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36 results on '"Karathanos, Athanasios"'

8. Clinical efficacy and safety outcomes of bempedoic acid for LDL-C lowering therapy in patients at high cardiovascular risk: a systematic review and meta-analysis

Author

Lin, Yingfeng, primary, Parco, Claudio, additional, Karathanos, Athanasios, additional, Krieger, Torben, additional, Schulze, Volker, additional, Chernyak, Nadja, additional, Icks, Andrea, additional, Kelm, Malte, additional, Brockmeyer, Maximilian, additional, and Wolff, Georg, additional

Published
2022
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11. Modern NCDR and ACTION risk models outperform the GRACE model for prediction of in-hospital mortality in acute coronary syndrome in a German cohort

Author

Parco, Claudio, primary, Brockmeyer, Maximilian, additional, Kosejian, Lucin, additional, Quade, Julia, additional, Tröstler, Jennifer, additional, Bader, Selina, additional, Lin, Yingfeng, additional, Karathanos, Athanasios, additional, Krieger, Torben, additional, Heinen, Yvonne, additional, Schulze, Volker, additional, Icks, Andrea, additional, Jung, Christian, additional, Kelm, Malte, additional, and Wolff, Georg, additional

Published
2021
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14. Uninterrupted anticoagulation during catheter ablation for atrial fibrillation: no difference in major bleeding and stroke between direct oral anticoagulants and vitamin K antagonists in an updated meta-analysis of randomised controlled trials

Author

Brockmeyer, Maximilian, primary, Lin, Yingfeng, additional, Parco, Claudio, additional, Karathanos, Athanasios, additional, Krieger, Torben, additional, Schulze, Volker, additional, Heinen, Yvonne, additional, Bejinariu, Alexandru, additional, Müller, Patrick, additional, Makimoto, Hisaki, additional, Kelm, Malte, additional, and Wolff, Georg, additional

Published
2020
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16. Uninterrupted anticoagulation during catheter ablation for atrial fibrillation: no difference in major bleeding and stroke between direct oral anticoagulants and vitamin K antagonists in an updated meta-analysis of randomised controlled trials.

Author

Brockmeyer, Maximilian, Yingfeng Lin, Parco, Claudio, Karathanos, Athanasios, Krieger, Torben, Schulze, Volker, Heinen, Yvonne, Bejinariu, Alexandru, Müller, Patrick, Hisaki Makimoto, Kelm, Malte, and Wolff, Georg

Subjects
ANTICOAGULANTS, CATHETER ablation, ELECTROSURGERY, RANDOMIZED controlled trials, MAGNETIC resonance imaging
Abstract

Background: Periprocedural uninterrupted anticoagulation for catheter ablation of atrial fibrillation (AF) became standard after positive results of vitamin K antagonist (VKA) trials. Previous studies of uninterrupted direct oral anticoagulants (DOACs) vs. VKA have given controversial results. We thus aimed to elucidate the risk/benefit ratio of uninterrupted DOAC vs. VKA during catheter ablation of AF in an updated meta-analysis of randomised controlled trials (RCTs). Methods: Online databases were searched for RCTs comparing uninterrupted DOAC to VKA in patients undergoing catheter ablation of AF. Data from retrieved studies were analysed in a comprehensive meta-analysis. Primary safety outcome was major bleeding; primary efficacy outcome was stroke or transient ischaemic attack (TIA). Secondary outcomes included a composite of major bleeding and stroke or TIA, minor bleeding, acute cerebral lesions on magnetic resonance imaging (MRI), and mortality. Results: Six eligible RCTs comprising 2,369 patients were included. There were no significant differences in DOAC vs. VKA concerning the rates of major bleeding (2.2% vs. 3.8%; odds ratio (OR) 0.69, 95% confidence interval (CI) 0.30-1.56; p=.37) and stroke or TIA (0.2% vs. 0.2%; OR 0.97, CI 0.20-4.72; p=.97). Pooled meta-analysis of secondary outcomes revealed no significant differences (OR 0.73, p=.49 for composite of major bleeding and stroke or TIA; OR 1.08, p=.52 for minor bleeding; OR 1.12, p=.59 for acute cerebral lesions on MRI; and OR 0.60, p=.64 for all-cause mortality). Conclusion: Our meta-analysis suggests that uninterrupted DOAC is not superior to VKA in patients undergoing catheter ablation of AF with comparable rates of major bleeding and stroke. [ABSTRACT FROM AUTHOR]

Published
2021
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17. Macrophage migration inhibitory factor and gremlin-1 in patients with coronary artery disease and diabetes: patterns of expression and interaction

Author

Karathanos, Athanasios and Geisler, Tobias (Prof. Dr.)

