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1. Manipulating the EphB4-ephrinB2 axis to reduce metastasis in HNSCC

Author

Abdelazeem, Khalid N. M., Nguyen, Diemmy, Corbo, Sophia, Darragh, Laurel B., Matsumoto, Mike W., Van Court, Benjamin, Neupert, Brooke, Yu, Justin, Olimpo, Nicholas A., Osborne, Douglas Grant, Gadwa, Jacob, Ross, Richard B., Nguyen, Alexander, Bhatia, Shilpa, Kapoor, Mohit, Friedman, Rachel S., Jacobelli, Jordan, Saviola, Anthony J., Knitz, Michael W., Pasquale, Elena B., and Karam, Sana D.

Published
2024
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2. Author Correction: Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors

Author

Darragh, Laurel B., Gadwa, Jacob, Pham, Tiffany T., Van Court, Benjamin, Neupert, Brooke, Olimpo, Nicholas A., Nguyen, Khoa, Nguyen, Diemmy, Knitz, Michael W., Hoen, Maureen, Corbo, Sophia, Joshi, Molishree, Zhuang, Yonghua, Amann, Maria, Wang, Xiao-Jing, Dow, Steven, Kedl, Ross M., Samedi, Von, Boss, Mary-Keara, and Karam, Sana D.

Published
2024
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4. Updates on radiotherapy-immunotherapy combinations: Proceedings of 6th annual ImmunoRad conference.

Author

Gregucci, Fabiana, Spada, Sheila, Barcellos-Hoff, Mary Helen, Bhardwaj, Nina, Chan Wah Hak, Charleen, Fiorentino, Alba, Guha, Chandan, Guzman, Monica L, Harrington, Kevin, Herrera, Fernanda G, Honeychurch, Jamie, Hong, Theodore, Iturri, Lorea, Jaffee, Elisabeth, Karam, Sana D, Knott, Simon RV, Koumenis, Constantinos, Lyden, David, Marciscano, Ariel E, Melcher, Alan, Mondini, Michele, Mondino, Anna, Morris, Zachary S, Pitroda, Sean, Quezada, Sergio A, Santambrogio, Laura, Shiao, Stephen, Stagg, John, Telarovic, Irma, Timmerman, Robert, Vozenin, Marie-Catherine, Weichselbaum, Ralph, Welsh, James, Wilkins, Anna, Xu, Chris, Zappasodi, Roberta, Zou, Weiping, Bobard, Alexandre, Demaria, Sandra, Galluzzi, Lorenzo, Deutsch, Eric, and Formenti, Silvia C

Subjects
Humans, Neoplasms, Immunotherapy, Combined Modality Therapy, FLASH radiotherapy, dose and fractionation, immune checkpoint inhibitors, immunomodulators, lymph node sparing, tumor-associated macrophages, Immunization, Cancer, Vaccine Related, Immunology, Oncology and Carcinogenesis
Abstract

Focal radiation therapy (RT) has attracted considerable attention as a combinatorial partner for immunotherapy (IT), largely reflecting a well-defined, predictable safety profile and at least some potential for immunostimulation. However, only a few RT-IT combinations have been tested successfully in patients with cancer, highlighting the urgent need for an improved understanding of the interaction between RT and IT in both preclinical and clinical scenarios. Every year since 2016, ImmunoRad gathers experts working at the interface between RT and IT to provide a forum for education and discussion, with the ultimate goal of fostering progress in the field at both preclinical and clinical levels. Here, we summarize the key concepts and findings presented at the Sixth Annual ImmunoRad conference.

Published
2023

9. Sensory nerve release of CGRP increases tumor growth in HNSCC by suppressing TILs

Author

Darragh, Laurel B., Nguyen, Alexander, Pham, Tiffany T., Idlett-Ali, Shaquia, Knitz, Michael W., Gadwa, Jacob, Bukkapatnam, Sanjana, Corbo, Sophia, Olimpo, Nicholas A., Nguyen, Diemmy, Van Court, Benjamin, Neupert, Brooke, Yu, Justin, Ross, Richard B., Corbisiero, Michaele, Abdelazeem, Khalid N.M., Maroney, Sean P., Galindo, David C., Mukdad, Laith, Saviola, Anthony, Joshi, Molishree, White, Ruth, Alhiyari, Yazeed, Samedi, Von, Van Bokhoven, Adrie, St. John, Maie, and Karam, Sana D.

