1. Comparative clinical pharmacology of intravenous cefoxitin and cephalothin.
- Author
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Sonneville PF, Kartodirdjo RR, Skeggs H, Till AE, and Martin CM
- Subjects
- Adult, Cefoxitin administration & dosage, Cefoxitin adverse effects, Cephalothin administration & dosage, Cephalothin adverse effects, Half-Life, Humans, Injections, Intravenous, Kinetics, Male, Metabolic Clearance Rate, Microbial Sensitivity Tests, Models, Biological, Cefoxitin metabolism, Cephalosporins metabolism, Cephalothin metabolism
- Abstract
Intravenous doses of 0.5, 1, and 2 g cephalothin and cefoxitin, a semi-synthetic cephamycin antibiotic highly resistant to bacterial cephalosporinase, were infused over a period of 3 minutes into 18 normal adult males by a randomized, crossover design. Serum and urine data on cefoxitin best fit a two-compartment open model. Serum concentrations following cefoxitin were higher and more prolonged and urine recoveries higher than those following equal doses of cephalothin. The terminal serum half-life of cefoxitin was longer at all dose levels. Renal clearance of cephalothin-like activity exceeded that of cefoxitin, which may possess dose-dependent kinetics. Whereas cephalothin has been reported to metabolize by greater than 35% to the less active desacetyl form, cefoxitin was metabolized by 0.1 to 6% to the descarbamyl form in individual subjects.
- Published
- 1976
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