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2. The effect of vitamin D supplementation on cardiovascular risk in patients with prediabetes: A secondary analysis of the D2d study

Author

Cyrus Desouza, Ranee Chatterjee, Ellen M. Vickery, Jason Nelson, Karen C. Johnson, Sangeeta R. Kashyap, Michael R. Lewis, Karen Margolis, Richard Pratley, Neda Rasouli, Patricia R. Sheehan, and Anastassios G. Pittas

Subjects
Adult, Male, Endocrinology, Diabetes and Metabolism, Vitamins, Middle Aged, Prediabetic State, Endocrinology, Diabetes Mellitus, Type 2, Double-Blind Method, Cardiovascular Diseases, Heart Disease Risk Factors, Risk Factors, Dietary Supplements, Internal Medicine, Humans, Female, Vitamin D
Abstract

Low blood 25(OH)D level is associated with increased cardiovascular disease (CVD) risk. Additionally, individuals with prediabetes are at higher risk for CVD than individuals with normoglycemia. We investigated the effects of vitamin D supplementation on CVD outcomes in the vitamin D and type 2 diabetes (D2d) study, a large trial among adults with prediabetes.2423 participants were randomized to 4000 IU/day of vitamin DMean age was 60 years, 45 % were women, 13 % had history of CVD. Twenty-one participants assigned to vitamin D and 12 participants assigned to placebo met the MACE outcome (HR 1.81, 95%CI 0.89 to 3.69). There were 27 expanded MACE outcomes in each group (HR 1.02, 95%CI, 0.59 to 1.76). There were no significant differences between vitamin D and placebo in individual CVD risk factors, but change in ASCVD risk score favored the vitamin D group (-0.45 %, 95%CI -0.75 to -0.15).In people with prediabetes not selected for vitamin D insufficiency and with intermediate CVD risk, vitamin D supplementation did not decrease MACE but had a small favorable effect on ASCVD risk score.D2d ClinicalTrials.gov number, NCT01942694, prospectively registered September 16, 2013.

Published
2022

3. Reach in a pragmatic hypertension trial: A critical RE-AIM component

Author

Meghan, JaKa, Anna, Bergdall, Mary Sue, Beran, Leif, Solberg, Beverly B, Green, Julia, Andersen, Amy, Kodet, Sarah, Norman, Pat, Haugen, Lauren, Crain, Nicole, Trower, Rashmi, Sharma, Dan, Rehrauer, Carlos, Maeztu, and Karen, Margolis

Subjects
Hypertension, Humans, Pharmacology (medical), General Medicine, Pharmacists
Abstract

Hypertension control is falling in the US yet efficacious interventions exist. Poor patient reach has limited the ability of pragmatic trials to demonstrate effectiveness. This paper uses quantitative and qualitative data to understand factors influencing reach in Hyperlink 3, a pragmatic hypertension trial testing an efficacious pharmacist-led Telehealth Care intervention in comparison to a physician-led Clinic-based Care intervention. Referrals to both interventions were ordered by physicians.A sequential-explanatory mixed methods approach was used to understand barriers and facilitators to reach. Reach was assessed quantitatively using EHR data, defined as the proportion of eligible patients attending intended follow-up hypertension care and qualitatively, via semi-structured interviews with patients who were and were not reached. Quantitative data were analyzed using descriptive and inferential statistics. Qualitative data were analyzed via combined deductive and inductive content analysis.Of those eligible, 27% of Clinic-based (n = 532/1945) and 21% of Telehealth patients (n = 385/1849) were reached. In both arms, the largest drop was between physician-signed orders and patients attending initial intended follow-up care. Qualitative analyses uncovered patient barriers related to motivation, capability, and opportunity to attend follow-up care.Although the proportion of eligible patients with signed orders was high in both arms, the proportion ultimately reached was lower. Patients described barriers related to the influence of one's own personal beliefs or priorities, decision making processes, logistics, and patient perceptions on physician involvement on reach. Addressing these barriers in the design of pragmatic interventions is critical for future effectiveness.NCT02996565.

