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1. Gunshot Injuries to the Head

Author

Kasper, Ekkehard M., Algethami, Hanan, Takroni, Radwan, Kasper, Burkhard S., Degiannis, Elias, editor, Doll, Dietrich, editor, and Velmahos, George C., editor

Published
2023
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4. ILAE neuroimaging task force highlight: Subcortical laminar heterotopia

Author

Kasper, Burkhard S., primary, Archer, John, additional, Bernhardt, Boris C., additional, Caciagli, Lorenzo, additional, Cendes, Fernando, additional, Chinvarun, Yotin, additional, Concha, Luis, additional, Federico, Paolo, additional, Gaillard, William, additional, Kobayashi, Eliane, additional, Ogbole, Godwin, additional, Vaudano, Anna Elisabetta, additional, Wang, Irene, additional, Wang, Shuang, additional, Winston, Gavin P., additional, and Rampp, Stefan, additional

Published
2024
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5. The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing

Author

Amunts, Katrin, primary, Axer, Markus, additional, Banerjee, Swati, additional, Bitsch, Lise, additional, Bjaalie, Jan G., additional, Brauner, Philipp, additional, Brovelli, Andrea, additional, Calarco, Navona, additional, Carrere, Marcel, additional, Caspers, Svenja, additional, Charvet, Christine J., additional, Cichon, Sven, additional, Cools, Roshan, additional, Costantini, Irene, additional, D'Angelo, Egidio Ugo, additional, De Bonis, Giulia, additional, Deco, Gustavo, additional, DeFelipe, Javier, additional, Destexhe, Alain, additional, Dickscheid, Timo, additional, Diesmann, Markus, additional, Düzel, Emrah, additional, Eickhoff, Simon B., additional, Einevoll, Gaute, additional, Eke, Damian, additional, Engel, Andreas K., additional, Evans, Alan C., additional, Evers, Kathinka, additional, Fedorchenko, Nataliia, additional, Forkel, Stephanie J., additional, Fousek, Jan, additional, Friederici, Angela D., additional, Friston, Karl, additional, Furber, Stephen, additional, Geris, Liesbet, additional, Goebel, Rainer, additional, Güntürkün, Onur, additional, Hamid, Aini Ismafairus Abd, additional, Herold, Christina, additional, Hilgetag, Claus C., additional, Hölter, Sabine M., additional, Ioannidis, Yannis, additional, Jirsa, Viktor, additional, Kashyap, Sriranga, additional, Kasper, Burkhard S., additional, d’Exaerde, Alban de Kerchove, additional, Kooijmans, Roxana, additional, Koren, István, additional, Kotaleski, Jeanette Hellgren, additional, Kiar, Gregory, additional, Klijn, Wouter, additional, Klüver, Lars, additional, Knoll, Alois C., additional, Krsnik, Zeljka, additional, Kämpfer, Julia, additional, Larkum, Matthew E, additional, Linne, Marja-Leena, additional, Lippert, Thomas, additional, Abdullah, Jafri Malin, additional, Maio, Paola Di, additional, Magielse, Neville, additional, Maquet, Pierre, additional, Mascaro, Anna Letizia Allegra, additional, Marinazzo, Daniele, additional, Mejias, Jorge, additional, Meyer-Lindenberg, Andreas, additional, Migliore, Michele, additional, Michael, Judith, additional, Morel, Yannick, additional, Morin, Fabrice O., additional, Muckli, Lars, additional, Nagels, Guy, additional, Oden, Lena, additional, Palomero-Gallagher, Nicola, additional, Panagiotaropoulos, Fanis, additional, Paolucci, Pier Stanislao, additional, Pennartz, Cyriel, additional, Peeters, Liesbet M., additional, Petkoski, Spase, additional, Petkov, Nicolai, additional, Petro, Lucy S., additional, Petrovici, Mihai A., additional, Pezzulo, Giovanni, additional, Roelfsema, Pieter, additional, Ris, Laurence, additional, Ritter, Petra, additional, Rockland, Kathleen, additional, Rotter, Stefan, additional, Rowald, Andreas, additional, Ruland, Sabine, additional, Ryvlin, Philippe, additional, Salles, Arleen, additional, Sanchez-Vives, Maria V., additional, Schemmel, Johannes, additional, Senn, Walter, additional, de Sousa, Alexandra A., additional, Ströckens, Felix, additional, Thirion, Bertrand, additional, Uludağ, Kâmil, additional, Vanni, Simo, additional, van Albada, Sacha Jennifer, additional, Vanduffel, Wim, additional, Vezoli, Julien, additional, Vincenz-Donnelly, Lisa, additional, Walter, Florian, additional, and Zaborszky, Laszlo, additional

