56 results on '"Kashino I"'
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2. Five‐year cumulative incidence of overweight and obesity, and longitudinal change in body mass index in Japanese workers: The Japan Epidemiology Collaboration on Occupational Health Study
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Hasegawa, Miyuki, Akter, Shamima, Hu, Huanhuan, Kashino, Ikuko, Kuwahara, Keisuke, Okazaki, Hiroko, Sasaki, Naoko, Ogasawara, Takayuki, Eguchi, Masafumi, Kochi, Takeshi, Miyamoto, Toshiaki, Nakagawa, Tohru, Honda, Toru, Yamamoto, Shuichiro, Murakami, Taizo, Shimizu, Makiko, Uehara, Akihiko, Yamamoto, Makoto, Imai, Teppei, Nishihara, Akiko, Tomita, Kentaro, Nagahama, Satsue, Hori, Ai, Konishi, Maki, Kabe, Isamu, Mizoue, Tetsuya, Kunugita, Naoki, Dohi, Seitaro, Mizoue, T., Akter, S., Hu, H., Inoue, Y., Fukunaga, A., Kashino, I., Islam, Z., Konishi, M., Nanri, A., Kurotani, K., Kuwahara, K., Nakagawa, T., Yamamoto, S., Honda, T., Watanabe, Y., Dohi, S., Okazaki, H., Imai, T., Nishihara, A., Sasaki, N., Ogasawara, T., Uehara, A., Yamamoto, M., Miyamoto, T., Hasegawa, M., Shirozu, M., Kabe, I., Kochi, T., Eguchi, M., Murakami, T., Shimizu, C., Shimizu, M., Gonmori, N., Ogasawara, A., Kato, N., Tomizawa, A., Tomita, K., Nagahama, S., Kunugita, N., Sone, T., Fukasawa, K., Hori, A., Nishiura, C., Kinugawa, C., Kuroda, R., Yamamoto, K., Ohtsu, M., Sakamoto, N., Osaki, Y., Totsuzaki, T., Endo, M., Itoh, T., Kawashima, M., Masuda, M., Kitahara, K., Yokoya, T., Fukai, K., Odagami, K., and Kobayashi, Y.
- Abstract
The present study aimed to estimate cumulative incidence of overweight and obesity and describe 5‐year longitudinal changes in body mass index (BMI) in a large occupational cohort in Japan. Participants were 55 229 Japanese employees, who were aged 20‐59 years and attended at all subsequent annual health check‐ups between 2009 and 2014. Mixed model analysis was performed to examine the effects of age and cohort by gender on BMI change, with age as a random variable. Cumulative incidence of overweight (23.0≤ BMI <27.5 kg/m2) and obesity (BMI ≥27.5 kg/m2) was calculated. Logistic regression analysis was used to estimate odds ratios for the incidence of overweight and obesity according to age group. The incidence of overweight and obesity was approximately double in men (28.3% and 6.7%, respectively) compared to women (14.3% and 3.9%, respectively).The incidence of obesity decreased with age in men, but did not differ according to age in women (Pfor trend: .02 and .89, respectively). Among overweight participants, the incidence of obesity was higher in women (18.9%) than men (14.5%) and decreased with advancing age (Pfor trend: <.001 in men and .003 in women). Mean BMI was higher in men than women in all age groups throughout the period. Younger cohorts tended to have a higher BMI change compared with older cohorts. In this Japanese occupational cohort, transition from overweight to obesity is higher in women than men, and the more recent cohorts had a higher change in mean BMI than the older cohorts.
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- 2020
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3. Development of the Scores for Traditional and Modified Japanese Diets.
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Miyake H, Kashino I, Nanri A, and Mizoue T
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- Humans, Animals, Vegetables, Fruit, Japan, East Asian People, Diet
- Abstract
Increasing attention is being paid to the role of diet quality in the prevention and management of non-communicable diseases. We developed a scoring system for the traditional Japanese diet and its modified version considering the dietary culture in Japan, dietary guidelines for the Japanese, and updated evidence for disease prevention. The traditional Japanese diet comprises white rice, miso soup, soybean products, vegetables, mushrooms, seaweeds, fish and shellfish, high-sodium foods, and green tea. In the modified Japanese diet, unprocessed or minimally refined rice and raw vegetables, milk and dairy products, and fruits were additionally considered, while salty food was reverse-scored. The cutoff for the intake frequency of each food/food group was determined with reference to a health survey of >12,000 workers. Among the participants in the validation study, we confirmed the nutritional gradient with increasing scores in the expected direction. The scores were closely correlated with the respondents' backgrounds, including occupational factors. This simple scoring system can be used for diet quality assessments and epidemiological research.
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- 2023
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4. Development, Relative Validity, and Reproducibility of a Short Food Frequency Questionnaire for the Japanese.
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Nanri A, Fujiwara A, Miyake H, Kashino I, and Mizoue T
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- Humans, Diet Surveys, Japan, Reproducibility of Results, Surveys and Questionnaires, Diet Records, Diet
- Abstract
We have developed a short food frequency questionnaire (FFQ) for use in assessing diet quality for Japan, with special reference to the prevention of non-communicable diseases. Here, we assessed the ranking performance of this FFQ and its reproducibility. We developed a 28-item (21 food groups and 7 beverage) FFQ with consideration to both Japanese dietary culture and evidence of disease prevention. Twenty-four university faculty members participated in the validation study. They completed 3-day photographic food record and answered the FFQ on the next day of the last food record (time 1) and a week later (time 2). We calculated Spearman correlation coefficients between intakes of food groups from photographic food records and the consumption frequency from the FFQs (ranking ability) and between the consumption frequency of food groups from the FFQs (time 1 and time 2) (reproducibility). Spearman correlation coefficients between the food records and FFQ (time 1) ranged from -0.12 to 0.86 (median 0.51). These values were comparable to those in comparison with FFQ (time 2). After energy adjustment of intakes from the food records, the corresponding values were somewhat weakened for many food groups. The correlation coefficients between two FFQs ranged from 0.14 to 0.96 (median 0.79). The short FFQ showed acceptable reproducibility and ability to rank the consumption of most food groups.
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- 2022
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5. Diagnosis-specific Cumulative Incidence of Return-to-work, Resignation, and Death Among Long-term Sick-listed Employees: Findings From the Japan Epidemiology Collaboration on Occupational Health Study.
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Nishiura C, Inoue Y, Kashino I, Nanri A, Endo M, Eguchi M, Kochi T, Kato N, Shimizu M, Imai T, Nishihara A, Yamamoto M, Okazaki H, Tomita K, Miyamoto T, Yamamoto S, Nakagawa T, Honda T, Ogasawara T, Sasaki N, Hori A, Kabe I, Mizoue T, and Dohi S
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- Humans, Incidence, Japan epidemiology, Return to Work, Sick Leave, Mental Disorders epidemiology, Occupational Health
- Abstract
Background: While it is essential to understand how long is sufficient for return-to-work when designing paid sick-leave systems, little attempt has been done to collect cause-specific information on when and how many of sickness absentees returned to work, became unemployed, or passed away., Methods: We studied the first sick-leave episode of ≥30 consecutive days in those ≤55 years of age during 2012-2013 among employees of 11 Japanese private companies (n = 1,209), which were followed until 2017. Overall and disease-specific cumulative incidences of return-to-work, resignations, and deaths were estimated using competing risk analysis., Results: During the 3.5-year period (follow-up rate: 99.9%), 1,014 returned to work, 167 became unemployed, and 27 died. Overall, return-to-work occurred within 1 year in 74.9% of all absentees and in 89.3% of those who successfully returned to work. Resignation occurred within 1 year in 8.7% of all absentees and in 62.9% of all subjects who resigned. According to ICD-10 chapters, the cumulative incidence of return-to-work ranged from 82.1% for mental disorders (F00-F99) to 95.3% for circulatory diseases (I00-I99). The cumulative incidence of return-to-work due to mental disorders ranged from 66.7% in schizophrenia (F20) to 95.8% in bipolar affective disorders (F31). Death was rarely observed except for cases of neoplasms (C00-D48), of which the cumulative incidence of death reached 14.2% by 1.5 years., Conclusion: Return-to-work and resignations occurred commonly within 1 year of sick leave among long-term sickness absentees in the Japanese private companies. Our findings may assist occupational physicians and employers in developing effective social protection schemes.
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- 2022
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6. Prospective association of confectionery intake with depressive symptoms among Japanese workers: the Furukawa Nutrition and Health Study.
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Shimmura N, Nanri A, Kashino I, Kochi T, Eguchi M, Kabe I, and Mizoue T
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- Male, Humans, Female, Prospective Studies, Nutritional Status, Surveys and Questionnaires, Vitamins, Japan epidemiology, Depression epidemiology, East Asian People
- Abstract
High intake of sweet foods such as cakes, cookies, chocolate and ice cream has been reported to be associated with depressive symptoms. However, prospective studies are scarce and no study has been conducted in Asian populations. We prospectively investigated the association between confectionery intake and depressive symptoms in a Japanese working population. Participants were 911 workers (812 men and 99 women; aged 19-68 years) without depressive symptoms at baseline who completed a 3-year follow-up survey. Dietary intake was assessed using a validated self-administered diet history questionnaire. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Multiple logistic regression was used to estimate the OR of depressive symptoms according to tertile of confectionery intake with adjustment for covariates. At the time of the 3-year follow-up survey, 153 (16·8 %) workers were newly identified as having depressive symptoms (CES-D score ≥ 16). Confectionery intake was significantly associated with increased odds of developing depressive symptoms. The multivariable-adjusted OR of depressive symptoms for the highest v . lowest tertile of confectionery intake was 1·72 (95 % CI 1·03, 2·86) after adjustment for covariates including dietary factors such as folate, vitamin B
6 , vitamin B12 , n -3 PUFA, Mg, Zn and soft drink ( Pfor trend = 0·012). Our results suggest that confectionery intake is associated with a higher risk of depressive symptoms in a Japanese working population predominantly comprised of men.- Published
- 2022
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7. The association between prenatal perfluoroalkyl substance exposure and symptoms of attention-deficit/hyperactivity disorder in 8-year-old children and the mediating role of thyroid hormones in the Hokkaido study.
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Itoh S, Yamazaki K, Suyama S, Ikeda-Araki A, Miyashita C, Ait Bamai Y, Kobayashi S, Masuda H, Yamaguchi T, Goudarzi H, Okada E, Kashino I, Saito T, and Kishi R
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- Child, Female, Humans, Infant, Newborn, Maternal Exposure adverse effects, Pregnancy, Prospective Studies, Thyroid Hormones, Attention Deficit Disorder with Hyperactivity etiology, Fluorocarbons adverse effects
- Abstract
Background: Disruption of thyroid hormone (TH) levels during pregnancy contributes to attention deficit hyperactivity disorder (ADHD). Exposure to perfluoroalkyl substances (PFAS) during gestation may affect levels of maternal and neonatal TH; however, little is known about the effect of PFAS on ADHD mediated by TH., Objectives: We investigated the impact of maternal PFAS exposure on children's ADHD symptoms with the mediating effect of TH., Methods: In a prospective birth cohort (the Hokkaido study), we included 770 mother-child pairs recruited between 2002 and 2005 for whom both prenatal maternal and cord blood samples were available. Eleven PFAS were measured in maternal serum obtained at 28-32 weeks of gestation using ultra-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry. TH and thyroid antibody, including thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) were measured in maternal blood during early pregnancy (median 11 gestational weeks) and in cord blood at birth. ADHD symptoms in the children at 8 years of age were rated by their parents using the ADHD-Rating Scale (ADHD-RS). The cut-off value was set at the 80th percentile for each sex., Results: Significant inverse associations were found between some PFAS in maternal serum and ADHD symptoms among first-born children. Assuming causality, we found only one significant association: maternal FT4 mediated 17.6% of the estimated effect of perfluoroundecanoic acid exposure on hyperactivity-impulsivity among first-born children., Discussion: Higher PFAS levels in maternal serum during pregnancy were associated with lower risks of ADHD symptoms at 8 years of age. The association was stronger among first-born children in relation to hyperactivity-impulsivity than with regard to inattention. There was little mediating role of TH during pregnancy in the association between maternal exposure to PFAS and reduced ADHD symptoms at 8 years of age., (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2022
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8. Smoking and Long-Term Sick Leave in a Japanese Working Population: Findings of the Japan Epidemiology Collaboration on Occupational Health Study.
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Hori A, Inoue Y, Kuwahara K, Kunugita N, Akter S, Nishiura C, Kinugawa C, Endo M, Ogasawara T, Nagahama S, Miyamoto T, Tomita K, Yamamoto M, Nakagawa T, Honda T, Yamamoto S, Okazaki H, Imai T, Nishihara A, Sasaki N, Uehara A, Murakami T, Shimizu M, Eguchi M, Kochi T, Konishi M, Kashino I, Yamaguchi M, Nanri A, Kabe I, Mizoue T, and Dohi S
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- Adult, Aged, Cardiovascular Diseases epidemiology, Female, Humans, Japan epidemiology, Male, Middle Aged, Neoplasms epidemiology, Prospective Studies, Risk Factors, Smoking psychology, Young Adult, Occupational Health trends, Sick Leave statistics & numerical data, Smokers psychology, Smoking epidemiology
- Abstract
Background: Few studies have investigated the association between tobacco smoking and sick leave (SL) in Japan., Methods: We followed 70 896 workers aged 20-59 years (60 133 males, 10 763 females) between April 2012 and March 2017. A Cox proportional hazards model was used to investigate the associations between smoking (smoking status and intensity) and long-term SL (ie, SL lasting ≥30 consecutive days). Cause-specific analyses were also conducted., Results: A total of 1777 people took long-term SL during a follow-up of 307 749 person years. Compared with never-smokers, current smokers were at a higher risk of long-term SL (hazard ratio [HR] = 1.32; 95% confidence interval [CI] = 1.19 to 1.48). Cause-specific analyses revealed that current smoking was associated with a higher risk of SL due to all physical disorders (HR = 1.44, 95% CI = 1.22 to 1.69), cancer (HR = 1.49, 95% CI = 1.10 to 2.01), cardiovascular disease (CVD; HR = 2.16, 95% CI = 1.31 to 3.55), and injuries/external causes (HR = 1.83, 95% CI = 1.31 to 2.58). Former smokers were at a higher risk of SL due to cancer at a borderline significance level (HR = 1.38, 95% CI = 0.99 to 1.92). Low-intensity smoking (ie, 1-10 cigarettes smoked per day) was associated with all-cause SL, SL due to CVD, and SL due to injuries/external causes compared with never-smokers., Conclusion: In a large cohort of working-age Japanese, smoking was associated with a greater risk of long-term SL. Greater effort is needed to mitigate disease burden associated with smoking at workplace in Japan., Implications: Our study contributes to the literature on the association between smoking and SL in several ways. First, the study was conducted among a Japanese working population. While the association has been extensively studied in Western setting, few attempts have been made elsewhere. Second, cause-specific analyses were undertaken in our study. Third, we paid attention to the effect of low-intensity smoking on SL given that there is growing evidence of an elevated health risk associated with low-intensity smoking., (© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved.For permissions, please e-mail: journals.permissions@oup.com.)
