasin S, Chaudhary P, and Raje D
- Abstract
Competing Interests: The authors have no conflicts of interest or financial disclosures to report.
- Published
- 2024
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33. Prescribing Yoga for Mental Wellness: Need for a Nuanced Approach.
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Shoib S, Chandradasa M, Saleem SM, Das S, Naqvi SAA, and Kar SK
- Abstract
Competing Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
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34. Multi-modal intervention for neuropsychological symptoms following traumatic brain injury: A case report.
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Kar SK, Choudhary P, Raje D, and Bharti V
- Abstract
Competing Interests: There are no conflicts of interest.
- Published
- 2024
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35. The digital health dilemma: Exploring cyberchondria, well-being, and smartphone addiction in medical and non-medical undergraduates.
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Agrawal V, Khulbe Y, Singh A, and Kar SK
- Abstract
Background: The Internet is a popular source of health information, but too much research can cause anxiety (cyberchondria). Medical and non-medical personnel interpret information differently, leading to varying rates of cyberchondria. Smartphone addiction may also contribute to cyberchondria and impact mental health., Methods: The study was an epidemiological survey-based investigation with a cross-sectional design involving undergraduate students (aged 18 years or older) from Indian universities or colleges. The study utilized the Cyberchondria Severity Scale-Short Form (CSS-12), WHO-5 well-being index, and Smartphone Addiction Scale-Short Version (SAS-SV)., Results: A total of 1033 participants (53.1% females and 46.4% males) were recruited in the survey. Of the participants, 58.5% were pursuing medical or paramedical courses, while the remaining 41.5% belonged to the non-medical group. High-severity cyberchondria was present in about 4.4% of the students. The medical cohort demonstrated a significantly lower cumulative CSS in comparison to the non-medical cohort (t = - 3.90; P < 0.01). Smartphone addiction was observed in 57.2% of individuals in the medical group and 55.9% of individuals in the non-medical group ( P = 0.68). Medical students had a significantly lower mean well-being score compared to non-medical students (58.4 vs. 59.6; P < 0.01). There was a positive correlation between cyberchondria severity and smartphone addiction, which was consistent across both groups., Conclusion: Medical students have less cyberchondria than non-medical students. Cyberchondria severity is linked to smartphone addiction. Non-medical students with cyberchondria have higher subjective well-being., Competing Interests: There are no conflicts of interest., (Copyright: © 2024 Indian Journal of Psychiatry.)
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- 2024
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36. Breaking the Binary: Unveiling Gender-specific Norms in Internet Addiction.
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Kar SK and Arafat SY
- Abstract
Competing Interests: The authors declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article.
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- 2024
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37. Gender and Geographical Distribution of Editorial Board Members of Three Leading Suicide Journals.
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Yasir Arafat SM, Kar SK, and Amin R
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- Humans, Female, Developing Countries, Africa, Periodicals as Topic
- Abstract
Background: Despite the recent progress of women in academia, there is an underrepresentation of female editors in academic journals. Additionally, although suicide affects more low- and middle-income countries (LMICs) than high-income countries, little is known about the geographical distribution of editors in suicidology journals. Aims: We aimed to determine the gender and geographical distribution of the editorial board members (EBMs) of leading suicide journals. Method: Data were collected between November 27 and 29, 2022. We purposively selected suicidology journals, searched the journal websites, and extracted data on the gender and affiliated country of the EBM to identify the continent and income category of the country. Results: The proportion of female EBMs was 32.37% with better representation in senior positions. Only six positions (3.47%) were occupied by four individuals affiliated with LMIC backgrounds. The highest number of EBMs was located in North America (58.38%) while one member was from Africa. Limitations: Only three purposively selected journals were scrutinized. Conclusion: This study reveals that approximately one third of the editorial positions were occupied by women and less than 4% of editors were from LMICs, where suicide represents a significant burden.
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- 2024
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38. Transcriptomic analysis of intestinal organoids, derived from pigs divergent in feed efficiency, and their response to Escherichia coli.