Published
2022
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4. On Training Students to Extract Gist from Expository Text.

Author

Samson, Karen Margolis

Abstract

A study examined the effects of an instructional intervention designed to improve high school students' ability to comprehend the gist of biology text materials. Subjects were divided into a strategy group, a read-study group, and a control group. The strategy subjects were given eight days of instruction in a procedure designed to help them analyze material sentence by sentence, look for relationships between ideas, and then extract the gist. The read-study subjects merely practiced the task of reading short passages, studying the information, and then recalling it. Subjects were given five test passages throughout the experiment, four biology and one history, and asked to produce an unprobed recall, answer six questions on main idea content, and rate their level of familiarity with the passage content. All subjects were tested before, during, and after the instructional period. The results did not support any one experimental condition over the others, but indicated certain commonalities between the two treatment groups, including the following: (1) those who recalled more total information also recalled more of the important ideas, (2) those who excelled did so throughout the entire experiment, (3) recall ability increased for the subject who excelled in each group. However, the recall of the strategy subjects tended to be more alike than that of the read-study subjects, and the lower-achieving strategy subject showed greater improvement on the question-answering tasks than did the lower-achieving read-study subject. The results reflect the need to consider individual student differences in comprehension in the classroom. (HTH)

Published
1982

5. The Use of the Picture Potency Formula in Selecting Pictures to Stimulate Stories.

Author

Samson, Karen Margolis and Wescott, Alice Legenza

Abstract

Reports on a study to validate the use of the Picture Potency Formula for predicting the extent to which pictures will stimulate story production. Twenty-four children were asked to tell stories about pictures rated by the formula as being high, medium, and low potency pictures. Discusses potential uses for the formula. (FL)

Published
1983

6. Association of 3 Different Antihypertensive Medications With Hip and Pelvic Fracture Risk in Older Adults: Secondary Analysis of a Randomized Clinical Trial

Author

Faye Norby, Craig Anderson, Kamal Sharma, Anum Abbas, Alokananda Ghosh, Vasilios Papademetriou, David Watson, James Tomlinson, Wanpen Vongpatanasin, Karen Margolis, Siddhartha Sharma, Raglan Maddox, and Jonathan Williams

Subjects
Male, medicine.medical_specialty, 030204 cardiovascular system & hematology, Lower risk, Risk Assessment, Article, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Lisinopril, Risk Factors, Internal medicine, Internal Medicine, medicine, Humans, Cumulative incidence, 030212 general & internal medicine, Amlodipine, Pelvic Bones, Thiazide, Antihypertensive Agents, Aged, Intention-to-treat analysis, business.industry, Hip Fractures, Chlorthalidone, United States, Surgery, Intention to Treat Analysis, Female, business, medicine.drug, Follow-Up Studies
Abstract

