81 results on '"Karimifar M"'
Search Results
2. Knock and knock intensity in a spark ignition engine
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Karimifar, M.
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621.43 ,Car engine knock measurement - Published
- 1988
Catalog
3. Triglyceride and high-density lipoprotein levels as the markers of disease activity and their association with TNF-α and TNF receptor system in systemic lupus erythematosus
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KARIMIFAR, M., GHARIBDOOST, F., AKBARIAN, M., MEYSAMIE, A. P., KHOSRAVI, S H., KARIMIFAR, Mozh, SHAHRAM, F., NADJI, A., JAMSHIDI, A. R., AKHLAGHI, M., YAZDANI, B., and DAVATCHI, F.
- Published
- 2007
4. A Study on the Relationship between Lipid Profile and Rheumatoid Arthritis Activity
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Salesi, M., Maryam Emami, Mostafavi, M., Zahed, A., Farajzadegan, Z., and Karimifar, M.
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Lipid profile ,lcsh:R5-920 ,lcsh:R ,lcsh:Medicine ,lipids (amino acids, peptides, and proteins) ,Rheumatoid arthritis ,lcsh:Medicine (General) ,Disease activity index - Abstract
Background: Rheumatoid arthritis (RA) is commonly associated with abnormalities in plasma lipoprotein levels, especially a significantly low level of high density lipoprotein (HDL). Most treatments for RA, particularly biological drugs, decrease atherogenic index. Improvement in lipoprotein profile has been found to be associated with decrease in inflammation in RA patients. This study was designed to survey the relationship between lipid profile and RA activity index. Methods: This cross-sectional study included a total of 200 randomly selected RA patients. After blood sampling, plasma levels of triglyceride (TG), cholesterol, low density lipoprotein (LDL), HDL were measured. The correlations between these indices and disease activity index were then evaluated using disease activity score calculator (DAS28). The collected data was statistically analyzed by SPSS18. Pierson and Spearman correlation coefficients were applied for data analysis. Multiple regression test and factorial model were used to control bias.. Findings: Examination of the relation between LDL levels and RA criteria revealed a direct significant association of 0.13. A significant association of 0.17 was also found between pain intensity (based on visual analogue scale) and LDL levels. Moreover, LDL and tender joints were significantly associated (0.16). There were no statistically significant associations between LDL, joint swelling and erythrocyte sedimentation rate (ESR). HDL levels did not show significant relations with ESR, pain intensity and tender joints (P > 0.05). However, there was a significant reverse association between HDL levels and joint swelling (0.16). Conclusion: This study showed that lipid profile and RA were significantly related in many aspects. This finding was in accordance with the results of other similar studies. Therefore, it seems advisable to check the lipid profile of patients with chronic inflammatory diseases, especially RA, on a regular basis. more...
- Published
- 2012
5. Triglyceride and high-density lipoprotein levels as the markers of disease activity and their association with TNF-? and TNF receptor system in systemic lupus erythematosus
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KARIMIFAR, M., primary, GHARIBDOOST, F., additional, AKBARIAN, M., additional, MEYSAMIE, A. P., additional, KHOSRAVI, SH., additional, KARIMIFAR, Mozh, additional, SHAHRAM, F., additional, NADJI, A., additional, JAMSHIDI, A. R., additional, AKHLAGHI, M., additional, YAZDANI, B., additional, and DAVATCHI, F., additional more...
- Published
- 2007
- Full Text
- View/download PDF
6. Radiative heat flux control over spherical surfaces.
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Karimifar, M., Aghanajafi, S., and Shabani, A.B.
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- 1997
- Full Text
- View/download PDF
7. WHO-ILAR COPCORD study (stage 1, urban study) in Iran.
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Davatchi F, Jamshidi A, Banihashemi AT, Gholami J, Forouzanfar MH, Akhlaghi M, Barghamdi M, Noorolahzadeh E, Khabazi A, Salesi M, Salari A, Karimifar M, Essalat-Manesh K, Hajialiloo M, Soroosh M, Farzad F, Moussavi H, Samadi F, Ghaznavi K, and Asgharifard H more...
- Published
- 2008
8. Evaluation of bone loss in diabetic postmenopausal women
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Karimifar, M., Pasha, M. A. P., Salari, A., Zamani, A., mansour salesi, and Motaghi, P.
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Diabetes mellitus ,lcsh:R ,Osteoporosis ,postmenopausal women ,lcsh:Medicine ,Original Article - Abstract
Background: Osteoporosis and diabetes mellitus are major and growing public health problems particularly among postmenopausal women. This study was conducted to evaluate the relationship between osteoporosis and osteopenia with type 2 diabetes mellitus (DM) in postmenopausal women. Materials and Methods: In a cross sectional study, we compared 200 diabetic postmenopausal women with 400 non-diabetic postmenopausal women over the age of 60 years. Age, Body Mass Index (BMI), T score of the lumbar vertebra (L2-L4) and femoral neck were measured with Dual Energy X-ray Absorptiometry (DXA) and were compared between the two groups. Hemoglobin A1C (HbA1C) was also measured in patients with type 2 DM and its relationship with osteoporosis was studied. Chi-square, Fisher′s exact test and Independent T-test was used for analyzing the data. The statistical significance was set at a P value of 0.05 or lower. Results: Mean, SD ages were 65.23 ± 4.80 vs. 66.91 ± 5.78 years and BMI were 28.94 ± 4.06 vs. 31.65 ± 4.42 kg/m 2 in non-diabetic and diabetic groups, respectively. Lumber T scores was -2.10 ± 1.08 vs.-2.16 ± 1.27 (P = 0.60), femoral neck T-score was -0.72 ± 1.00 vs. -1.09 ± 0.96 (P = 0.00) in non-diabetic and diabetic groups, respectively. There was a significant difference in femoral neck T score between the diabetic and non-diabetic group (P = 0.00). In diabetic women, bone loss was more common in those with HbA1C ≥7 compare to those with HbA1C more...
9. Serum cryoglobulins and disease activity in systematic lupus erythematosus
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Karimifar, M., Pourajam Samaneh, Tahmasebi, A., and Mottaghi, P.
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Cryoglobulinemia ,systemic lupus erythematosus ,lcsh:R ,lcsh:Medicine ,Original Article ,disease activity index ,skin and connective tissue diseases - Abstract
Background: To determine the prevalence of cryoglobulins in Iranian patients with systemic lupus erythematosus (SLE) and evaluate the correlation of cryoglobulins with disease activity in these patients. Materials and Methods: In a cross-sectional study, we investigated 80 consecutive women who fulfilled the 1982 revised criteria of the American College of Rheumatology for the classification of SLE. All the patients had undergone a medical interview and general physical examination by a rheumatologist for clinical and serologic characteristics of SLE. For the determination of cryoglobulins, sera were collected by a standard protocol at 37°C, and after incubation at 4°C for seven days, the level of cryoglobulins was estimated for each patient. Results: Cryoglobulins were detected in the sera of 39 (48.8%) patients. All of these patients had cryocrit over 5%. Disease was active in 30 patients [SLEDAI ≥6 (DAI: disease activity index)] and inactive in 50 (SLEDAI more...
10. Is vitamin D effective on the disease activity index (DAS28) in rheumatoid arthritis?
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Salesi, M., ziba farajzadegan, and Karimifar, M.
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lcsh:R5-920 ,lcsh:R ,lcsh:Medicine ,Vitamin D ,Rheumatoid arthritis ,lcsh:Medicine (General) ,Disease activity index - Abstract
Background: We can prevent developing osteoporosis in rheumatoid arthritis (RA) patients with compounds containing calcium and vitamin D. In some of the studies, patients who received more vitamin D had better disease control. Our aim in this study was to observe whether the vitamin D could be effective on the rheumatoid arthritis disease activity or not? Methods: This study was a double blind randomized controlled clinical trial on 117 patients with rheumatoid arthritis. In Intervention group, in addition to drug therapy, vitamin D 50000 units per week were prescribed. Control group also received placebo tablets. In the end of study, results in both groups compared. Data analysis was performed by paired t-test, Student t-test and General linear Model. Finding: There were no significant differences in baseline disease severity, and DAS-28 in both groups. DAS-28 in intervention and control groups was 5.4 ± 1.1 and 5.5 ± 1.3, respectively (P > 0.05). In both groups, all clinical and laboratory parameters after intervention were reduced. The amount of reductions in intervention group was more than the placebo group but it is not significant. Conclusion: According to this research vitamin D can use as an adjuvant therapy for rheumatoid arthritis. more...
11. The protein creatinine ratio in spot morning urine samples and 24 hour urinary protein excretion in patients with systemic lupus erythematosus
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mansour salesi, Karimifar, M., Farajzadegan, Z., Esalatmanesh, K., Khosravi, S., Falahi, P., and Akbarian, M.