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Madsen O, Rikkers RSC, Wells JM, Bergsma R, Kar SK, Taverne N, Taverne-Thiele AJ, Ellen ED, and Woelders H
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- Animals, Swine, Immunity, Innate, Gene Expression Profiling, Organoids, Escherichia coli genetics, Intestines
- Abstract
Background: There is increasing interest in using intestinal organoids to study complex traits like feed efficiency (FE) and host-microbe interactions. The aim of this study was to investigate differences in the molecular phenotype of organoids derived from pigs divergent for FE as well as their responses to challenge with adherent and invasive Escherichia coli (E. coli)., Results: Colon and ileum tissue from low and high FE pigs was used to generate 3D organoids and two dimensional (2D) monolayers of organoid cells for E. coli challenge. Genome-wide gene expression was used to investigate molecular differences between pigs that were phenotypically divergent for FE and to study the difference in gene expression after challenge with E. coli. We showed, (1) minor differences in gene expression of colon organoids from pigs with low and high FE phenotypes, (2) that an E. coli challenge results in a strong innate immune gene response in both colon and ileum organoids, (3) that the immune response seems to be less pronounced in the colon organoids of high FE pigs and (4) a slightly stronger immune response was observed in ileum than in colon organoids., Conclusions: These findings demonstrate the potential for using organoids to gain insights into complex biological mechanisms such as FE., (© 2024. The Author(s).)
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- 2024
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39. Relevance of extended sessions and maintenance transcranial direct current stimulation in management of obsessive-compulsive disorder: A case study.
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Joshi M and Kar SK
- Subjects
- Humans, Transcranial Magnetic Stimulation, Treatment Outcome, Transcranial Direct Current Stimulation, Obsessive-Compulsive Disorder therapy
- Abstract
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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- 2024
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40. A case report of obsessive-compulsive disorder in craniopharyngioma: Moderating effect of tumor.
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Saroj A, Kar SK, and Jaiswal AK
- Abstract
Competing Interests: There are no conflicts of interest.
- Published
- 2024
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41. Investigating the impact of adjunctive priming repetitive transcranial magnetic stimulation in late-life depression: a pilot single-blind randomized control study.
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Vidya KL, Srivastava S, Singh B, and Kar SK
- Subjects
- Adult, Humans, Aged, Single-Blind Method, Treatment Outcome, Antidepressive Agents, Prefrontal Cortex, Double-Blind Method, Transcranial Magnetic Stimulation methods, Depression therapy
- Abstract
Background: Conventional treatment methods have limited effectiveness in addressing late-life depression (LLD) that does not respond well. While a new approach called priming repetitive transcranial magnetic stimulation (rTMS) has shown promise in treating depression in adults, its effectiveness in LLD has not been explored. This study aimed to investigate the impact of priming rTMS on LLD., Methods: This study investigated the effectiveness of priming rTMS in 31 patients with LLD who did not improve after an adequate trial of antidepressants. Patients were randomly assigned to receive either active priming rTMS or sham priming rTMS. Active priming rTMS was delivered over the right dorsolateral prefrontal cortex for 10 sessions, lasting 31 minutes each, over a period of 2 weeks., Results: The group receiving active priming rTMS demonstrated greater improvements in scores on the Hamilton Rating Scale for Depression ( p < 0.037; partial η
2 0.141) and the Geriatric Depression Rating Scale ( p < 0.045; partial η2 0.131) compared to the sham priming group, with a mild effect size. At the end of the second and fourth weeks, the priming rTMS group achieved a response rate of 50%, while the sham priming group had response rates of 26.7% and 6.7%, respectively. No adverse effects requiring intervention were observed., Conclusion: Priming rTMS is well-tolerated for the treatment of LLD and not only reduces the severity of depression but also maintains the achieved response over time.- Published
- 2024
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42. Electroconvulsive therapy in South Asia: Past, present, and future.
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Menon V, Kar SK, Gupta S, Baminiwatta A, Mustafa AB, Sharma P, Abhijita B, and Arafat SMY
- Subjects
- Humans, Surveys and Questionnaires, India, Asia, Southern, Electroconvulsive Therapy methods, Schizophrenia therapy
- Abstract
The practice of electroconvulsive therapy (ECT) varies both between and within countries. We aimed to review historical and current trends in ECT practices, perceptions, and legislations in South Asia, a region with a high burden of mental illness and suicide. We searched MEDLINE (PubMed) and Google Scholar databases for relevant literature on ECT from each country. Additionally, a team of country-specific investigators performed supplemental searches and contacted key country contacts for relevant information. Relevant data were abstracted under the following headings: ECT practices, perceptions, and legislations. Knowledge gaps and research priorities were synthesized. Modified bitemporal ECT, delivered using brief pulse devices, was most commonly offered across institutions. Schizophrenia, not affective illness, was the most common indication. Electroencephalographic monitoring of seizures was rarely practiced. Thiopentone or propofol was preferred for anesthetic induction, while the favored muscle relaxant was succinylcholine. In India and Sri Lanka, perceptions about ECT were largely favorable; not so in Pakistan and Nepal. Only India and Pakistan had laws that governed any aspect of ECT practice; ECT practice guidelines were available only in India. There is a lack of research on efficacy, ECT in special populations, continuation ECT practices, and interventions to improve ECT-related perceptions. Most regional institutions offered modified brief-pulse ECT, and schizophrenia was the most common indication. Knowledge of and attitude towards ECT varied between countries. There is a need to develop a regional ECT consortium to facilitate uniform training, advocacy efforts, and the development of regional practice guidelines., Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest relevant to the contents of the manuscript., (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Published
- 2024
- Full Text
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43. Dietary strategies can increase cloacal endotoxin levels and modulate the resident microbiota in broiler chickens.