Importance On the basis of observational studies, the use of thiazide diuretics for the treatment of hypertension is associated with reduced fracture risk compared with nonuse. Data from randomized clinical trials are lacking. Objective To examine whether the use of thiazide diuretics for the treatment of hypertension is associated with reduced fracture risk compared with nonuse. Design, Setting, and Participants Using Veterans Affairs and Medicare claims data, this study examined hip and pelvic fracture hospitalizations in Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial participants randomized to first-step therapy with a thiazide-type diuretic (chlorthalidone), a calcium channel blocker (amlodipine besylate), or an angiotensin-converting enzyme inhibitor (lisinopril). Recruitment was from February 1994 to January 1998; in-trial follow-up ended in March 2002. The mean follow-up was 4.9 years. Posttrial follow-up was conducted through the end of 2006, using passive surveillance via national databases. For this secondary analysis, which used an intention-to-treat approach, data were analyzed from February 1, 1994, through December 31, 2006. Main Outcomes and Measures Hip and pelvic fracture hospitalizations. Results A total of 22 180 participants (mean [SD] age, 70.4 [6.7] years; 43.0% female; and 49.9% white non-Hispanic, 31.2% African American, and 19.1% other ethnic groups) were followed for up to 8 years (mean [SD], 4.9 [1.5] years) during masked therapy. After trial completion, 16 622 participants for whom claims data were available were followed for up to 5 additional years (mean [SD] total follow-up, 7.8 [3.1] years). During the trial, 338 fractures occurred. Participants randomized to receive chlorthalidone vs amlodipine or lisinopril had a lower risk of fracture on adjusted analyses (hazards ratio [HR], 0.79; 95% CI, 0.63-0.98;P = .04). Risk of fracture was significantly lower in participants randomized to receive chlorthalidone vs lisinopril (HR, 0.75; 95% CI, 0.58-0.98;P = .04) but not significantly different compared with those randomized to receive amlodipine (HR, 0.82; 95% CI, 0.63-1.08;P = .17). During the entire trial and posttrial period of follow-up, the cumulative incidence of fractures was nonsignificantly lower in participants randomized to receive chlorthalidone vs lisinopril or amlodipine (HR, 0.87; 95% CI, 0.74-1.03;P = .10) and vs each medication separately. In sensitivity analyses, when 1 year after randomization was used as the baseline (to allow for the effects of medications on bone to take effect), similar results were obtained for in-trial and in-trial plus posttrial follow-up. Conclusions and Relevance These findings from a large randomized clinical trial provide evidence of a beneficial effect of thiazide-type diuretic therapy in reducing hip and pelvic fracture risk compared with treatment with other antihypertensive medications. Trial Registration clinicaltrials.gov Identifier:NCT00000542

Published
2016

10. Abstract 136: Recidivism to Uncontrolled Blood Pressure in Patients with Previously Controlled Hypertension

Author

Amneet Sandhu, Michael Ho, Steve Asche, David Magid, Karen Margolis, JoAnn Sperl-Hillen, Bill Rush, David W. Price, Heidi Ekstrom, Heather Tavel, Olga Godlevsky, and Patrick J. O'Connor

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Objectives: Control of hypertension has improved nationally with focus on identifying and treating elevated blood pressures (BP) to guideline recommended levels. However, once BP control is achieved, the frequency in which BP falls out of control and the factors associated with BP recidivism is unknown. The objective of this study is to examine rates and predictors of blood pressure recidivism in adults with controlled hypertension. Study Design: A retrospective cohort study in two large, integrated health care systems in Minnesota and Colorado. Methods: Patients with a prior diagnosis of hypertension based on a combination of ICD-9 codes, receipt of anti-hypertensive medications and/or elevated blood pressure readings were eligible to be included. We defined controlled hypertension as normotensive blood pressure (BP) readings (less than 140/90 mmHg or less than 130/80 mmHg if coexistent diabetes or chronic kidney disease present) at 2 consecutive primary care visits. Following these visits among patients with controlled BP, we followed patients for BP recidivism defined by the mean of the last 2 blood pressure readings greater than 140/90 mm Hg or 130/80 mm Hg for those with diabetes or chronic kidney disease during a mean follow-up period of 13.2 months . Results: A total of 22,275 patients with controlled hypertension were included in this study. The proportion of patients with hypertension recidivism was 16.4%. A linear increase in blood pressure recidivism was noted with time between the index visit and last observed blood pressure reading. Major predictors of recidivism included female gender (OR 1.14, p = 0.02), history of diabetes (OR 2.32, p < 0.001) and black race (OR 1.37, p = 0.02). Age 50-64 displayed a protective effect against recidivism (OR 0.80, p = 0.02). Conclusions: Hypertensive recidivism occurs in a significant portion of patients with controlled hypertension. Patient factors associated with recidivism include age, race and prior history of diabetes among other characteristics. Strategies to minimize hypertension recidivism have significant potential to improve overall levels of blood pressure control and hypertension related quality measures from a health care systems perspective.