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lcsh:R5-920 ,lcsh:R ,lcsh:Medicine ,lcsh:Medicine (General) - Abstract
Background: 24-h urinary pr is a standard way to diagnose lupus nephritis. Assessment of Pr/Cr ratio in morning spot urine is a valuable method in diabetic patients but it has no use in SLE patients routinely. In this study Pr/Cr ratio in spot urine was compared with 24-h urine Pr. If they have valuable correlation, we can use this test instead of 24-h urinary Pr. The aim of this study was to evaluate the correlation of spot urine protein-creatinine ratio for prediction of significant proteinuria (> or = 300 mg/24 h) in patients with systemic lupus erythematous. Methods: A cross-section study was conducted in 74 hospitalized women with systemic lupus erythematous. The correlation between Prot/Cr in first morning urine specimens and urinary protein excretion were analyzed in 24-h collections. Findings: Correlation between Prot/Cr ratio in spot morning urine specimens and urinary protein excretion in 24-h collections was significant. Conclusion: A high correlation and precision of agreement were demonstrated between the two methods of assessment proteinuria in lupus patients. The difference between the two methods was less than the biological variability in the protein excretion and its measurement, enabling the methods to be used interchangeably creatinine ratio in spot morning urine samples is a precise indicator of proteinuria in patients with lupus nephritis and represents a simple and inexpensive procedure in establishing severity of proteinuria in patients with systemic lupus erythematous. Key words: Systemic Lupus Erythematous, 24-h urine protein measurement, protein / creatinine ratio. more...
12. Rapid improvement of genital aphthae by topical FK-506 in Behcet's disease
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Karimifar, M., mansour salesi, Karimzadeh, H., Bonakdar, Z. S., Mottaghi, P., and Fatemi, A. M.
13. Primary amyloidosis (A case report)
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mansour salesi, Karimzadeh, H., Karimifar, M., Mottaghi, P., Bonakdar, Z. S., and Rajabi, P.
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lcsh:R5-920 ,integumentary system ,lcsh:R ,lcsh:Medicine ,lcsh:Medicine (General) - Abstract
Primary amyloidosis is the most prevalent form of systemic amyloidosis and clinical sign of this disease is in association with the extent of amyloid deposition in organ systems. Most of the organs, except central nervous system, involved in this disease (heart, kidneys, liver, GI system, spleen, thyroid, adrenals, lymph nodes, bone marrow, lung, synovium, skin, skeletal muscle and tongue). Background: We describe a 43 years Iranian female patient with sign of hardness of skin and joints (scleroderma skin like), nonspecific mechanical pain, shoulder bigness, dysphasia, hoarseness, popular skin lesions, and signs of carpal tunnel syndrome, which hospitalized because of dyspnea. In the skin biopsy and with light microscopy there was epidermal atrophy and in papillary dermis deposition of amorphous eosinophilic material. In congo-red staining amyloidosis was proved. Case Presentation: In spite of this point that the primary amyloidosis is the most prevalent form of systemic amyloidosis, in our country this is the very rare disease and the diagnosis especially in early stages is difficult. In early stages, skin manifestations of disease can confuse with other diseases like hypothyroidism and scleroderma in edematous stage and in our patient waxy form papules was similar to familiar hypercholesterolemia. Because of this presentation we fall in mistake in primary evaluation but the proteinuria cause the suspicious of amyloidosis and finally the diagnosis. Conclusion: Shoulder pad sign, tongue bigness, primary amyloidosis Key words more...
14. The comparison of serum zinc level in Behcet patients and healthy controls
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Esalatmanesh, K., Jamshidi, A., Shahram, F., Davatchi, F., Soleimani, Z., Movahedi, S., mansour salesi, and Karimifar, M.
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lcsh:R5-920 ,lcsh:R ,lcsh:Medicine ,lcsh:Medicine (General) - Abstract
Background: Zinc was suggested as an antioxidant and immunomodulator trace element in parallel with other trace elements and antioxidant enzymes. Recently selenium deficiency was indicated in Behcet disease. In this study, we evaluated the correlation of serum zinc level and Behcet disease. Methods: In a cross-sectional, descriptive study serum level of zinc was measured in 49 cases satisfying International Study Group criteria and 51 controls. Serum zinc level was measured by atomic absorption spectrometry and compared the mean of Findings: serum selenium levels in both case and control and was analyzed by T-test statistical test. Serum zinc level (mean±SD) in patients (66.4±15.38) were significantly (p more...
15. Behcet's disease with abdominal aortic aneurism: A case report
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Karimifar, M., Karimzadeh, H., mansour salesi, Bonakdar, Z. S., and Mottaghi, P.
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lcsh:R5-920 ,lcsh:R ,lcsh:Medicine ,lcsh:Medicine (General) - Abstract
Background: Behcet's disease is a multisystem disease and mainly classified as a vasculitis. In this disease many organs like skin, mucosa, eyes, joints, vessels, nervous system, gastrointestinal tract, testis, heart and lungs maybe involved. Case Report: This case is a rare presentation of Behcet's disease with multiple saccular aneurisms in a 33 year old man. A patient with a permanent pain in back and flanks with radiation to the testis without relationship with position and feeding was admitted in Al-Zahra Hospital, Isfahan. In the abdominopelvic ultrasonography, an abdominal aneurism with thick wall borders and 37 mm in total diameter and 15 mm in open lumen diameter was reported. In spiral CT-scan of abdomen and pelvis with contrast, aneurism of abdominal aorta (4 × 4.5 cm in diameter) beginning below the renal arteries was seen, that extended downwardly to the near of the aortic bifurcation. Finally in MRA multiple saccular aneurism of the abdominal aorta at the same places was reported. After repairing of aneurism by surgical operation .The patient was referred to the clinic of rheumatology. After taking of history and physical and laboratory examination, because of the recurrent oral aphthous, erythemnodosum, positive result on pathergy test and abdominal aorta aneurism, the diagnosis of behcet's disease was confirmed and the patient was treated with medical drugs. Key words: Behcet's disease, Abdominal aorta aneurism, Vasculitis more...
16. Osteoporosis screening tools in Iranian postmenopausal women
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Peyman Mottaghi, Karimifar, M., Salesi, M., and Mehrabi, A.
17. Clinical and laboratory signs among systemic lupus erythematosus patients in Isfahan
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Bonakdar, Z. S., Nasiri, S., Karimifar, M., Karimzadeh, H., mansour salesi, and Motaghi, P.
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lcsh:R5-920 ,Systemic lupus erythematosus ,lcsh:R ,lcsh:Medicine ,Disease activity ,Clinical symptoms ,lcsh:Medicine (General) ,Laboratory signs ,BILAG index - Abstract
Background: Systemic lupus erythematosus is an inflammatory disease with unknown etiology which affects different organs in the body. Since lupus has different features in various ethnic groups, we decided to evaluate lupus patients in Isfahan, Iran. Methods: In this study, 200 patients (183 women and 17 men) with definitive diagnosis of the disease were evaluated in the rheumatology clinic, Alzahra Hospital, Isfahan, Iran, during 2004-2005. Findings: The mean age of patients was 31.6 ± 10 years. Clinical signs and symptoms due to which the patients referred to the clinic for first time referred included musculoskeletal symptoms (65%), hematological symptoms (57%), mucocutaneous signs (52%), general symptoms (fever, fatigue, weakness and lethargy) (41%), renal symptoms (28%), cardiovascular symptoms (14%), neurological signs (12%), cardiac and pulmonary defects (11%) and gastrointestinal symptoms (3%). According to the results, anti-nuclear antibodies appeared in 92% of the patients, anti-dsDNA antibodies in 81%, CRP in 25%, lupus anticoagulant in 72.5%, and IgM and IgG anti-cardiolipin in respectively 24.2% and 31.2%. Anemia with hemoglobin levels less than 10 mg/dl was seen in 49 patients (24.5%), leukopenia with white blood cell counts less than 4000/mm3 in 38 patients (19%) and thrombocytopenia with platelets less than 150,000 mm3 in 18 patients (9%). Erythrocyte sedimentation rates above 30 mm3 were also detected in 55% of the patients. Conclusion: Considering the diversity of symptoms in patients with lupus and the impacts these symptoms have on the disease prognosis, accurate examinations need to be performed routinely and as soon as lupus is diagnosed. more...
18. Comparison of severity of osteoporosis in women with primary hypothyroidism and healthy women
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Esmaili, F., Salari, A. H., Karimifar, M., Kachuei, A., ziba farajzadegan, Nazemzadeh, N., Salesi, M., and Karimzadeh, H.
19. A case of Takayasu's arteritis with pulsatile neck mass
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Karimifar, M., Fereshteh Salimi, and Behjati, M.
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Vasculitis ,Pulselessness ,Case Report ,Aneurysm ,Takayasu's Arteritis - Abstract
Takayasu's arteritis (TA), also known as pulseless disease or occlusive thromboaortopathy, is a form of vasculitis of unknown cause that chiefly affects the aorta and its major branches, most frequently in young women. We describe an 18-year-old female with a soft and pulsatile mass in the left side of her neck. more...
20. Radiative heat flux control over spherical surfaces
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Karimifar, M., primary, Aghanajafi, S., additional, and Shabani, A.B., additional
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- View/download PDF
21. Investigation of cardiovascular risk factors in diabetic and nondiabetic patients with nonalcoholic fatty liver disease.