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- 2021
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9. Prospective association of soft drink consumption with depressive symptoms.
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Kashino I, Kochi T, Imamura F, Eguchi M, Kuwahara K, Nanri A, Kurotani K, Akter S, Hu H, Miki T, Kabe I, and Mizoue T
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- Adult, Asia, Cross-Sectional Studies, Humans, Japan epidemiology, Prospective Studies, Carbonated Beverages adverse effects, Depression epidemiology, Depression etiology
- Abstract
Objective: Consumption of soft drinks has become a serious public health issue worldwide. However, prospective evidence is limited regarding the relationship between soft drink consumption and depression, especially in Asia. The aim of this study was to investigate the prospective association between soft drink consumption and the development of depressive symptoms., Methods: We evaluated an occupational cohort of 935 adults in Japan (2012-2016), who were free from depressive symptoms at baseline and attended a 3-y follow-up assessment. Soft drink consumption was assessed using a self-administered diet history questionnaire. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression scale. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from multivariate logistic regression analysis controlling for sociodemographic, lifestyle, dietary, and occupational covariates., Results: Over the 3-y study period, 16.9% (158 cases) of the study participants reported depressive symptoms. Higher soft drink consumption was associated with higher odds of depressive symptoms. The multivariable-adjusted OR was 1.91 (95% CI, 1.11-3.29; P
trend = 0.015) when comparing soft drink consumption of ≥4 cups/wk with consumption of <1 cup/wk., Conclusion: The present results suggested that greater consumption of soft drinks would increase the likelihood of exhibiting depressive symptoms., (Copyright © 2020 Elsevier Inc. All rights reserved.)- Published
- 2021
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10. Effect of prenatal exposure to per- and polyfluoroalkyl substances on childhood allergies and common infectious diseases in children up to age 7 years: The Hokkaido study on environment and children's health.
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Ait Bamai Y, Goudarzi H, Araki A, Okada E, Kashino I, Miyashita C, and Kishi R
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- Child, Child Health, Child, Preschool, Female, Humans, Pregnancy, Alkanesulfonic Acids, Communicable Diseases, Environmental Pollutants, Fluorocarbons toxicity, Hypersensitivity epidemiology, Prenatal Exposure Delayed Effects epidemiology
- Abstract
Per- and polyfluoroalkyl substances (PFAS) are widely used bio-accumulative chemicals in many industrial and household products. Experimental studies reported that exposure to PFAS results in immunotoxicity. We have previously reported that prenatal exposure to PFAS decreased the risk of allergies, while it increased the risk of infectious diseases at ages 2 and 4 years. However, it remains unclear whether the adverse effects of PFAS on allergies and infectious diseases continue until a reliable age of diagnosing allergies. This study aimed at investigating the effects of prenatal exposure to PFAS on the prevalence of allergies and infectious diseases in children up to age 7, from the Hokkaido Study. Among mother-child pairs enrolled in the Hokkaido study and followed up until the age of 7 years, 2689 participants with maternal PFAS, 1st trimester of pregnancy and 7-year-old questionnaire survey data were included in this study. Eleven PFAS in the 3rd-trimester plasma were measured using ultra-performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry. Wheeze, rhino-conjunctivitis, and eczema were defined using the International Study of Asthma and Allergies on Childhood (ISAAC) questionnaire. History childhood infectious diseases diagnosed by a doctor was assessed by a mother-reported questionnaire at child's age 7. The relative risk of childhood allergies was calculated by generalized estimating equation models. The odds ratio of an episode of infectious diseases was calculated by logistic regression analysis, adjusted for potential confounders. The prevalence of various allergies and infectious diseases was: wheeze, 11.9%; rhino-conjunctivitis, 11.3%; eczema, 21.0%; chickenpox, 61.5%; otitis media, 55.7%; pneumonia, 30.6%; and respiratory syncytial virus infection, 16.8%. Prenatal exposure to perfluorooctanoic acid, perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) was inversely associated with rhino-conjunctivitis, while that for perfluorooctanoate (PFOA), perfluorooctane sulfonate, PFUnDA, perfluorododecanoic acid (PFDoDA), and perfluorotridecanoic acid was inversely associated with eczema. For infectious diseases, PFDA and PFDoDA were associated with increased risk of pneumonia and PFOA was associated with increased risk of RSV infection among children not having any siblings (only-one-child). Our results corroborate the hypothesis on immunosuppressive and immunomodulating effects of PFAS on allergies and infectious diseases in children. These effects observed previously at 2 and 4 years continued until the age of 7 years. However, additional studies assessing inflammatory biomarkers along with ISAAC questionnaires, doctor-diagnosed allergies, and longer follow-ups are necessary to better assess the effects of exposure to chemicals on human immune outcomes., (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2020
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11. Cross-Sectional Study on the Association between Dietary Non-Enzymatic Antioxidant Capacity and Serum Liver Enzymes: The Furukawa Nutrition and Health Study.
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Nanri H, Kashino I, Kochi T, Eguchi M, Akter S, Nanri A, Kabe I, and Mizoue T
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- Adolescent, Adult, Aged, Antioxidants metabolism, Cross-Sectional Studies, Diet Surveys, Female, Humans, Japan, Liver metabolism, Male, Middle Aged, Nutritional Status, Oxygen Radical Absorbance Capacity, Young Adult, Alanine Transaminase blood, Antioxidants administration & dosage, Aspartate Aminotransferases blood, Diet statistics & numerical data, gamma-Glutamyltransferase blood
- Abstract
We examined the association of dietary non-enzymatic antioxidant capacity (NEAC) in overall diet, and separately from foods and beverages, with serum liver enzymes in a Japanese working population. This cross-sectional study was conducted among 1791 employees aged 18-69 years, who underwent a comprehensive health checkup in 2012-2013. A brief validated self-administered diet-history questionnaire was used for dietary assessment, and dietary NEAC intake was determined from databases of NEAC values, obtained using ferric reducing-antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC) assays. The dietary NEAC intake was calculated by multiplying the estimated NEAC values by the amounts consumed and summing the resulting values. A multiple-regression analysis was performed to explore the association between dietary NEAC intake and the serum levels of liver enzymes (aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyltransferase (GGT)), after adjustment for confounding factors. No significant associations were found between overall dietary NEAC intake and AST (FRAP, p for trend = 0.97; ORAC, p = 0.72), ALT (FRAP, p = 0.73; ORAC, p = 0.92), and GGT (FRAP, p = 0.96; ORAC, p = 0.19) levels. Food-derived, but not beverage-derived, NEAC intake was inversely associated with serum GGT levels (FRAP, p for trend = 0.001; ORAC, p = 0.02), particularly among older participants and those with high serum ferritin concentrations. The results imply that overall dietary NEAC intake is not associated with liver dysfunction, and that the NEAC values from foods may be inversely associated with serum GGT levels.
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- 2020
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12. Prospective study on the association between dietary non-enzymatic antioxidant capacity and depressive symptoms.
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Miki T, Eguchi M, Kochi T, Akter S, Hu H, Kashino I, Kuwahara K, Kabe I, Nanri A, and Mizoue T
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- Adult, Aged, Depression epidemiology, Eating, Female, Humans, Japan epidemiology, Male, Middle Aged, Odds Ratio, Oxidative Stress, Prospective Studies, Surveys and Questionnaires, Antioxidants therapeutic use, Depression diet therapy, Depression physiopathology, Diet
- Abstract
Background & Aims: Oxidative stress has been suggested to play an important role in the pathophysiology of depression, and a diet high in antioxidants may improve mood. However, studies addressing this issue are scarce. The aim of this cohort study was to investigate the prospective association between dietary non-enzymatic antioxidant capacity (NEAC) in overall diet and depressive symptoms in Japanese employees. Additionally, we examined the association separated by dietary NEAC sources., Method: Participants were 911 workers without depressive symptoms at baseline and participated in 3-y follow-up survey. Dietary NEAC was determined from a database of NEAC measurements obtained by ferric reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC). Dietary NEAC was calculated by multiplying the estimated NEAC values with the consumed amount and summing up those values. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale. Logistic regression was used to estimate odds ratios of depressive symptoms according to overall NEAC and separately from foods and beverages., Results: At 3-y follow-up, 153 (16.8%) workers were newly identified as having depressive symptom. No significant associations were found between higher level of overall dietary NEAC and decreased risk of depressive symptoms after adjustment for potential confounders (overall: FRAP, P for trend = 0.19 and ORAC, P for trend = 0.20). Likewise, neither higher dietary NEAC from foods nor beverages were related with lower depressive symptoms., Conclusion: Our findings did not support an inverse association between dietary NEAC and the risk of depressive symptoms in Japanese workers., Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest. T.K. and M.E. are health professionals at the Furukawa Electric Corporation. I. Kabe is a health professional at Kubota Corporation., (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2020
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13. Prospective Association between Whole Grain Consumption and Hypertension: The Furukawa Nutrition and Health Study.
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Kashino I, Eguchi M, Miki T, Kochi T, Nanri A, Kabe I, and Mizoue T
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- Adult, Aged, Female, Humans, Japan, Male, Middle Aged, Nutrition Surveys, Prospective Studies, Surveys and Questionnaires, Young Adult, Diet statistics & numerical data, Hypertension epidemiology, Whole Grains
- Abstract
Hypertension has become a major public health issue worldwide. Whole grains contain higher levels and a broader range of nutrients with potential health benefits and may decrease the risk of hypertension. However, no prospective studies have investigated this association in the high-income Asia Pacific region, which has the lowest whole grain intake worldwide. Thus, we examined the prospective association between whole grain consumption and the development of hypertension in Japan. Participants included 944 working Japanese adults aged 19-68 years who had no hypertension at baseline and completed a 3-year follow-up survey. Whole grain consumption was assessed via a self-administered dietary questionnaire. Multivariate logistic regression analysis was carried out to examine the association between whole grain consumption and hypertension, adjusting for potential confounding factors, such as sociodemographic, lifestyle, dietary, and occupational characteristics. After 3 years, 9.4% (86 cases) of the study participants had developed hypertension. More frequent whole grain consumption, classified as an intake frequency of "sometimes or always", was associated with lower odds of hypertension (multivariate-adjusted odds ratio: 0.36; 95% confidence interval: 0.16-0.83; p for trend = 0.04) compared with no consumption. Consuming more whole grains may decrease the risk of developing hypertension., Competing Interests: The authors declare no conflicts of interest. M.E., T.K., and I.K. (Isamu Kabe) are healthcare professionals and employees of the Furukawa Electric Corporation.
- Published
- 2020
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14. Obesity and risk of hearing loss: A prospective cohort study.
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Hu H, Tomita K, Kuwahara K, Yamamoto M, Uehara A, Kochi T, Eguchi M, Okazaki H, Hori A, Sasaki N, Ogasawara T, Honda T, Yamamoto S, Nakagawa T, Miyamoto T, Imai T, Nishihara A, Nagahama S, Murakami T, Shimizu M, Akter S, Kashino I, Yamaguchi M, Kabe I, Mizoue T, Sone T, and Dohi S
- Subjects
- Adult, Cohort Studies, Comorbidity, Female, Follow-Up Studies, Humans, Japan epidemiology, Male, Middle Aged, Prospective Studies, Risk Assessment, Young Adult, Hearing Loss epidemiology, Obesity epidemiology
- Abstract
Background & Aims: The existing yet limited prospective studies reported conflicting results about obesity and hearing loss. We investigated the prospective association between obesity and hearing loss in a large-scale Japanese working population, as well as the association between metabolic phenotype and hearing loss., Methods: The study included 48,549 employees aged 20-64 years and free of hearing loss at baseline. Pure-tone audiometric testing was performed annually to identify hearing loss at 1 and 4 kHz. Cox proportional hazards regression was used to investigate the risk of hearing loss associated with body mass index (BMI) and metabolic phenotype (based on a BMI of ≥25.0/<25.0 kg/m
2 and presence/absence of ≥2 components of metabolic syndrome, except waist circumference). Baseline and updated information were obtained from annual health checkups., Results: With a median follow-up of 7 years, 1595 and 3625 individuals developed unilateral hearing loss at 1 and 4 kHz, respectively. The adjusted hazard ratios (HR) for hearing loss at 1 kHz were 1.21 (1.08, 1.36) and 1.66 (1.33, 2.08) for those with BMI 25.0-29.9 kg/m2 and BMI ≥30.0 kg/m2 , respectively, compared to individuals with BMI <25.0 kg/m2 . For hearing loss at 4 kHz, the corresponding HRs were 1.14 (1.05, 1.23) and 1.29 (1.09, 1.52). Compared with metabolically healthy non-obese individuals, the adjusted HRs for hearing loss at 1 kHz were 1.19 (1.03, 1.39), 1.27 (1.01, 1.61), and 1.48 (1.25, 1.76) for unhealthy non-obese, healthy obese, and unhealthy obese individuals, respectively. For hearing loss at 4 kHz, the corresponding HRs were 1.13 (1.04, 1.25), 1.21 (1.04, 1.41), and 1.26 (1.12, 1.41)., Conclusions: Overweight and obesity are associated with an increased risk of hearing loss, and metabolically unhealthy obesity may confer additional risk., (Copyright © 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.)- Published
- 2020
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15. Prenatal exposure to 11 perfluoroalkyl substances and fetal growth: A large-scale, prospective birth cohort study.