Published
2024
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10. Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors

Author

Darragh, Laurel B, Gadwa, Jacob, Pham, Tiffany T, Van Court, Benjamin, Neupert, Brooke, Olimpo, Nicholas A, Nguyen, Khoa, Nguyen, Diemmy, Knitz, Michael W, Hoen, Maureen, Corbo, Sophia, Joshi, Molishree, Zhuang, Yonghua, Amann, Maria, Wang, Xiao-Jing, Dow, Steven, Kedl, Ross M, Samedi, Von, Boss, Mary-Keara, and Karam, Sana D

Subjects
Immunization, Rare Diseases, Vaccine Related, Cancer, Dental/Oral and Craniofacial Disease, Humans, Head and Neck Neoplasms, Combined Modality Therapy, Sentinel Lymph Node, Lymph Node Excision, Immunotherapy
Abstract

In the setting of conventional radiation therapy, even when combined with immunotherapy, head and neck cancer often recurs locally and regionally. Elective nodal irradiation (ENI) is commonly employed to decrease regional recurrence. Given our developing understanding that immune cells are radio-sensitive, and that T cell priming occurs in the draining lymph nodes (DLNs), we hypothesize that radiation therapy directed at the primary tumor only will increase the effectiveness of immunotherapies. We find that ENI increases local, distant, and metastatic tumor growth. Multi-compartmental analysis of the primary/distant tumor, the DLNs, and the blood shows that ENI decreases the immune response systemically. Additionally, we find that ENI decreases antigen-specific T cells and epitope spreading. Treating the primary tumor with radiation and immunotherapy, however, fails to reduce regional recurrence, but this is reversed by either concurrent sentinel lymph node resection or irradiation. Our data support using lymphatic sparing radiation therapy for head and neck cancer.

Published
2022

12. Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma

Author

Strait, Alexander A, Woolaver, Rachel A, Hall, Spencer C, Young, Christian D, Karam, Sana D, Jimeno, Antonio, Lan, Yan, Raben, David, Wang, Jing H, and Wang, Xiao-Jing

Subjects
Cancer, Animals, B7-H1 Antigen, Carcinoma, Squamous Cell, Female, Mice, Mice, Inbred C57BL, Transforming Growth Factor beta, Tumor Microenvironment
Abstract

Transforming growth factor beta (TGFβ) and programmed death-ligand 1 (PD-L1) are often overproduced in refractory squamous cell carcinoma (SCC). We examined spatial patterns of PD-L1+ cells in mouse and human SCCs and found that PD-L1 was primarily expressed on infiltrating leukocytes. Although combined TGFβ and PD-L1 blockade are undergoing cancer clinical trials, there are no predictive markers for therapeutic responders. To address this, we used both a small molecule TGFβ inhibitor in combination with anti-PD-L1 and a bifunctional fusion protein targeting both TGFβ and PD-L1 to treat mouse SCCs and found TGFβ inhibition enhanced PD-L1 blockade-induced tumor eradication in multiple tumor models. Furthermore, we identified distinct cell populations of responders and non-responders to bintrafusp alfa, with responders showing a shift toward a more immune-permissive microenvironment. The cellular and molecular signatures of responders versus non-responders to combined TGFβ and PD-L1 blockade provide important insights into future personalized immunotherapy in SCC.

Published
2021

15. PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models

Author

Hernandez, Ariel L, Young, Christian D, Bian, Li, Weigel, Kelsey, Nolan, Kyle, Frederick, Barbara, Han, Gangwen, He, Guanting, Trahan, G Devon, Rudolph, Michael C, Jones, Kenneth L, Oweida, Ayman J, Karam, Sana D, Raben, David, and Wang, Xiao-Jing