Subjects
Gremlin, MIF, Thrombozyt , Akutes Koronarsyndrom , Herzinfarkt , Diabetes mellitus , Arteriosklerose , Herzinsuffizienz , Koronare Herzkrankheit
Abstract

Die Progression der Atherosklerose ist ein langjähriger Prozess und Diabetes mellitus stellt einen der wichtigsten Risikofaktoren der koronaren Herzkrankheit dar. Thrombozyten spielen eine wichtige Rolle bei der Hämostase, aber auch bei inflammatorischen Prozessen und bei der Atherosklerose sind sie wesentlich beteiligt, unter anderem, durch die zahlreiche Zytokine die sie beherbergen und die Bildung von Thromben auf rupturierten Plaques, was zum akuten Verschluss und damit zum akuten Myokardinfarkt führt. Makrophage migration inhibitory factor (MIF) ist ein ubiquitärer Mediator mit proinflammatorischer Wirkung. Seine Interaktion mit GREM1 in der Atherosklerose in APO-Mäusen wurde durch unsere Gruppe beschrieben und die Rolle von GREM1 als endogener Inhibitor von MIF erläutert. Um die Expression, Funktion und Interaktion von MIF und GREM1 in der Atherogenese zu analysieren, untersuchten wir in 300 KHK-Patienten die Expression von MIF und GREM1 von Thrombozyten mittels Western Blotting und Durchflusszytometrie und deren Plasma-Spiegel durch ELISA. Die MIF und GREM1 Expression war unabhängig von Thrombozytenzahl, Leukozytenzahl und begleitender medikamentöser Therapie, inklusive Thrombozytenaggregationshemmer. Bei Diabetikern waren Thrombozytenaktivierungsmarker signifikant höher und korrelierten sich mit der thrombozytären Expression von MIF und GREM1. Zudem waren bei Diabetikern die MIF- und GREM1-Konzentration im Serum höher und die thrombozytenassozierte Expression von MIF und GREM1 korrelierten signifikant mit dem HbA1c-Wert, mit dem Troponin und mit der Ejektions- Fraktion. Unsere Ergebnisse lassen darauf schließen, dass Thrombozyten als Quelle von MIF und GREM1 dienen, die als Mediatoren der vaskulären Inflammation bei Diabetikern agieren. Diese Erkenntnisse bringen wichtige Informationen über mögliche Interaktionen von MIF und GREM1 und die damit verbundene mögliche Entwicklung spezifischer Inhibitoren, womit neue Therapieansätze in der Behandlung der vaskulären Komplikationen des Diabetes mellitus geschaffen werden können.

Published
2018
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18. Endovascular Thrombectomy as a Means to Improve Survival in Acute Ischemic Stroke

Author

Lin, Yingfeng, primary, Schulze, Volker, additional, Brockmeyer, Maximilian, additional, Parco, Claudio, additional, Karathanos, Athanasios, additional, Heinen, Yvonne, additional, Gliem, Michael, additional, Hartung, Hans-Peter, additional, Antoch, Gerald, additional, Jander, Sebastian, additional, Turowski, Bernd, additional, Perings, Stefan, additional, Kelm, Malte, additional, and Wolff, Georg, additional

Published
2019
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19. Validation of National Cardiovascular Data Registry risk models for mortality, bleeding and acute kidney injury in interventional cardiology at a German Heart Center

Author

Wolff, Georg, primary, Lin, Yingfeng, additional, Quade, Julia, additional, Bader, Selina, additional, Kosejian, Lucin, additional, Brockmeyer, Maximilian, additional, Karathanos, Athanasios, additional, Parco, Claudio, additional, Krieger, Torben, additional, Heinen, Yvonne, additional, Perings, Stefan, additional, Albert, Alexander, additional, Icks, Andrea, additional, Kelm, Malte, additional, and Schulze, Volker, additional