Published
2014
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11. Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol

Author

Leslie A. Lange, Youna Hu, He Zhang, Chenyi Xue, Ellen M. Schmidt, Zheng-Zheng Tang, Chris Bizon, Ethan M. Lange, Joshua D. Smith, Emily H. Turner, Goo Jun, Hyun Min Kang, Gina Peloso, Paul Auer, Kuo-ping Li, Jason Flannick, Ji Zhang, Christian Fuchsberger, Kyle Gaulton, Cecilia Lindgren, Adam Locke, Alisa Manning, Xueling Sim, Manuel A. Rivas, Oddgeir L. Holmen, Omri Gottesman, Yingchang Lu, Douglas Ruderfer, Eli A. Stahl, Qing Duan, Yun Li, Peter Durda, Shuo Jiao, Aaron Isaacs, Albert Hofman, Joshua C. Bis, Adolfo Correa, Michael E. Griswold, Johanna Jakobsdottir, Albert V. Smith, Pamela J. Schreiner, Mary F. Feitosa, Qunyuan Zhang, Jennifer E. Huffman, Jacy Crosby, Christina L. Wassel, Ron Do, Nora Franceschini, Lisa W. Martin, Jennifer G. Robinson, Themistocles L. Assimes, David R. Crosslin, Elisabeth A. Rosenthal, Michael Tsai, Mark J. Rieder, Deborah N. Farlow, Aaron R. Folsom, Thomas Lumley, Ervin R. Fox, Christopher S. Carlson, Ulrike Peters, Rebecca D. Jackson, Cornelia M. van Duijn, André G. Uitterlinden, Daniel Levy, Jerome I. Rotter, Herman A. Taylor, Vilmundur Gudnason, David S. Siscovick, Myriam Fornage, Ingrid B. Borecki, Caroline Hayward, Igor Rudan, Y. Eugene Chen, Erwin P. Bottinger, Ruth J.F. Loos, Pål Sætrom, Kristian Hveem, Michael Boehnke, Leif Groop, Mark McCarthy, Thomas Meitinger, Christie M. Ballantyne, Stacey B. Gabriel, Christopher J. O’Donnell, Wendy S. Post, Kari E. North, Alexander P. Reiner, Eric Boerwinkle, Bruce M. Psaty, David Altshuler, Sekar Kathiresan, Dan-Yu Lin, Gail P. Jarvik, L. Adrienne Cupples, Charles Kooperberg, James G. Wilson, Deborah A. Nickerson, Goncalo R. Abecasis, Stephen S. Rich, Russell P. Tracy, Cristen J. Willer, David M. Altshuler, Gonçalo R. Abecasis, Hooman Allayee, Sharon Cresci, Mark J. Daly, Paul I.W. de Bakker, Mark A. DePristo, Peter Donnelly, Tim Fennell, Kiran Garimella, Stanley L. Hazen, Daniel M. Jordan, Adam Kiezun, Guillaume Lettre, Bingshan Li, Mingyao Li, Christopher H. Newton-Cheh, Sandosh Padmanabhan, Sara Pulit, Daniel J. Rader, David Reich, Muredach P. Reilly, Steve Schwartz, Laura Scott, John A. Spertus, Nathaniel O. Stitziel, Nina Stoletzki, Shamil R. Sunyaev, Benjamin F. Voight, Ermeg Akylbekova, Larry D. Atwood, Maja Barbalic, R. Graham Barr, Emelia J. Benjamin, Joshua Bis, Donald