Search

This article discusses the development of a new method for synthesizing tetrasubstituted pyrroles, which are important in the pharmaceutical industry. The method combines three different components in one step, resulting in a more efficient and selective process with less waste. The researchers used readily available starting materials and performed the reaction without the need for a catalyst or solvent. The optimized conditions produced high yields of the desired product. The method was found to be environmentally friendly and the reaction mechanism involves the formation of new bonds. [Extracted from the article]

A tandem formal [3+3]-cycloaddition/oxidation between chalcones and β-enamine esters, employing iodine as a catalyst, was developed for the construction of various substituted m -terphenyls. A wide range of chalcones and β-enamine esters were tested under metal- and solvent-free conditions for the synthesis of substituted m -terphenyls in good to excellent yields in the presence of sulfur as an oxidant. This reaction proceeds with the formation of four new bonds and one new ring, with a high atom economy. [ABSTRACT FROM AUTHOR]