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29 results on '"Kasirye, Philip"'

3. Processes and experiences of satellite haemophilia clinic set-ups in Uganda – a short report

Author

Kasirye Philip, Kisakye Agnes, Nakalyango Annette, and Barnabas Atwiine

Subjects
haemophilia, haemophilia treatment centre, patient organisations, uganda, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Haemophilia knowledge and care are largely missing in much of sub-Saharan Africa and there is a need for concerted efforts to ensure access to care services by affected persons. Haemophilia Foundation Uganda, supported by the global haemophilia community and working with the Uganda Ministry of Health, has set up eight satellite haemophilia treatment centres (HTCs) as part of a wider initiative to raise awareness and improve haemophilia care. Setting up the HTCs has involved a six-step process involving stakeholders in government, healthcare and the community, and ranging from securing initial support to an ongoing follow-up programme of mentorship and training. Over 1,700 healthcare professionals have been trained and 186 patients have been registered at these peripheral facilities over the past five years. This is helping to improve access to care, but there are still shortcomings around diagnostic capacity, available healthcare personnel, and facilities to procure recombinant factor products. We will continue and further our advocacy for budgetary inclusion of haemophilia at political and facility levels. We also propose a continued strengthening of the haemophilia care teams through mentorship, networking, and mobilisation for diagnostic support at large public hospitals.

Published
2022
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7. Neurofilament light chain: A potential biomarker for cerebrovascular disease in children with sickle cell anaemia

Author

Green, Nancy S., primary, Rosano, Caterina, additional, Bangirana, Paul, additional, Opoka, Robert, additional, Munube, Deogratias, additional, Kasirye, Philip, additional, Kawooya, Michael, additional, Lubowa, Samson K., additional, Mupere, Ezekiel, additional, Conroy, Andrea, additional, Minja, Frank J., additional, Boehme, Amelia K., additional, Kang, Min Suk, additional, Honig, Lawrence S., additional, and Idro, Richard, additional

Published
2023
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8. Burden of neurological and neurocognitive impairment in pediatric sickle cell anemia in Uganda (BRAIN SAFE): a cross-sectional study

Author

Green, Nancy S., Munube, Deogratias, Bangirana, Paul, Buluma, Linda Rosset, Kebirungi, Bridget, Opoka, Robert, Mupere, Ezekiel, Kasirye, Philip, Kiguli, Sarah, Birabwa, Annet, Kawooya, Michael S., Lubowa, Samson K., Sekibira, Rogers, Kayongo, Edwards, Hume, Heather, Elkind, Mitchell, Peng, Weixin, Li, Gen, Rosano, Caterina, LaRussa, Philip, Minja, Frank J., Boehme, Amelia, and Idro, Richard

Published
2019
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11. Once vs twice-daily abacavir and lamivudine in African children

Author

Musiime, Victor, Kasirye, Philip, Naidoo-James, Bethany, Nahirya-Ntege, Patricia, Mhute, Tawanda, Cook, Adrian, Mugarura, Lincoln, Munjoma, Marshall, Thoofer, Navdeep K., Ndashimye, Emmanuel, Nankya, Immaculate, Spyer, Moira J., Thomason, Margaret J., Snowden, Wendy, Gibb, Diana M., and Walker, Ann Sarah

Published
2016
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15. Multidisciplinary Subspecialty Capacity Building for Global Pediatric Oncology

Author

Namazzi, Ruth, primary, Wasswa, Peter, additional, Mupere, Ezekiel, additional, Wilson-Lewis, Kristina, additional, Allen, Carl, additional, Kasirye, Philip, additional, Munube, Deogratias, additional, Nuchtern, Jed, additional, Airewele, Gladstone, additional, Chintagumpala, Murali, additional, Torrey, Susan, additional, Sekabira, John, additional, Poplack, David, additional, and Lubega, Joseph, additional

Published
2020
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16. Association between Inflammatory Markers and Abnormal Neurological, Neurocognitive and Magnetic Resonance Imaging (MRI) Findings in Children with Sickle Cell Anemia in Uganda

Author

Boehme, Amelia, primary, Ashrafi, Adiba, additional, Idro, Richard, additional, Bangirana, Paul, additional, Munube, Deogratias, additional, Opoka, Robert, additional, Kasirye, Philip, additional, Lee, Margaret T., additional, Green, Nancy S., additional, and Hornig, Mady, additional

Published
2019
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17. Radiological Findings By Magnetic Resonance (MRI) and Arteriography (MRA) Brain Imaging Compared to Neurological, Stroke and TCD Assessment in Children with Sickle Cell Anemia in Uganda