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Kashino I, Sasaki S, Okada E, Matsuura H, Goudarzi H, Miyashita C, Okada E, Ito YM, Araki A, and Kishi R
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- Caprylates, Cohort Studies, Female, Humans, Infant, Newborn, Japan, Pregnancy, Prospective Studies, Alkanesulfonic Acids, Environmental Pollutants toxicity, Fetal Development, Fluorocarbons toxicity, Prenatal Exposure Delayed Effects
- Abstract
Background: Prenatal maternal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) has been reportedly associated with decreased birth weight. Although a majority of epidemiological studies concerning perfluoroalkyl substances (PFAS) have focused on PFOS and PFOA, epidemiological studies of PFAS with longer carbon chains are scarce. In this study, we investigated whether prenatal maternal exposure to 11 PFAS, in particular those with longer carbon chains, is associated with fetal growth., Methods: The study included 1985 mother-infant pairs (inclusive of preterm and post-term infants), who enrolled in a large-scale, prospective birth cohort study in any of the 37 hospitals in Hokkaido, Japan between 2003 and 2009. The concentration of 11 PFAS was measured in maternal plasma collected during the third trimester of pregnancy, using ultra-performance liquid chromatography in combination with triple quadrupole mass spectrometry. Associations between the measured PFAS values and weight, length, and head circumference of all newborns at birth were examined using multiple regression analyses with adjustment for potential confounders based on data collected from medical records, questionnaires, and those for maternal plasma samples., Results: Of the 11 PFAS analyzed, prenatal perfluorononanoic acid (PFNA) [per log10-unit: regression coefficient (β) = -96.2 g, 95% confidence intervals (95% CI), -165.3 to -27.1] and perfluorodecanoic acid (PFDA) (β = -72.2 g, 95% CI, -138.1 to -6.3) concentrations were inversely associated with birth weight. Furthermore, PFNA concentrations were inversely associated with birth length (per Log
10 unit: β = -0.48 cm, 95% CI; - 0.86 to -0.11). Maternal perfluorotridecanoic acid (PFTrDA) exposure showed a significant inverse association with birth weight only for female infants (per Log10 unit: β = -99.8 g, 95% CI, - 193.7 to -6.0) (P for interaction = 0.04)., Conclusions: Our findings suggest that prenatal, maternal exposure to PFAS with longer carbon chains tends to be inversely associated with birth size of newborn infants, which may indicate that these commercially used compounds have an adverse effect on fetal growth., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)- Published
- 2020
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16. Association between anthropometric indices of obesity and risk of cardiovascular disease in Japanese men.
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Xiang M, Hu H, Imai T, Nishihara A, Sasaki N, Ogasawara T, Hori A, Nakagawa T, Yamamoto S, Honda T, Okazaki H, Uehara A, Yamamoto M, Miyamoto T, Kochi T, Eguchi M, Murakami T, Shimizu M, Tomita K, Nagahama S, Nanri A, Konishi M, Akter S, Kuwahara K, Kashino I, Yamaguchi M, Kabe I, Mizoue T, Kunugita N, and Dohi S
- Subjects
- Adult, Case-Control Studies, Humans, Japan, Male, Middle Aged, Risk Factors, Body Mass Index, Cardiovascular Diseases etiology, Obesity complications, Waist Circumference, Waist-Height Ratio
- Abstract
Objectives: We aimed to compare the association of body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) with risk of cardiovascular disease (CVD) among middle-aged working Japanese men., Methods: A nested case-control study was performed among middle-aged male employees who underwent periodic health checkup. A total of 241 CVD cases were identified and matched individually on age, gender, and worksite with 1205 controls. Data on BMI, WC, WHtR, smoking, hypertension, diabetes, and dyslipidemia collected at 4 years before the event/index date were retrieved. Associations between BMI, WC, WHtR, and CVD risk were assessed by using conditional logistic regression models., Results: The strength of the association of BMI, WC, and WHtR with CVD risk was similar. The smoking-adjusted odds ratio (95% confidence interval) for CVD was 1.60 (1.38-1.85), 1.53 (1.33-1.78), and 1.56 (1.35-1.81) for a 1 SD unit increase in BMI, WC, and WHtR respectively. After further adjustment for hypertension, diabetes, and dyslipidemia, these associations were attenuated but remained statistically significant., Conclusions: Measures of general (BMI) and abdominal (WC and WHtR) obesity were similarly associated with CVD in middle-aged Japanese men., (© 2019 The Authors. Journal of Occupational Health published by John Wiley & Sons Australia, Ltd on behalf of The Japan Society for Occupational Health.)
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- 2020
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17. Association between perfluoroalkyl substance exposure and thyroid hormone/thyroid antibody levels in maternal and cord blood: The Hokkaido Study.
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Itoh S, Araki A, Miyashita C, Yamazaki K, Goudarzi H, Minatoya M, Ait Bamai Y, Kobayashi S, Okada E, Kashino I, Yuasa M, Baba T, and Kishi R
- Subjects
- Adult, Cohort Studies, Female, Fluorocarbons blood, Humans, Infant, Newborn, Male, Pregnancy, Prospective Studies, Sex Characteristics, Autoantibodies blood, Fetal Blood chemistry, Fluorocarbons toxicity, Thyroid Hormones blood
- Abstract
Background: Thyroid antibodies (TAs) are the most common cause of hypothyroidism during gestation. Although previous studies found that prenatal exposure to perfluoroalkyl substances (PFASs) disrupts thyroid hormones (THs) in humans, their effects on TAs during the perinatal period have not been investigated., Objective: To explore the associations between prenatal exposure to eleven different PFASs from two different groups (carboxylates and sulfonates) and the expression of THs and TAs in maternal and cord blood while considering maternal TA status., Methods: In a prospective birth cohort (the Hokkaido Study), we included 701 mother‑neonate pairs recruited in 2002-2005 for whom both prenatal maternal and cord blood samples were available. Eleven PFASs were measured in maternal plasma obtained at 28-32 weeks of gestation using ultra-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry. THs and TAs including thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) were measured in maternal blood during early pregnancy (median 11 gestational weeks), and in cord blood at birth., Results: The median levels of TgAb and TPOAb in maternal serum were 15.0 and 6.0 IU/mL, respectively. The median TgAb level in neonates was 38.0 IU/mL, and TPOAb were detected in only 12.3% of samples. Maternal FT3 level was positively associated with PFAS levels in both TA-positive and TA-negative mothers. Maternal perfluorooctanoate was inversely associated with maternal TPOAb. Among boys, some maternal PFASs were associated with higher TSH and lower FT3 levels in maternal TA-negative group, while perfluorodecanoic acid was associated with lower TSH in maternal TA-positive group. Among girls, some PFAS of mothers showed associations with lower TSH and higher FT3 in maternal TA-negative group, while perfluorododecanoic acid was associated with lower FT4 in maternal TA-positive. Maternal PFASs showed associations with boy's TgAb inversely in maternal TA-negative group and with girl's TgAb positively in maternal TA-positive group., Conclusions: Our results suggest thyroid disrupting effects of PFAS exposure and susceptibility vary depending on maternal TA levels., (Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2019
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18. Meat subtypes and colorectal cancer risk: A pooled analysis of 6 cohort studies in Japan.
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Islam Z, Akter S, Kashino I, Mizoue T, Sawada N, Mori N, Yamagiwa Y, Tsugane S, Naito M, Tamakoshi A, Wada K, Nagata C, Sugawara Y, Tsuji I, Matsuo K, Ito H, Lin Y, Kitamura Y, Sadakane A, Tanaka K, Shimazu T, and Inoue M
- Subjects
- Animals, Asian People, Body Mass Index, Cattle, Colon, Confidence Intervals, Female, Food Handling, Humans, Japan, Male, Meat classification, Poultry, Red Meat adverse effects, Risk Assessment, Sex Factors, Swine, Colonic Neoplasms etiology, Meat adverse effects, Rectal Neoplasms etiology
- Abstract
Red meat and processed meat have been suggested to increase risk of colorectal cancer (CRC), especially colon cancer. However, it remains unclear whether these associations differ according to meat subtypes or colon subsites. The present study addressed this issue by undertaking a pooled analysis of large population-based cohort studies in Japan: 5 studies comprising 232 403 participants (5694 CRC cases) for analysis based on frequency of meat intake, and 2 studies comprising 123 635 participants (3550 CRC cases) for analysis based on intake quantity. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using the Cox proportional hazards model and then pooled using the random effect model. Comparing the highest vs lowest quartile, beef intake was associated with an increased risk of colon cancer in women (pooled HR 1.20; 95% CI, 1.01-1.44) and distal colon cancer (DCC) risk in men (pooled HR 1.30; 95% CI, 1.05-1.61). Frequent intake of pork was associated with an increased risk of distal colon cancer in women (pooled HR 1.44; 95% CI, 1.10-1.87) for "3 times/wk or more" vs "less than 1 time/wk". Frequent intake of processed red meat was associated with an increased risk of colon cancer in women (pooled HR 1.39; 95% CI, 0.97-2.00; P trend = .04) for "almost every day" vs "less than 1 time/wk". No association was observed for chicken consumption. The present findings support that intake of beef, pork (women only), and processed red meat (women only) might be associated with a higher risk of colon (distal colon) cancer in Japanese., (© 2019 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.)
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- 2019
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19. Relationship between dietary non-enzymatic antioxidant capacity and type 2 diabetes risk in the Japan Public Health Center-based Prospective Study.
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Kashino I, Serafini M, Kurotani K, Akter S, Mizoue T, Ishihara J, Kotemori A, Sawada N, Inoue M, Iwasaki M, Noda M, and Tsugane S
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- Adult, Aged, Female, Humans, Japan, Male, Middle Aged, Prospective Studies, Public Health, Antioxidants metabolism, Diabetes Mellitus, Type 2 metabolism, Diet methods
- Abstract
Objective: Intake of antioxidants may reduce the risk for type 2 diabetes (T2D) by reducing oxidative stress. However, it is unclear whether dietary non-enzymatic antioxidant capacity (NEAC), which represents the cumulative action of dietary antioxidants and their synergistic effects in foods, is associated with decreased T2D risk. The aim of this study was to investigate the associations between dietary NEAC and T2D., Methods: The study included 64 660 adults (27 809 men and 36 851 women), 44 to 76 y of age without history of T2D in the Japan Public Health Center-based Prospective Study. Dietary NEAC was estimated using databases of NEAC measurements compiled from results for three different assays: ferric reducing-antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC), and total radical-trapping antioxidant parameter (TRAP). A multiple logistic regression model was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of self-reported physician-diagnosed T2D over 5 y with adjustment for potential confounders., Results: In all, 1191 cases of newly diagnosed T2D were reported. Dietary NEACs were not significantly associated with T2D. The multivariate-adjusted ORs were 1.04 (95% CI, 0.88-1.23; P
trend = 0.56) for FRAP, 1.11 (95% CI, 0.93-1.32; Ptrend = 0.26) for ORAC, and 0.99 (95% CI, 0.84-1.18; Ptrend = 0.84) for TRAP. Similar associations were observed in men and women (Pinteraction = 0.46 for FRAP, 0.35 for ORAC, and 0.63 for TRAP). In stratified analyses of major prooxidant factors, no notable associations with smoking and obesity status were observed., Conclusions: This finding suggests that dietary NEAC may not be appreciably associated with T2D in Japanese adults., (Copyright © 2019. Published by Elsevier Inc.)- Published
- 2019
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20. Higher Dietary Non-enzymatic Antioxidant Capacity Is Associated with Decreased Risk of All-Cause and Cardiovascular Disease Mortality in Japanese Adults.
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Kashino I, Mizoue T, Serafini M, Akter S, Sawada N, Ishihara J, Kotemori A, Inoue M, Yamaji T, Goto A, Iwasaki M, Noda M, and Tsugane S
- Abstract
Background: Few studies have assessed associations of non-enzymatic antioxidant capacity (NEAC) in the overall diet with all-cause or specific mortality, and their results have been inconsistent., Objectives: The present study investigated the association between dietary NEAC and all-cause or cause-specific mortality., Methods: The study was a large-scale population-based prospective cohort study in Japan consisting of 42,520 men and 50,207 women aged 44-76 y, who had no history of cancer, stroke, ischemic heart disease, or chronic liver disease. We evaluated FFQ-based dietary NEAC with use of published databases in which the NEACs of individual foods were analyzed by ferric reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC) assays. Dietary NEAC was calculated by multiplying the estimated NEAC with the consumed amount and summing up those values for all foods, and was categorized in quartiles. We identified death and cause of death with use of residential registry and death certificates. HRs and 95% Cls for death from the second survey, which was conducted from April 1995 to December 2014 were estimated with Cox proportional hazards regression analysis., Results: After 1,498,308 person-years of follow-up, 12,978 total deaths occurred. The multivariable-adjusted HRs (95% Cls) for all-cause mortality for the highest compared with the lowest quartile of FRAP and ORAC were 0.85 (0.80, 0.89) and 0.84 (0.79, 0.89), respectively. Dietary NEACs were inversely associated with mortality from cardiovascular disease (CVD), but not from cancer. The multivariable-adjusted HRs (95% Cls) for CVD for the highest compared with the lowest quartile of FRAP and ORAC were 0.83 (0.75, 0.92) and 0.79 (0.70, 0.89), respectively., Conclusions: Higher dietary NEACs from FRAP and ORAC were associated with lower risk of all-cause mortality and mortality from CVD in Japanese adults., (Copyright © American Society for Nutrition 2019.)