Subjects
Cancer, Human Genome, Genetics, Rare Diseases, Dental/Oral and Craniofacial Disease, Animals, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Cell Proliferation, Cetuximab, Disease Models, Animal, Female, Head and Neck Neoplasms, Humans, Mice, Mice, Nude, Phthalazines, Piperazines, Poly(ADP-ribose) Polymerase Inhibitors, Prognosis, Smad4 Protein, Squamous Cell Carcinoma of Head and Neck, Tumor Cells, Cultured, Xenograft Model Antitumor Assays, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeSMAD4 loss causes genomic instability and the initiation/progression of head and neck squamous cell carcinoma (HNSCC). Here, we study whether SMAD4 loss sensitizes HNSCCs to olaparib (PARP inhibitor) in combination with radiotherapy (RT).Experimental designWe analyzed HNSCC The Cancer Genome Atlas data for SMAD4 expression in association with FANC/BRCA family gene expression. Human HNSCC cell lines were screened for sensitivity to olaparib. Isogenic HNSCC cell lines were generated to restore or reduce SMAD4 expression and treated with olaparib, radiation, or the combination. HNSCC pretreatment specimens from a phase I trial investigating olaparib were analyzed.ResultsSMAD4 levels correlated with levels of FANC/BRCA genes in HNSCC. HNSCC cell lines with SMAD4 homozygous deletion were sensitive to olaparib. In vivo, olaparib or RT monotherapy reduced tumor volumes in SMAD4-mutant but not SMAD4-positive tumors. Olaparib with RT dual therapy sustained tumor volume reduction in SMAD4-deficient (mutant or knockdown) xenografts, which exhibited increased DNA damage and cell death compared with vehicle-treated tumors. In vitro, olaparib alone or in combination with radiation caused lower clonogenic survival, more DNA damage-associated cell death, and less proliferation in SMAD4-deficient cells than in SMAD4-positive (endogenous SMAD4 or transduced SMAD4) cells. Applicable to clinic, 5 out of 6 SMAD4-negative HNSCCs and 4 out of 8 SMAD4-positive HNSCCs responded to a standard treatment plus olaparib in a phase I clinical trial, and SMAD4 protein levels inversely correlated with DNA damage.ConclusionsSMAD4 levels are causal in determining sensitivity to PARP inhibition in combination with RT in HNSCCs.

Published
2020

16. Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis

Author

Piper, Miles, Hoen, Maureen, Darragh, Laurel B., Knitz, Michael W., Nguyen, Diemmy, Gadwa, Jacob, Durini, Greta, Karakoc, Idil, Grier, Abby, Neupert, Brooke, Van Court, Benjamin, Abdelazeem, Khalid N.M., Yu, Justin, Olimpo, Nicholas A., Corbo, Sophia, Ross, Richard Blake, Pham, Tiffany T., Joshi, Molishree, Kedl, Ross M., Saviola, Anthony J., Amann, Maria, Umaña, Pablo, Codarri Deak, Laura, Klein, Christian, D’Alessandro, Angelo, and Karam, Sana D.

Published
2023
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17. A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC

Author

Darragh, Laurel B., Knitz, Michael M., Hu, Junxiao, Clambey, Eric T., Backus, Jennifer, Dumit, Andrew, Samedi, Von, Bubak, Andrew, Greene, Casey, Waxweiler, Timothy, Mehrotra, Sanjana, Bhatia, Shilpa, Gadwa, Jacob, Bickett, Thomas, Piper, Miles, Fakhoury, Kareem, Liu, Arthur, Petit, Joshua, Bowles, Daniel, Thaker, Ashesh, Atiyeh, Kimberly, Goddard, Julie, Hoyer, Robert, Van Bokhoven, Adrie, Jordan, Kimberly, Jimeno, Antonio, D’Alessandro, Angelo, Raben, David, McDermott, Jessica D., and Karam, Sana D.

Published
2022
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18. Inter‐ and intra‐tumor heterogeneity of SMAD4 loss in head and neck squamous cell carcinomas

Author

Hernandez, Ariel L, Wang, Ying, Somerset, Hilary L, Keysar, Stephen B, Aisner, Dara L, Marshall, Carrie, Bowles, Daniel W, Karam, Sana D, Raben, David, Jimeno, Antonio, Varella‐Garcia, Marileila, and Wang, Xiao‐Jing