Author

Boehme, Amelia, primary, Idro, Richard, additional, Munube, Deogratias, additional, Bangirana, Paul, additional, Mupere, Ezekiel, additional, Opoka, Robert, additional, Kawooya, Michael, additional, Lubowa, Samson K., additional, Lignelli, Angela, additional, Kasirye, Philip, additional, LaRussa, Philip, additional, Green, Nancy S., additional, and Minja, Frank, additional

Published
2019
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19. Brain Magnetic Resonance Imaging and Angiography Findings in Ugandan Children with Sickle Cell Anemia; A Cross Sectional Study

Author

Idro, Richard, primary, Green, Nancy S., additional, Munube, Deogratias, additional, Buluma, Linda Rosset, additional, Kebirungi, Bridget, additional, Opoka, Robert, additional, Bangirana, Paul, additional, Mupere, Ezekiel, additional, Kayongo, Edward, additional, Sekibira, Rogers, additional, Kasirye, Philip, additional, Lubowa, Samson K., additional, Kawooya, Michael, additional, LaRussa, Phillip, additional, and Minja, Frank, additional

Published
2018
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23. Once- versus twice-daily abacavir and lamivudine in African children: the randomised controlled ARROW Trial

Author

Musiime, Victor, Kasirye, Philip, Naidoo-James, Bethany, Nahirya-Ntege, Patricia, Mhute, Tawanda, Cook, Adrian, Mugarura, Lincoln, Munjoma, Marshall, Thoofer, Navdeep K, Ndashimye, Emmanuel, Nankya, Immaculate, Spyer, Moira J., Thomason, Margaret J., Snowden, Wendy, Gibb, Diana M., and Walker, A. Sarah

Subjects
Male, Adolescent, Drug-Related Side Effects and Adverse Reactions, Sustained Virologic Response, Anti-HIV Agents, Infant, HIV Infections, Article, Dideoxynucleosides, Medication Adherence, Immune Reconstitution, Treatment Outcome, Lamivudine, Child, Preschool, Africa, Drug Resistance, Viral, Humans, Female, Child
Abstract

Antiretroviral therapy (ART) adherence is critical for successful HIV treatment outcomes. Once-daily dosing could improve adherence. Plasma concentrations of once-daily vs twice-daily abacavir + lamivudine are bioequivalent in children, but no randomized trial has compared virological outcomes.Children taking abacavir + lamivudine-containing first-line regimens twice daily for more than 36 weeks in the ARROW trial (NCT02028676, ISRCTN24791884) were randomized to continue twice-daily vs move to once-daily abacavir + lamivudine (open-label). Co-primary outcomes were viral load suppression at week 48 (12% noninferiority margin, measured retrospectively) and lamivudine or abacavir-related grade 3/4 adverse events.Six hundred and sixty-nine children (median 5 years, range 1-16) were randomized to twice daily (n = 333) vs once daily (n = 336) after median 1.8 years on twice-daily abacavir + lamivudine-containing first-line ART. Children were followed for median 114 weeks. At week 48, 242/331 (73%) twice daily vs 236/330 (72%) once daily had viral load less than 80 copies/ml [difference -1.6% (95% confidence interval -8.4,+5.2%) P = 0.65]; 79% twice daily vs 78% once daily had viral load less than 400 copies/ml (P = 0.76) (week 96 results similar). One grade 3/4 adverse event was judged uncertainly related to abacavir + lamivudine (hepatitis; once daily). At week 48, 9% twice daily vs 10% once daily reported missing one or more ART pills in the last 4 weeks (P = 0.74) and 8 vs 8% at week 96 (P = 0.90). Carers strongly preferred once-daily dosing. There was no difference between randomized groups in postbaseline drug-resistance mutations or drug-susceptibility; WHO 3/4 events; ART-modifying, grade 3/4 or serious adverse events; CD4% or weight-for-age/height-for-age (all P 0.15).Once-daily abacavir + lamivudine was noninferior to twice daily in viral load suppression, with similar resistance, adherence, clinical, immunological and safety outcomes. Abacavir + lamivudine provides the first once-daily nucleoside backbone across childhood that can be used to simplify ART.

Published
2016

24. Paediatric immunisation and chemoprophylaxis in a Ugandan sickle cell disease clinic.

Author

Chen, Chung‐Jen, Bakeera‐Kitaka, Sabrina, Mupere, Ezekiel, Kasirye, Philip, Munube, Deogratias, Idro, Richard, Hume, Heather, Pfeffer, Betsy, LaRussa, Philip, Green, Nancy S, Chen, Chung-Jen, and Bakeera-Kitaka, Sabrina

Subjects
SICKLE cell anemia, CHEMOPREVENTION, PNEUMOCOCCAL vaccines, CHILD care
Abstract