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- 2019
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21. Smoking, Smoking Cessation, and the Risk of Hearing Loss: Japan Epidemiology Collaboration on Occupational Health Study.
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Hu H, Sasaki N, Ogasawara T, Nagahama S, Akter S, Kuwahara K, Kochi T, Eguchi M, Kashino I, Murakami T, Shimizu M, Uehara A, Yamamoto M, Nakagawa T, Honda T, Yamamoto S, Hori A, Nishiura C, Okazaki H, Imai T, Nishihara A, Miyamoto T, Tomita K, Kabe I, Mizoue T, Kunugita N, and Dohi S
- Subjects
- Adult, Cohort Studies, Female, Humans, Japan epidemiology, Male, Middle Aged, Prospective Studies, Risk Factors, Time Factors, Tobacco Smoking trends, Young Adult, Hearing Loss diagnosis, Hearing Loss epidemiology, Occupational Health trends, Smoking Cessation methods, Tobacco Smoking adverse effects, Tobacco Smoking epidemiology
- Abstract
Introduction: We aimed to determine the prospective association of smoking status, smoking intensity, and smoking cessation with the risk of hearing loss in a large Japanese cohort., Methods: The cohort study included 50195 employees, who were aged 20-64 years and free of hearing loss at baseline. Participants were followed up for a maximum of 8 years. Pure-tone audiometric testing was performed annually to identify hearing loss at 1 and 4 kHz. Cox proportional hazards regression models were used to investigate the association between smoking and hearing loss., Results: During follow-up, 3532 individuals developed high-frequency hearing loss, and 1575 developed low-frequency hearing loss. The hazard ratio (HR) associated with current smokers was 1.6 (95% confidence interval [CI] = 1.5 to 1.7) and 1.2 (95% CI = 1.1 to 1.4) for high- and low-frequency hearing loss, respectively, as compared with never smokers. The risk of high- and low-frequency hearing loss increased with the number of cigarettes smoked per day (both p for trend <.001). The HR associated with former smokers was 1.2 (95% CI = 1.1 to 1.3) and 0.9 (95% CI = 0.8 to 1.1) for high- and low-frequency hearing loss, respectively. The analysis by quitting years showed a decline in risk of hearing loss after quitting smoking, even among those who quitted less than 5 years before baseline., Conclusions: Smoking is associated with increased risk of hearing loss, especially at the high frequency, in a dose-response manner. The excess risk of hearing loss associated with smoking disappears in a relatively short period after quitting., Implications: The prospective association between smoking and hearing loss has not been well studied. To the best of our knowledge, our study is the largest to date investigating the association between smoking and incident hearing loss. Our results indicate that smoking is associated with increased risk of hearing loss in a dose-response manner. Quitting smoking virtually eliminates the excess risk of hearing loss, even among quitters with short duration of cessation. These results suggest that smoking may be a causal factor for hearing loss, although further research would be required to confirm this. If so, this would emphasize the need for tobacco control to prevent or delay the development of hearing loss., (© The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2019
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22. Breakfast consumption and the risk of depressive symptoms: The Furukawa Nutrition and Health Study.
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Miki T, Eguchi M, Kuwahara K, Kochi T, Akter S, Kashino I, Hu H, Kurotani K, Kabe I, Kawakami N, Nanri A, and Mizoue T
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- Adult, Aged, Cross-Sectional Studies, Depression diagnosis, Depression epidemiology, Female, Humans, Japan epidemiology, Male, Middle Aged, Prospective Studies, Surveys and Questionnaires, Young Adult, Breakfast physiology, Breakfast psychology, Depression psychology, Diet psychology, Nutritional Status physiology
- Abstract
Breakfast consumption has been suggested to influence mood, but prospective evidence on this issue is limited. We prospectively investigated the association between the frequency of breakfast consumption and the risk of depressive symptoms in Japanese employees. Participants were 716 employees aged 19-68 years who were free from depressive symptoms and mental disorders at baseline and who attended the 3-year follow-up survey. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale. The frequency of breakfast consumption was categorized into "daily", "5-6 times/week", "3-4 times/week", "1-2 times/week", or "≤1 times/week". Logistic regression was used to estimate odds ratios of depressive symptoms according to breakfast consumption adjusted for dietary and lifestyle factors. Participants who consumed breakfast ≤1 times/week had an increased risk of depressive symptoms compared to those who ate breakfast every day, even after adjusting for other dietary factors (multivariable-adjusted odds ratio 2.92; 95% confidence interval, 1.37-6.22) The risk of depressive symptoms tended to increase with decreasing frequency of breakfast consumption (P for trend = 0.02). The omission of breakfast is related to increased risk of depressive symptoms among Japanese employees, independently of other dietary and non-dietary factors., (Copyright © 2019. Published by Elsevier B.V.)
- Published
- 2019
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23. Leisure-time physical activity and DNA damage among Japanese workers.
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Kawakami R, Kashino I, Kasai H, Kawai K, Li YS, Nanri A, Higuchi M, and Mizoue T
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- 8-Hydroxy-2'-Deoxyguanosine, Adult, Aged, Asian People, Biomarkers urine, Cross-Sectional Studies, Deoxyguanosine analogs & derivatives, Deoxyguanosine urine, Female, Guanine analogs & derivatives, Guanine urine, Humans, Japan, Linear Models, Male, Middle Aged, Occupations, Young Adult, DNA Damage, Exercise, Leisure Activities
- Abstract
Background: It remains unclear whether daily physical activity is associated with DNA damage. This cross-sectional study examined the association between leisure-time physical activity and urinary 8-hydroxydeoxyguanosine (8-OH-dG), a biomarker of oxidative DNA damage, or urinary 7-methylguanine (m7Gua), a biomarker of methylating DNA damage., Methods: Participants included 501 workers (294 men and 207 women), aged 20-65 years, from municipal offices in Japan. Urinary 8-OH-dG and m7Gua were measured using column-switching HPLC. Physical activity was evaluated using a self-reported questionnaire. The associations between leisure-time physical activity and urinary DNA damage markers were assessed by multiple linear regression analysis, with stratification by occupational physical activity., Results: After adjusting for covariates, leisure-time physical activity showed a suggestive inverse correlation with urinary 8-OH-dG levels (P for trend = 0.06), and a significant inverse association with urinary m7Gua levels (P for trend = 0.03). In analysis stratified by occupation, inverse correlations were observed in sedentary workers (walking < 30 min/day at work: P for trend = 0.06 and = 0.03 for urinary 8-OH-dG and m7Gua, respectively), but not in physically active workers (walking ≥ 30 min/day at work). In analysis for each intensity of leisure-time physical activity, light-intensity exercise was associated with lower levels of urinary 8-OH-dG (P for trend = 0.03), whereas moderate-to-high-intensity exercise was associated with lower levels of urinary m7Gua (P for trend = 0.02)., Conclusions: Our results suggest that high levels of leisure-time physical activity are associated with decreased levels of DNA damage in individuals with low physical activity at work., Competing Interests: The authors have declared that no competing interests exist.
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- 2019
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24. The association of work-related stressors and their changes over time with the development of metabolic syndrome: The Furukawa Nutrition and Health Study.
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Yamaguchi M, Eguchi M, Akter S, Kochi T, Hu H, Kashino I, Kuwahara K, Kabe I, and Mizoue T
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- Adult, Aged, Female, Follow-Up Studies, Health Surveys, Humans, Japan epidemiology, Logistic Models, Male, Manufacturing and Industrial Facilities, Middle Aged, Occupational Stress epidemiology, Risk Factors, Workload, Young Adult, Metabolic Syndrome epidemiology, Metabolic Syndrome psychology, Occupational Diseases epidemiology, Occupational Diseases psychology, Occupational Stress psychology, Workplace psychology
- Abstract
Objective: To investigate associations of work-related stressors and their changes over time with the risk of developing metabolic syndrome (MetS) among Japanese manufacturing workers., Methods: Participants were 1,040 employees aged 19 to 68 years who were free from MetS at baseline and completed the three year-interval follow-up survey. MetS was defined according to the Joint Interim Statement. Work-related stressors (job strain, job demands, job control, and worksite social support) were assessed based on the Job Content Questionnaire and were split into two categories (low and high) by the median value at each survey. Multivariable logistic regression was performed to investigate the associations of baseline work-related stressors and their changes over time with the incidence of MetS., Results: Three years later, 61 workers developed MetS. Higher job demands at baseline were significantly associated with a lower risk of MetS (adjusted odds ratio 0.46, 95% confidential interval: 0.24, 0.89). In the analyses of the changes in stressors over time, those whose job demands changed from low to high showed significantly higher risk of MetS (adjusted odds ratio 3.27, 95% confidential interval: 1.46, 7.34), compared with those who reported low job demands in both surveys., Conclusions: Results suggest that an increase in job demands over time, but not higher job demands at baseline, is associated with increased risk of MetS.
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- 2018
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25. Smoking, Smoking Cessation, and Risk of Mortality in a Japanese Working Population - Japan Epidemiology Collaboration on Occupational Health Study.
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Akter S, Nakagawa T, Honda T, Yamamoto S, Kuwahara K, Okazaki H, Hu H, Imai T, Nishihara A, Miyamoto T, Sasaki N, Ogasawara T, Uehara A, Yamamoto M, Murakami T, Shimizu M, Eguchi M, Kochi T, Hori A, Nagahama S, Tomita K, Konishi M, Kashino I, Nanri A, Kabe I, Mizoue T, Kunugita N, and Dohi S
- Subjects
- Adult, Female, Follow-Up Studies, Humans, Japan epidemiology, Male, Middle Aged, Cardiovascular Diseases etiology, Cardiovascular Diseases mortality, Neoplasms etiology, Neoplasms mortality, Occupational Health, Smoking adverse effects, Smoking mortality, Smoking Cessation
- Abstract
Background: The effect of smoking on mortality in working-age adults remains unclear. Accordingly, we compared the effects of cigarette smoking and smoking cessation on total and cause-specific mortality in a Japanese working population., Methods and results: This study included 79,114 Japanese workers aged 20-85 years who participated in the Japan Epidemiology Collaboration on Occupational Health Study. Deaths and causes of death were identified from death certificates, sick leave documents, family confirmation, and other sources. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated via Cox proportional hazards regression. During a maximum 6-year follow-up, there were 252 deaths in total. Multivariable-adjusted HRs (95% CIs) for total mortality, cardiovascular disease (CVD) mortality, and tobacco-related cancer mortality were 1.49 (1.10-2.01), 1.79 (0.99-3.24), and 1.80 (1.02-3.19), respectively, in current vs. never smokers. Among current smokers, the risks of total, tobacco-related cancer, and CVD mortality increased with increasing cigarette consumption (P
trend <0.05 for all). Compared with never smokers, former smokers who quit <5 and ≥5 years before baseline had HRs (95% CIs) for total mortality of 1.80 (1.00-3.25) and 1.02 (0.57-1.82), respectively., Conclusions: In this cohort of workers, cigarette smoking was associated with increased risk of death from all and specific causes (including CVD and tobacco-related cancer), although these risks diminished 5 years after smoking cessation.- Published
- 2018
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26. The Validity and Reproducibility of Dietary Non-enzymatic Antioxidant Capacity Estimated by Self-administered Food Frequency Questionnaires.
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Kashino I, Serafini M, Ishihara J, Mizoue T, Sunami A, Maruyama K, Sawada N, Inoue M, Nanri A, Kurotani K, Akter S, Iwasaki M, and Tsugane S
- Subjects
- Female, Humans, Male, Middle Aged, Reproducibility of Results, Antioxidants administration & dosage, Diet statistics & numerical data, Diet Surveys
- Abstract
Background: High dietary non-enzymatic antioxidant capacity (NEAC) has been inversely related to the incidence of degenerative diseases. However, few studies have investigated the validity and reproducibility of dietary NEAC estimated from a food frequency questionnaire (FFQ). We assessed the validity and reproducibility of FFQ-based dietary NEAC against a dietary record (DR)., Methods: Participants were 244 men and 253 women who completed a 28-day DR and FFQs. NEAC for each food item was estimated according to available databases of antioxidant capacity, as measured by ferric reducing-antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC), and total radical-trapping antioxidant parameter (TRAP). Using Spearman's rank correlation coefficients (CCs), we assessed the validity for dietary NEACs from a 28-day DR and a FFQ, and the reproducibility for them from two FFQs administered at a 1-year interval. Additionally, joint classification and the Bland-Altman method were applied to assess agreement between the two methods., Results: Regarding validation, deattenuated CCs for the energy-adjusted overall dietary NEACs between FFQ and DR for FRAP, ORAC, and TRAP were 0.52, 0.54, and 0.52, respectively, for all subjects. Extreme miscategorization rates by joint classification analysis were 2% for FRAP and ORAC and 1% for TRAP. Regarding reproducibility, CCs between the energy-adjusted dietary NEACs from two FFQs were 0.64 for FRAP and 0.65 for ORAC and TRAP., Conclusion: The validity and reproducibility of dietary NEAC of total food from the FFQ were moderate. Estimations of dietary NEAC using FFQ would be useful in studying disease relationships by categorizing habitual dietary NEAC.
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- 2018
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27. Haemoglobin A1c and hearing impairment: longitudinal analysis using a large occupational health check-up data of Japan.
