1. Profiling the neuroimmune cascade in 3xTg-AD mice exposed to successive mild traumatic brain injuries
- Author
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Alyssa F. Pybus, Sara Bitarafan, Rowan O. Brothers, Alivia Rohrer, Arushi Khaitan, Felix Rivera Moctezuma, Kareena Udeshi, Brae Davies, Sydney Triplett, Martin N. Griffin, Eric B. Dammer, Srikant Rangaraju, Erin M. Buckley, and Levi B. Wood
- Subjects
Traumatic brain injury ,Mild traumatic brain injury ,Alzheimer’s pathology ,Cytokines ,Neuroinflammation ,MAPK ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Repetitive mild traumatic brain injuries (rmTBI) sustained within a window of vulnerability can result in long term cognitive deficits, depression, and eventual neurodegeneration associated with tau pathology, amyloid beta (Aβ) plaques, gliosis, and neuronal and functional loss. However, a comprehensive study relating acute changes in immune signaling and glial reactivity to neuronal changes and pathological markers after single and repetitive mTBIs is currently lacking. In the current study, we addressed the question of how repeated injuries affect the brain neuroimmune response in the acute phase of injury (
- Published
- 2024
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