Published
2019
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20. Kidney function stratified outcomes of percutaneous left atrial appendage occlusion in patients with atrial fibrillation and high bleeding risk

Author

Brockmeyer, Maximilian, primary, Wolff, Georg, additional, Krieger, Torben, additional, Lin, Yingfeng, additional, Karathanos, Athanasios, additional, Afzal, Shazia, additional, Zeus, Tobias, additional, Westenfeld, Ralf, additional, Polzin, Amin, additional, Heinen, Yvonne, additional, Perings, Stefan, additional, Kelm, Malte, additional, and Schulze, Volker, additional

Published
2019
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24. Kidney function stratified outcomes of percutaneous left atrial appendage occlusion in patients with atrial fibrillation and high bleeding risk.

Author

Brockmeyer, Maximilian, Wolff, Georg, Krieger, Torben, Lin, Yingfeng, Karathanos, Athanasios, Afzal, Shazia, Zeus, Tobias, Westenfeld, Ralf, Polzin, Amin, Heinen, Yvonne, Perings, Stefan, Kelm, Malte, and Schulze, Volker

Subjects
CHRONIC kidney failure, ATRIAL fibrillation, ANTICOAGULANTS, STROKE, HEMORRHAGE
Abstract

Background: Patients with chronic kidney disease (CKD) and atrial fibrillation have increased risks for stroke and bleeding under oral anticoagulation (OAC). We investigated an alternative therapy of percutaneous left atrial appendage occlusion (LAAO) in CKD patients in this study. Methods: Consecutive patients undergoing LAAO were included in a retrospective analysis and stratified for kidney function into CKD/Non-CKD groups (cutoff eGFR 60 ml/min). Procedural characteristics, in-hospital and follow-up events were analysed and compared between groups. Results: LAAO was performed in 146 patients (81 CKD; 65 Non-CKD), mean follow-up was 391 days. Groups differed in eGFR (40.1 (CKD) vs. 75.1 (Non-CKD) ml/min) and CHA2DS2VASc scores (4.65 ± 1.3 (CKD) vs. 4.06 ± 1.4 (Non-CKD)). Procedural success was 98.6%, contrast-induced acute kidney injury was significantly more frequent in CKD patients (11.1% vs. 0%; p =.004). Follow-up mortality was higher in CKD (10.5/100 PY vs. 4.2/100 PY; p =.156). Follow-up stroke rates were 2.3/100 (CKD) patient-years (PY) and 1.4/100 PY (Non-CKD) (p = 1.000), corresponding to a relative risk reduction (RRR) of 60% (all), 68% (CKD) and 71% (Non-CKD) compared to expected stroke rates. Follow-up major bleeding rates were 3.5/100 PY (CKD) and 4.2/100 PY (Non-CKD), corresponding to RRR of 57% (all), 61% (CKD) and 53% (Non-CKD) compared to OAC. Conclusions: Left atrial appendage occlusion shows comparable efficacy for stroke and bleeding prevention in CKD and Non-CKD patients. CKD patients experience more adverse events during follow-up and a significantly increased risk for periprocedural contrast-induced acute kidney injury. [ABSTRACT FROM AUTHOR]

Published
2020
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25. High Platelet Reactivity in Patients with Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention: Randomised Controlled Trial Comparing Prasugrel and Clopidogrel

Author

Geisler, Tobias, primary, Booth, Jean, additional, Tavlaki, Elli, additional, Karathanos, Athanasios, additional, Müller, Karin, additional, Droppa, Michal, additional, Gawaz, Meinrad, additional, Yanez-Lopez, Monica, additional, Davidson, Simon J., additional, Stables, Rod H., additional, Banya, Winston, additional, Zaman, Azfar, additional, Flather, Marcus, additional, and Dalby, Miles, additional

Published
2015
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26. Evaluation of Clinical Risk Factors to Predict High On-Treatment Platelet Reactivity and Outcome in Patients with Stable Coronary Artery Disease (PREDICT-STABLE)

Author

Droppa, Michal, primary, Tschernow, Dimitri, additional, Müller, Karin A. L., additional, Tavlaki, Elli, additional, Karathanos, Athanasios, additional, Stimpfle, Fabian, additional, Schaeffeler, Elke, additional, Schwab, Matthias, additional, Tolios, Alexander, additional, Siller-Matula, Jolanta M., additional, Gawaz, Meinrad, additional, and Geisler, Tobias, additional