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Nagahama S, Kashino I, Hu H, Nanri A, Kurotani K, Kuwahara K, Dan M, Michikawa T, Akter S, Mizoue T, Murakami Y, and Nishiwaki Y
- Subjects
- Adult, Aged, Audiometry, Pure-Tone, Diabetes Mellitus blood, Female, Hearing Loss diagnosis, Humans, Incidence, Japan epidemiology, Longitudinal Studies, Male, Middle Aged, Physical Examination, Proportional Hazards Models, Smoking epidemiology, Diabetes Mellitus epidemiology, Glycated Hemoglobin metabolism, Hearing Loss blood, Hearing Loss epidemiology, Occupational Health
- Abstract
Objectives: The aim of this study was to determine whether haemoglobin A1c (HbA1c) level is associated with the incidence of hearing impairment accounting for smoking status and diabetic condition at baseline., Methods: Participants were 131 689 men and 71 286 women aged 30-65 years and free of hearing impairment at baseline (2008) who attended Japanese occupational annual health check-ups from 2008 to 2015. We defined low-frequency hearing impairment at a hearing threshold >30 dB at 1 kHz and high frequency at >40 dB at 4 kHz in the better ear in pure-tone audiometric tests. HbA1c was categorised into seven categories. The association between HbA1c and hearing impairment was assessed using the Cox proportional hazards model., Results: On 5 years mean follow-up, high HbA1c was associated with high-frequency hearing impairment. In non-smokers, HbA1c≥8.0% was associated with high-frequency hearing impairment, with a multivariable HR (95% CI) compared with HbA1c 5.0%-5.4% of 1.46 (1.10 to 1.94) in men and 2.15 (1.13 to 4.10) in women. There was no significant association between HbA1c and hearing impairment in smokers. A J-shaped association between HbA1c and high-frequency hearing impairment was observed for participants with diabetes at baseline. HbA1c was not associated with low-frequency hearing impairment among any participants., Conclusions: HbA1c ≥8.0% of non-smokers and ≥7.3% of participants with diabetes was associated with high-frequency hearing impairment. These findings indicate that appropriate glycaemic control may prevent diabetic-related hearing impairment., Competing Interests: Competing interests: SN is occupational physicians in All Japan Labor Welfare Foundation., (© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2018
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28. Development and validation of risk models to predict the 7-year risk of type 2 diabetes: The Japan Epidemiology Collaboration on Occupational Health Study.
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Hu H, Nakagawa T, Yamamoto S, Honda T, Okazaki H, Uehara A, Yamamoto M, Miyamoto T, Kochi T, Eguchi M, Murakami T, Shimizu M, Tomita K, Nagahama S, Imai T, Nishihara A, Sasaki N, Ogasawara T, Hori A, Nanri A, Akter S, Kuwahara K, Kashino I, Kabe I, Mizoue T, Sone T, and Dohi S
- Subjects
- Adult, Cohort Studies, Diabetes Mellitus, Type 2 metabolism, Female, Follow-Up Studies, Humans, Incidence, Japan epidemiology, Male, Middle Aged, Prognosis, Proportional Hazards Models, ROC Curve, Risk Factors, Biomarkers analysis, Diabetes Mellitus, Type 2 diagnosis, Diabetes Mellitus, Type 2 epidemiology, Occupational Health
- Abstract
Aims/introduction: We previously developed a 3-year diabetes risk score in the working population. The objective of the present study was to develop and validate flexible risk models that can predict the risk of diabetes for any arbitrary time-point during 7 years., Materials and Methods: The participants were 46,198 Japanese employees aged 30-59 years, without diabetes at baseline and with a maximum follow-up period of 8 years. Incident diabetes was defined according to the American Diabetes Association criteria. With routine health checkup data (age, sex, abdominal obesity, body mass index, smoking status, hypertension status, dyslipidemia, glycated hemoglobin and fasting plasma glucose), we developed non-invasive and invasive risk models based on the Cox proportional hazards regression model among a random two-thirds of the participants, and used another one-third for validation., Results: The range of the area under the receiver operating characteristic curve increased from 0.73 (95% confidence interval 0.72-0.74) for the non-invasive prediction model to 0.89 (95% confidence interval 0.89-0.90) for the invasive prediction model containing dyslipidemia, glycated hemoglobin and fasting plasma glucose. The invasive models showed improved integrated discrimination and reclassification performance, as compared with the non-invasive model. Calibration appeared good between the predicted and observed risks. These models performed well in the validation cohort., Conclusions: The present non-invasive and invasive models for the prediction of diabetes risk up to 7 years showed fair and excellent performance, respectively. The invasive models can be used to identify high-risk individuals, who would benefit greatly from lifestyle modification for the prevention or delay of diabetes., (© 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)
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- 2018
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29. Coffee drinking and colorectal cancer and its subsites: A pooled analysis of 8 cohort studies in Japan.
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Kashino I, Akter S, Mizoue T, Sawada N, Kotemori A, Matsuo K, Oze I, Ito H, Naito M, Nakayama T, Kitamura Y, Tamakoshi A, Tsuji I, Sugawara Y, Inoue M, Nagata C, Sadakane A, Tanaka K, Tsugane S, and Shimazu T
- Subjects
- Adult, Aged, Cohort Studies, Colorectal Neoplasms etiology, Female, Humans, Incidence, Japan epidemiology, Male, Middle Aged, Proportional Hazards Models, Coffee chemistry, Colorectal Neoplasms epidemiology, Phytochemicals administration & dosage
- Abstract
Coffee is a rich source of bioactive compounds that have potential anticarcinogenic effects. However, it remains unclear whether coffee drinking is associated with colorectal cancer. Also, despite different etiological factors involved in gut physiology, few studies have investigated this association by anatomical site of the lesion. To address these issues, this study examined the association between coffee drinking and colorectal cancer in a pooled analysis from 8 cohort studies conducted in Japan. Among 320,322 participants followed up for 4,503,274 person-years, 6,711 incident colorectal cancer cases were identified. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using the random effects model. Coffee drinking was not materially associated with colorectal cancer risk in men or women (pooled HR 0.92, 95% CI 0.82-1.03 in men and pooled HR 0.90, 95% CI 0.76-1.07 in women). Analysis by subsite showed a lower risk of colon cancer among female drinkers of ≥3 cups coffee/day (pooled HR 0.80, 95% CI 0.64-0.99). There was no such association in men. Coffee drinking was not associated with risk of rectal cancer in men or women. Results were virtually the same among never smokers except for an increased risk of rectal cancer associated with frequent coffee consumption. Coffee drinking may be associated with lower risk of colon cancer in Japanese women., (© 2018 UICC.)
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- 2018
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30. Determinants and Temporal Trends of Perfluoroalkyl Substances in Pregnant Women: The Hokkaido Study on Environment and Children's Health.
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Tsai MS, Miyashita C, Araki A, Itoh S, Bamai YA, Goudarzi H, Okada E, Kashino I, Matsuura H, and Kishi R
- Subjects
- Adult, Chromatography, Cotinine blood, Female, Humans, Japan, Linear Models, Prospective Studies, Tandem Mass Spectrometry, Time Factors, Alkanesulfonic Acids blood, Environmental Monitoring, Environmental Pollutants blood, Fatty Acids blood, Fluorocarbons blood, Lauric Acids blood, Maternal Exposure statistics & numerical data, Pregnancy blood
- Abstract
Perfluoroalkyl substances (PFAS) are persistent bio-accumulative chemicals that impact the health of pregnant women and their children. PFAS derive from environmental and consumer products, which depend on human lifestyle, socioeconomic characteristics, and time variation. Here, we aimed to explore the temporal trends of PFAS in pregnant women and the characteristics related to maternal PFAS concentration. Our study is part of the Hokkaido Study on Environment and Children's Health, the Hokkaido large-scale cohort that recruited pregnant women between 2003 and 2011. Blood samples were acquired from pregnant women during the third trimester to measure PFAS and cotinine concentrations. Maternal basic information was collected with a baseline structured questionnaire. Eleven PFAS were measured from 2123 samples with ultra-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry. Eight PFAS were above 80% detection rate and were included in the final analysis. We used multivariable linear regression to analyze the association of pregnant women characteristics with the levels of eight PFAS. The temporal trend of PFAS was observed in two periods (August 2003 to January 2006 and February 2006 to July 2012). The concentration of perfluorooctane sulfonate (PFOS) significantly decreased from August 2003 to January 2006 and from February 2006 to July 2012. The concentrations of perfluorododecanoic acid (PFDoDA), perfluoroundecanoic acid (PFUnDA), and perfluorotridecanoic acid (PFTrDA) increased significantly between August 2003 and January 2006, whereas they decreased significantly between February 2006 and July 2012. Women with pre-pregnancy body mass index (BMI) >25 kg/m² had lower PFUnDA, PFDoDA, and PFTrDA levels than did those with normal BMI (18.5⁻24.9 kg/m²). Pregnant women, who were active smokers (cotinine > 11.49 ng/mL), had higher PFOS than the non-smokers (cotinine < 0.22 ng/mL). Lower levels of PFHxS, PFOS, PFOA, PFNA, and PFDA were observed in women, who had given birth to more than one child. There were also significant positive associations between PFAS levels and annual income or maternal education. PFAS levels varied in women with higher pre-pregnancy BMI, active smoking status, higher education level and annual income. The causes of the individual PFAS differences should be explored in an independent study., Competing Interests: The authors declare no conflict of interest.
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- 2018
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31. Longitudinal adherence to a dietary pattern and risk of depressive symptoms: the Furukawa Nutrition and Health Study.
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Miki T, Eguchi M, Akter S, Kochi T, Kuwahara K, Kashino I, Hu H, Kabe I, Kawakami N, Nanri A, and Mizoue T
- Subjects
- Adult, Depression epidemiology, Diet methods, Female, Follow-Up Studies, Fruit, Humans, Japan epidemiology, Male, Middle Aged, Multivariate Analysis, Nutrition Surveys, Nutritional Status, Occupational Diseases epidemiology, Odds Ratio, Patient Compliance psychology, Prospective Studies, Psychiatric Status Rating Scales, Regression Analysis, Vegetables, Depression etiology, Diet psychology, Feeding Behavior psychology, Occupational Diseases psychology
- Abstract
Objective: We explored the association of 3-year adherence to a dietary pattern based on nutrients that may be related to mood with the development of depressive symptoms in Japanese employees., Methods: Participants were 903 employees free from depressive symptoms at baseline and who attended the 3-year follow-up. Participants with depressive symptoms were defined as those with a score ≥16 on the Center for Epidemiologic Studies Depression Scale. Dietary patterns were derived using reduced-rank regression at baseline and at the 3-year follow-up survey using a validated, self-administered diet history questionnaire. Based on changes in dietary pattern scores between baseline and follow-up surveys, participants were categorized into four groups: Maintained high scores, improved scores, decreased scores, and maintained low scores. Logistic regression was used to estimate odds ratios of depressive symptoms according to changes in dietary pattern scores., Results: Maintaining high or improving adherence to a diet rich in vegetables, mushrooms, seaweeds, soybean products, green tea, potatoes, fruits, and fish and low in rice over 3 y was associated with a decreased risk of depressive symptoms. The multivariable-adjusted odds ratio (95% confidence intervals) of developing depressive symptoms for maintained high scores versus maintained low scores was 0.57 (0.35-0.93) and for improved scores versus maintained low scores was 0.54 (0.29-1.01). The association with the severe depressive status was more pronounced., Conclusion: Maintaining high or improving adherence to a dietary pattern derived by reduced-rank regression is associated with a lower risk of depression among Japanese employees., (Copyright © 2017 Elsevier Inc. All rights reserved.)
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- 2018
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32. Association of dietary and serum magnesium with glucose metabolism markers: The Furukawa Nutrition and Health Study.
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Akter S, Eguchi M, Nanri A, Kochi T, Kashino I, Kuwahara K, Hu H, Miki T, Kabe I, and Mizoue T
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- Adult, Aged, Asian People, Biomarkers metabolism, Cross-Sectional Studies, Female, Humans, Japan epidemiology, Male, Middle Aged, Nutrition Surveys, Nutritional Status, Surveys and Questionnaires, Young Adult, Blood Glucose metabolism, Diet, Insulin Resistance physiology, Magnesium metabolism
- Abstract
Background & Aims: Magnesium may play an important role in cardio-metabolic abnormalities, including type 2 diabetes, but epidemiological evidence linking magnesium status to glucose metabolism is limited among Asians. We cross-sectionally examined the association of dietary and serum magnesium with markers of glucose metabolism among Japanese subjects., Methods: Subjects were 1796 workers, aged 18-78 years, who participated in a health survey. Dietary magnesium intake was assessed with a validated brief diet history questionnaire. Serum magnesium concentrations were measured using an enzymatic method. Multivariable linear regression models were used to estimate means of fasting insulin, fasting plasma glucose, homeostatic model assessment of insulin resistance (HOMA-IR), homeostatic model assessment of β-cell function (HOMA-β), and glycated hemoglobin (HbA1c), with adjustments made for potential confounding variables., Results: Dietary magnesium was inversely associated with HOMA-IR (P
trend = 0.01). Multivariable-adjusted means (95% confidence intervals) of HOMA-IR for the lowest to highest quartiles of dietary magnesium were 0.94 (0.89-0.99), 0.92 (0.88-0.97), 0.88 (0.83-0.92), and 0.86 (0.81-0.90). Serum magnesium concentrations were also inversely associated with HOMA-IR (Ptrend = 0.04) and HbA1c (Ptrend <0.01). Multivariable-adjusted means (95% confidence intervals) for the lowest to highest quartiles of serum magnesium were 0.94 (0.90-0.98), 0.87 (0.83-0.91), 0.90 (0.85-0.95), and 0.86 (0.81-0.92) for HOMA-IR and 5.41 (5.36-5.45), 5.33 (5.28-5.37), 5.30 (5.25-5.36), and 5.28 (5.22-5.35) for HbA1c. Excluding subjects with diabetes did not materially change the association between dietary magnesium and HOMA-IR (Ptrend <0.01), while it attenuated the association of serum magnesium with HOMA-IR (Ptrend = 0.27) and HbA1c (Ptrend = 0.15)., Conclusions: The present findings suggest that lower dietary magnesium, but not serum magnesium, is associated with IR in apparently healthy adults., (Copyright © 2018 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.)- Published
- 2018
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33. Dietary non-enzymatic antioxidant capacity and DNA damage in a working population.