Aim: We aimed to assess the receipt of recommended care for young children with sickle cell disease (SCD) in a central SCD clinic in Kampala Uganda, focusing on standard vaccination and antibacterial and antimalarial prophylaxis.Methods: A cross-sectional assessment of immunisation status and timeliness and prescribed antibacterial and antimalarial prophylaxis was performed in a sample with SCD aged ≤71 months in Mulago Hospital SCD Clinic. Government-issued immunisation cards and clinic-issued visit records for prescribed prophylaxis were reviewed.Results: Vaccinations were documented by immunisation cards in 104 patients, mean age 31.7 months (range 3-70 months). Only 48 (46.2%) received all doses of each of the four recommended vaccine types, including pneumococcal 10-valent conjugate vaccine (pneumococcal conjugate vaccine (PCV)-10), which became available in 2014. Vaccination completion was associated with younger age and, for polio, maternal employment. PCV-10 series was completed in 54.8% of the sample and in 18.2% of those aged 48-71 months. Of children completing all vaccination types, an average 68.8% were immunised on time, defined as <60 days beyond the recommended age. Only 17 (13.5%) children were both fully and timely vaccinated. In an overlapping sample of 147 children, with a mean age of 38.4 months (4-70 months), 81.6% had ≥1 documented prescription for penicillin and/or antimalarial prophylaxis.Conclusions: Standardised vaccination and antibacterial and antimalarial protective measures for young children at this central SCD clinic were incomplete, especially PCV-10 for age ≥24 months, and often late. Child age, but not general maternal demographics, were associated with vaccination and chemoprophylaxis. Clinic-based oversight may improve timely uptake of these preventative measures. [ABSTRACT FROM AUTHOR]

Published
2019
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25. Malaria in Children with Sickle Cell Anaemia in Areas with Low, Moderate and High Transmission in Uganda

Author

Namazzi, Ruth, Idro, Richard, Kalibala, Dennis, Ssenkusu, John, Akun, Pamela, Mboizi, Vincent, Gondwe, Thandile Nkosi, Munube, Deogratias, Kasirye, Philip, Nabaggala, Catherine, John, Chandy C., Green, Nancy S., Robberstat, Bjarne, Hensbroek, Boele van, Kuile, Feiko ter, Phiri, Kamija S., and Opoka, Robert

Abstract

Background. Few large prospective studies have evaluated burden and outcomes of malaria in children with sickle cell anaemia (SCA) in malaria endemic countries. We evaluated the incidence, complications and outcome of malaria in three cohorts of Ugandan children with SCA in three areas with differing malaria transmission.

Published
2023
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27. MOESM1 of Burden of neurological and neurocognitive impairment in pediatric sickle cell anemia in Uganda (BRAIN SAFE): a cross-sectional study

Author

Green, Nancy, Deogratias Munube, Bangirana, Paul, Buluma, Linda, Kebirungi, Bridget, Opoka, Robert, Mupere, Ezekiel, Kasirye, Philip, Kiguli, Sarah, Birabwa, Annet, Kawooya, Michael, Lubowa, Samson, Rogers Sekibira, Edwards Kayongo, Hume, Heather, Elkind, Mitchell, Weixin Peng, Rosano, Caterina, LaRussa, Philip, Minja, Frank, Boehme, Amelia, and Idro, Richard

Subjects
3. Good health
Abstract

Additional file 1. Transcranial doppler ultrasound: training and tester reliability.

28. MOESM1 of Burden of neurological and neurocognitive impairment in pediatric sickle cell anemia in Uganda (BRAIN SAFE): a cross-sectional study

Author

Green, Nancy, Deogratias Munube, Bangirana, Paul, Buluma, Linda, Kebirungi, Bridget, Opoka, Robert, Mupere, Ezekiel, Kasirye, Philip, Kiguli, Sarah, Birabwa, Annet, Kawooya, Michael, Lubowa, Samson, Rogers Sekibira, Edwards Kayongo, Hume, Heather, Elkind, Mitchell, Weixin Peng, Rosano, Caterina, LaRussa, Philip, Minja, Frank, Boehme, Amelia, and Idro, Richard

Subjects
3. Good health
Abstract

Additional file 1. Transcranial doppler ultrasound: training and tester reliability.

29. Stroke in Pediatric Sickle Cell Disease in Sub-Saharan Africa: Systematic Review and Estimated Prevalence

Author

Marks, Lianna J., Munube, Deogratias, Kasirye, Philip, Mupere, Ezekiel, Jin, Zhezhen, LaRussa, Phillip, Idro, Richard, and Green, Nancy S.

Abstract

Background: Most people with sickle cell disease (SCD) live in Sub-Saharan Africa (SSA); many do not survive to adulthood (Grosse et al. Am J Prev Med 2011). Stroke is a common complication of SCD in the region (Ohene-Frempong et al.Blood 1998), yet the region's burden of pediatric SCD stroke is unknown. This systematic review aims to describe what is known, and to estimate the number of children affected by SCD stroke in SSA.

Published
2017
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