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Barati M, Teimouri A, Feizi A, Iraj B, and Karimifar M
- Abstract
Background: The current study aims to assess cardiovascular risk factors (CVRFs) among diabetic versus nondiabetic nonalcoholic fatty liver disease (NAFLD) patients. NAFLD is the most common hepatic disorder worldwide which is directly associated with diverse CVRFs such as type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS)., Materials and Methods: The current cross-sectional population-based study has been conducted on 1031 NAFLD patients. After excluding 340 prediabetes patients, the NAFLD patients were divided into T2DM and normal blood glucose (NBG). Then, CVRFs were compared between the two groups., Results: Out of 691 NAFLD cases included in the study, 337 (48.8%) patients had T2DM. In the T2DM and NBG groups, the body mass index (BMI) was 31.2 ± 4.6 and 29.9 ± 4.3 kg/m2, respectively (P = 0.001). The waist circumference was 102.2 ± 10.2 and 97.6 ± 10.6 cm, respectively (P < 0.001). The systolic blood pressure was 123.3 ± 15.6 and 119.6 ± 13.6 mmHg, respectively (P = 0.043). The triglyceride levels were 191.9 ± 104.7 and 176.5 ± 89.6 mg/dL, respectively (P = 0.042). Generally, these factors were significantly higher among the diabetic patients. Besides, cardiovascular disease (CVD), hypertension, and MS were statistically more prevalent in NAFLD patients with T2DM ( P < 0.001) than nondiabetic NAFLD patients. In multiple logistic regression models, the odds ratio of CVD, hypertension, and MS was 2.18, 2.12, and 6.63 for patients with T2DM compared with NBG, respectively. Adjustment was made for age, sex, BMI, smoking, and physical activity., Conclusion: CVRFs were higher in NAFLD patients with T2DM than NAFLD patients with NBG., Competing Interests: There are no conflicts of interest., (Copyright: © 2024 Journal of Research in Medical Sciences.) more...
- Published
- 2024
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22. Successful Stem Cell Mobilization and CD34+ Cell Collection in a Poor Mobilizer: A Case Report Utilizing a Combination of Recombinant Growth Colony Stimulating Factor, Recombinant Human Growth Factor, and Plerixafor.
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Najafabadi MK, Moghaddas A, Karimifar M, and Darakhshandeh A
- Abstract
Diffuse large B-cell lymphoma is the most prevalent form of non-Hodgkin's lymphoma that is usually treated with chemoimmunotherapy. If the disease proves refractory or recurrent, the primary treatment approach involves high-dose chemotherapy with bone marrow transplantation. The collection of peripheral blood stem cells before transplantation plays a vital role in the treatment process, necessitating the mobilization of blood stem cells from the bone marrow to the peripheral blood. Despite using standard methods such as granulocyte colony-stimulating factor (G-CSF), chemotherapy, and plerixafor, some patients cannot collect an optimal count of CD34+ cells for transplantation. Managing these patients with poor mobilization poses significant challenges. In this article, we present a case of a poor mobilizer patient who achieved prosperous mobilization by using recombinant human G-CSF, recombinant human growth hormone, and plerixafor., Competing Interests: There are no conflicts of interest., (Copyright: © 2024 Journal of Research in Pharmacy Practice.) more...
- Published
- 2024
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23. Appetite sensation improvement by synbiotic supplementation in patients with metabolic syndrome: A randomized controlled clinical trial.
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Hosseini F, Pourjam M, Mirzaeian S, Karimifar M, Feizi A, Entezari MH, and Saraf-Bank S
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The potential link between dysbiosis, features of metabolic syndrome (MetS), inflammation, and sensation impairment has been recently recognized. However, in this context, there are few indications available regarding the effects of co-supplementation with Bacillus indicus , Bacillus coagulans , and fructooligosaccharide (FOS) prebiotics on patients with MetS. Therefore, this study aimed to investigate the effects of synbiotic supplementation on glycemic indices, inflammatory biomarkers, and appetite among adults with MetS. This study is a randomized, double-blind, placebo-controlled clinical trial conducted in the Endocrine and Metabolism Research Center outpatient clinic in Isfahan, Iran. Fifty-eight MetS patients were randomly assigned to receive either synbiotics ( n = 29) or placebo ( n = 29) supplementation twice per day for 8 weeks. Finally, 55 patients were recruited for analyses (28 in the intervention group and 27 in the placebo group). Random permuted blocks and a computer-generated random number table were used for treatment allocation. No adverse effects were reported during the study. There were no significant differences in glycemic indices and inflammatory markers within- and between groups (all p > .05). However, a significant increase in the sensation of fullness was documented in the synbiotic group. In conclusion, the eight-week treatment did not improve glycemic control and inflammatory markers. Nevertheless, it demonstrated potential efficacy in enhancing participants' appetite sensations, warranting further evaluation in longer intervention periods during future clinical trials., Competing Interests: The authors declare no conflict of interest., (© 2024 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.) more...
- Published
- 2024
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24. Comparison of bone mineral density of osteoporotic and osteopenia menopausal women treated with oral bisphosphonates before stopping the treatment and 1 year after drug holiday period.
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Rizi MM, Salari A, Salesi M, Rasooli L, and Karimifar M
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- Humans, Female, Treatment Interruption, Diphosphonates therapeutic use, Menopause, Lumbar Vertebrae diagnostic imaging, Bone Density, Osteoporosis drug therapy
- Abstract
Background: Osteoporosis is a skeletal and bone disorder characterized by bone fractures and decreased bone mineral density (BMD). Bisphosphonates have a great tendency to bind to minerals, and their long-term use can increase the risk of bone fragility in patients. Stopping bisphosphonates after a period of time is called a drug holiday (DH). Recent evidence has shown that patients' BMD may decrease again during DH. However, few studies have been done in this regard. In the present study, we compared the BMD of postmenopausal women during bisphosphonates treatment and 1 year after DH., Material and Methods: A total of 202 patients were selected with osteopenia (n = 95) and osteoporosis (n = 107); they had been treated with alendronate for 5 years (a rheumatologist confirmed the diagnosis of osteopenia and osteoporosis) and had undergone DH for 1 year. At the arrival of all patients, BMD was checked with the DXA (dual-energy X-ray absorptiometry) method using the 2007 American Explorer model Hologic device based on the Caucasian race. One year later, patients were reassessed for BMD by the same device., Result: The analysis of femoral neck (FN) and lumbar spine (LS) T-score indices in the osteopenia and the osteoporosis groups showed reduction after DH, and the difference was statistically significant in both groups (p = 0.001). After 1 year of stopping bisphosphonate treatment, the average of FN and LS BMD decreased in both groups (p = 0.001)., Conclusion: In general, it can be said that DH can reduce FN and LS T-scores. The results indicated a significant reduction in BMD after the DH period for both the osteoporosis and osteopenia groups in the early months. Also, the effect of DH in osteoporosis patients was more compared to the osteopenia individuals, which could have implications for their treatment approach, and also its effect on bone health. Key Points • The DH can reduce FN and LS T-scores • The BMD reduced after the DH period for both the osteoporosis and osteopenia groups • After 1 year of stopping bisphosphonate treatment, the average of FN and LS BMD decreased in both groups., (© 2024. The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR).) more...
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- 2024
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25. Associations between empirically derived dietary patterns and oxidative stress and inflammation in adults with primary hypothyroidism: a case-control study.
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Taherinia S, Heidari Z, Salehidoost R, Karimifar M, Arab A, Alshahrani SH, and Askari G
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- Humans, Adult, Case-Control Studies, Iran epidemiology, Inflammation, Antioxidants, Oxidative Stress, Hypothyroidism
- Abstract
Background: Primary hypothyroidism is a common endocrine disorder caused by impaired production of thyroid hormones. Recent studies have shown that dietary habits, oxidative stress, and inflammation may play roles in thyroid hypofunction. Thus, the present article aimed to determine the relationship between major dietary patterns and oxidative stress and inflammation in primary hypothyroid patients and healthy people in Iranian adults., Methods: This matched case-control study was conducted on 200 participants (100 cases and 100 controls). The presence of primary hypothyroidism was determined by endocrinologists based on American Thyroid Association (ATA) criteria. Dietary intake was assessed using a validated 168-item, semi-quantitative food frequency questionnaire (FFQ). The principal component analysis (PCA) method was used to derive major dietary patterns. Statistical analysis was performed using logistic regression analysis, and the findings were reported using odds ratios (ORs) with 95% CIs., Results: We identified 2 major dietary patterns (i.e., healthy and Western dietary patterns). After adjusting for confounding variables, participants in the highest tertile of the healthy eating pattern had lower odds of primary hypothyroidism. Also, there was a significant relationship between total antioxidant capacity (TAC) levels and thyroid hypofunction; however, no significant correlation was seen between the Western dietary pattern and malondialdehyde (MDA) and C-reactive protein (CRP) with hypothyroidism., Conclusions: There were statistically direct associations between healthy dietary patterns (loaded with vegetables, nuts and seeds, fruits, dried fruits, olives, garlic, black pepper, starchy vegetables, low-fat dairy, and legumes) and increased TAC levels with a decreased risk of thyroid hypofunction. However, Western dietary patterns and MDA and CRP levels did not associate with an underactive thyroid., (© 2023. The Author(s).) more...