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Kashino I, Li YS, Kawai K, Nanri A, Miki T, Akter S, Kobayashi S, Kasai H, and Mizoue T
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- 8-Hydroxy-2'-Deoxyguanosine, Adult, Aged, Deoxyguanosine analogs & derivatives, Deoxyguanosine urine, Female, Guanine analogs & derivatives, Guanine urine, Humans, Male, Middle Aged, Oxygen Radical Absorbance Capacity, Risk Factors, Young Adult, Antioxidants analysis, DNA Damage, Diet statistics & numerical data
- Abstract
Objective: The aim of this study was to investigate the potential links between dietary non-enzymatic antioxidant capacity (NEAC) in overall diet and separately from foods and beverages and markers of DNA damage., Methods: The participants were 513 employees, 20 to 65 y of age. Urinary levels of 8-hydroxydeoxyguanosine (8-OHdG) and 7-methylguanine (m
7 Gua) were measured using column-switching high-performance liquid chromatography. Dietary NEAC was determined from databases of NEAC measurements obtained by different assays: ferric reducing-antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC), and total radical-trapping antioxidant parameter (TRAP). Dietary NEAC for each participant was calculated by multiplying the estimated NEAC values with the consumed amount and summing up those values, which was ascertained by a validated brief self-administered diet history questionnaire. Multiple-regression analyses were performed to assess the associations between dietary NEAC and 8-OHdG and m7 Gua, with adjustment for potential confounders., Results: No statistically significant associations were found between overall dietary NEAC or NEAC from either foods or beverages and urinary 8-OHdG levels, after adjustment for potential confounders (overall: FRAP, Ptrend = 0.40; ORAC, P = 0.27; TRAP, P = 0.45). Likewise, no association was found between overall dietary NEAC and m7 Gua levels (FRAP, Ptrend = 0.30; ORAC, P = 0.65; TRAP, P = 0.41). However, we did identify significant inverse association between NEAC from foods, as estimated by TRAP, and m7 Gua levels (Ptrend = 0.049)., Conclusion: Overall, dietary NEAC was not associated with 8-OHdG or m7 Gua levels. In contrast, dietary NEAC from foods but not beverages may be inversely associated with DNA damage caused by methylation., (Copyright © 2017 Elsevier Inc. All rights reserved.)- Published
- 2018
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34. Metabolic Syndrome Over 4 Years Before the Onset of Cardiovascular Disease - Nested Case-Control Study.
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Hu H, Nakagawa T, Honda T, Yamamoto S, Nanri A, Konishi M, Okazaki H, Kuwahara K, Hori A, Nishiura C, Kashino I, Imai T, Nishihara A, Akter S, Miyamoto T, Sasaki N, Ogasawara T, Uehara A, Yamamoto M, Murakami T, Shimizu M, Eguchi M, Kochi T, Nagahama S, Tomita K, Kabe I, Mizoue T, Sone T, and Dohi S
- Subjects
- Adult, Cardiovascular Diseases epidemiology, Case-Control Studies, Female, Humans, Japan, Life Style, Male, Metabolic Syndrome epidemiology, Middle Aged, Time Factors, Cardiovascular Diseases etiology, Metabolic Syndrome complications
- Abstract
Background: We investigated the risk of cardiovascular disease (CVD) with duration of metabolic syndrome (MetS) for the past 4 years before the CVD event.Methods and Results:We performed a nested case-control study within the Japan Epidemiology Collaboration on Occupational Health Study. A total of 139 registered cases of CVD and 561 self-reported cases of CVD were identified and matched individually on age, sex, and worksite with 695 and 2,803 controls, respectively. MetS was defined by the Joint Interim Statement definition. The odds ratio (95% confidence interval) for registered CVD was 4.7 (2.9, 7.5) for people with persistent MetS (positive for MetS for ≥3 assessments) and 1.9 (1.1, 3.3) for those with intermittent MetS (positive for MetS for 1-2 assessments), compared with people without MetS during the past 4 years before the event/index date (P for trend <0.001). The corresponding odds ratio for self-reported CVD was 2.7 (2.2, 3.5) and 1.8 (1.4, 2.3) (P for trend <0.001). The association with MetS duration was stronger for myocardial infarction than for other CVD subtypes. Similar results were obtained when using the Japanese MetS criteria., Conclusions: The risk of CVD increases with increasing MetS duration. These findings contribute to risk stratification and encourage lifestyle modification for people with MetS to minimize their health risk.
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- 2018
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35. Age-, sex-, and diagnosis-specific incidence rate of medically certified long-term sick leave among private sector employees: The Japan Epidemiology Collaboration on Occupational Health (J-ECOH) study.
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Nishiura C, Nanri A, Kashino I, Hori A, Kinugawa C, Endo M, Kato N, Tomizawa A, Uehara A, Yamamoto M, Nakagawa T, Yamamoto S, Honda T, Imai T, Okino A, Miyamoto T, Sasaki N, Tomita K, Nagahama S, Kochi T, Eguchi M, Okazaki H, Murakami T, Shimizu C, Shimizu M, Kabe I, Mizoue T, Sone T, and Dohi S
- Subjects
- Adult, Age Distribution, Cohort Studies, Female, Humans, Incidence, Japan epidemiology, Male, Mental Disorders epidemiology, Middle Aged, Neoplasms epidemiology, Pregnancy, Pregnancy Complications epidemiology, Sex Distribution, Time Factors, Young Adult, Mental Disorders diagnosis, Neoplasms diagnosis, Pregnancy Complications diagnosis, Private Sector statistics & numerical data, Sick Leave statistics & numerical data
- Abstract
Background: Long-term sick-leave is a major public health problem, but data on its incidence in Japan are scarce. We aimed to present reference data for long-term sick-leave among private sector employees in Japan., Methods: The study population comprised employees of 12 companies that participated in the Japan Epidemiology Collaboration on Occupational Health Study. Details on medically certified sick-leave lasting ≥30 days were collected from each company. Age- and sex-specific incidence rate of sick-leave was calculated for the period of April 2012 to March 2014., Results: A total of 1422 spells in men and 289 in women occurred during 162,989 and 30,645 person-years of observation, respectively. The three leading causes of sick-leave (percentage of total spells) were mental disorders (52%), neoplasms (12%), and injury (8%) for men; and mental disorders (35%), neoplasms (20%), and pregnancy-related disease (14%) for women. Incidence rate of sick-leave due to mental disorders was relatively high among men in their 20s-40s but tended to decrease with age among women. Incidence rate of sick-leave due to neoplasms started to increase after age 50 in men and after age 40 in women, making neoplasms the leading cause of sick-leave after age 50 for women and after age 60 for men and the second leading cause after age 40 for women and after age 50 for men. Pregnancy-related disease was the second leading cause of sick-leave among women aged 20-39 years., Conclusions: These results suggest that mental disorder, neoplasms, and pregnancy-related disease are the major causes of long-term sick-leave among private sector employees in Japan., (Copyright © 2017 The Authors. Production and hosting by Elsevier B.V. All rights reserved.)
- Published
- 2017
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36. Circulating ferritin concentrations are differentially associated with serum adipokine concentrations in Japanese men and premenopausal women.
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Kimura Y, Yasuda K, Kurotani K, Akter S, Kashino I, Hayabuchi H, Sato M, and Mizoue T
- Subjects
- Adult, Biomarkers blood, Body Mass Index, Cross-Sectional Studies, Exercise, Female, Humans, Japan, Male, Middle Aged, Nicotinamide Phosphoribosyltransferase blood, Nutrition Assessment, Plasminogen Activator Inhibitor 1 blood, Premenopause, Adipokines blood, Asian People, Ferritins blood
- Abstract
Purpose: Increased iron storage, as measured by circulating ferritin, has been linked to an increased risk of various diseases including diabetes. We examined the association of circulating ferritin with serum adiponectin, leptin, resistin, plasminogen activator inhibitor-1 (PAI-1), and visfatin levels., Methods: We conducted a cross-sectional study among 429 Japanese employees (284 men and 145 premenopausal women, mean age: 42.5 ± 10.5 years). Serum adipokines were measured using Luminex suspension bead-based multiplexed array, and serum ferritin was determined using a chemiluminescence immunoassay. Multivariable regression analysis was performed to calculate mean concentrations of adipokine according to the tertile of ferritin concentrations with adjustment for potential confounders., Results: Leptin and visfatin concentrations increased with increasing ferritin concentrations in men after multivariable adjustment of physical activity, smoking, alcohol use, and body mass index (P for trend = 0.02 and 0.01 for leptin and visfatin, respectively). Serum ferritin concentrations were inversely and significantly associated with adiponectin in women (P for trend = 0.01). Resistin and PAI-1 were not appreciably associated with ferritin concentration., Conclusions: Increased iron storage may be associated with higher circulating concentrations of leptin and visfatin in men and with lower concentrations of adiponectin in women.
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- 2017
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37. Metabolic syndrome components and diabetes incidence according to the presence or absence of impaired fasting glucose: The Japan Epidemiology Collaboration on Occupational Health Study.
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Kurotani K, Miyamoto T, Kochi T, Eguchi M, Imai T, Nishihara A, Tomita K, Uehara A, Yamamoto M, Murakami T, Shimizu C, Shimizu M, Nagahama S, Nakagawa T, Honda T, Yamamoto S, Okazaki H, Sasaki N, Hori A, Nishiura C, Kuwahara K, Kuroda R, Akter S, Kashino I, Nanri A, Kabe I, Mizoue T, Kunugita N, and Dohi S
- Subjects
- Adult, Diabetes Mellitus blood, Female, Humans, Incidence, Japan epidemiology, Male, Metabolic Syndrome blood, Middle Aged, Obesity, Abdominal blood, Obesity, Abdominal epidemiology, Occupational Health, Proportional Hazards Models, Prospective Studies, Risk, Blood Glucose metabolism, Diabetes Mellitus epidemiology, Fasting blood, Metabolic Syndrome epidemiology
- Abstract
Background: We prospectively examined the association of diabetes risk with the number of metabolic abnormalities, as well as their combinations, according to the presence or absence of impaired fasting glucose (IFG) in a large-scale Japanese working population., Methods: Participants included 55,271 workers at 11 companies who received periodic health check-ups between 2008 and 2013. The metabolic syndrome (MetS) components were defined using the 2009 Joint Interim Statement. IFG was defined as fasting plasma glucose 5.6-6.9 mmol/L. Diabetes newly diagnosed after the baseline examination was defined according to the American Diabetes Association criteria. We calculated the hazard ratios (HRs) for diabetes incidence using the Cox proportional hazards model., Results: During the follow-up period (median 4.95 years), 3183 subjects developed diabetes. In individuals with normal fasting glucose levels, the risk of diabetes increased steadily with the increasing number of MetS components; the multivariable-adjusted HRs for incident diabetes for the number of MetS components were 2.0, 4.3, 7.0, and 10.0 for one, two, three, or four MetS components, respectively, compared with the absence of components. A similar association was observed among individuals with IFG; the corresponding HRs were 17.6, 23.8, 33.9, and 40.7. The combinations that included central obesity appeared to be more strongly associated with diabetes risk than other combinations with the same number of MetS components within the same glucose status., Conclusions: Our findings indicate that risk stratification of individuals by the presence or absence of IFG and the number of MetS components can detect individuals with a high risk of diabetes., (Copyright © 2017 The Authors. Production and hosting by Elsevier B.V. All rights reserved.)
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- 2017
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38. Prenatal exposure to perfluoroalkyl acids and prevalence of infectious diseases up to 4years of age.
- Author
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Goudarzi H, Miyashita C, Okada E, Kashino I, Chen CJ, Ito S, Araki A, Kobayashi S, Matsuura H, and Kishi R
- Subjects
- Adult, Child, Preschool, Female, Humans, Infant, Male, Odds Ratio, Prevalence, Tandem Mass Spectrometry, Alkanesulfonic Acids blood, Communicable Diseases epidemiology, Environmental Pollutants blood, Fatty Acids blood, Fluorocarbons blood, Pregnancy blood, Prenatal Exposure Delayed Effects epidemiology
- Abstract
Perfluoroalkyl acids (PFAAs) are synthetic chemicals with ability to repel oils and water, and have been widely used in many industrial and household applications such as adhesives and water- and stain-repellent surfaces to nonstick coatings. Animal studies have shown that PFAAs have immunotoxic effects. However, few epidemiological studies have investigated the effects of PFAAs on infectious diseases occurrence. We examined the relationship between prenatal exposure to PFAAs and prevalence of infectious diseases up to 4years of life. A total of 1558 mother-child pairs, who were enrolled in the Hokkaido Study on Environment and Children's Health, were included in this data analysis. Eleven PFAAs were measured in maternal plasma taken at 28-32weeks of gestation using ultra-performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry. Participant characteristics were obtained from medical birth records and self-administered questionnaires during pregnancy and after delivery. Physicians' diagnosis of common infectious diseases including otitis media, pneumonia, respiratory syncytial virus infection, and varicella up to 4years were extracted from the mother-reported questionnaires. The number of children who developed infectious diseases up to 4years of age was as follows: otitis media, 649 (41.4%); pneumonia, 287 (18.4%); respiratory syncytial virus infection, 197 (12.6%); varicella 589 (37.8%). A total of 1046 (67.1%) children had at least one of the diseases defined as total infectious diseases. After adjusting for appropriate confounders, PFOS levels in the highest quartile were associated with increased odds ratios (ORs) of total infectious diseases (Q4 vs. Q1 OR: 1.61; 95% CI: 1.18, 2.21; p for trend=0.008) in all children. In addition, perfluorohexane sulfonate (PFHxS) was associated with a higher risk of total infectious diseases only among girls (Q4 vs. Q1 OR: 1.55, 95% CI: 0.976, 2.45; p for trend=0.045). We found no association between infectious diseases and other examined PFAAs. Our findings suggest that prenatal exposure to PFOS and PFHxS may associated with infectious diseases occurrence in early life. Therefore, prenatal exposure to PFAAs may be immunotoxic for the immune system in offspring., (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Published
- 2017
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39. Even- and odd-chain saturated fatty acids in serum phospholipids are differentially associated with adipokines.