- Author
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Perricone V, Schokker D, Bossers A, de Bruijn A, Kar SK, Te Pas MFW, Rebel JMJ, Wouters IM, and de Jong IC
- Subjects
- Humans, Animals, Male, Endotoxins, Diet veterinary, Dietary Supplements analysis, Diet, Protein-Restricted veterinary, Fatty Acids, Inulin, Animal Feed analysis, Animal Nutritional Physiological Phenomena, Chickens microbiology, Microbiota
- Abstract
Endotoxins released from poultry feces have been associated with impaired human health. Because endotoxins are released from gram-negative intestinal bacteria, it was hypothesized that dietary strategies may influence endotoxin excretion via modulation of gut microbiota. We therefore tested dietary strategies that could potentially reduce cloacal endotoxin levels in broiler chickens. One-day-old male Ross 308 (N = 1,344) broilers were housed in 48 pens (N = 8 pens/treatment, 28 chickens per pen) and fed 1 of 6 diets for 35 days (d) in a 3-phase feeding program: a basic diet (CON) that served as the reference diet, or basic diet supplemented with butyrate (BUT), inulin (INU), medium-chain fatty acids (MCFA) or Original XPC™LS (XPC), or a high-fiber-low-protein (HF-LP) diet. A significant (P < 0.05) increase in cloacal endotoxin concentration at d 35 was observed in BUT as compared to CON. Analysis of cloacal microbiota showed a trend (P < 0.07) for a higher gram-negative/gram-positive ratio and for a higher relative abundance of gram-negative bacteria at d 35 (P ≤ 0.08) in BUT and HF-LP as compared to CON. A significant (P < 0.05) increase in average daily gain (ADG) and improved feed conversion ratio (P < 0.05) were observed in MCFA during the grower phase (d 14-28), and a significant (P < 0.05) increase in average daily feed intake (ADFI) was observed in MCFA during d 0 to 28. Broilers fed HF-LP had a significantly (P < 0.05) higher FCR and lower ADG throughout the rearing period. No treatment effects were found on footpad dermatitis, but BUT had worst hock burn scores at d 35 (P < 0.01) and MCFA had worst cleanliness scores at d 21 but not at d 35 (treatment*age P < 0.05), while INU had better cleanliness as compared to CON at d 35 (P < 0.05). In conclusion, especially BUT and HF-LP were able to modulate resident microbiota and BUT also increased cloacal endotoxin levels, which was opposite to our hypothesis. The present study indicates that cloacal endotoxin release can be affected by the diet but further study is needed to find dietary treatments that can reduce cloacal endotoxin release., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
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44. Factor structure, reliability, and validity of the revised Suicide Crisis Inventory in major depression: A multicentric Indian study.