- Published
- 2023
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26. Evaluation of the effectiveness of topical oily solution containing frankincense extract in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial.
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Mohsenzadeh A, Karimifar M, Soltani R, and Hajhashemi V
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- Humans, Iran, Knee Joint, Plant Extracts, Frankincense, Osteoarthritis, Knee
- Abstract
Objective: Pharmacological treatments of osteoarthritis (OA) have several side effects. Boswellia serrata resin (frankincense) is rich in boswellic acids that have antioxidant and anti-inflammatory effects; though, their oral bioavailability is low. The aim of this study was evaluation of the clinical effectiveness of frankincense extract in the treatment of knee OA. In a randomized double-blind placebo-controlled clinical trial, eligible patients with knee OA were randomly divided into two groups of drug (33 patients) and control (37 patients), to use oily solution of frankincense extract or placebo, respectively, on the involved knee three times daily for four weeks. WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index), VAS (visual analogue scale; for pain severity), and PGA (patient global assessment) scores were determined before and after intervention., Results: For all evaluated outcome variables, there was a significant decrease from baseline in both groups (P < 0.001 for all). Furthermore, the end-of-intervention values for all parameters were significantly lower in drug group than placebo group (P < 0.001 for all), showing more effectiveness of drug compared to placebo., Conclusion: Topical oily solution containing enriched extract of boswellic acids could decrease pain severity and improve the function in patients with knee OA. Trial Registration Trial registration number: IRCT20150721023282N14. Trial registration date: September 20, 2020. The study was retrospectively registered in Iranian Registry of Clinical Trials (IRCT)., (© 2023. The Author(s).) more...
- Published
- 2023
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27. The effect of linagliptin on microalbuminuria in patients with diabetic nephropathy: a randomized, double blinded clinical trial.
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Karimifar M, Afsar J, Amini M, Moeinzadeh F, Feizi A, and Aminorroaya A
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- Humans, Kidney, Albuminuria drug therapy, Diabetes Mellitus, Diabetic Nephropathies drug therapy, Linagliptin therapeutic use
- Abstract
The aim of the present study was to investigate the effect of linagliptin on microalbuminuria in patients with diabetic nephropathy (DN). The present double-blind randomized placebo-controlled clinical trial was performed on 92 patients with DN who were divided into two groups. The intervention and control groups received linagliptin 5 mg and placebo for 24 weeks, respectively. Blood pressure, lipid profile, liver enzymes, fasting plasma glucose (FPG), and urine albumin-creatinine ratio (UACR) were assessed and recorded before, 12 weeks, and 24 weeks after the beginning of the intervention. The mean value of UACR decrease was significant over time in both groups, with higher decrease in linagliptin group, however, the differences between two groups were not, statistically significant (P > 0.05). However, the percentage of improvement in microalbuminuria (UACR < 30 mg/g) in the linagliptin group was significantly higher than that of the control group during 24 weeks of intervention (68.3% vs. 25%; P-value < 0.001). There was no statistically significant difference in the mean value of the UACR and other parameters between linagliptin treated and placebo treated patients with diabetic nephropathy. Further studies, with longer periods of follow-up are suggested to examine these patients' renal outcomes., (© 2023. The Author(s).) more...
- Published
- 2023
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28. Effect of bread fortification with pomegranate peel powder on glycemic indicators, antioxidant status, inflammation and mood in patients with type 2 diabetes: study protocol for a randomized, triple-blind, and placebo-controlled trial.
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Zare M, Goli AH, Karimifar M, Tarrahi MJ, Rezaei A, and Amani R
- Abstract
Background: The oxidative stress caused by the creation and breakdown of reactive oxygen species affects glucose tolerance, B-cell function, insulin resistance, and metabolites containing free fatty acids. Functioning foods are therefore becoming increasingly popular because they provide health benefits and prevent oxidative stress. This research aims to assess strategies to alleviate oxidative stress and inflammation in patients with type 2 diabetes (T2DM). In the present study, the metabolic effect wheat bread fortified with pomegranate peel powder(PPP) will be assessed in participants with type 2 diabetes., Methods: A randomized, triple-blind, placebo-controlled, and parallel arms clinical trial will be conducted on 90 patients with T2DM. Run-in courses will last for two weeks. The intervention and control groups will receive wheat bread with and without PPP, respectively. Anthropometric data, fasting plasma glucose, hemoglobin A1C, lipid profile, insulin level, high-sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), Total antioxidant capacity(TAC), and mood state, will be measured at the baseline and three months post-intervention. Beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) will also be assessed., Discussion: This trial will provide novel data on the impact of fortified bread with PPP on metabolic profile and mood state of patients with type 2 diabetes. The results will demonstrate the potential of such intervention in glycemic indices, antioxidant status, inflammation and mood in these patients., Trial Registration: Trial is registered in the Iranian Registry of Clinical Trials (ID: IRCT20191209045672N1). Date of registration 21/09/2020. https://en.irct.ir/trial/48132., Competing Interests: Conflict of interestsThe authors declare that they have no conflict of interest., (© The Author(s), under exclusive licence to Tehran University of Medical Sciences 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.) more...
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- 2023
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29. Single Nucleotide Polymorphism rs6445975 in the PXK Gene Is Correlated with Susceptibility and Clinical Characteristics of Systemic Lupus Erythematosus.
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Karimifar M, Sereshti N, Salehi R, Mousavi M, Karimzadeh H, Salehi A, and Pakzad B
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Background: Recently, genome-wide association studies (GWAS) have discovered several single nucleotide polymorphisms (SNPs) and loci associated with the risk of systemic lupus erythematosus (SLE). rs6445975 (T>G; intronic variant) polymorphism in the PXK gene is one of these loci. However, there was an inconsistency between the results of replicative studies on European and Asia ancestry. This study aimed to assess the possible association between rs6445975 polymorphism with SLE risk in the Iranian population., Methods: Genotype and allele distribution of rs6445975 polymorphism were investigated in 110 patients with SLE and 115 healthy controls in Isfahan University of Medical Sciences, Isfahan, Iran in 2019 via real-time PCR high resolution melting method (HRM)., Results: GG and TG genotypes, but not TT genotype, were associated with increased risk of SLE (GG vs TT; OR= 7.538; 95%CI [3.47, 17.066] and TG vs TT; OR=2.21; 95%CI [1.06, 4.72]). Inheritance analysis revealed that TG + GG was correlated with the increased risk of SLE disease in the dominant model (OR=3.928; 95%CI [2.056, 7.74]). Moreover, subjects with the G allele were more frequently affected with SLE than individuals with the T allele (OR= 3.55; 95%CI [2.37, 5.36]). The G allele in patients was correlated with serum concentration of CRP, ESR, anti-dsDNA antibody, C3, and C4 and presentation of some clinical manifestations such as kidney involvements and skin lesions ( P <0.05)., Conclusion: Our findings suggest a substantial association between rs6445975 polymorphism in the PXK gene with susceptibility and clinical characteristics of SLE in the Iranian population., Competing Interests: Conflict of interest The authors declare that there is no conflict of interest., (Copyright © 2022 Karimifar et al. Published by Tehran University of Medical Sciences.) more...
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- 2022
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30. Evaluation of Diagnostic Accuracy of Alpha-Fodrin Antibody in Iranian Patients with Sjogren's Disease.
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Rostamian A, Baradaran A, Mottaghi P, Salesi M, Karimifar M, and Mansouri V
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Background: Sjogren's syndrome, as a chronic autoimmune disease, involves in lymphocytic infiltration in the exocrine glands. As the result of exocrine glands disruption, the clinical hallmark of this disease including dryness of mouth and eyes along with fatigue and joint pain occur. However, heterogeneity of clinical presentations among newly diagnosed adult patients with Sjogren's syndrome leads to difficulty in its diagnosis. One of the diagnostic criteria for Sjogren's syndrome is the presence of autoantibodies in patient serum. One of the novel biomarkers suggested for diagnosis of Sjogren is alpha-fodrin antibody. In this study, we aimed to evaluate the diagnostic power of anti-α-fodrin antibody among the Iranian population for the first time., Materials and Methods: We recruited 82 individuals in this study. Alpha-fodrin were measured in case and control with Elisa kit as 16.71 (9.84) and 18.44 (11.54)., Results: There was no any significant difference between two groups regarding alpha-fodrin level ( P = 0.35). Then we applied the receiver operating characteristic (ROC) curve analysis to determine the predictive value of alpha-fodrin for diagnosing Sjogren's disease. The area under curve of the ROC curve was calculated as 0.5453. Also, there were significant association between age and alpha-fodrin antibody., Conclusions: Alpha-fodrin test did not have acceptable predictive power for predicting Sjogren's disease; however, it could be associated with disease progression., Competing Interests: There are no conflicts of interest., (Copyright: © 2022 Advanced Biomedical Research.) more...
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- 2022
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31. Correction to: Impacts of FcγRIIB and FcγRIIIA gene polymorphisms on systemic lupus erythematous disease activity index.
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Karimifar M, Akbari K, ArefNezhad R, Fathi F, Ghasroldasht MM, and Motedayyen H
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- 2022
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32. The effects of wheat germ consumption on mental health and brain-derived neurotrophic factor in subjects with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial.