Published
2024
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11. Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study

Author

Aichholzer, Martin, Amorim, Isabel, Aparicio, Javier, Aronica, Eleonora, Arzimanoglou, Alexis, Barba, Carmen, Beck, Jürgen, Becker, Albert, Beckervordersandforth, Jan C, Bien, Christian G, Blümcke, Ingmar, Bodi, Istvan, Braun, Kees PJ, Catenoix, Helene, Chassoux, Francine, Chipaux, Mathilde, Cloppenborg, Thomas, Coras, Roland, Cross, J Helen, De Palma, Luca, De Tisi, Jane, Deleo, Francesco, Devaux, Bertrand, Di Gennaro, Giancarlo, Dorfmüller, Georg, Duncan, John S, Elger, Christian, Ernst, Katharina, Esposito, Vincenzo, Feucht, Martha, Gadze, Zeljka Petelin, Garbelli, Rita, Geleijns, Karin, Gil-Nagel, Antonio, Grote, Alexander, Grunwald, Thomas, Guerrini, Renzo, Hamer, Hajo, Honavar, Mrinalini, Jacques, Thomas S, Jakovcevic, Antonia, Jutila, Leena, Kalina, Adam, Kälviäinen, Reetta, Klein, Karl Martin, Koenig, Kristina, Krsek, Pavel, Kudernatsch, Manfred, Kudr, Martin, Lamberink, Herm J, Malmgren, Kristina, Marusic, Petr, Melikyan, Armen, Menzler, Katja, Noachtar, Soheyl, Otte, Willem M, Özkara, Çiğdem, Pieper, Tom, Pimentel, Jose, Raicevic, Savo, Rheims, Sylvain, Ribeiro, Joana, Rosenow, Felix, Rössler, Karl, Rydenhag, Bertil, Sales, Francisco, San Antonio-Arce, Victoria, Schaller, Karl Lothar, Schijns, Olaf, Scholl, Theresa, Schramm, Johannes, Schulze-Bonhage, Andreas, Sciot, Raf, Seeck, Margitta, Shishkina, Lyudmila, Sokic, Dragoslav, Specchio, Nicola, Theys, Tom, Thom, Maria, Delgado, Rafael Toledano, Toulouse, Joseph, Uzan, Mustafa, van Loon, Johannes, Van Paesschen, Wim, von Oertzen, Tim J, Jansen, Floor, Leijten, Frans, van Rijen, Peter, Spliet, Wim GM, Mühlebner, Angelika, Kasper, Burkhard S, Fauser, Susanne, Polster, Tilman, Kalbhenn, Thilo, Delev, Daniel, McEvoy, Andrew, Miserocchi, Anna, Landré, Elisabeth, Turak, Bares, Varlet, Pascale, Ferrand-Sorbets, Sarah, Fohlen, Martine, Bulteau, Christine, Edelvik, Anna, Shah, Mukesch J, Scheiwe, Christian, Delicado, Eva Gutierrez, Tisdall, Martin, Eltze, Christin, Akkol, Serdar, Deniz, Kaancan, Oz, Buge, Holthausen, Hans, Hartlieb, Till, Staudt, Martin, Casciato, Sara, Quarato, Pier P, Giangaspero, Felice, Streichenberger, Nathalie, Guenot, Marc, Isnard, Jean, Valentijn, Antonio, Chang, Amanda, Mullatti, Nandini, Zamecnik, Josef, Zarubova, Jana, Tomasek, Martin, Immonen, Arto, Saarela, Anni, Rauramaa, Tuomas, Lobrinus, Johannes A, Egervari, Kristof, Momjian, Shahan, Harti, Elisabeth, Lohr, Hannah, Kroell, Judith, Vermeulen, Lynn, Cleeren, Evy, Vlasov, Pavel, Kozlova, Antonia, Vorobyev, Alexey, Goeppel, Gudrun, Samueli, Sharon, Czech, Thomas, Hainfellner, Johannes, Puttinger, Gertraud, Schwarz, Gabriele, Stefanits, Harald, Weis, Serge, Spreafico, Roberto, Villani, Flavio, Rossini, Laura, Hermsen, Anke, Knake, Susanne, Nimsky, Christopher, Carl, Barbara, Belohlavkova, Anezka, Benova, Barbora, Bisschop, Jeroen, Colon, Albert, van Kranen-Mastenbroek, Vivianne, Rouhl, Rob PW, Hoogland, Govert, Rumiá, Jordi, Ramírez-Camacho, Alia, Candela-Cantó, Santiago, Ostrowsky-Coste, Karine, Panagiotakaki, Eleni, Montavont, Alexandra, Kosal, Pascale Keo, Gokce-Samar, Zeynep, Milleret, Clara, Buccoliero, Anna M, Giordano, Flavio, Sulentic, Vlatko, Mrak, Goran, Desnica, Andrej, CarfíPavia, Giusy, De Benedictis, Alessandro, Marras, Carlo E, Bascarevic, Vladimir, Vojvodic, Nikola, Ristic, Aleksandar, Rebelo, Olinda, Aledo-Serrano, Angel, Garcia-Morales, Irene, Anciones, Carla, and Braun, Kees P J