Published
2015
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27. Impact of counterbalance between macrophage migration inhibitory factor and its inhibitor Gremlin-1 in patients with coronary artery disease

Author

Müller, Iris I., primary, Müller, Karin A.L., additional, Karathanos, Athanasios, additional, Schönleber, Heiko, additional, Rath, Dominik, additional, Vogel, Sebastian, additional, Chatterjee, Madhumita, additional, Schmid, Martina, additional, Haas, Maximilian, additional, Seizer, Peter, additional, Langer, Harald, additional, Schaeffeler, Elke, additional, Schwab, Matthias, additional, Gawaz, Meinrad, additional, and Geisler, Tobias, additional

Published
2014
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28. Platelet expression of transforming growth factor beta 1 is enhanced and associated with cardiovascular prognosis in patients with acute coronary syndrome

Author

Rath, Dominik, primary, Chatterjee, Madhumita, additional, Müller, Iris, additional, Müller, Karin, additional, Böckmann, Corinna, additional, Droppa, Michal, additional, Stimpfle, Fabian, additional, Karathanos, Athanasios, additional, Borst, Oliver, additional, Seizer, Peter, additional, Langer, Harald, additional, Schwab, Matthias, additional, Gawaz, Meinrad, additional, and Geisler, Tobias, additional

Published
2014
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29. Impact of antithrombotic treatment on short-term outcomes after percutaneous coronary intervention for left main disease: a pooled analysis from REPLACE-2, ACUITY, and HORIZONS-AMI trials

Author

Geisler, Tobias, primary, Müller, Karin, additional, Karathanos, Athanasios, additional, Bocksch, Wolfgang, additional, Gawaz, Meinrad, additional, Deliargyris, Efthymios, additional, Bernstein, Debra, additional, Lincoff, A. Michael, additional, Mehran, Roxana, additional, Dangas, George, additional, and Stone, Gregg W., additional

Published
2014
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30. Increased platelet Ca2+ channel Orai1 expression upon platelet activation and in patients with acute myocardial infarction

Author

Münzer, Patrick, primary, Liu, Guoxing, primary, Towhid, Syeda, primary, Karathanos, Athanasios, primary, Tavlaki, Elli, primary, Geisler, Tobias, primary, Seizer, Peter, primary, May, Andreas, primary, Bigalke, Boris, primary, Borst, Oliver, primary, Gawaz, Meinrad, primary, Tolios, Alexander, additional, Gatidis, Sergios, additional, and Lang, Florian, additional

Published
2013
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35. [Update ESC-Guideline: Management of cardiovascular diseases during pregnancy - What is important?]

Author

Klein K, Karathanos A, and Heinen Y

Subjects
Female, Humans, Practice Guidelines as Topic, Pregnancy, Cardiovascular Diseases therapy, Pregnancy Complications, Cardiovascular therapy
Abstract

The treatment of pregnant patients with a cardiovascular disease is a special challenge to deal with. Before getting pregnant all cardiac patients should get medical advice accordingly to their risk profile in the modified World Health Organization classification of maternal cardiovascular risk. This article has the aim to give an overview of the new or changed recommendations of the new ESC-Guideline for the management of cardiovascular diseases during pregnancy., Competing Interests: Die Autoren geben an, dass kein Interessenkonflikt besteht., (© Georg Thieme Verlag KG Stuttgart · New York.)

Published
2019
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36. [Emergency sonography of the heart - step by step].

Author

Klein K, Karathanos A, Heinen Y, and Zeus T

Subjects
Aortic Valve Stenosis diagnostic imaging, Cardiac Tamponade diagnostic imaging, Emergency Treatment instrumentation, Heart Atria diagnostic imaging, Heart Failure diagnostic imaging, Heart Ventricles diagnostic imaging, Humans, Mitral Valve Insufficiency diagnostic imaging, Pericardial Effusion diagnostic imaging, Vena Cava, Inferior diagnostic imaging, Ventricular Function, Left, Ventricular Function, Right, Aorta diagnostic imaging, Cardiovascular Diseases diagnostic imaging, Echocardiography methods, Emergency Treatment methods, Heart diagnostic imaging
Abstract

Competing Interests: Disclosure The authors report no conflicts of interest in this work.

Published
2018
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