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Mohammadi H, Karimifar M, Heidari Z, Zare M, and Amani R
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- Anthropometry, Depression prevention & control, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 psychology, Double-Blind Method, Humans, Stress, Psychological prevention & control, Brain-Derived Neurotrophic Factor blood, Diabetes Mellitus, Type 2 diet therapy, Diet, Mental Health, Triticum
- Abstract
Objectives: Herbals, as bioactive foods, have been one of the most popular alternatives and complementary treatments in preventing and controlling type 2 diabetes mellitus (T2DM). The aim of the present trial was to examine the effects of wheat germ consumption on mental health and brain-derived neurotrophic factor (BDNF) among patients with T2DM. Methods: Eighty participants with T2DM were randomly allocated to receive 20 g wheat germ ( n = 40) or placebo ( n = 40) in a randomized double-blind clinical trial for 12 weeks. Depression, anxiety, stress scale-21 (DASS-21) questionnaire was used to assess the mental health of study participants. Serum BDNF was assessed at the baseline and end of intervention. Anthropometric indices were measured at the baseline, 6 and 12 weeks during the intervention. Results: A total of 75 subjects completed the trial. Compared with the placebo, wheat germ consumption led to a significant reduction in depression ( P = .03) and stress ( P = .04) scores. Moreover, a significant increase in serum BDNF concentrations was observed in the wheat germ group ( P = .004), while there was no significant difference between the groups. Wheat germ intake had no significant effects on anthropometric indices and anxiety scores between the groups. Conclusion: Our findings showed that wheat germ consumption for 12 weeks could significantly reduce the stress and depression scores but had no significant effects on anxiety scale and anthropometric outcomes in patients with T2DM. more...
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- 2022
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33. Impacts of FcγRIIB and FcγRIIIA gene polymorphisms on systemic lupus erythematous disease activity index.
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Karimifar M, Akbari K, ArefNezhad R, Fathi F, Mousaei Ghasroldasht M, and Motedayyen H
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- Genotype, Humans, Iran, Polymorphism, Single Nucleotide, Lupus Erythematosus, Systemic genetics, Receptors, IgG genetics
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Objective: Systemic lupus erythematous (SLE) disease is a chronic autoimmune disease with unknown etiology that can involve different organs. Polymorphisms in Fcγ receptors have been identified as genetic factors in susceptibility to SLE. This study was aimed to investigate effects of two single nucleotide polymorphisms (SNPs) within FcγRIIB and FcγRIIIA genes on systemic lupus erythematous disease activity index (SLEDAI) in an Iranian population., Results: Our findings indicated TT and GG genotypes were the common genotypes of FcγRIIB and FcγRIIIA SNPs in SLE patients, respectively. There were no significant differences in genotype and allele frequencies of FcγRIIB and FcγRIIIA SNPs in SLE and healthy subjects. However, the frequencies of genotypes and alleles of FcγRIIB and FcγRIIIA SNPs were significantly associated with some clinical manifestations used to determine SLEDAI (P < 0.001-0.5)., (© 2021. The Author(s).) more...
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- 2021
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34. Isfahan Thyroid Cohort Study (ITCS).
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Shahrokh Esfahani S, Tabatabaee A, Aminorroaya A, Amini M, Feizi A, Janghorbani M, Tabatabaei A, Meamar R, Adibi A, Abyar M, Karimifar M, Sajad R, Salehidoost R, Faghih Imani E, Hovsepian S, Sirous M, and Aminorroaya Yamini S more...
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- Cohort Studies, Female, Humans, Male, Hyperthyroidism epidemiology, Hypothyroidism epidemiology, Thyroid Diseases
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Background: The Isfahan Thyroid Cohort Study (ITCS) is one of the few population-based epidemiological studies in Iran that investigates the prevalence and incidence of thyroid disorders including hypothyroidism, hyperthyroidism, goiter, nodule, and iodine status., Methods: This cohort is located in Isfahan, Iran. The first phase was initiated in 2006 with 2523 participants (1275 males, 1248 females). The participants were selected using multi-stage cluster sampling from the general residents of Isfahan, Iran. The study had two phases (2006 and 2011) and its third stage is planned for 2020-2021., Results: The prevalence of thyroid function states was euthyroid (89.3%, 95% CI: 88%-90%), overt hypothyroidism (2.8%, 95% CI: 2%‒3%), subclinical hypothyroidism (5.8%, 95% CI: 4%-6%), overt hyperthyroidism (0.8%, 95% CI: 0.4%‒1%), and subclinical hyperthyroidism (0.99%, 95% CI: 0.6%-1%). Hypothyroidism and hyperthyroidism were significantly associated with goiter. The incidence of thyroid dysfunction was reported as follows: overt hypothyroidism (2.7, 95% CI: 1.6-3.7), subclinical hypothyroidism (20.6, 95% CI: 18-23), overt hyperthyroidism (1.9, 95% CI: 1-2.7) and subclinical hyperthyroidism (2.7, 95% CI: 1.6-3.7) per 1000 (person-year)., Conclusion: We assessed the prevalence and incidence of thyroid disorders in Isfahan in the first and second phase, respectively. We are conducting the third phase of the ITCS in order to study the associations between thyroid peroxidase antibody (TPOAb) level and environmental factors such as infection., (© 2021 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.) more...
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- 2021
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35. Assessment of Treatment Safety and Quality of Life in Patients Receiving Etanercept Biosimilar for Autoimmune Arthritis (ASQA): A Multicenter Post-marketing Surveillance Study.
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Gharibdoost F, Salari AH, Salesi M, Ebrahimi Chaharom F, Mottaghi P, Hosseini M, Sahebari M, Nazarinia M, Mirfeizi Z, Shakibi M, Moussavi H, Karimifar M, Mowla K, Karimzadeh H, Anjidani N, and Jamshidi A more...
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- Etanercept, Humans, Infant, Product Surveillance, Postmarketing, Prospective Studies, Quality of Life, Treatment Outcome, Antirheumatic Agents therapeutic use, Arthritis drug therapy, Autoimmune Diseases drug therapy, Biosimilar Pharmaceuticals
- Abstract
Introduction: Phase IV post-marketing surveillance studies are needed to evaluate the real-world safety and effectiveness of drug products. This study aimed to evaluate the safety and effectiveness of biosimilar etanercept (Altebrel, AryoGen Co., Iran) in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)., Methods: In this open-label, multicenter, prospective, observational, post-marketing surveillance study, 583 patients received biosimilar etanercept 25 mg twice weekly or 50 mg once weekly and were followed up to 12 months. The primary objective was to evaluate the safety of biosimilar etanercept by documenting all the adverse events in the case report forms throughout the study period. The secondary objective was to evaluate the effectiveness of biosimilar etanercept in study patients, where longitudinal changes in health assessment questionnaire (HAQ), pain, and disease activity scores were assessed., Results: A total of 583 patients (44.80 ± 13.09 years of age) were included and followed for an average of 8.12 ± 3.96 months. Among all patients, 172 (29.50%) experienced at least one adverse event, and injection site reaction, abdominal pain, and upper respiratory tract infection were the most common. HAQ scores decreased from 1.32 ± 0.77 at baseline to 0.81 ± 0.61 at 12 months in patients with RA/PsA (p < 0.01) and from 0.82 ± 0.58 at baseline to 0.66 ± 0.63 at 12 months in patients with AS (p = 0.18). Pain scores decreased from 6.49 ± 2.41 at baseline to 3.51 ± 2.39 at 12 months (p < 0.01)., Conclusion: The results demonstrated the real-world safety and effectiveness of biosimilar etanercept in patients with RA, PsA, and AS., Trial Registration: ClinicalTrials.gov identifier NCT04582084. more...
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- 2021
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36. Ultrasound-guided ethanol injection for the treatment of parathyroid adenoma: A prospective self-controlled study.
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Yazdani AA, Khalili N, Siavash M, Shemian A, Goharian AR, Karimifar M, Tavakoli B, and Yazdi M
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Background: Parathyroidectomy, the standard treatment of primary hyperparathyroidism (PHP) due to parathyroid adenoma, is not suitable for all patients. We evaluated the efficacy of ultrasound-guided ethanol ablation of parathyroid adenoma in a group of patients with PHP., Materials and Methods: In a prospective self-controlled trial, 39 patients with parathyroid adenoma, who were not candidates for surgery, were enrolled. Ethanol injections were performed by two experienced interventional radiologists under the guidance of real-time ultrasonography. Adenoma size changes were assessed at about 1 month later. Serum levels of parathyroid hormone, calcium, phosphate, 25-OH Vitamin D, and alkaline phosphatase were evaluated at the baseline, 1, 3, 6, and 12 months after the injections. The treatment effects on outcome variables were assessed by repeated measures analysis., Results: Volume of the adenomas decreased during the study period from 1.87±6.45 cm
3 to 0.38± 0.48cm3 ( P < 0.001). Corrected serum calcium levels decreased from 10.40 ± 0.96 mg/dl to 8.82 ± 0.58 mg/dl ( P < 0.001), and remained stable during one year follow-up. Serum levels of parathyroid hormone decreased gradually from 129.85 ± 63.37 to 72.58 ± 53.86 pg/mL after 3 months and to 44.78 ± 28.04 pg/mL after 1 year ( P < 0.001). Overall, 46% of the patients improved after 1 month of ethanol ablation therapy which increased to 84.5% during 1-year follow-up. No major complications were observed., Conclusion: The current study showed the efficacy of ultrasound-guided ethanol injection in PHP and may be considered as a suitable alternative treatment in patients who are not candidates for the surgery. It has also a good safety profile without major complications if performed by experienced hands., Competing Interests: There are no conflicts of interest., (Copyright: © 2020 Journal of Research in Medical Sciences.) more...- Published
- 2020
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37. The effect of synbiotic supplementation on anthropometric indices, appetite, and constipation in people with hypothyroidism: A randomized, double-blind, placebo-controlled trial.