Published
2020
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12. ILAEneuroimaging task force highlight: Subcortical laminar heterotopia

Author

Kasper, Burkhard S., Archer, John, Bernhardt, Boris C., Caciagli, Lorenzo, Cendes, Fernando, Chinvarun, Yotin, Concha, Luis, Federico, Paolo, Gaillard, William, Kobayashi, Eliane, Ogbole, Godwin, Vaudano, Anna Elisabetta, Wang, Irene, Wang, Shuang, Winston, Gavin P., and Rampp, Stefan

Abstract

The ILAE Neuroimaging Task Force publishes educational case reports that highlight basic aspects of neuroimaging in epilepsy consistent with the ILAE's educational mission. Subcortical laminar heterotopia, also known as subcortical band heterotopia (SBH) or “double cortex,” is an intriguing and rare congenital malformation of cortical development. SBH lesions are part of a continuum best designated as agyria‐pachygyria‐band‐spectrum. The malformation is associated with epilepsy that is often refractory, as well as variable degrees of developmental delay. Moreover, in an increasing proportion of cases, a distinct molecular‐genetic background can be found. Diagnosing SBH can be a major challenge for many reasons, including more subtle lesions, and “non‐classic” or unusual MRI‐appearances. By presenting an illustrative case, we address the challenges and needs of diagnosing and treating SBH patients in epilepsy, especially the value of high‐resolution imaging and specialized MRI‐protocols.

Published
2024
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13. Gunshot Injuries to the Head

Author

Kasper, Ekkehard M., Laviv, Yosef, Stippler, Martina, Kasper, Burkhard S., Velmahos, George C., editor, Degiannis, Elias, editor, and Doll, Dietrich, editor

Published
2017
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17. Cécile & Oskar Vogt: Leben, Werk und ihr Beitrag zur Epileptologie

Author

Kasper, Burkhard S.

Abstract

Cécile und Oskar Vogt waren Gehirnforscher, die Struktur und Funktion des Zentralnervensystems über Jahrzehnte gemeinsam systematisch studierten. Im Berlin der Jahrhundertwende begannen sie noch vor 1900 ihre umfassenden zyto- und myeloarchitektonischen Studien an humanen Ganzhirnschnitten und mit Stimulationsexperimenten der Hirnrinde verschiedener Species, die sie bis zu ihrem Tod fortsetzen. Unter einfachen Bedingungen in einer Berliner Privatwohnung begannen sie ihre „Neurologische Centralstation“, die 1902 zum Neurologischen Laboratorium der Universität und 1914 zum Kaiser-Wilhelm-Institut (KWI) für Hirnforschung umgewidmet wurde. 1931 erst bezogen sie das neu gebaute KWI in Berlin-Buch, dem ersten Hirnforschungsinstitut seiner Art weltweit. Dies war wesentlich ermöglicht durch Zuwendungen von Krupp und der Rockefeller-Stiftung. In der NS-Zeit aus Berlin und dem Institut gedrängt, führten sie ihre Arbeit an einem neuen Institut im Schwarzwald fort, dessen Nachfolge heute das Cécile & Oskar Vogt Institut für Hirnforschung in Düsseldorf darstellt. In der Gruppe um die Vogts erarbeitete Korbinian Brodmann die berühmte Rindenkarte. Ihre Stimulationserkenntnisse diskutierten sie und glichen diese u. a. mit Otfried Foerster und Wilder Penfield ab. Die Vogts selbst arbeiteten an vielfältigen Themen. Wenngleich sie nicht direkt die Epilepsie studierten, so stellt die Ammonshornsklerose (AHS) eine zentrale Läsion in ihrer Überlegung zu ihrer Beobachtung der selektiven Vulnerabilität bestimmter Rindenregionen dar. Diese formulierten sie in der sog. Pathoklisetheorie, die gerade für Epilepsie und AHS kontrovers diskutiert wurde, sich aber als weitsichtig und i. W. als richtig erwies, wenngleich die Vogts sie mit den Mitteln ihrer Zeit noch nicht verifizieren konnten. Ihre Erkenntnisse wirken bis heute nach und stellen ein Fundament der modernen Epileptologie dar.

