Search

Arthrofibrosis, which causes joint motion restrictions, is a common complication following total knee arthroplasty (TKA). Key features associated with arthrofibrosis include myofibroblast activation, knee stiffness, and excessive scar tissue formation. We previously demonstrated that adiponectin levels are suppressed within the knee tissues of patients affected by arthrofibrosis and showed that AdipoRon, an adiponectin receptor agonist, exhibited anti‐fibrotic properties in human mesenchymal stem cells. In this study, the therapeutic potential of AdipoRon was evaluated on TGFβ1‐mediated myofibroblast differentiation of primary human knee fibroblasts and in a mouse model of knee stiffness. Picrosirius red staining revealed that AdipoRon reduced TGFβ1‐induced collagen deposition in primary knee fibroblasts derived from patients undergoing primary TKA and revision TKA for arthrofibrosis. AdipoRon also reduced mRNA and protein levels of ACTA2, a key myofibroblast marker. RNA‐seq analysis corroborated the anti‐myofibrogenic effects of AdipoRon. In our knee stiffness mouse model, 6 weeks of knee immobilization, to induce a knee contracture, in conjunction with daily vehicle (DMSO) or AdipoRon (1, 5, and 25 mg/kg) via intraperitoneal injections were well tolerated based on animal behavior and weight measurements. Biomechanical testing demonstrated that passive extension angles (PEAs) of experimental knees were similar between vehicle and AdipoRon treatment groups in mice evaluated immediately following immobilization. Interestingly, relative to vehicle‐treated mice, 5 mg/kg AdipoRon therapy improved the PEA of the experimental knees in mice that underwent 4 weeks of knee remobilization following the immobilization and therapy. Together, these studies revealed that AdipoRon may be an effective therapeutic modality for arthrofibrosis. [ABSTRACT FROM AUTHOR]

The present paper focuses on the phenomenon of normativity and genericity in language and cognition. More specifically, it investigates the use of normative generics, which are generalizations that state an ideal norm for a given category, in the context of norm breaching in parent-child interactions in English. This issue is researched by means of a specially designed questionnaire including 8 norm breaching parent-child interactions, which has been completed online by ca. 70 English-speaking female respondents. The paper uses qualitative and quantitative methods to address two specific research issues. First, it compares the frequency of use of normative generics in norm breaching situations vis-à-vis the use of other types of normative linguistic expressions. Second, it analyses selected factors that are believed to favour the use of normative generics, including interactive openness of a given situation, norm salience, and perceived norm importance. Moreover, the paper sketches an explanatory model of normative generics that draws upon insights from the Conceptual Metonymy Theory, Construction Grammar, and Dual System Theory.

The generic overgeneralization effect is an attested tendency to accept false universal generalizations such as “all eagles fly” or “all snakes lay eggs” as true. In this paper, we discuss the generic overgeneralization effect demonstrated by Polish adult speakers. We asked 313 native speakers of Polish to evaluate universal quantified generalizations such as “all eagles fly” or “all snakes lay eggs” as true or false. The control group of 107 respondents provided data on the acceptance rates of the corresponding generic generalizations such as “eagles fly” or “snakes lay eggs”. By determining the impact of test fillers on the participants’ acceptance rates, the study aimed to identify the scope of the generic overgeneralization effect. We manipulated four conditions: the universal negative, positive, neutral, and generic control conditions. The results showed significant differences between the first two conditions, but neither the negative nor the positive condition differed from the neutral one. The overall acceptance rates of universal statements were 63% for the negative condition, 49% for the positive condition, 55% for the neutral condition, and 90% for the control group. Overall, the participants accepted universal quantified statements at high rates even when they were prompted to reject them. The results may be interpreted as another piece of evidence in support of the generic overgeneralization effect.