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Talebi S, Karimifar M, Heidari Z, Mohammadi H, Asbaghi O, Hadi A, Marx W, and Askari G
- Subjects
- Adolescent, Adult, Aged, Double-Blind Method, Female, Humans, Hypothyroidism drug therapy, Male, Middle Aged, Young Adult, Anthropometry methods, Appetite drug effects, Constipation drug therapy, Dietary Supplements analysis, Hypothyroidism complications, Obesity complications, Obesity drug therapy, Synbiotics analysis
- Abstract
Hypothyroidism and obesity are two highly prevalent conditions that appear to be closely related. Hypothyroidism is correlated with weight gain, loss of appetite, constipation, and a higher incidence of obesity. The present study aimed to investigate the effects of synbiotic supplementation on anthropometric indices, appetite, and constipation in subjects with hypothyroidism. Sixty subjects with hypothyroidism were assigned into two groups to receive either 500 mg/day of synbiotic (n = 30) or a placebo (n = 30) per day for 8 weeks. Anthropometric indices, appetite, and constipation were assessed at study baseline and end of the trial. At the end of trial, waist-to-hip ratio was significantly decreased in the synbiotic group (p = .030), whereas there were no significant differences between groups. We did not observe any statistically significant change in appetite or other anthropometric indices (p > .05). Compared with the placebo synbiotic supplementation led to a significant reduction in constipation (p = .048). The results of the present trial indicated that synbiotic supplementation may have favorable results in constipation among subjects with hypothyroidism for 8 weeks. Further studies with larger sample size and longer duration are needed to confirm our findings., (© 2020 John Wiley & Sons, Ltd.) more...
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- 2020
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38. The effects of wheat germ supplementation on metabolic profile in patients with type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial.
- Author
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Mohammadi H, Karimifar M, Heidari Z, Zare M, and Amani R
- Subjects
- Adult, Aged, Antioxidants pharmacology, Blood Glucose drug effects, Blood Glucose metabolism, Double-Blind Method, Female, Glycated Hemoglobin drug effects, Glycated Hemoglobin metabolism, Humans, Iran, Male, Middle Aged, Oxidative Stress drug effects, Placebos, Triglycerides blood, Diabetes Mellitus, Type 2 diet therapy, Diabetes Mellitus, Type 2 metabolism, Dietary Supplements, Metabolome drug effects, Triticum chemistry
- Abstract
The aim of the present trial was to examine the effects of wheat germ (WG) consumption on metabolic control and oxidative stress status of type 2 diabetes mellitus (T2DM) patients. Eighty participants with T2DM were randomly allocated to receive 20-g WG (n = 40) or placebo (n = 40) in a randomized double-blind clinical trial for 12 weeks. Serum lipid profiles, glycaemic indices, total antioxidant capacity, and malondialdhyde (MDA) were assessed. A total of 75 subjects completed the trial. Compared with the placebo, WG consumption led to significant reduction in total cholesterol (TC) concentrations (p = .04). There was a trend regarding TC to high density lipoprotein ratio (p = .08) following 12 weeks WG consumption, although they were not statistically significant after correcting for multiple testing. In addition, within-group comparison revealed a significant rise in total antioxidant capacity concentration (p = .001) in WG group. We observed no significant effects of WG intake on glycaemic status, blood pressure, MDA, triglyceride, and low density lipoprotein levels. WG consumption for 12 weeks could decrease serum TC levels and had no significant effects on other metabolic variables and MDA in patients with T2DM. Though observed health benefit effects were small, it might lead to a major impact on wider public health., (© 2019 John Wiley & Sons, Ltd.) more...
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- 2020
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39. The effects of synbiotic supplementation on thyroid function and inflammation in hypothyroid patients: A randomized, double‑blind, placebo‑controlled trial.
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Talebi S, Karimifar M, Heidari Z, Mohammadi H, and Askari G
- Subjects
- Adult, Blood Pressure, C-Reactive Protein analysis, Double-Blind Method, Female, Humans, Inflammation, Male, Surveys and Questionnaires, Thyroid Gland physiopathology, Thyroid Hormones analysis, Hypothyroidism therapy, Synbiotics administration & dosage, Thyroid Gland physiology
- Abstract
Background: There is a positive link between thyroid homeostasis and the composition of gut microbiota. A limited number of studies have suggested the efficacy of probiotic products on levothyroxine metabolism and thyroid hormone activity. Therefore, the purpose of this study was to investigate the effect of synbiotic supplementation on thyroid function, inflammation markers, and blood pressure in subjects with hypothyroidism., Methods: This study was conducted as a randomized, double-blind, placebo-controlled trial involving 60 patients with hypothyroidism. Participants were randomly recruited into two groups to receive either 500 mg/day of synbiotic (n = 30) or a placebo (n = 30) for 8 weeks., Results: Thyroid-stimulating hormone concentration, levothyroxine dose, and fatigue severity scale score were significantly decreased after the 8-week intervention in the synbiotic group (P < 0.05), while there were no significant differences seen in the placebo group. In addition, FT
3 at the end of intervention was significantly higher (P = 0.001) in both groups, although these changes were not significant between the two groups (P = 0.259). Synbiotic supplements led to a significant elevation in serum CRP (P = 0.006), but this increase was not significant between groups (P = 0.699). Moreover, no statistical significance was observed within or between groups in terms of anti-thyroid peroxidase, systolic blood pressure and diastolic blood pressure (P > 0.05)., Conclusion: Synbiotic supplementation among hypothyroid patients for 8 weeks may have beneficial effects on thyroid function. Further studies with larger sample size and longer duration are needed to confirm the current findings., Competing Interests: Declaration of Competing Interest The authors declare that they have no conflict of interest., (Copyright © 2019. Published by Elsevier Ltd.) more...- Published
- 2020
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40. Interferon-induced protein 44-like gene promoter is differentially methylated in peripheral blood mononuclear cells of systemic lupus erythematosus patients.
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Karimifar M, Pakzad B, Karimzadeh H, Mousavi M, Kazemi M, Salehi A, Vatandoust N, Amini G, Akbari M, and Salehi R
- Abstract
Background: The objectives of this study were to compare the interferon-induced protein 44-like (IFI44L) promoter methylation level between systemic lupus erythematosus (SLE) patients and healthy controls and to evaluate its diagnostic value in SLE., Materials and Methods: The IFI44L promoter methylation level was measured in 49 patients with SLE and 50 healthy controls. Quantitative analysis of promoter methylation IFI44L gene in genomic DNA samples extracted from peripheral blood mononuclear cells was examined in SLE patients and healthy controls. The level of DNA methylation was compared between SLE patients and healthy controls as well as within SLE patient groups based on the presence of renal involvement. Moreover, diagnostic values of IFI44L were calculated., Results: The IFI44L promoter methylation level in SLE patients was significantly lower than healthy controls (median, 43.8 vs. 57, respectively; P = 0.008). The level of IFI44L promoter methylation was not significantly different between SLE patients with renal involvement and SLE patients without renal involvement (84.6% vs. 92.7%, respectively; P = 0.774). The IFI44L promoter methylation level ≤94.3% was the best cutoff point with a sensitivity of 91.8% and a specificity of 38% to distinguish patients with SLE from healthy individuals., Conclusion: The level of IFI44L promoter methylation from whole peripheral blood in Iranian SLE patients was significantly lower than healthy controls. Furthermore, the DNA methylation level of IFI44L promoter was not associated with renal damage in patients with SLE., Competing Interests: There are no conflicts of interest., (Copyright: © 2019 Journal of Research in Medical Sciences.) more...
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- 2019
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41. Alendronate improves fasting plasma glucose and insulin sensitivity, and decreases insulin resistance in prediabetic osteopenic postmenopausal women: A randomized triple-blind clinical trial.