Published
2024
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23. Gunshot Injuries to the Head

Author

Kasper, Ekkehard M., Luedi, Markus M., Kasper, Burkhard S., Velmahos, George C., editor, Degiannis, Elias, editor, and Doll, Dietrich, editor

Published
2012
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24. 7 tricks for 7 T CEST: Improving the reproducibility of multipool evaluation provides insights into the effects of age and the early stages of Parkinson's disease.

Author

Mennecke, Angelika, Khakzar, Katrin M., German, Alexander, Herz, Kai, Fabian, Moritz S., Liebert, Andrzej, Blümcke, Ingmar, Kasper, Burkhard S., Nagel, Armin M., Laun, Frederik B., Schmidt, Manuel, Winkler, Jürgen, Dörfler, Arnd, and Zaiss, Moritz

Subjects
PARKINSON'S disease, OVERHAUSER effect (Nuclear physics), AGE differences, MAGNETIZATION transfer, SUBSTANTIA nigra
Abstract

The objective of the current study was to optimize the postprocessing pipeline of 7 T chemical exchange saturation transfer (CEST) imaging for reproducibility and to prove this optimization for the detection of age differences and differences between patients with Parkinson's disease versus normal subjects. The following 7 T CEST MRI experiments were analyzed: repeated measurements of a healthy subject, subjects of two age cohorts (14 older, seven younger subjects), and measurements of 12 patients with Parkinson's disease. A slab‐selective, B1+‐homogeneous parallel transmit protocol was used. The postprocessing, consisting of motion correction, smoothing, B0‐correction, normalization, denoising, B1+‐correction and Lorentzian fitting, was optimized regarding the intrasubject and intersubject coefficient of variation (CoV) of the amplitudes of the amide pool and the aliphatic relayed nuclear Overhauser effect (rNOE) pool within the brain. Seven "tricks" for postprocessing accomplished an improvement of the mean voxel CoV of the amide pool and the aliphatic rNOE pool amplitudes of less than 5% and 3%, respectively. These postprocessing steps are: motion correction with interpolation of the motion of low‐signal offsets (1) using the amide pool frequency offset image as reference (2), normalization of the Z‐spectrum using the outermost saturated measurements (3), B0 correction of the Z‐spectrum with moderate spline smoothing (4), denoising using principal component analysis preserving the 11 highest intensity components (5), B1+ correction using a linear fit (6) and Lorentzian fitting using the five‐pool fit model (7). With the optimized postprocessing pipeline, a significant age effect in the amide pool can be detected. Additionally, for the first time, an aliphatic rNOE contrast between subjects with Parkinson's disease and age‐matched healthy controls in the substantia nigra is detected. We propose an optimized postprocessing pipeline for CEST multipool evaluation. It is shown that by the use of these seven "tricks", the reproducibility and, thus, the statistical power of a CEST measurement, can be greatly improved and subtle changes can be detected. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Linear projection‐based chemical exchange saturation transfer parameter estimation.