W. Bowden, Jennifer Brody, Matthew Budoff, Greg Burke, Sarah Buxbaum, Jeff Carr, Donna T. Chen, Ida Y. Chen, Wei-Min Chen, Pat Concannon, Ralph D’Agostino, Anita L. DeStefano, Albert Dreisbach, Josée Dupuis, J. Peter Durda, Jaclyn Ellis, Caroline S. Fox, Ervin Fox, Vincent Funari, Santhi K. Ganesh, Julius Gardin, David Goff, Ora Gordon, Wayne Grody, Myron Gross, Xiuqing Guo, Ira M. Hall, Nancy L. Heard-Costa, Susan R. Heckbert, Nicholas Heintz, David M. Herrington, DeMarc Hickson, Jie Huang, Shih-Jen Hwang, David R. Jacobs, Nancy S. Jenny, Andrew D. Johnson, Craig W. Johnson, Steven Kawut, Richard Kronmal, Raluca Kurz, Martin G. Larson, Mark Lawson, Cora E. Lewis, Dalin Li, Honghuang Lin, Chunyu Liu, Jiankang Liu, Kiang Liu, Xiaoming Liu, Yongmei Liu, William T. Longstreth, Cay Loria, Kathryn Lunetta, Aaron J. Mackey, Rachel Mackey, Ani Manichaikul, Taylor Maxwell, Barbara McKnight, James B. Meigs, Alanna C. Morrison, Solomon K. Musani, Josyf C. Mychaleckyj, Jennifer A. Nettleton, Kari North, Daniel O’Leary, Frank Ong, Walter Palmas, James S. Pankow, Nathan D. Pankratz, Shom Paul, Marco Perez, Sharina D. Person, Joseph Polak, Aaron R. Quinlan, Leslie J. Raffel, Vasan S. Ramachandran, Kenneth Rice, Jill P. Sanders, Pamela Schreiner, Sudha Seshadri, Steve Shea, Stephen Sidney, Kevin Silverstein, Nicholas L. Smith, Nona Sotoodehnia, Asoke Srinivasan, Kent Taylor, Fridtjof Thomas, Michael Y. Tsai, Kelly A. Volcik, Chrstina L. Wassel, Karol Watson, Gina Wei, Wendy White, Kerri L. Wiggins, Jemma B. Wilk, O. Dale Williams, Gregory Wilson, Phillip Wolf, Neil A. Zakai, John Hardy, James F. Meschia, Michael Nalls, Andrew Singleton, Brad Worrall, Michael J. Bamshad, Kathleen C. Barnes, Ibrahim Abdulhamid, Frank Accurso, Ran Anbar, Terri Beaty, Abigail Bigham, Phillip Black, Eugene Bleecker, Kati Buckingham, Anne Marie Cairns, Daniel Caplan, Barbara Chatfield, Aaron Chidekel, Michael Cho, David C. Christiani, James D. Crapo, Julia Crouch, Denise Daley, Anthony Dang, Hong Dang, Alicia De Paula, Joan DeCelie-Germana, Allen DozorMitch Drumm, Maynard Dyson, Julia Emerson, Mary J. Emond, Thomas Ferkol, Robert Fink, Cassandra Foster, Deborah Froh, Li Gao, William Gershan, Ronald L. Gibson, Elizabeth Godwin, Magdalen Gondor, Hector Gutierrez, Nadia N. Hansel, Paul M. Hassoun, Peter Hiatt, John E. Hokanson, Michelle Howenstine, Laura K. Hummer, Jamshed Kanga, Yoonhee Kim, Michael R. Knowles, Michael Konstan, Thomas Lahiri, Nan