- Author
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Menon V, Balasubramanian I, Rogers ML, Grover S, Lakdawala B, Ranjan R, Sarkhel S, Nebhinani N, Kallivayalil RA, Raghavan V, Mishra KK, Aneja J, Abhivant N, Deep R, Singh LK, De Sousa A, Nongpiur A, Subramanyam AA, Mohapatra D, Kar SK, Dhiman V, Kumar PNS, Shreekantiah U, Bhandari SS, Ransing R, Ramasubramanian V, and Praharaj SK
- Subjects
- Adult, Humans, Female, Middle Aged, Male, Depression, Reproducibility of Results, Cross-Sectional Studies, Surveys and Questionnaires, Psychometrics, Depressive Disorder, Major diagnosis, Suicide
- Abstract
Background: The revised Suicide Crisis Inventory (SCI)-2 is a self-report measure to assess the suicide crisis syndrome (SCS). We aimed to assess the factor structure, reliability, and validity of SCI-2 among adults with major depression., Methods: Using a cross-sectional design, between November 2021 and August 2022, the Hindi SCI-2, along with other self-report measures, was administered to Indian adult respondents clinically diagnosed with major depression across 24 centers in India. Confirmatory factor analysis was carried out to test the factor structure of SCI-2. Additionally, convergent, discriminant, and criterion validity were tested using bivariate or biserial correlations, as appropriate., Results: We obtained responses from 654 participants (Mean age = 36.9 ± 11.9 years, 50.2 % female). The SCI-2 fit both a one-factor (χ
2 [1769] = 14,150.74, p < .001, CFI = 0.98, RMSEA = 0.10), and five-factor solution (χ2 [1759] = 13,130.83, p < .001,CFI = 0.98, RMSEA = 0.10) with the five-factor solution providing a significantly better fit. Internal consistencies of the SCI-2 total and subscale scores ranged from good to excellent. Most subscales significantly converged with each other and with other relevant measures although these associations were weak for thwarted belongingness and goal reengagement subscales. Small to moderate associations were noted in support of discriminant and criterion validity., Limitations: We could not assess the predictive validity of SCI-2 for suicidal behaviors., Conclusion: Consistent with prior data, the Hindi SCI-2 fit a five-factor solution and showed good psychometric properties. These findings support the use of SCI-2 to assess SCS among Indian adults with major depression., Competing Interests: Declaration of competing interest None. The authors have no conflicts to declare with regard to the contents of this manuscript., (Copyright © 2023 Elsevier B.V. All rights reserved.)- Published
- 2024
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45. Out-of-pocket and catastrophic health expenditure among patients of sexually transmitted infections at a tertiary care center: A cross-sectional study.
- Author
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Suvirya S, Tripathi S, Shukla M, Verma P, Kar SK, and Sachan S
- Abstract
Context: Economic burden imposed by sexually transmitted infections (STIs) is substantial in low-middle-income countries like India, in spite of the fact that national programs for controlling STIs are operational., Aims: The aim of this study was to estimate the out-of-pocket expenses and catastrophic health expenditure (CHE) incurred by patients of STIs and analyze expenditure pattern in relation to various clinical and sociodemographic characteristics., Settings and Design: This was a hospital-based cross-sectional study among patients attending Suraksha Clinic., Subject and Methods: The study was conducted among patients aged ≥18 years. Data were collected regarding various direct and indirect expenses incurred, after adjusting any reimbursement or waive off. Total costs exceeding 10% of annual household income were considered catastrophic. Stepwise regression analysis was used to analyze predictors, and P < 0.05 was considered statistically significant., Results: Out of 157 patients, most were suffering from herpetic ulcers (27.4%). The median and interquartile range (IQR) for total OOPE of STI management was ₹1950 (IQR 1035-5725). Direct expenditure constituted major expenses with a median of ₹1850 (IQR 787.50-5385.0). The cost of STI management was catastrophic in 15.2% of cases. Lower socioeconomic status, longer traveling distance, overnight stay as a part of seeking treatment at Suraksha Clinic, previous history of other than allopathic treatment, and quack consultation were found to be independent predictors of CHE., Conclusions: Despite free diagnostic and treatment services to STI patients under the National AIDS Control Programme, many incurred considerable costs and catastrophic expenditure toward STI care. Better outreach of health services is required to maximize STI control and lower financial morbidity., Competing Interests: There are no conflicts of interest., (Copyright: © 2024 Indian Journal of Sexually Transmitted Diseases and AIDS.)
- Published
- 2024
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46. Perception of self and it's effect on anxiety and depression among adolescent girls.
- Author
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Singh S, Singh SK, Kar SK, Manar MK, and Gupta A
- Abstract
Introduction: Perception of self is a primary source for fostering negative influences in an adolescent's life. This stage may increase the risk for various psychiatric disorders., Objectives: To assess the grade of anxiety and depression and to study their relationship with various factors of perception of self, among adolescent girls., Materials and Methods: School-going adolescent girls from two government schools at Lucknow were selected using a two-stage random sampling technique. A total of 200 participants were personally interviewed for their socio-demographic details, perception of self, and screened for symptoms of anxiety and depression., Results: Of the 200 school-going adolescent girls who participated in the study, 63.5% screened positive for the symptoms of anxiety and 73.0% for symptoms of depression. A total of 11.5% and 3.5% school-going adolescent girls had severe anxiety and major depression; severe severity, respectively. Both anxiety and depression among school-going adolescent girls were significantly associated with factors like possessing qualities that they are ashamed of ( P = 0.005 and 0.011), body image dissatisfaction ( P = 0.004 and 0.017), and getting suicidal thoughts in times of difficulties ( P < 0.001)., Conclusion: A fair number of adolescent girls had severe anxiety and major depression of severe severity. Therefore, adolescents must be screened for mental disorders from time to time and those at high risk must be identified., Competing Interests: There are no conflicts of interest., (Copyright: © 2024 Journal of Family Medicine and Primary Care.)