Author

Glang, Felix, Fabian, Moritz S., German, Alexander, Khakzar, Katrin M., Mennecke, Angelika, Liebert, Andrzej, Herz, Kai, Liebig, Patrick, Kasper, Burkhard S., Schmidt, Manuel, Zuazua, Enrique, Nagel, Armin M., Laun, Frederik B., Dörfler, Arnd, Scheffler, Klaus, and Zaiss, Moritz

Subjects
MAGNETIZATION transfer, PARAMETER estimation, FEATURE selection, CURVE fitting, BRAIN tumors
Abstract

Isolated evaluation of multiparametric in vivo chemical exchange saturation transfer (CEST) MRI often requires complex computational processing for both correction of B0 and B1 inhomogeneity and contrast generation. For that, sufficiently densely sampled Z‐spectra need to be acquired. The list of acquired frequency offsets largely determines the total CEST acquisition time, while potentially representing redundant information. In this work, a linear projection‐based multiparametric CEST evaluation method is introduced that offers fast B0 and B1 inhomogeneity correction, contrast generation and feature selection for CEST data, enabling reduction of the overall measurement time. To that end, CEST data acquired at 7 T in six healthy subjects and in one brain tumor patient were conventionally evaluated by interpolation‐based inhomogeneity correction and Lorentzian curve fitting. Linear regression was used to obtain coefficient vectors that directly map uncorrected data to corrected Lorentzian target parameters. L1‐regularization was applied to find subsets of the originally acquired CEST measurements that still allow for such a linear projection mapping. The linear projection method allows fast and interpretable mapping from acquired raw data to contrast parameters of interest, generalizing from healthy subject training data to unseen healthy test data and to the tumor patient dataset. The L1‐regularization method shows that a fraction of the acquired CEST measurements is sufficient to preserve tissue contrasts, offering up to a 2.8‐fold reduction of scan time. Similar observations as for the 7‐T data can be made for data from a clinical 3‐T scanner. Being a fast and interpretable computation step, the proposed method is complementary to neural networks that have recently been employed for similar purposes. The scan time acceleration offered by the L1‐regularization ("CEST‐LASSO") constitutes a step towards better applicability of multiparametric CEST protocols in a clinical context. [ABSTRACT FROM AUTHOR]

Published
2023
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28. 7 tricks for 7 T CEST: Improving the reproducibility of multipool evaluation provides insights into the effects of age and the early stages of Parkinson's disease

Author

Mennecke, Angelika, primary, Khakzar, Katrin M., additional, German, Alexander, additional, Herz, Kai, additional, Fabian, Moritz S., additional, Liebert, Andrzej, additional, Blümcke, Ingmar, additional, Kasper, Burkhard S., additional, Nagel, Armin M., additional, Laun, Frederik B., additional, Schmidt, Manuel, additional, Winkler, Jürgen, additional, Dörfler, Arnd, additional, and Zaiss, Moritz, additional

Published
2022
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30. Linear projection‐based CEST parameter estimation

Author

Glang, Felix, primary, Fabian, Moritz S., additional, German, Alexander, additional, Khakzar, Katrin M., additional, Mennecke, Angelika, additional, Liebert, Andrzej, additional, Herz, Kai, additional, Liebig, Patrick, additional, Kasper, Burkhard S., additional, Schmidt, Manuel, additional, Zuazua, Enrique, additional, Nagel, Armin M., additional, Laun, Frederik B., additional, Dörfler, Arnd, additional, Scheffler, Klaus, additional, and Zaiss, Moritz, additional

Published
2022
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43. Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study