Laird, Christoph Lange, Lin Lin, Xihong Lin, Tin L. Louie, David Lynch, Barry Make, Thomas R. Martin, Steve C. Mathai, Rasika A. Mathias, John McNamara, Sharon McNamara, Deborah Meyers, Susan Millard, Peter Mogayzel, Richard Moss, Tanda Murray, Dennis Nielson, Blakeslee Noyes, Wanda O’Neal, David Orenstein, Brian O’Sullivan, Rhonda Pace, Peter Pare, H. Worth Parker, Mary Ann Passero, Elizabeth Perkett, Adrienne Prestridge, Nicholas M. Rafaels, Bonnie Ramsey, Elizabeth Regan, Clement Ren, George Retsch-Bogart, Michael Rock, Antony Rosen, Margaret Rosenfeld, Ingo Ruczinski, Andrew Sanford, David Schaeffer, Cindy Sell, Daniel Sheehan, Edwin K. Silverman, Don Sin, Terry Spencer, Jackie Stonebraker, Holly K. Tabor, Laurie Varlotta, Candelaria I. Vergara, Robert Weiss, Fred Wigley, Robert A. Wise, Fred A. Wright, Mark M. Wurfel, Robert Zanni, Fei Zou, Phil Green, Jay Shendure, Joshua M. Akey, Carlos D. Bustamante, Evan E. Eichler, P. Keolu Fox, Wenqing Fu, Adam Gordon, Simon Gravel, Jill M. Johnsen, Mengyuan Kan, Eimear E. Kenny, Jeffrey M. Kidd, Fremiet Lara-Garduno, Suzanne M. Leal, Dajiang J. Liu, Sean McGee, Timothy D. O’Connor, Bryan Paeper, Peggy D. Robertson, Jeffrey C. Staples, Jacob A. Tennessen, Gao Wang, Qian Yi, Rebecca Jackson, Garnet Anderson, Hoda Anton-Culver, Paul L. Auer, Shirley Beresford, Henry Black, Robert Brunner, Robert Brzyski, Dale Burwen, Bette Caan, Cara L. Carty, Rowan Chlebowski, Steven Cummings, J. David Curb, Charles B. Eaton, Leslie Ford, Stephanie M. Fullerton, Margery Gass, Nancy Geller, Gerardo Heiss, Barbara V. Howard, Li Hsu, Carolyn M. Hutter, John Ioannidis, Karen C. Johnson, Lewis Kuller, Andrea LaCroix, Kamakshi Lakshminarayan, Dorothy Lane, Norman Lasser, Erin LeBlanc, Kuo-Ping Li, Marian Limacher, Benjamin A. Logsdon, Shari Ludlam, JoAnn E. Manson, Karen Margolis, Lisa Martin, Joan McGowan, Keri L. Monda, Jane Morley Kotchen, Lauren Nathan, Judith Ockene, Mary Jo O’Sullivan, Lawrence S. Phillips, Ross L. Prentice, John Robbins, Jacques E. Rossouw, Haleh Sangi-Haghpeykar, Gloria E. Sarto, Sally Shumaker, Michael S. Simon, Marcia L. Stefanick, Evan Stein, Hua Tang, Kira C. Taylor, Cynthia A. Thomson, Timothy A. Thornton, Linda Van Horn, Mara Vitolins, Jean Wactawski-Wende, Robert Wallace, Sylvia Wassertheil-Smoller, Donglin Zeng, Deborah Applebaum-Bowden, Michael Feolo, Weiniu Gan, Dina N. Paltoo, Phyliss Sholinsky, Anne Sturcke, Epidemiology, and Internal Medicine