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Orphan Drug, Cancer, Human Genome, Rare Diseases, Genetic Testing, Genetics, Dental/Oral and Craniofacial Disease, Good Health and Well Being, Animals, Carcinoma, Squamous Cell, Chromosome Aberrations, Gene Deletion, Gene Expression Regulation, Neoplastic, Genetic Heterogeneity, Head and Neck Neoplasms, Humans, In Situ Hybridization, Fluorescence, Mice, Smad4 Protein, Tumor Cells, Cultured, Xenograft Model Antitumor Assays, Aneuploidy, Chromosomal SMAD4 deletion, genomic instability, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Reports regarding the frequency of SMAD4 loss in human head and neck squamous cell carcinoma (HNSCC) vary significantly. We have shown that SMAD4 deletion contributes to HNSCC initiation and progression. Therefore, accurately detecting genetic SMAD4 loss is critical to determine prognosis and therapeutic interventions in personalized medicine. We developed a SMAD4 fluorescence in situ hybridization (FISH) assay to identify chromosomal SMAD4 loss at the single cell level of primary HNSCC specimens and patient derived xenograft (PDX) tumors derived from HNSCCs. SMAD4 heterozygous loss was detected in 35% of primary HNSCCs and 41.3% of PDX tumors. Additionally, 4.3% of PDX tumors had SMAD4 homozygous loss. These frequencies of SMAD4 loss were similar to those in The Cancer Genome Atlas (TCGA). However, we identified significant heterogeneities of SMAD4 loss (partial or complete) among cells within each tumor. We also found that aneuploidy (monosomy and polysomy) contributed greatly to how to define chromosomal SMAD4 deletion. Furthermore, in cultured PDX tumors, SMAD4 mutant cells outcompeted SMAD4 wildtype cells, resulting in establishing homogenous SMAD4 mutant HNSCC cell lines with partial or complete genomic SMAD4 loss, suggesting a survival advantage of SMAD4 mutant cells. Taken together, our study reveals inter- and intra-tumor heterogeneities of SMAD4 chromosomal loss in HNSCCs. Further, SMAD4 FISH assay provides a platform for future clinical diagnosis of SMAD4 chromosomal loss that potentially serves as a molecular marker for prognosis and therapeutic intervention in cancer patients.

Published
2019

21. EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment

Author

Bhatia, Shilpa, Nguyen, Diemmy, Darragh, Laurel B., Van Court, Benjamin, Sharma, Jaspreet, Knitz, Michael W., Piper, Miles, Bukkapatnam, Sanjana, Gadwa, Jacob, Bickett, Thomas E., Bhuvane, Shiv, Corbo, Sophia, Wu, Brian, Lee, Yichien, Fujita, Mayumi, Joshi, Molishree, Heasley, Lynn E., Ferris, Robert L., Rodriguez, Olga, Albanese, Christopher, Kapoor, Mohit, Pasquale, Elena B., and Karam, Sana D.

Published
2022
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25. Figure S1-S7 from PPARα Agonism Enhances Immune Response to Radiotherapy While Dietary Oleic Acid Results in Counteraction

Author

Ross, Richard Blake, primary, Gadwa, Jacob, primary, Yu, Justin, primary, Darragh, Laurel B., primary, Knitz, Michael W., primary, Nguyen, Diemmy, primary, Olimpo, Nicholas A., primary, Abdelazeem, Khalid N.M., primary, Nguyen, Alexander, primary, Corbo, Sophia, primary, Van Court, Benjamin, primary, Beynor, Jessica, primary, Neupert, Brooke, primary, Saviola, Anthony J., primary, D'Alessandro, Angelo, primary, and Karam, Sana D., primary

Published
2024
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27. PPARα Agonism Enhances Immune Response to Radiotherapy While Dietary Oleic Acid Results in Counteraction

Author

Ross, Richard Blake, primary, Gadwa, Jacob, additional, Yu, Justin, additional, Darragh, Laurel B., additional, Knitz, Michael W., additional, Nguyen, Diemmy, additional, Olimpo, Nicholas A., additional, Abdelazeem, Khalid N.M., additional, Nguyen, Alexander, additional, Corbo, Sophia, additional, Van Court, Benjamin, additional, Beynor, Jessica, additional, Neupert, Brooke, additional, Saviola, Anthony J., additional, D'Alessandro, Angelo, additional, and Karam, Sana D., additional

Published
2024
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29. Response to radiotherapy in pancreatic ductal adenocarcinoma is enhanced by inhibition of myeloid-derived suppressor cells using STAT3 anti-sense oligonucleotide

Author

Oweida, Ayman J., Mueller, Adam C., Piper, Miles, Milner, Dallin, Van Court, Benjamin, Bhatia, Shilpa, Phan, Andy, Bickett, Thomas, Jordan, Kimberly, Proia, Theresa, Schulick, Richard, Messersmith, Wells A., Del Chiaro, Marco, Clambey, Eric, Gough, Michael J., Williams, Jason, Hansen, Kirk, Goodman, Karyn, and Karam, Sana D.