- Author
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Kurotani K, Sato M, Yasuda K, Kashima K, Tanaka S, Hayashi T, Shirouchi B, Akter S, Kashino I, Hayabuchi H, and Mizoue T
- Subjects
- Adult, Aged, Cross-Sectional Studies, Female, Humans, Limit of Detection, Male, Middle Aged, Young Adult, Adipokines blood, Fatty Acids blood, Phospholipids blood
- Abstract
Background: Saturated fatty acids are generally thought to have detrimental effects on health. However, a recent study showed that even- and odd-chain saturated fatty acids had opposite associations with type 2 diabetes. Limited studies of Western populations examined the associations of circulating saturated fatty acids with adipokines, an important role in glucose metabolism., Objective: We examined the associations of saturated fatty acids in serum phospholipids with circulating levels of adipokines among a Japanese population., Design: A cross-sectional study was conducted among 484 Japanese employees (284 men and 200 women) aged 20-65 years. The serum fatty acid composition in the phospholipid fraction was measured by gas-chromatography. Serum leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), resistin, and visfatin were measured using a Luminex suspension bead-based multiplexed array. Multiple linear regression analysis was performed to assess the association between saturated fatty acids and adipokines, with adjustment for potential confounding variables., Results: Even- and odd-chain saturated fatty acids were differentially associated with adipokines. Higher levels of even-chain saturated fatty acids (14:0 myristic, 16:0 palmitic, and 18:0 stearic acids) were associated with higher levels of resistin (P for trend = 0.048) and lower levels of adiponectin (P for trend = 0.003). By contrast, odd-chain saturated fatty acids (15:0 pentadecanoic and 17:0 heptadecanoic acids) showed inverse associations with leptin and PAI-1 (P for trend = 0.048 and 0.02, respectively). Visfatin was positively associated with both even- and odd-chain saturated fatty acids., Conclusions: The results suggest that even- and odd-chain saturated fatty acids are differentially associated with adipokine profile.
- Published
- 2017
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40. Serum 25-hydroxyvitamin D and metabolic syndrome in a Japanese working population: The Furukawa Nutrition and Health Study.
- Author
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Akter S, Eguchi M, Kurotani K, Kochi T, Kashino I, Ito R, Kuwahara K, Tsuruoka H, Kabe I, and Mizoue T
- Subjects
- Adolescent, Adult, Aged, Blood Glucose metabolism, Blood Pressure, Body Mass Index, Calcium, Dietary administration & dosage, Cholesterol blood, Cross-Sectional Studies, Exercise, Female, Humans, Japan epidemiology, Logistic Models, Male, Metabolic Syndrome blood, Metabolic Syndrome prevention & control, Middle Aged, Multilevel Analysis, Multivariate Analysis, Nutritional Status, Prevalence, Risk Factors, Triglycerides blood, Vitamin D administration & dosage, Vitamin D blood, Vitamin D Deficiency blood, Waist Circumference, Young Adult, Asian People, Metabolic Syndrome epidemiology, Vitamin D analogs & derivatives, Vitamin D Deficiency epidemiology
- Abstract
Objective: Increasing evidence has suggested a protective role of vitamin D on metabolic syndrome (MetS). However, studies addressing this issue are limited in Asia and it remains unclear whether calcium could modify the association. We examined the association of serum 25-hydroxyvitamin D (25(OH)D) status with MetS, and the potential effect modification by calcium intake in a Japanese working population., Methods: Study subjects were 1790 workers, ages 18 to 69 y, who participated in a health survey at the time of periodic checkup. MetS was defined according to the joint interim statement. Serum 25(OH)D was measured by a protein binding assay. Multilevel logistic regression was used to estimate the odds ratio (OR) with adjustment for potential confounding variables., Results: An inverse trend was observed between 25(OH)D and MetS. Compared with those with a 25(OH)D of <20 ng/mL, multivariable adjusted OR (95% confidence interval) for MetS was 0.79 (0.55-1.15) and 0.52 (0.25-1.04) for those with a 25(OH)D of 20 to 29 ng/mL and ≥30 ng/mL, respectively (P for trend = 0.051). Similar association was observed in the analysis using quartile categories of 25(OH)D; the OR in the highest quartile of 25(OH)D compared with the lowest quartile was 0.61 (0.36-1.01) (P for trend = 0.046). This association was noted only in older subjects (≥44 y). The inverse association between serum 25(OH)D and MetS was more pronounced in subjects with high calcium intake. The inverse association between 25(OH)D and MetS appears to be linear according to restricted cubic spline regression. There was inverse, but statistically nonsignificant, associations between 25(OH)D and each component of MetS., Conclusion: Our results suggest that higher circulating vitamin D is associated with decreased likelihood of having MetS among Japanese adults., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2017
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41. Duration and degree of weight change and risk of incident diabetes: Japan Epidemiology Collaboration on Occupational Health Study.
- Author
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Hu H, Nagahama S, Nanri A, Tomita K, Akter S, Okazaki H, Kuwahara K, Imai T, Nishihara A, Kashino I, Sasaki N, Ogasawara T, Eguchi M, Kochi T, Miyamoto T, Nakagawa T, Honda T, Yamamoto S, Murakami T, Shimizu M, Uehara A, Yamamoto M, Hori A, Nishiura C, Kabe I, Mizoue T, Kunugita N, and Dohi S
- Subjects
- Body Mass Index, Diabetes Mellitus, Type 2 diagnosis, Female, Humans, Japan epidemiology, Longitudinal Studies, Male, Middle Aged, Risk Factors, Diabetes Mellitus, Type 2 epidemiology, Obesity, Weight Gain physiology
- Abstract
We prospectively examined diabetes risk in association with a summary measure of degree and duration of weight change. The study participants were 51,777 employees from multiple companies in Japan, who were aged 30-59years, free of diabetes at baseline, and followed up for 7years (2008-2015). Exposure was cumulative body mass index (BMI)-years, which was defined as the area of BMI units above or below baseline BMI during follow-up, and was treated as a time-dependent variable in the Cox proportional hazards regression models. During the 263,539 person-years of follow-up, 3465 participants developed diabetes. The adjusted hazard ratio (HR) of diabetes for a 1-unit increase in cumulative BMI-years was 1.11 (95% confidence interval (CI): 1.09, 1.12). The association was more pronounced among overweight (HR=1.11; 95% CI: 1.08, 1.14) and obese (HR=1.12; 95% CI: 1.08, 1.15) adults compared with normal- and under-weight (HR=1.07; 95% CI: 1.03, 1.11) adults (P for interaction of cumulative BMI-years X baseline BMI-group=0.002). The association of higher cumulative BMI-years with incident diabetes did not substantially differ by metabolic phenotype. The present results emphasize the importance of avoiding additional weight gain over an extended period of time for the prevention of type 2 diabetes, especially among overweight and obese adults, irrespective of metabolic health status., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2017
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42. Effects of prenatal exposure to perfluoroalkyl acids on prevalence ofallergic diseases among 4-year-old children.
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Goudarzi H, Miyashita C, Okada E, Kashino I, Kobayashi S, Chen CJ, Ito S, Araki A, Matsuura H, Ito YM, and Kishi R
- Subjects
- Adult, Animals, Child, Preschool, Eczema epidemiology, Female, Humans, Japan, Male, Odds Ratio, Pregnancy, Prevalence, Prospective Studies, Respiratory Sounds, Surveys and Questionnaires, Alkanesulfonic Acids adverse effects, Environmental Pollutants adverse effects, Fatty Acids adverse effects, Fluorocarbons adverse effects, Hypersensitivity epidemiology, Prenatal Exposure Delayed Effects
- Abstract
Perfluoroalkyl acids (PFAAs) are ubiquitous chemicals extremely resistant and widespread throughout the environment, frequently being detected in human blood samples. Animal studies have revealed that exposure to PFAAs results in immunotoxicity. However, the association between PFAAs, especially long-chain PFAAs, and allergies in humans is not well established. We examined whether prenatal exposure to PFAAs is associated with allergic diseases among 4-year-old children in a large-scale prospective birth cohort in Hokkaido, Japan. In total, 1558 mother-child pairs were included in this study and prenatal levels of eleven PFAAs were measured in maternal plasma samples obtained between 28 and 32weeks of pregnancy by using ultra-performance liquid chromatography-tandem mass spectrometry. Participant demographic and characteristic information were obtained from self-administered pre- and postnatal questionnaires and medical birth records. Infant allergies were assessed using the Japanese version of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three questionnaire, which was administered 4years post-delivery. Symptoms included eczema, wheezing and rhinoconjunctivitis with a prevalence of 19.0%, 18.7%, and 5.4%, respectively. Associations of PFAA quartiles with allergic outcomes were examined using logistic models. Adjusted odds ratios (ORs) in the 4th quartile vs. 1st quartile (Q4 vs. Q1) for total allergic diseases (including at least one allergic outcome) significantly decreased for perfluorododecanoic acid (PFDoDa) (Q4 vs. Q1 OR: 0.621; 95% confidence interval (CI): 0.454, 0.847) and perfluorotridecanoic acid (PFTrDA) (Q4 vs. Q1 OR: 0.712; 95% CI: 0.524, 0.966) in all children. We obtained similar results when examining the association between PFAAs and eczema. The adjusted OR (Q4 vs. Q1) for wheezing in relation to higher maternal PFHxS levels was 0.728 (95% CI: 0.497, 1.06) in all children. In conclusion, prenatal exposure to long-chain PFAAs, such as PFDoDa and PFTrDA may have an immunosuppressive effect on allergic diseases in 4-year-old children., (Copyright © 2016. Published by Elsevier Ltd.)
- Published
- 2016
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43. Coffee drinking and colorectal cancer risk: an evaluation based on a systematic review and meta-analysis among the Japanese population.
- Author
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Akter S, Kashino I, Mizoue T, Matsuo K, Ito H, Wakai K, Nagata C, Nakayama T, Sadakane A, Tanaka K, Tamakoshi A, Sugawara Y, Sawada N, Inoue M, Tsugane S, and Sasazuki S
- Subjects
- Case-Control Studies, Coffee toxicity, Cohort Studies, Colorectal Neoplasms etiology, Databases, Factual, Humans, Japan epidemiology, Odds Ratio, Risk, Coffee chemistry, Colorectal Neoplasms epidemiology
- Abstract
Objective: It remains unclear whether coffee drinking is associated with colorectal cancer risk. We performed a systematic review and meta-analysis of epidemiologic studies on this issue among the Japanese population., Methods: Original data were obtained from MEDLINE searches using PubMed or from searches of the 'Ichushi' database, complemented with manual searches. Meta-analysis was performed by using the random effects model to estimate the summary relative risk with 95% confidence interval according to the study design. The final judgment was made based on a consensus of the research group members with consideration for both epidemiological evidence and biological plausibility., Results: We identified five cohort studies and nine case-control studies. Of these, one cohort study reported a strong inverse association (in women only), whereas three case-control studies reported a strong inverse association with colon or rectal cancer. In meta-analysis, high consumption of coffee was not appreciably associated with colorectal cancer risk among cohort studies, whereas it was associated with significantly lower risk of colorectal or colon cancer among case-control studies. The summary relative risk/odds ratio (95% confidence interval) for the highest versus lowest categories of coffee consumption was 0.95 (0.77-1.17) and 0.78 (0.65-0.95) for cohort and case-control studies, respectively., Conclusions: The evidence is insufficient to support that coffee drinking increases or decreases the risk of colorectal cancer among the Japanese population., (© The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Published
- 2016
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44. Hba1c, Blood Pressure, and Lipid Control in People with Diabetes: Japan Epidemiology Collaboration on Occupational Health Study.
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Hu H, Hori A, Nishiura C, Sasaki N, Okazaki H, Nakagawa T, Honda T, Yamamoto S, Tomita K, Miyamoto T, Nagahama S, Uehara A, Yamamoto M, Murakami T, Shimizu C, Shimizu M, Eguchi M, Kochi T, Imai T, Okino A, Kuwahara K, Kashino I, Akter S, Kurotani K, Nanri A, Kabe I, Mizoue T, Kunugita N, and Dohi S
- Subjects
- Adult, Aged, Antihypertensive Agents pharmacology, Antihypertensive Agents therapeutic use, Diabetes Mellitus physiopathology, Female, Humans, Hypolipidemic Agents pharmacology, Hypolipidemic Agents therapeutic use, Japan epidemiology, Male, Middle Aged, Prevalence, Risk Factors, Young Adult, Blood Pressure drug effects, Cooperative Behavior, Diabetes Mellitus blood, Diabetes Mellitus epidemiology, Glycated Hemoglobin analysis, Lipids blood, Occupational Health
- Abstract
Aims: The control of blood glucose levels, blood pressure (BP), and low-density lipoprotein cholesterol (LDL-C) levels reduces the risk of diabetes complications; however, data are scarce on control status of these factors among workers with diabetes. The present study aimed to estimate the prevalence of participants with diabetes who meet glycated hemoglobin (HbA1c), BP, and LDL-C recommendations, and to investigate correlates of poor glycemic control in a large working population in Japan., Methods: The Japan Epidemiology Collaboration on Occupational Health (J-ECOH) Study is an ongoing cohort investigation, consisting mainly of employees in large manufacturing companies. We conducted a cross-sectional analysis of 3,070 employees with diabetes (2,854 men and 216 women) aged 20-69 years who attended periodic health examinations. BP was measured and recorded using different company protocols. Risk factor targets were defined using both American Diabetes Association (ADA) guidelines (HbA1c < 7.0%, BP < 140/90 mmHg, and LDL-C < 100 mg/dL) and Japan Diabetes Society (JDS) guidelines (HbA1c < 7.0%, BP < 130/80 mmHg, and LDL-C < 120 mg/dL). Logistic regression models were used to explore correlates of poor glycemic control (defined as HbA1c ≥ 8.0%)., Results: The percentages of participants who met ADA (and JDS) targets were 44.9% (44.9%) for HbA1c, 76.6% (36.3%) for BP, 27.1% (56.2%) for LDL-C, and 11.2% (10.8%) for simultaneous control of all three risk factors. Younger age, obesity, smoking, and uncontrolled dyslipidemia were associated with poor glycemic control. The adjusted odds ratio of poor glycemic control was 0.58 (95% confidence interval, 0.46-0.73) for participants with treated but uncontrolled hypertension, and 0.47 (0.33-0.66) for participants with treated and controlled hypertension, as compared with participants without hypertension. There was no significant difference in HbA1c levels between participants with treated but uncontrolled hypertension and those with treated and controlled hypertension., Conclusion: Data from a large working population, predominantly composed of men, suggest that achievement of HbA1c, BP, and LDL-C targets was less than optimal, especially in younger participants. Uncontrolled dyslipidemia was associated with poor glycemic control. Participants not receiving antihypertensive treatment had higher HbA1c levels.