- Author
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Karimi Fard M, Aminorroaya A, Kachuei A, Salamat MR, Hadi Alijanvand M, Aminorroaya Yamini S, Karimifar M, Feizi A, and Amini M
- Subjects
- Female, Humans, Middle Aged, Biomarkers analysis, Fasting, Follow-Up Studies, Glucose Tolerance Test, Glycated Hemoglobin analysis, Postmenopause, Prognosis, Alendronate therapeutic use, Blood Glucose analysis, Bone Density Conservation Agents therapeutic use, Bone Diseases, Metabolic complications, Bone Diseases, Metabolic drug therapy, Insulin Resistance, Prediabetic State complications, Prediabetic State drug therapy
- Abstract
Aims/introduction: Postmenopausal women receive bisphosphonates for osteoporosis treatment. The effect of these medications on developing diabetes mellitus in prediabetic patients is yet to be investigated. We aimed to determine the effect of alendronate on plasma glucose, insulin indices of postmenopausal women with prediabetes and osteopenia., Materials and Methods: The present triple-blind randomized controlled clinical trial included 60 postmenopausal women, aged 45-60 years. All patients were vitamin D sufficient. They were randomly enrolled in intervention (70 mg/week alendronate for 12 weeks) and control (placebo tablet per week for 12 weeks) groups. The morning 8-h fasting blood samples were collected at the baseline and follow-up visits to measure the fasting plasma glucose (mg/dL), insulin and hemoglobin A1c (HbA1c). Plasma glucose and insulin concentration were measured 30, 60 and 120 min after the glucose tolerance test. The Matsuda Index, homeostasis model assessment of insulin resistance, homeostasis model assessment of β-cell function and the area under the curves of glucose and insulin were calculated., Results: The mean (standard deviation) fasting plasma glucose (102.43 [1.46] mg/dL vs 94.23 [1.17] mg/dL, P = 0.001), 120-min insulin concentration (101.86 [15.70] mU/L vs 72.60 [11.36] mU/L, P = 0.026), HbA1c (5.60 [0.06]% vs 5.40 [0.05]%, P = 0.001), homeostasis model assessment of insulin resistance (3.57 [0.45] vs 2.62 [0.24], P = 0.021) and Matsuda Index (7.7 [0.41] vs 9.2 [0.4], P = 0.001) significantly improved in the alendronate-treated group. There were more statistically significant reductions in fasting plasma glucose (-8.2 [8.63] mg/dL vs -2.5 [14.26] mg/dL, P = 0.002) and HbA1c (-0.2 [0.23]% vs -0.09 [0.26]%, P = 0.015) observed in the alendronate-treated group than the placebo group during the study course, respectively., Conclusions: Administration of 70 mg/week alendronate improves fasting plasma glucose, HbA1c and insulin indices in postmenopausal women., (© 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.) more...
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- 2019
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42. The effects of conventional drugs in the treatment of rheumatoid arthritis on the serum lipids.
- Author
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Karimifar M, Sepehrifar MS, Moussavi H, Sepehrifar MB, Mottaghi P, Siavash M, and Karimifar M
- Abstract
Background: Rheumatoid arthritis (RA) is a common chronic autoimmune disorder that leads to damage of human joints. There are various treatment approaches in which different drugs are prescribed which have several alterations in serum lipids. This research aimed to study the effect of RA treatments on the serum lipids., Materials and Methods: Two hundred randomly selected patients with RA were randomly assigned to three different groups. The first group of patients was treated with a combination of prednisolone (PRD) and hydroxychloroquine (HCQ). The second group was treated with three drugs including PRD, HCQ, and methotrexate (MTX). The third group was treated with four medications including PRD, HCQ, MTX, and sulfasalazine. Within each group, the lipid factors such as triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), and high-density lipoprotein (HDL), erythrocyte sedimentation rate, and visual analog scale were measured at the beginning of the experiment and 6 months after exposing the treatments. For each group, we also calculated the Disease Activity Score-28 (DAS-28). The analysis of variance revealed that the overall DAS-28 was significantly different among the three groups., Results: In the first group, the level of TG and TC significantly decreased ( P = 0.015 and P ≤ 0.001, respectively). In the second group, the level of TG and LDL significantly decreased ( P = 0.009). In the third group, the LDL level increased considerably ( P < 0.001). The HDL level significantly increased in all three groups ( P = 0.012, P = 0.014, and P = 0.028, respectively)., Conclusion: The treatment PRD + HCQ + MTX was more effective in reducing the LDL level and increasing the HDL level. To reduce the risk of cardiovascular diseases in patients with RA, it is important to prescribe the combination of drugs which leads and normalizes the lipid profile levels., Competing Interests: There are no conflicts of interest. more...
- Published
- 2018
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43. A Case of Functional Metastatic Follicular Thyroid Carcinoma that Presented with Hip Fracture and Hypercalcemia.
- Author
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Karimifar M
- Abstract
Thyroid follicular cancers are one of the thyroid gland cancers. This cancer can lead to metastases to various areas of the body. We describe a patient with thyroid follicular carcinoma who after total thyroidectomy had severe hypercalcemia, increased creatinine, and thyrotoxicosis due to extensive bone metastases. The patient was a 52-year-old man who had femoral neck fracture as the first manifestation of thyroid cancer. He was hospitalized for some time after orthopedic measures because of thyrotoxicosis and deep-venous thrombosis. The study found that the origin of metastatic lesions was thyroid follicular cancer, leading to extensive bone metastases. After administering of methimazole and control of thyrotoxicosis, he was subjected to total thyroidectomy. Methimazole was discontinued immediately after surgery. One month after surgery, ultrasound confirmed that the thyroid was completely removed. However, T3 (triiodothyronine) remained high; besides the patient had hypercalcemia and increased creatinine due to dehydration. The patient was retreated with methimazole due to thyrotoxicosis, and for hypercalcemia fluid therapy, intravenous zoledronic acid was prescribed. These measures led to the normalization of creatinine and glomerular filtration rate. The purpose of introducing this case report was that these symptoms are a rare manifestation of functional metastases of follicular thyroid carcinoma after total thyroidectomy. Bone metastases of follicular thyroid carcinoma may be functional and are lytic that can lead to hypercalcemia and its complications., Competing Interests: There are no conflicts of interest. more...
- Published
- 2018
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44. Ultrasonographic findings of rheumatoid arthritis patients who are in clinical remission.
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Karimzadeh H, Karami M, Bazgir N, Karimifar M, Yadegarfar G, and Mohammadzadeh Z
- Abstract
Background: The aim of this study was to recognize the findings of ultrasonography (US) in remitted rheumatic arthritis (RA) patients for detection subclinical arthritis., Materials and Methods: This descriptive study was conducted during 2016 in a rheumatology center. A total of 70 patients with remitted RA were included in the study. Sonography was performed on all 70 patients who did not show any clinical arthritis in clinical examination to find synovitis and effusion were evaluated with gray scale and hyperemia with power Doppler US., Results: Nearly 44.3% ( n = 31) of our patients had positive sonography results including 20% synovitis, 21.4% hyperemia, and 18.6% ( n = 13) effusion. A total of 1960 joints of 70 patients were evaluated, in which 3.2% ( n = 63) of joints had positive sonography findings including 1.2% synovitis, 1.5% hyperemia, and 1.1 with effusion., Conclusion: US can diagnosis subclinical arthritis in patients with remitted RA who does not show any joint involvement in clinical examination., Competing Interests: There are no conflicts of interest. more...
- Published
- 2018
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45. Evaluation of the effect of Elaeagnus angustifolia alone and combined with Boswellia thurifera compared with ibuprofen in patients with knee osteoarthritis: a randomized double-blind controlled clinical trial.
- Author
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Karimifar M, Soltani R, Hajhashemi V, and Sarrafchi S
- Subjects
- Adult, Boswellia, Double-Blind Method, Elaeagnaceae, Female, Humans, Male, Middle Aged, Pain Measurement, Treatment Outcome, Analgesics therapeutic use, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Ibuprofen therapeutic use, Osteoarthritis, Knee drug therapy, Pain drug therapy, Plant Extracts therapeutic use
- Abstract
Osteoarthritis (OA) is one of the most common articular disorders. Many patients do not respond to acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs), the mainstay of pharmacotherapy for knee OA. The plants Elaeagnus angustifolia and Boswellia thurifera have anti-inflammatory and analgesic properties. This study aimed to evaluate the effect of E. angustifolia alone and in combination with B. thurifera compared with ibuprofen in patients with knee osteoarthritis. In a randomized double-blind controlled clinical trial, 75 patients with knee OA were randomly and equally assigned to one of three groups Elaeagnus (n = 23), Elaeagnus/Boswellia (n = 26), and ibuprofen (n = 26) to receive the capsules of Elaeagnus, Elaeagnus/Boswellia, and ibuprofen, respectively, three times daily with meals for 4 weeks. Pain severity based on VAS (visual analog scale, 0 to 10 scale) and the scores of LPFI (Lequesne Pain and Function Index) and PGA (patient global assessment) were determined pre- and post-intervention for all patients. All interventions had significant lowering effects on VAS, LPFI, and PGA scores (P < 0.001 for all parameters) with no significant difference between groups in terms of effects on all evaluated parameters. Consumption of E. angustifolia fruit extract either alone or in combination with Boswellia oleo-gum resin extract could decrease pain and improve function in patients with knee osteoarthritis comparable to ibuprofen. more...
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- 2017
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46. Prevalence of Chondrocalcinosis in Patients above 50 Years and the Relationship with Osteoarthritis.