Published
2021
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30. Author Correction: A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC

Author

Darragh, Laurel B., Knitz, Michael M., Hu, Junxiao, Clambey, Eric T., Backus, Jennifer, Dumit, Andrew, Samedi, Von, Bubak, Andrew, Greene, Casey, Waxweiler, Timothy, Mehrotra, Sanjana, Bhatia, Shilpa, Gadwa, Jacob, Bickett, Thomas, Piper, Miles, Fakhoury, Kareem, Liu, Arthur, Petit, Joshua, Bowles, Daniel, Thaker, Ashesh, Atiyeh, Kimberly, Goddard, Julie, Hoyer, Robert, Van Bokhoven, Adrie, Jordan, Kimberly, Jimeno, Antonio, D’Alessandro, Angelo, Raben, David, McDermott, Jessica D., and Karam, Sana D.

Published
2023
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33. Figure S6 from Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer

Author

Mueller, Adam C., primary, Piper, Miles, primary, Goodspeed, Andrew, primary, Bhuvane, Shiv, primary, Williams, Jason S., primary, Bhatia, Shilpa, primary, Phan, Andy V., primary, Van Court, Benjamin, primary, Zolman, Kathryn L., primary, Peña, Brisa, primary, Oweida, Ayman J., primary, Zakem, Sara, primary, Meguid, Cheryl, primary, Knitz, Michael W., primary, Darragh, Laurel, primary, Bickett, Thomas E., primary, Gadwa, Jacob, primary, Mestroni, Luisa, primary, Taylor, Matthew R.G., primary, Jordan, Kimberly R., primary, Dempsey, Peter, primary, Lucia, M. Scott, primary, McCarter, Martin D., primary, Chiaro, Marco Del, primary, Messersmith, Wells A., primary, Schulick, Richard D., primary, Goodman, Karyn A., primary, Gough, Michael J., primary, Greene, Casey S., primary, Costello, James C., primary, Neto, Antonio Galveo, primary, Lagares, David, primary, Hansen, Kirk C., primary, Van Bokhoven, Adrie, primary, and Karam, Sana D., primary

Published
2023
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34. Supplementary Legends from Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer

Author

Mueller, Adam C., primary, Piper, Miles, primary, Goodspeed, Andrew, primary, Bhuvane, Shiv, primary, Williams, Jason S., primary, Bhatia, Shilpa, primary, Phan, Andy V., primary, Van Court, Benjamin, primary, Zolman, Kathryn L., primary, Peña, Brisa, primary, Oweida, Ayman J., primary, Zakem, Sara, primary, Meguid, Cheryl, primary, Knitz, Michael W., primary, Darragh, Laurel, primary, Bickett, Thomas E., primary, Gadwa, Jacob, primary, Mestroni, Luisa, primary, Taylor, Matthew R.G., primary, Jordan, Kimberly R., primary, Dempsey, Peter, primary, Lucia, M. Scott, primary, McCarter, Martin D., primary, Chiaro, Marco Del, primary, Messersmith, Wells A., primary, Schulick, Richard D., primary, Goodman, Karyn A., primary, Gough, Michael J., primary, Greene, Casey S., primary, Costello, James C., primary, Neto, Antonio Galveo, primary, Lagares, David, primary, Hansen, Kirk C., primary, Van Bokhoven, Adrie, primary, and Karam, Sana D., primary

Published
2023
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35. Data from Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer

