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Your search keyword '"Karev, Vadim"' showing total 27 results
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27 results on '"Karev, Vadim"'

2. Glycyrrhizinic Acid and Phosphatidylcholine Combination as a Preventive Therapy for Experimental Murine Non-Alcoholic Steatohepatitis.

Author

Prikhodko, Veronika A., Matuzok, Tatyana M., Karev, Vadim E., Karavaeva, Anna V., Spasenkova, Olga M., Kirillova, Nadezhda V., Ivkin, Dmitry Yu., and Okovityi, Sergey V.

Subjects
PREVENTION of mental depression, NON-alcoholic fatty liver disease, TRITERPENES, COMBINATION drug therapy, BIOLOGICAL models, DATA analysis, ERYTHROCYTES, RESEARCH funding, POLYMERASE chain reaction, LECITHIN, TREATMENT effectiveness, DESCRIPTIVE statistics, DIETARY fats, MICE, EXPERIMENTAL design, KAPLAN-Meier estimator, LOG-rank test, MESSENGER RNA, ANIMAL experimentation, ONE-way analysis of variance, STATISTICS, ANIMAL behavior, DATA analysis software, PROPORTIONAL hazards models, DIETARY supplements, DISEASE risk factors
Abstract

Non-alcoholic metabolic-associated steatohepatitis (MASH) is a condition characterized by increasingly high prevalence and incidence, and also represents an important unmet medical need when it comes to effective pharmacotherapy. In this work, we aimed to explore the therapeutic possibilities of the synergistic combined use of glycyrrhizinic acid (GA) and phosphatidylcholine (PC) to prevent experimental MASH. Adult C57Bl/6 mice were used to model dietary/toxic MASH and treated orally by either GA (34.3 mg/kg/d) or a GA + PC combination (34.3 + 158.1 mg/kg/d) for 3 months. Animal locomotion, behaviour, short-term memory, physical performance, neuromuscular joint function, blood biochemistry, and oxidative stress marker levels were evaluated, followed by histological examination of the liver, skeletal muscle and sciatic nerve with tissue ammonia and lipid content determination. Real-time polymerase chain reaction was used to measure the relative expression of several pathogenetic transcript markers. GA and PC showed moderate additive synergism in their anti-inflammatory, antioxidant, hypoammonaemic, hypoglycaemic, and pro-cognitive activities. Differential effects of the agents were seen in regard to anxiety- and depression-like behaviour as well as gene expression. Our results indicate partial pharmacological synergism between GA and PC and validate further research of its potential clinical applications. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Possibilities of antifibrotic therapy and correction of cognitive disorders in experimentally induced severe liver fibrosis and cirrhosis in rats

Author

Chernenok, Maksim G., primary, Saulevich, Andrey V., additional, Zhdanov, Konstantin V., additional, Zakharkiv, Yuriy F., additional, Kozlov, Konstantin V., additional, Sukachev, Vitaliy S., additional, Zakharenko, Sergey M., additional, Mukhtarov, Ruslan M., additional, Karev, Vadim E., additional, Gavrilyuk, Timofey V., additional, Ivanov, Konstantin S., additional, Lyashenko, Yuriy I., additional, and Zhabrov, Sergey S., additional

Published
2022
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11. Molecular and Cellular Mechanisms of M. tuberculosis and SARS-CoV-2 Infections—Unexpected Similarities of Pathogenesis and What to Expect from Co-Infection

Author

Starshinova, Anna A., primary, Kudryavtsev, Igor, additional, Malkova, Anna, additional, Zinchenko, Ulia, additional, Karev, Vadim, additional, Kudlay, Dmitry, additional, Glushkova, Angela, additional, Starshinova, Anastasiya Y., additional, Dominguez, Jose, additional, Villar-Hernández, Raquel, additional, Dovgalyk, Irina, additional, and Yablonskiy, Piotr, additional

Published
2022
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21. Prevention of Influenza A(H7N9) and Bacterial Infections in Mice Using Intranasal Immunization With Live Influenza Vaccine and the Group B Streptococcus Recombinant Polypeptides

Author

Desheva, Yulia A, primary, Leontieva, Galina F, additional, Kramskaya, Tatiana A, additional, Smolonogina, Tatiana A, additional, Grabovskaya, Kornelia B, additional, Landgraf, Galina O, additional, Karev, Vadim E, additional, Suvorov, Alexander N, additional, and Rudenko, Larisa G, additional

Published
2017
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22. Expression of CD68 and Fas Ligand in Colon Mucosa of Patients with Inflammatory Bowel Disease as Prognostic Markers of Cancerogenesis

Author

Santimov, Andrey V, primary, Kolobov, Andrey V, additional, Karev, Vadim E, additional, Kolobova, Oksana L, additional, Kostik, Mikhail M, additional, Dubko, Margarita F, additional, Kalashnikova, Olga V, additional, Masalova, Vera V, additional, Snegireva, Lyudmila S, additional, Volkova, Natalia L, additional, Khvatov, Andrey A, additional, Belogurova, Margarita B, additional, and Chasnyk, Vyacheslav G, additional

Published
2016
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27. Prevention of Influenza A(H7N9) and Bacterial Infections in Mice Using Intranasal Immunization With Live Influenza Vaccine and the Group B Streptococcus Recombinant Polypeptides.

Author

Desheva YA, Leontieva GF, Kramskaya TA, Smolonogina TA, Grabovskaya KB, Landgraf GO, Karev VE, Suvorov AN, and Rudenko LG

Abstract

We investigate the protective effect of combined vaccination based on live attenuated influenza vaccine (LAIV) and group B streptococcus (GBS) recombinant polypeptides against potential pandemic H7N9 influenza infection followed by GBS burden. Mice were intranasally immunized using 107 50% egg infectious dose (EID 50 ) of H7N3 LAIV, the mix of the 4 GBS peptides (group B streptococcus vaccine [GBSV]), or combined LAIV + GBSV vaccine. The LAIV raised serum hemagglutination-inhibition antibodies against H7N9 in higher titers than against H7N3. Combined vaccination provided advantageous protection against infections with A/Shanghai/2/2013(H7N9)CDC-RG influenza and serotype II GBS. Combined vaccine significantly improved bacterial clearance from the lungs after infection compared with other vaccine groups. The smallest lung lesions due to combined LAIV + GBSV vaccination were associated with a prevalence of lung interferon-γ messenger RNA expression. Thus, combined viral and bacterial intranasal immunization using H7N3 LAIV and recombinant bacterial polypeptides induced balanced adaptive immune response, providing protection against potential pandemic influenza H7N9 and bacterial complications., Competing Interests: DECLARATION OF CONFLICTING INTERESTS: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Published
2017
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