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Karimzadeh H, Sirous M, Sadati SN, Bashshash M, Mottaghi P, Ommani B, and Karimifar M
- Abstract
Background: Some studies showed a relation between chondrocalcinosis and osteoarthritis (OA). Hence, considering the importance of chondrocalcinosis diagnosis andnecessity for its integration with OA, the current study aims at investigating prevalence of chondrocalcinosis in patients above 50 years admitted to Isfahan Al-Zahra Medical Center and its relationship with OA., Materials and Methods: In a cross-sectional study, 600 patients who referred to the radiology units of Al-Zahra Hospital for radiography of different joints were studied during 2013-2014. The patients images were studied for chondrocalcinosis and OA by a radiologist and also examined clinically and results of imaging by an expert rheumatologist. The prevalence of chondrocalcinosis and it relation with OA was determined by Statistical Package for Social Sciences software and using of Chi-square and t -test., Results: 23 patients under study had chondrocalcinosis (3.83%). patients with chondrocalcinosis had higher age average, and they were in age group of 70 years and older, but no significant difference was observed regarding the prevalence of the disease in both genders. Chondrocalcinosis prevalence in terms of body mass index showed significant differences ( P = 0.001). All patients with chondrocalcinosis had a history of joint disease and prevalence of chondrocalcinosis in terms of joint disease history showed a significant difference ( P < 0.001)., Conclusion: Prevalence of chondrocalcinosis is relatively high in the Iranian population of 70 years and older. Hence, more investigation considering to the diagnosis of chondrocalcinosis among patients with OA is very important., Competing Interests: There are no conflicts of interest. more...
- Published
- 2017
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47. The effect of Vitamin D supplementation in disease activity of systemic lupus erythematosus patients with Vitamin D deficiency: A randomized clinical trial.
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Karimzadeh H, Shirzadi M, and Karimifar M
- Abstract
Background: The aim of this study was to check the effectiveness of Vitamin D supplementation on the disease activity of Vitamin D-deficient systemic lupus erythematosus (SLE) patients., Materials and Methods: In this randomized, double-blind, placebo-controlled trial, 45 Vitamin D-deficient SLE patients were studied in two groups, namely interventional and placebo groups. The interventional group patients were treated with Vitamin D (50,000 unit/weekly Vitamin D for 12 weeks and then 50,000 unit/monthly for 3 months) and placebo group patients were only administered the placebo. The level of Vitamin D and the level of disease activity using SLE disease activity index (SLEDAI) were measured before and after intervention period in each group, and for intra- and between-groups comparison, we used t -test and repeated measure ANOVA., Results: A total of 90 patients were enrolled in this study. The mean of Vitamin D was increased significantly after therapy in interventional group (17.36 ± 4.26 ng/ml vs. 37.69 ± 5.92 ng/ml, P < 0.001). The mean of Vitamin D had no significant difference before and after intervention in placebo group (16.78 ± 4.39 ng/ml vs. 16.62 ± 4.61 ng/ml, P = 0.53). The mean of disease activity (SLEDAI) was not different significantly before and after Vitamin D administration in interventional group (3.09 vs. 1.62 ± 1.25, P = 0.39). The mean of disease activity (SLEDAI) was not different significantly before and after intervention in placebo group (3.09 vs. 1.98 ± 2.47, P = 0.42)., Conclusion: According to our study, it is suggested that using Vitamin D in patients with SLE could not have better outcomes in this regard. However, there are many unknown environmental or biological factors which are associated with the disease activity of SLE and have not been identified yet., Competing Interests: There are no conflicts of interest. more...
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- 2017
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48. Effect of metformin on thyroid stimulating hormone and thyroid volume in patients with prediabetes: A randomized placebo-controlled clinical trial.
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Karimifar M, Aminorroaya A, Amini M, Mirfendereski T, Iraj B, Feizi A, and Norozi A
- Abstract
Background: The people with prediabetes have insulin resistance (IR). IR may affect thyroid function, size and nodules. We investigated the effects of metformin on the thyroid gland in prediabetic people., Materials and Methods: In a randomized, double-blind placebo-control clinical trial, 89 people with prediabetes, aged 18-65 years were studied for 3 months. They were divided into two, metformin (n = 43) and placebo (n = 46) treated groups. Serum thyroid stimulating hormone (TSH) was measured and thyroid nodules and volume was studied by ultrasonography. The data were compared between and within groups, before and after the study., Results: Mean of the baseline characteristics in metformin and placebo-treated groups had no statistically significant difference. At the end of the study, serum TSH was not significantly different between the two groups. However, if the TSH range was divided into two low normal (0.3-2.5 μU/ml) and high-normal (2.6-5.5 μU/ml) ranges, significant decrease was observed in metformin-treated group with a high-normal basal serum TSH (P = 0.01). Thyroid volume did not change in metformin-treated group. However, in placebo-treated group, the thyroid was enlarged (P = 0.03). In 53.9% of participants, thyroid nodule was observed. There was just a decrease in the volume of small solid (not mixed) nodules from median of 0.07 ml to 0.04 ml in metformin-treated group (P = 0.01)., Conclusion: In prediabetic people, metformin decreases serum TSH, only, in those people with TSH >2.5 μU/ml and reduces the size of small solid thyroid nodules. It also prevents an increase in the thyroid volume. more...
- Published
- 2014
49. The association of immunoglobulin A, immunoglobulin G and anti-cyclic citrullinated peptide antibodies with disease activity in seronegative rheumatoid arthritis patients.
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Karimifar M, Moussavi H, Babaei M, and Akbari M
- Abstract
Background: Rheumatoid arthritis (RA) is a common autoimmune disease that is associated with progressive disability, systemic complications, and early death. The present study was aimed to investigate the level of immunoglobulin G (IgG) and IgA isotypes and anti-cyclic citrullinated peptide (CCP) antibody and to assess their association with disease severity based on disease activity score (DAS-28) in patients with IgM rheumatoid factor (IgM-RF) negative RA., Materials and Methods: In this cross-sectional study, 62 RA patients with IgM-RF negative were assessed. Radiographs were obtained for all RA patients. The RF (IgG, and IgA) and anti-CCP were measured by using the enzyme-linked immunosorbent assay. Values of cut-off points over 15 UI/mL for IgA IgA-RF, 20 UI/mL for IgG-RF and over 20 units for anti-CCP were considered positive. DAS-28 score was compared in regard to the IgA-RF and IgG-RF and anti-CCP positivity using Mann-Whitney test., Results: DAS-28 score in IgA-RF positive was significantly higher than IgA-RF negative (mean score, 6.03 ± 0.33 vs. 5.44 ± 0.76 respectively, P = 0.035). In IgG-RF positive patients, DAS-28 score was similar to patients with IgG-RF negative (5.64 ± 0.59 vs. 5.46 ± 0.78 respectively, P = 0.396). Furthermore, in patients with anti-CCP positive DAS-28 score was significantly higher than patients with anti-CCP negative (5.72 ± 0.61 vs. 5.38 ± 0.79 respectively, P = 0.049)., Conclusion: Findings indicated that there was a significant association between the amounts of IgA and anti-CCP with severity of disease in RF negative RA patients while there was no significant association between the amounts of IgG and severity of RA disease. more...
- Published
- 2014
50. Effects of Levothyroxine and thyroid stimulating hormone on bone loss in patients with primary hypothyroidism.
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Karimifar M, Esmaili F, Salari A, Kachuei A, Faragzadegan Z, and Karimifar M
- Abstract
Objective: Previous studies on bone mineral density (BMD) abnormalities associated with hypothyroidism are scarce and not conclusive. The effect of thyroid hormone therapy on BMD has shown mixed results. The aim of the present study was to determine the severities of osteoporosis in female patients with hypothyroidism in comparison to healthy women., Methods: This cross-sectional descriptive study was performed on 150 women aged over 50 years. Totally, 100 patients with primary hypothyroidism and 50 healthy subjects were enrolled in this study and divided into three groups. Group A, which consisted the patients who had been recently diagnosed with primary hypothyroidism. The second group of patients diagnosed with primary hypothyroidism for at least 2 years and was treated with levothyroxine (Group B). The third group of healthy individuals was selected as a control group (Group C). Blood samples were taken for the measurements of thyroid stimulating hormone (TSH), and bone densitometry was performed to determine the BMD reported as T-score in order to measure the severity of osteoporosis. T-score of the lumbar vertebra (L2-L4) and femoral neck were measured with dual energy X-ray absorptiometry and were compared between the three groups. Data were analyzed by SPSS using regression analysis and Mann-Whitney, Kruskal-Wallis, or analysis of variances statistical tests. The statistical significance was set at a P < 0.05., Findings: The average age of patients and baseline serum TSH levels in Group B was significantly different from the other two groups (P < 0.001). T-score of the lumbar spine (L2-L4) in Group B was significantly lower than the other groups (P = 0.01). The linear regression between serum TSH levels and BMD categories were not clearly associated. However, after removing the effect of the baseline TSH level in Group B, bone loss was significantly greater than the other two groups (P = 0.01)., Conclusion: According to the present study, it seems that the treatment of hypothyroidism with thyroid hormones reduces both serum levels of TSH and bone density. Hence, proper control of this risk factor can be an effective way in prevention of osteoporosis. more...
- Published
- 2014
- Full Text
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