Author

Mueller, Adam C., primary, Piper, Miles, primary, Goodspeed, Andrew, primary, Bhuvane, Shiv, primary, Williams, Jason S., primary, Bhatia, Shilpa, primary, Phan, Andy V., primary, Van Court, Benjamin, primary, Zolman, Kathryn L., primary, Peña, Brisa, primary, Oweida, Ayman J., primary, Zakem, Sara, primary, Meguid, Cheryl, primary, Knitz, Michael W., primary, Darragh, Laurel, primary, Bickett, Thomas E., primary, Gadwa, Jacob, primary, Mestroni, Luisa, primary, Taylor, Matthew R.G., primary, Jordan, Kimberly R., primary, Dempsey, Peter, primary, Lucia, M. Scott, primary, McCarter, Martin D., primary, Chiaro, Marco Del, primary, Messersmith, Wells A., primary, Schulick, Richard D., primary, Goodman, Karyn A., primary, Gough, Michael J., primary, Greene, Casey S., primary, Costello, James C., primary, Neto, Antonio Galveo, primary, Lagares, David, primary, Hansen, Kirk C., primary, Van Bokhoven, Adrie, primary, and Karam, Sana D., primary

Published
2023
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36. Supplementary Tables from Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer

Author

Mueller, Adam C., primary, Piper, Miles, primary, Goodspeed, Andrew, primary, Bhuvane, Shiv, primary, Williams, Jason S., primary, Bhatia, Shilpa, primary, Phan, Andy V., primary, Van Court, Benjamin, primary, Zolman, Kathryn L., primary, Peña, Brisa, primary, Oweida, Ayman J., primary, Zakem, Sara, primary, Meguid, Cheryl, primary, Knitz, Michael W., primary, Darragh, Laurel, primary, Bickett, Thomas E., primary, Gadwa, Jacob, primary, Mestroni, Luisa, primary, Taylor, Matthew R.G., primary, Jordan, Kimberly R., primary, Dempsey, Peter, primary, Lucia, M. Scott, primary, McCarter, Martin D., primary, Chiaro, Marco Del, primary, Messersmith, Wells A., primary, Schulick, Richard D., primary, Goodman, Karyn A., primary, Gough, Michael J., primary, Greene, Casey S., primary, Costello, James C., primary, Neto, Antonio Galveo, primary, Lagares, David, primary, Hansen, Kirk C., primary, Van Bokhoven, Adrie, primary, and Karam, Sana D., primary

Published
2023
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37. Supplementary Methods from Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer

Author

Mueller, Adam C., primary, Piper, Miles, primary, Goodspeed, Andrew, primary, Bhuvane, Shiv, primary, Williams, Jason S., primary, Bhatia, Shilpa, primary, Phan, Andy V., primary, Van Court, Benjamin, primary, Zolman, Kathryn L., primary, Peña, Brisa, primary, Oweida, Ayman J., primary, Zakem, Sara, primary, Meguid, Cheryl, primary, Knitz, Michael W., primary, Darragh, Laurel, primary, Bickett, Thomas E., primary, Gadwa, Jacob, primary, Mestroni, Luisa, primary, Taylor, Matthew R.G., primary, Jordan, Kimberly R., primary, Dempsey, Peter, primary, Lucia, M. Scott, primary, McCarter, Martin D., primary, Chiaro, Marco Del, primary, Messersmith, Wells A., primary, Schulick, Richard D., primary, Goodman, Karyn A., primary, Gough, Michael J., primary, Greene, Casey S., primary, Costello, James C., primary, Neto, Antonio Galveo, primary, Lagares, David, primary, Hansen, Kirk C., primary, Van Bokhoven, Adrie, primary, and Karam, Sana D., primary

Published
2023
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43. Cancer immunotherapy responses persist after lymph node resection

Author

Zhou, Hengbo, primary, Baish, James W., additional, O’Melia, Meghan J., additional, Darragh, Laurel B., additional, Specht, Emma, additional, Czapla, Juliane, additional, Lei, Pin-ji, additional, Menzel, Lutz, additional, Rajotte, Johanna J., additional, Nikmaneshi, Mohammad R., additional, Razavi, Mohammad S., additional, Heiden, Matthew G. Vander, additional, Ubellacker, Jessalyn M., additional, Munn, Lance L., additional, Boland, Genevieve M., additional, Cohen, Sonia, additional, Karam, Sana D., additional, and Padera, Timothy P., additional