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- 2016
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45. Dietary fiber intake and depressive symptoms in Japanese employees: The Furukawa Nutrition and Health Study.
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Miki T, Eguchi M, Kurotani K, Kochi T, Kuwahara K, Ito R, Kimura Y, Tsuruoka H, Akter S, Kashino I, Kabe I, Kawakami N, and Mizoue T
- Subjects
- Adult, Aged, Confounding Factors, Epidemiologic, Cross-Sectional Studies, Depression epidemiology, Depression ethnology, Dietary Fiber analysis, Female, Humans, Japan epidemiology, Logistic Models, Male, Middle Aged, Nutrition Surveys, Occupational Health ethnology, Prevalence, Psychiatric Status Rating Scales, Risk Factors, Solubility, Young Adult, Depression prevention & control, Diet ethnology, Dietary Fiber therapeutic use, Fruit chemistry, Vegetables chemistry
- Abstract
Objective: Dietary fiber may play a favorable role in mood through gut microbiota, but epidemiologic evidence linking mood to dietary fiber intake is scarce in free-living populations. We investigated cross-sectionally the associations of dietary intakes of total, soluble, insoluble, and sources of fiber with depressive symptoms among Japanese workers., Methods: Participants were 1977 employees ages 19-69 y. Dietary intake was assessed via a validated, brief self-administered diet history questionnaire. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale. Logistic regression was used to estimate odds ratios of depressive symptoms adjusted for a range of dietary and non-dietary potential confounders., Results: Dietary fiber intake from vegetables and fruits was significantly inversely associated with depressive symptoms. The multivariable-adjusted odds ratios (95% confidence intervals) for the lowest through the highest tertile of vegetable and fruit fiber were 1.00 (reference), 0.80 (0.60-1.05), and 0.65 (0.45-0.95), respectively (P for trend = 0.03). Dietary intake of total, soluble, insoluble, and cereal fiber was not associated with depressive symptoms., Conclusions: Higher dietary fiber intake from vegetables and fruits may be associated with lower likelihood of having depressive symptoms., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
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46. High Dietary Acid Load Score Is Associated with Increased Risk of Type 2 Diabetes in Japanese Men: The Japan Public Health Center-based Prospective Study.
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Akter S, Kurotani K, Kashino I, Goto A, Mizoue T, Noda M, Sawada N, and Tsugane S
- Subjects
- Adult, Asian People, Diabetes Mellitus, Type 2 metabolism, Diet Surveys, Female, Humans, Japan, Kidney metabolism, Male, Middle Aged, Prospective Studies, Public Health, Risk Factors, Sex Factors, Acidosis complications, Acids metabolism, Diabetes Mellitus, Type 2 etiology, Diet adverse effects, Feeding Behavior
- Abstract
Background: Diet-induced metabolic acidosis has been linked to cardiometabolic abnormalities in Westerners, but the evidence on this issue is scarce in Asians., Objective: The present study prospectively examined the association between dietary acid load and type 2 diabetes (T2D) in Japanese adults., Methods: Study participants were 27,809 men and 36,851 women, aged 45-75 y, who completed a dietary questionnaire of the second survey of the Japan Public Health Center-based Prospective Study and had no previous history of T2D. Dietary intake was assessed by using a validated 147-item food-frequency questionnaire. Potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores were derived from the nutrient intake. A multilevel logistic regression model was used to estimate ORs and 95% CIs of self-reported, physician-diagnosed T2D over 5 y, with adjustment for potential confounding variables., Results: A total of 1191 cases of newly diagnosed T2D were reported. PRAL score was positively associated with T2D in men; the multivariable-adjusted ORs (95% CIs) for the lowest through the highest quartiles of PRAL were 1.00, 1.09 (0.87, 1.36), 1.10 (0.88, 1.37), and 1.25 (1.01, 1.55) (P-trend = 0.047). Further adjustment for dietary intake strengthened the association. NEAP score was not associated with the risk of T2D (P-trend = 0.20). In stratified analyses, the positive association between PRAL and T2D was confined to younger men (age <50 y; P-trend = 0.046). There was no association between dietary acid load score and T2D in women., Conclusion: A high dietary acid load score is associated with an increased risk of T2D in Japanese men., (© 2016 American Society for Nutrition.)
- Published
- 2016
- Full Text
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47. Quality of diet and mortality among Japanese men and women: Japan Public Health Center based prospective study.
- Author
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Kurotani K, Akter S, Kashino I, Goto A, Mizoue T, Noda M, Sasazuki S, Sawada N, and Tsugane S
- Subjects
- Aged, Diet Surveys, Female, Follow-Up Studies, Humans, Japan epidemiology, Male, Middle Aged, Multivariate Analysis, Nutrition Policy, Proportional Hazards Models, Prospective Studies, Diet statistics & numerical data, Health Behavior, Mortality
- Abstract
Objective: To examine the association between adherence to the Japanese Food Guide Spinning Top and total and cause specific mortality., Design: Large scale population based prospective cohort study in Japan with follow-up for a median of 15 years., Setting: 11 public health centre areas across Japan., Participants: 36,624 men and 42,970 women aged 45-75 who had no history of cancer, stroke, ischaemic heart disease, or chronic liver disease., Main Outcome Measures: Deaths and causes of death identified with the residential registry and death certificates., Results: Higher scores on the food guide (better adherence) were associated with lower total mortality; the multivariable adjusted hazard ratios (95% confidence interval) of total mortality for the lowest through highest scores were 1.00, 0.92 (0.87 to 0.97), 0.88 (0.83 to 0.93), and 0.85 (0.79 to 0.91) (P<0.001 for trend) and the multivariable adjusted hazard ratio associated with a 10 point increase in food guide scores was 0.93 (0.91 to 0.95; P<0.001 for trend). This score was inversely associated with mortality from cardiovascular disease (hazard ratio associated with a 10 point increase 0.93, 0.89 to 0.98; P=0.005 for trend) and particularly from cerebrovascular disease (0.89, 0.82 to 0.95; P=0.002 for trend). There was some evidence, though not significant, of an inverse association for cancer mortality (0.96, 0.93 to 1.00; P=0.053 for trend)., Conclusion: Closer adherence to Japanese dietary guidelines was associated with a lower risk of total mortality and mortality from cardiovascular disease, particularly from cerebrovascular disease, in Japanese adults., (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.)
- Published
- 2016
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48. Optimal waist circumference cut-off points and ability of different metabolic syndrome criteria for predicting diabetes in Japanese men and women: Japan Epidemiology Collaboration on Occupational Health Study.
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Hu H, Kurotani K, Sasaki N, Murakami T, Shimizu C, Shimizu M, Nakagawa T, Honda T, Yamamoto S, Okazaki H, Nagahama S, Uehara A, Yamamoto M, Tomita K, Imai T, Nishihara A, Kochi T, Eguchi M, Miyamoto T, Hori A, Kuwahara K, Akter S, Kashino I, Kabe I, Liu W, Mizoue T, Kunugita N, and Dohi S
- Subjects
- Adult, Aged, Diabetes Mellitus epidemiology, Female, Humans, Japan epidemiology, Male, Metabolic Syndrome epidemiology, Middle Aged, Predictive Value of Tests, Reference Standards, Young Adult, Diabetes Mellitus diagnosis, Metabolic Syndrome diagnosis, Occupational Health, Waist Circumference
- Abstract
Background: We sought to establish the optimal waist circumference (WC) cut-off point for predicting diabetes mellitus (DM) and to compare the predictive ability of the metabolic syndrome (MetS) criteria of the Joint Interim Statement (JIS) and the Japanese Committee of the Criteria for MetS (JCCMS) for DM in Japanese., Methods: Participants of the Japan Epidemiology Collaboration on Occupational Health Study, who were aged 20-69 years and free of DM at baseline (n = 54,980), were followed-up for a maximum of 6 years. Time-dependent receiver operating characteristic analysis was used to determine the optimal cut-off points of WC for predicting DM. Time-dependent sensitivity, specificity, and positive and negative predictive values for the prediction of DM were compared between the JIS and JCCMS MetS criteria., Results: During 234,926 person-years of follow-up, 3180 individuals developed DM. Receiver operating characteristic analysis suggested that the most suitable cut-off point of WC for predicting incident DM was 85 cm for men and 80 cm for women. MetS was associated with 3-4 times increased hazard for developing DM in men and 7-9 times in women. Of the MetS criteria tested, the JIS criteria using our proposed WC cut-off points (85 cm for men and 80 cm for women) had the highest sensitivity (54.5 % for men and 43.5 % for women) for predicting DM. The sensitivity and specificity of the JCCMS MetS criteria were ~37.7 and 98.9 %, respectively., Conclusion: Data from the present large cohort of workers suggest that WC cut-offs of 85 cm for men and 80 cm for women may be appropriate for predicting DM for Japanese. The JIS criteria can detect more people who later develop DM than does the JCCMS criteria.
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- 2016
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49. Vegetable consumption and colorectal cancer risk: an evaluation based on a systematic review and meta-analysis among the Japanese population.
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Kashino I, Mizoue T, Tanaka K, Tsuji I, Tamakoshi A, Matsuo K, Wakai K, Nagata C, Inoue M, Tsugane S, and Sasazuki S
- Subjects
- Aged, Asian People, Case-Control Studies, Cohort Studies, Humans, Incidence, Japan epidemiology, Male, Risk, Colorectal Neoplasms epidemiology, Diet, Feeding Behavior, Vegetables
- Abstract
Objective: The association between vegetable consumption and colorectal cancer risk remains unclear and may differ by region. We performed a systematic review and meta-analysis of epidemiologic studies on this issue among the Japanese population., Methods: A systematic review and meta-analysis was performed by searching MEDLINE through PubMed and the Ichushi database for cohort and case-control studies that were published by the end of December 2014. Associations were evaluated based on their magnitude and the strength of the evidence. Meta-analysis was performed by using the random effects model to estimate the summary relative risk with 95% confidence interval according to the study design. The final judgment was made based on a consensus of the research group members with consideration for both epidemiological evidence and biological plausibility., Results: We identified six cohort studies and 11 case-control studies on vegetable intake and colorectal cancer among the Japanese population. Of the cohort studies, one study showed a weak inverse association with colon cancer and another study showed a weak positive association with rectal cancer in men, but other studies found no associations between vegetable consumption and colon and rectal cancers. With regard to case-control studies, one study found a strong inverse association with colon cancer, and three studies showed a weak-to-strong inverse association with rectal cancer. In meta-analysis, the summary relative risk (95% confidence interval) for the highest vs. the lowest categories of vegetable consumption were 1.00 (0.92-1.10) and 0.75 (0.59-0.96) for cohort and case-control studies, respectively., Conclusions: There was insufficient evidence to support an association between intake of vegetables and the risk of colorectal cancer among the Japanese population., (© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Published
- 2015
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50. Association of dietary patterns with serum adipokines among Japanese: a cross-sectional study.
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Kashino I, Nanri A, Kurotani K, Akter S, Yasuda K, Sato M, Hayabuchi H, and Mizoue T
- Subjects
- Adult, Body Mass Index, Cross-Sectional Studies, Diet, Diet, Western, Female, Humans, Male, Meat, Middle Aged, Nicotinamide Phosphoribosyltransferase blood, Nutrition Assessment, Plasminogen Activator Inhibitor 1 blood, Principal Component Analysis, Reproducibility of Results, Surveys and Questionnaires, Young Adult, Adipokines blood, Asian People, Feeding Behavior
- Abstract
Background: Diet may influence disease risk by modulating adipokines. Although some foods and nutrients have been linked to circulating adipokine levels, little is known about the role of dietary patterns on adipokines. We investigated the association between major dietary patterns and circulating levels of adiponectin, leptin, resistin, visfatin, and plasminogen activator inhibitor-1 (PAI-1) in a working population., Methods: The subjects were 509 employees (296 men and 213 women), aged 20 to 65 years, of two municipal offices. Serum adipokines were measured using a Luminex suspension bead-based multiplexed array. Dietary patterns were derived by using principal component analysis of the consumption of 52 food and beverage items, which were ascertained by a validated diet history questionnaire. Multiple regression analysis was performed to assess the association between dietary pattern scores and adipokine concentrations, with adjustment for potential confounders., Results: Three major dietary patterns were extracted: a Japanese, a Westernized breakfast, and a meat food patterns. Of these, we found significant, inverse associations of the Westernized breakfast pattern, which was characterized by higher intake of confectioneries, bread, and milk and yogurt but lower intake of alcoholic beverages and rice, with serum leptin and PAI-1 concentrations in a fully adjusted model (P for trend = 0.04 for both leptin and PAI-1). The other adipokines were not significantly associated with any dietary pattern., Conclusion: The Westernized breakfast dietary pattern may be associated with lower circulating levels of leptin and PAI-1.
- Published
- 2015
- Full Text
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