Author

Lamberink, Herm J, primary, Otte, Willem M, additional, Blümcke, Ingmar, additional, Braun, Kees P J, additional, Aichholzer, Martin, additional, Amorim, Isabel, additional, Aparicio, Javier, additional, Aronica, Eleonora, additional, Arzimanoglou, Alexis, additional, Barba, Carmen, additional, Beck, Jürgen, additional, Becker, Albert, additional, Beckervordersandforth, Jan C, additional, Bien, Christian G, additional, Bodi, Istvan, additional, Braun, Kees PJ, additional, Catenoix, Helene, additional, Chassoux, Francine, additional, Chipaux, Mathilde, additional, Cloppenborg, Thomas, additional, Coras, Roland, additional, Cross, J Helen, additional, De Palma, Luca, additional, De Tisi, Jane, additional, Deleo, Francesco, additional, Devaux, Bertrand, additional, Di Gennaro, Giancarlo, additional, Dorfmüller, Georg, additional, Duncan, John S, additional, Elger, Christian, additional, Ernst, Katharina, additional, Esposito, Vincenzo, additional, Feucht, Martha, additional, Gadze, Zeljka Petelin, additional, Garbelli, Rita, additional, Geleijns, Karin, additional, Gil-Nagel, Antonio, additional, Grote, Alexander, additional, Grunwald, Thomas, additional, Guerrini, Renzo, additional, Hamer, Hajo, additional, Honavar, Mrinalini, additional, Jacques, Thomas S, additional, Jakovcevic, Antonia, additional, Jutila, Leena, additional, Kalina, Adam, additional, Kälviäinen, Reetta, additional, Klein, Karl Martin, additional, Koenig, Kristina, additional, Krsek, Pavel, additional, Kudernatsch, Manfred, additional, Kudr, Martin, additional, Lamberink, Herm J, additional, Malmgren, Kristina, additional, Marusic, Petr, additional, Melikyan, Armen, additional, Menzler, Katja, additional, Noachtar, Soheyl, additional, Özkara, Çiğdem, additional, Pieper, Tom, additional, Pimentel, Jose, additional, Raicevic, Savo, additional, Rheims, Sylvain, additional, Ribeiro, Joana, additional, Rosenow, Felix, additional, Rössler, Karl, additional, Rydenhag, Bertil, additional, Sales, Francisco, additional, San Antonio-Arce, Victoria, additional, Schaller, Karl Lothar, additional, Schijns, Olaf, additional, Scholl, Theresa, additional, Schramm, Johannes, additional, Schulze-Bonhage, Andreas, additional, Sciot, Raf, additional, Seeck, Margitta, additional, Shishkina, Lyudmila, additional, Sokic, Dragoslav, additional, Specchio, Nicola, additional, Theys, Tom, additional, Thom, Maria, additional, Delgado, Rafael Toledano, additional, Toulouse, Joseph, additional, Uzan, Mustafa, additional, van Loon, Johannes, additional, Van Paesschen, Wim, additional, von Oertzen, Tim J, additional, Jansen, Floor, additional, Leijten, Frans, additional, van Rijen, Peter, additional, Spliet, Wim GM, additional, Mühlebner, Angelika, additional, Kasper, Burkhard S, additional, Fauser, Susanne, additional, Polster, Tilman, additional, Kalbhenn, Thilo, additional, Delev, Daniel, additional, McEvoy, Andrew, additional, Miserocchi, Anna, additional, Landré, Elisabeth, additional, Turak, Bares, additional, Varlet, Pascale, additional, Ferrand-Sorbets, Sarah, additional, Fohlen, Martine, additional, Bulteau, Christine, additional, Edelvik, Anna, additional, Shah, Mukesch J, additional, Scheiwe, Christian, additional, Delicado, Eva Gutierrez, additional, Tisdall, Martin, additional, Eltze, Christin, additional, Akkol, Serdar, additional, Deniz, Kaancan, additional, Oz, Buge, additional, Holthausen, Hans, additional, Hartlieb, Till, additional, Staudt, Martin, additional, Casciato, Sara, additional, Quarato, Pier P, additional, Giangaspero, Felice, additional, Streichenberger, Nathalie, additional, Guenot, Marc, additional, Isnard, Jean, additional, Valentijn, Antonio, additional, Chang, Amanda, additional, Mullatti, Nandini, additional, Zamecnik, Josef, additional, Zarubova, Jana, additional, Tomasek, Martin, additional, Immonen, Arto, additional, Saarela, Anni, additional, Rauramaa, Tuomas, additional, Lobrinus, Johannes A, additional, Egervari, Kristof, additional, Momjian, Shahan, additional, Harti, Elisabeth, additional, Lohr, Hannah, additional, Kroell, Judith, additional, Vermeulen, Lynn, additional, Cleeren, Evy, additional, Vlasov, Pavel, additional, Kozlova, Antonia, additional, Vorobyev, Alexey, additional, Goeppel, Gudrun, additional, Samueli, Sharon, additional, Czech, Thomas, additional, Hainfellner, Johannes, additional, Puttinger, Gertraud, additional, Schwarz, Gabriele, additional, Stefanits, Harald, additional, Weis, Serge, additional, Spreafico, Roberto, additional, Villani, Flavio, additional, Rossini, Laura, additional, Hermsen, Anke, additional, Knake, Susanne, additional, Nimsky, Christopher, additional, Carl, Barbara, additional, Belohlavkova, Anezka, additional, Benova, Barbora, additional, Bisschop, Jeroen, additional, Colon, Albert, additional, van Kranen-Mastenbroek, Vivianne, additional, Rouhl, Rob PW, additional, Hoogland, Govert, additional, Rumiá, Jordi, additional, Ramírez-Camacho, Alia, additional, Candela-Cantó, Santiago, additional, Ostrowsky-Coste, Karine, additional, Panagiotakaki, Eleni, additional, Montavont, Alexandra, additional, Kosal, Pascale Keo, additional, Gokce-Samar, Zeynep, additional, Milleret, Clara, additional, Buccoliero, Anna M, additional, Giordano, Flavio, additional, Sulentic, Vlatko, additional, Mrak, Goran, additional, Desnica, Andrej, additional, CarfíPavia, Giusy, additional, De Benedictis, Alessandro, additional, Marras, Carlo E, additional, Bascarevic, Vladimir, additional, Vojvodic, Nikola, additional, Ristic, Aleksandar, additional, Rebelo, Olinda, additional, Aledo-Serrano, Angel, additional, Garcia-Morales, Irene, additional, and Anciones, Carla, additional