Published
2023
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44. FIGURE 4 from Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

Author

Amo-Aparicio, Jesus, primary, Dominguez, Adrian, primary, Atif, Shaikh M., primary, Dinarello, Alberto, primary, Azam, Tania, primary, Alula, Kibrom M., primary, Piper, Miles, primary, Lieu, Christopher H., primary, Lentz, Robert W., primary, Leal, Alexis D., primary, Bagby, Stacey M., primary, Messersmith, Wells A., primary, Karam, Sana D., primary, Dinarello, Charles A., primary, Pitts, Todd M., primary, and Marchetti, Carlo, primary

Published
2023
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45. Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

Author

Amo-Aparicio, Jesus, primary, Dominguez, Adrian, additional, Atif, Shaikh M., additional, Dinarello, Alberto, additional, Azam, Tania, additional, Alula, Kibrom M., additional, Piper, Miles, additional, Lieu, Christopher H., additional, Lentz, Robert W., additional, Leal, Alexis D., additional, Bagby, Stacey M., additional, Messersmith, Wells A., additional, Karam, Sana D., additional, Dinarello, Charles A., additional, Pitts, Todd M., additional, and Marchetti, Carlo, additional

Published
2023
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46. FIGURE 1 from Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

Author

Amo-Aparicio, Jesus, primary, Dominguez, Adrian, primary, Atif, Shaikh M., primary, Dinarello, Alberto, primary, Azam, Tania, primary, Alula, Kibrom M., primary, Piper, Miles, primary, Lieu, Christopher H., primary, Lentz, Robert W., primary, Leal, Alexis D., primary, Bagby, Stacey M., primary, Messersmith, Wells A., primary, Karam, Sana D., primary, Dinarello, Charles A., primary, Pitts, Todd M., primary, and Marchetti, Carlo, primary

Published
2023
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47. Data from Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

Author

Amo-Aparicio, Jesus, primary, Dominguez, Adrian, primary, Atif, Shaikh M., primary, Dinarello, Alberto, primary, Azam, Tania, primary, Alula, Kibrom M., primary, Piper, Miles, primary, Lieu, Christopher H., primary, Lentz, Robert W., primary, Leal, Alexis D., primary, Bagby, Stacey M., primary, Messersmith, Wells A., primary, Karam, Sana D., primary, Dinarello, Charles A., primary, Pitts, Todd M., primary, and Marchetti, Carlo, primary

Published
2023
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48. FIGURE 3 from Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

Author

Amo-Aparicio, Jesus, primary, Dominguez, Adrian, primary, Atif, Shaikh M., primary, Dinarello, Alberto, primary, Azam, Tania, primary, Alula, Kibrom M., primary, Piper, Miles, primary, Lieu, Christopher H., primary, Lentz, Robert W., primary, Leal, Alexis D., primary, Bagby, Stacey M., primary, Messersmith, Wells A., primary, Karam, Sana D., primary, Dinarello, Charles A., primary, Pitts, Todd M., primary, and Marchetti, Carlo, primary

Published
2023
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49. FIGURE 8 from Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

Author

Amo-Aparicio, Jesus, primary, Dominguez, Adrian, primary, Atif, Shaikh M., primary, Dinarello, Alberto, primary, Azam, Tania, primary, Alula, Kibrom M., primary, Piper, Miles, primary, Lieu, Christopher H., primary, Lentz, Robert W., primary, Leal, Alexis D., primary, Bagby, Stacey M., primary, Messersmith, Wells A., primary, Karam, Sana D., primary, Dinarello, Charles A., primary, Pitts, Todd M., primary, and Marchetti, Carlo, primary

Published
2023
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50. FIGURE 6 from Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

Author

Amo-Aparicio, Jesus, primary, Dominguez, Adrian, primary, Atif, Shaikh M., primary, Dinarello, Alberto, primary, Azam, Tania, primary, Alula, Kibrom M., primary, Piper, Miles, primary, Lieu, Christopher H., primary, Lentz, Robert W., primary, Leal, Alexis D., primary, Bagby, Stacey M., primary, Messersmith, Wells A., primary, Karam, Sana D., primary, Dinarello, Charles A., primary, Pitts, Todd M., primary, and Marchetti, Carlo, primary

Published
2023
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