- Published
- 2024
- Full Text
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47. Effects of early postnatal gastric and colonic microbiota transplantation on piglet gut health.
- Author
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Larsen C, Offersen SM, Brunse A, Pirolo M, Kar SK, Guadabassi L, and Thymann T
- Abstract
Background: Diarrhea is a major cause of reduced growth and mortality in piglets during the suckling and weaning periods and poses a major threat to the global pig industry. Diarrhea and gut dysbiosis may in part be prevented via improved early postnatal microbial colonization of the gut. To secure better postnatal gut colonization, we hypothesized that transplantation of colonic or gastric content from healthy donors to newborn recipients would prevent diarrhea in the recipients in the post-weaning period. Our objective was to examine the impact of transplanting colonic or gastric content on health and growth parameters and paraclinical parameters in recipient single-housed piglets exposed to a weaning transition and challenged with enterotoxigenic Escherichia coli (ETEC)., Methods: Seventy-two 1-day-old piglets were randomized to four groups: colonic microbiota transplantation (CMT, n = 18), colonic content filtrate transplantation (CcFT, n = 18), gastric microbiota transplantation (GMT, n = 18), or saline (CON, n = 18). Inoculations were given on d 2 and 3 of life, and all piglets were milk-fed until weaning (d 20) and shortly after challenged with ETEC (d 24). We assessed growth, diarrhea prevalence, ETEC concentration, organ weight, blood parameters, small intestinal morphology and histology, gut mucosal function, and microbiota composition and diversity., Results: Episodes of diarrhea were seen in all groups during both the milk- and the solid-feeding phase, possibly due to stress associated with single housing. However, CcFT showed lower diarrhea prevalence on d 27, 28, and 29 compared to CON (all P < 0.05). CcFT also showed a lower ETEC prevalence on d 27 (P < 0.05). CMT showed a higher alpha diversity and a difference in beta diversity compared to CON (P < 0.05). Growth and other paraclinical endpoints were similar across groups., Conclusion: In conclusion, only CcFT reduced ETEC-related post-weaning diarrhea. However, the protective effect was marginal, suggesting that higher doses, more effective modalities of administration, longer treatment periods, and better donor quality should be explored by future research to optimize the protective effects of transplantation., (© 2023. The Author(s).)
- Published
- 2023
- Full Text
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48. An Adolescent Girl With Systematic Lupus Erythematosus Presenting With Treatment Suprarefractory Catatonia: Moderating Role of Steroid and the Response to ECT.
- Author
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Kar SK, Kumar P, Rohatgi K, and Dwivedi S
- Subjects
- Female, Adolescent, Humans, Treatment Outcome, Steroids, Catatonia complications, Catatonia therapy, Electroconvulsive Therapy, Lupus Erythematosus, Systemic therapy
- Abstract
Competing Interests: The authors have no conflicts of interest or financial disclosures to report.
- Published
- 2023
- Full Text
- View/download PDF
49. Borderline personality disorder and cognition: unraveling the enigma one piece at a time!
- Author
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Kar SK and Chak S
- Subjects
- Humans, Impulsive Behavior, Psychiatric Status Rating Scales, Cognition, Borderline Personality Disorder
- Published
- 2023
- Full Text
- View/download PDF
50. Anomic suicides on rise during recently emerging crises: revisiting Durkheim's model.
- Author
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Kar SK and Singh S
- Subjects
- Humans, Male, Female, Adolescent, Social Support, Suicidal Ideation, Suicide psychology
- Abstract
Suicide is a global public health issue, with behavior differing across genders, age groups, places, and sociopolitical settings. Emile Durkheim characterized anomic suicide as occurring when social standards fail, resulting in purposelessness and directionlessness. Young people who are experiencing social issues are in danger, even if they do not voice suicidal ideas. Prevention interventions should target these people by strengthening resilience, minimizing social dysregulation stress, and fostering the development of life skills, coping resources, and social support. Anomic suicide has important psychological and societal implications, emphasizing the importance of fostering social cohesion and assisting persons experiencing purposelessness or a lack of direction in life.
- Published
- 2023
- Full Text
- View/download PDF
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