Subjects
Male, Genome-wide association study, 030204 cardiovascular system & hematology, Cohort Studies, 0302 clinical medicine, Gene Frequency, Receptors, Genotype, Dyslipidemias/blood, Receptors, LDL/genetics, Genetics(clinical), Exome, Genetics (clinical), Exome sequencing, Genetics, 0303 health sciences, Serine Endopeptidases, Single Nucleotide, Middle Aged, 3. Good health, Cholesterol, Phenotype, Genetic Code, Cholesterol, LDL/genetics, Female, lipids (amino acids, peptides, and proteins), Proprotein Convertases, Proprotein Convertase 9, Sequence Analysis, Adult, Apolipoproteins E/blood, LDL/genetics, Serine Endopeptidases/genetics, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, Apolipoproteins E, SDG 3 - Good Health and Well-being, Humans, Polymorphism, Allele frequency, 030304 developmental biology, Genetic association, Aged, Dyslipidemias, PCSK9, DNA, Cholesterol, LDL, Lipase, Sequence Analysis, DNA, Receptors, LDL, Lipase/genetics, Proprotein Convertases/genetics, Follow-Up Studies, Genome-Wide Association Study
Abstract

Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated with lipid levels but are not well suited to assess the impact of rare and low-frequency variants. To determine whether rare or low-frequency coding variants are associated with LDL-C, we exome sequenced 2,005 individuals, including 554 individuals selected for extreme LDL-C (>98(th) or

Published
2014

17. A Culinary Cosmos

Author

Karen Margolis and Thomas O. Höllmann

Subjects
biology, Cosmos (plant), media_common.quotation_subject, Art history, Art, biology.organism_classification, media_common
Published
2013
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20. Genome-wide Association Analysis of Blood-Pressure Traits in African-Ancestry Individuals Reveals Common Associated Genes in African and Non-African Populations

Author

Nora Franceschini, Ervin Fox, Zhaogong Zhang, Todd L. Edwards, Michael A. Nalls, Yun Ju Sung, Bamidele O. Tayo, Yan V. Sun, Omri Gottesman, Adebawole Adeyemo, Andrew D. Johnson, J. Hunter Young, Ken Rice, Qing Duan, Fang Chen, Yun Li, Hua Tang, Myriam Fornage, Keith L. Keene, Jeanette S. Andrews, Jennifer A. Smith, Jessica D. Faul, Zhang Guangfa, Wei Guo, Yu Liu, Sarah S. Murray, Solomon K. Musani, Sathanur Srinivasan, Digna R. Velez Edwards, Heming Wang, Lewis C. Becker, Pascal Bovet, Murielle Bochud, Ulrich Broeckel, Michel Burnier, Cara Carty, Daniel I. Chasman, Georg Ehret, Wei-Min Chen, Guanjie Chen, Wei Chen, Jingzhong Ding, Albert W. Dreisbach, Michele K. Evans, Xiuqing Guo, Melissa E. Garcia, Rich Jensen, Margaux F. Keller, Guillaume Lettre, Vaneet Lotay, Lisa W. Martin, Jason H. Moore, Alanna C. Morrison, Thomas H. Mosley, Adesola Ogunniyi, Walter Palmas, George Papanicolaou, Alan Penman, Joseph F. Polak, Paul M. Ridker, Babatunde Salako, Andrew B. Singleton, Daniel Shriner, Kent D. Taylor, Ramachandran Vasan, Kerri Wiggins, Scott M. Williams, Lisa R. Yanek, Wei Zhao, Alan B. Zonderman, Diane M. Becker, Gerald Berenson, Eric Boerwinkle, Erwin Bottinger, Mary Cushman, Charles Eaton, Fredrik Nyberg, Gerardo Heiss, Joel N. Hirschhron, Virginia J. Howard, Konrad J. Karczewsk, Matthew B. Lanktree, Kiang Liu, Yongmei Liu, Ruth Loos, Karen Margolis, Michael Snyder, Bruce M. Psaty, Nicholas J. Schork, David R. Weir, Charles N. Rotimi, Michele M. Sale, Tamara Harris, Sharon L.R. Kardia, Steven C. Hunt, Donna Arnett, Susan Redline, Richard S. Cooper, Neil J. Risch, D.C. Rao, Jerome I. Rotter, Aravinda Chakravarti, Alex P. Reiner, Daniel Levy, Brendan J. Keating, Xiaofeng Zhu, Min Jin Go, Young Jin Kim, Jong-Young Lee, Jae-Pil Jeon, Sung Soo Kim, Bok-Ghee Han, Yoon Shin Cho, Xueling Sim, Wan Ting Tay, Rick Twee Hee Ong, Mark Seielstad, Jian Jun Liu, Tin Aung, Tien Yin Wong, Yik Ying Teo, E. Shyong Tai, Chien-Hsiun Chen, Li-ching Chang, Yuan-Tsong Chen, Jer-Yuarn Wu, Tanika N. Kelly, Dongfeng Gu, James E. Hixson, Jiang He, Yasuharu Tabara, Yoshihiro Kokubo, Tetsuro Miki, Naoharu Iwai, Norihiro Kato, Fumihiko Takeuchi, Tomohiro Katsuya, Toru Nabika, Takao Sugiyama, Yi Zhang, Wei Huang, Xuegong Zhang, Xueya Zhou, Li Jin, Dingliang Zhu, Bochud, Murielle, and Ehret, Georg Benedikt