Published
2020
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46. Psychological long-term outcome in patients with psychogenic nonepileptic seizures

Author

Walther, Katrin, Volbers, Bastian, Erdmann, Laura, Dogan Onugoren, Müjgan, Gollwitzer, Stephanie, Kasper, Burkhard S, Kurzbuch, Katrin, Lang, Johannes, Schwab, Stefan, Schwarz, Michael, and Hamer, Hajo M

Subjects
610 Medicine & health
Abstract

OBJECTIVE To examine the long-term outcome of psychological status, personality, and health-related quality of life (HRQoL) in patients with psychogenic nonepileptic seizures (PNES) and to define predictors of favorable outcome of cessation of PNES. METHOD Patients diagnosed with PNES during video-electroencephalography (EEG) monitoring at the Erlangen Epilepsy Center were contacted 1-16 years after communicating the diagnosis. Follow-up information from each participant was obtained by interview (PNES outcome) and by self-reported questionnaires of psychological symptoms (Beck Depression Inventory-II, Symptom Checklist-90-Standard, Dissociative Symptoms questionnaire), personality traits (Freiburg Personality Inventory-Revised), and HRQoL (36-Item Short Form Health Survey). RESULTS Fifty-two patients participated in the study (mean age ± standard deviation [SD] 40.5 ± 14.0 years; 75% female, follow-up: 5.3 ± 4.2 years). Nineteen patients (37%) were free of PNES for the past 12 months. Patients with persisting PNES were older at disease onset (32.9 vs 22.3 years, P

Published
2019
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48. Magnetoencephalography for epileptic focus localization in a series of 1000 cases

Author

Rampp, Stefan, primary, Stefan, Hermann, additional, Wu, Xintong, additional, Kaltenhäuser, Martin, additional, Maess, Burkhard, additional, Schmitt, Friedhelm C, additional, Wolters, Carsten H, additional, Hamer, Hajo, additional, Kasper, Burkhard S, additional, Schwab, Stefan, additional, Doerfler, Arndt, additional, Blümcke, Ingmar, additional, Rössler, Karl, additional, and Buchfelder, Michael, additional

Published
2019
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49. Genomic DNA methylation distinguishes subtypes of human focal cortical dysplasia

Author

Kobow, Katja, primary, Ziemann, Mark, additional, Kaipananickal, Harikrishnan, additional, Khurana, Ishant, additional, Mühlebner, Angelika, additional, Feucht, Martha, additional, Hainfellner, Johannes A., additional, Czech, Thomas, additional, Aronica, Eleonora, additional, Pieper, Tom, additional, Holthausen, Hans, additional, Kudernatsch, Manfred, additional, Hamer, Hajo, additional, Kasper, Burkhard S., additional, Rössler, Karl, additional, Conti, Valerio, additional, Guerrini, Renzo, additional, Coras, Roland, additional, Blümcke, Ingmar, additional, El‐Osta, Assam, additional, and Kaspi, Antony, additional

Published
2019
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