Subjects
Blood Pressure/genetics, Black People, Genome-wide association study, Locus (genetics), Blood Pressure, 030204 cardiovascular system & hematology, Biology, Quantitative trait locus, Polymorphism, Single Nucleotide, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Quantitative Trait, Heritable, Report, Databases, Genetic, Genetics, Humans, Genetics(clinical), Genetic Predisposition to Disease, Gene, Genetics (clinical), 030304 developmental biology, Genetic association, ddc:616, 0303 health sciences, African Continental Ancestry Group/genetics, Reproducibility of Results, Polymorphism, Single Nucleotide/genetics, 3. Good health, Genetic Loci, Meta-analysis, Multiple comparisons problem, Genetic Loci/genetics, Africa, Trait, Genome-Wide Association Study
Abstract

High blood pressure (BP) is more prevalent and contributes to more severe manifestations of cardiovascular disease (CVD) in African Americans than in any other United States ethnic group. Several small African-ancestry (AA) BP genome-wide association studies (GWASs) have been published, but their findings have failed to replicate to date. We report on a large AA BP GWAS meta-analysis that includes 29,378 individuals from 19 discovery cohorts and subsequent replication in additional samples of AA (n = 10,386), European ancestry (EA) (n = 69,395), and East Asian ancestry (n = 19,601). Five loci (EVX1-HOXA, ULK4, RSPO3, PLEKHG1, and SOX6) reached genome-wide significance (p < 1.0 × 10(-8)) for either systolic or diastolic BP in a transethnic meta-analysis after correction for multiple testing. Three of these BP loci (EVX1-HOXA, RSPO3, and PLEKHG1) lack previous associations with BP. We also identified one independent signal in a known BP locus (SOX6) and provide evidence for fine mapping in four additional validated BP loci. We also demonstrate that validated EA BP GWAS loci, considered jointly, show significant effects in AA samples. Consequently, these findings suggest that BP loci might have universal effects across studied populations, demonstrating that multiethnic samples are an essential component in identifying, fine mapping, and understanding their trait variability.

Published
2013

21. The Long and Winding Roads (reflections on Beyond the Fragments)

Author

Karen Margolis

Subjects
Gender Studies, Wainwright, Arts and Humanities (miscellaneous), Feeling, media_common.quotation_subject, Cultural studies, Gender studies, Human sexuality, Sociology, Feminism, media_common
Abstract

I wrote this article as an initial response to Beyond the Fragments, by Sheila Rowbotham, Lynne Segal and Hilary Wainwright; and also to Elizabeth Wilson's contribution, Beyond the Ghetto, published in Feminist Review number 4. I wanted to add my personal feelings and doubts to the debate opened by Beyond the Fragments, in the hope that it would develop further than the 'Leninism versus feminism' dichotomy posed by the left groups.

Published
1980
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22. Calcium Plus Vitamin D Supplementation and the Risk of Colorectal Cancer.

Author

Jean Wactawski-Wende, Jane Kotchen, Garnet Anderson, Annlouise Assaf, Robert Brunner, Mary O’Sullivan, Karen Margolis, Judith Ockene, Lawrence Phillips, Linda Pottern, Ross Prentice, John Robbins, Thomas Rohan, Gloria Sarto, Santosh Sharma, Marcia Stefanick, Linda Horn, Robert Wallace, Evelyn Whitlock, and Tamsen Bassford

Published
2006
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