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6. A national comparative effectiveness study to assess definitive chemoradiation regimens in proximal oesophageal squamous cell cancer

Author

de Vos-Geelen, J., primary, Hoebers, F.J.P., additional, Geurts, S.M.E., additional, Hoeben, A., additional, de Greef, B.T.A., additional, Voncken, F.E.M., additional, Bogers, J.A., additional, Braam, P.M., additional, Muijs, C.T., additional, de Jong, M.A., additional, Kasperts, N., additional, Rozema, T., additional, Jeene, P.M., additional, Blom, G.J., additional, Hulshof, M., additional, van Laarhoven, H.W.M., additional, Grabsch, H.I., additional, Lemmens, V E P P, additional, Tjan-Heijnen, V.C.G., additional, and Nieuwenhuijzen, G.A.P., additional

Published
2019
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9. 'First in man' treatments with the MRI-linac provide clinical proof of the concept

Author

Jurgenliemk-Schulz, I. M., Raaymakers, B. W., Van Asselen, B., Bol, G. H., Brown, K. J., Doornaert, P., De Groot-van Breugel, E. N., Hackett, S. L., Kasperts, N., Kiekebosch, I. H., Kerkmeijer, L. G. W., Kok, J. G. M., Kotte, A. N. T., Meijers, L. T. C., Nomden, C. N., Pais, B. R., Philippens, M. E. P., Sikkes, G. G., Tersteeg, J. H. A., Tijssen, R. H. N., Wolthaus, J. W. H., Woodings, S. J., and Lagendijk, J. J. W.

Published
2018

14. Impact of body fat distribution and sarcopenia on the overall survival in patients with spinal metastases receiving radiotherapy treatment: a prospective cohort study.

Author

Pielkenrood, B. J., van Urk, P. R., van der Velden, J. M., Kasperts, N., Verhoeff, J. J. C., Bol, G. H., Verkooijen, H. M., and Verlaan, J. J.

Subjects
ADIPOSE tissues, CANCER patients, LONGITUDINAL method, METASTASIS, STATISTICS, SURVIVAL analysis (Biometry), SPINAL tumors, MULTIPLE regression analysis, SARCOPENIA, DESCRIPTIVE statistics, KARNOFSKY Performance Status
Abstract

Introduction: An increasing number of patients is diagnosed with spinal metastases due to elevated cancer incidence and improved overall survival. Patients with symptomatic spinal bone metastases often receive radiotherapy with or without surgical stabilisation. Patients with a life expectancy of less than 3 months are generally deemed unfit for surgery, therefore adequate pre-treatment assessment of life expectancy is necessary. The aim of this study was to assess new factors associated with overall survival for this category of patients. Patients and methods: Patients who received radiotherapy for thoracic or lumbar spinal metastases from June 2013 to December 2016 were included in this study. The pre-treatment planning CT for radiotherapy treatment was used to assess the patient's visceral fat area, subcutaneous fat area, total muscle area and skeletal muscle density on a single transverse slice at the L3 level. The total muscle area was used to assess sarcopenia. Furthermore, data were collected on age, sex, primary tumour, Karnofsky performance score, medical history, number of bone metastases, non-bone metastases and neurological symptoms. Univariable and multivariable cox regressions were performed to determine the association between our variables of interest and the survival at 90 and 365 days. Results: A total of 310 patients was included. The median age was 67 years. Overall survival rates for 90 and 365 days were 71% and 36% respectively. For 90- and 365-day survival, the Karnofsky performance score, muscle density and primary tumour were independently significantly associated. The visceral or subcutaneous fat area and their ratio and sarcopenia were not independently associated with overall survival. Conclusions: Of the body morphology, only muscle density was statistically significant associated with overall survival after 90 and 365 days in patients with spinal bone metastases. Body fat distribution was not significantly associated with overall survival. [ABSTRACT FROM AUTHOR]

Published
2020
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16. PO-0863: “First in Man” treatments with the MRI-linac provide clinical proof of the concept

Author

Jürgenliemk-Schulz, I.M., primary, Raaymakers, B.W., additional, Van Asselen, B., additional, Bol, G.H., additional, Brown, K.J., additional, Doornaert, P., additional, De Groot-van Breugel, E.N., additional, Hackett, S.L., additional, Kasperts, N., additional, Kiekebosch, I.H., additional, Kerkmeijer, L.G.W., additional, Kok, J.G.M., additional, Kotte, A.N.T., additional, Meijers, L.T.C., additional, Nomden, C.N., additional, Pais, B.R., additional, Philippens, M.E.P., additional, Sikkes, G.G., additional, Tersteeg, J.H.A., additional, Tijssen, R.H.N., additional, Wolthaus, J.W.H., additional, Woodings, S.J., additional, and Lagendijk, J.J.W., additional

Published
2018
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18. First patients treated with a 1.5 T MRI-Linac: clinical proof of concept of a high-precision, high-field MRI guided radiotherapy treatment

Author

Raaymakers, B W, primary, Jürgenliemk-Schulz, I M, additional, Bol, G H, additional, Glitzner, M, additional, Kotte, A N T J, additional, van Asselen, B, additional, de Boer, J C J, additional, Bluemink, J J, additional, Hackett, S L, additional, Moerland, M A, additional, Woodings, S J, additional, Wolthaus, J W H, additional, van Zijp, H M, additional, Philippens, M E P, additional, Tijssen, R, additional, Kok, J G M, additional, de Groot-van Breugel, E N, additional, Kiekebosch, I, additional, Meijers, L T C, additional, Nomden, C N, additional, Sikkes, G G, additional, Doornaert, P A H, additional, Eppinga, W S C, additional, Kasperts, N, additional, Kerkmeijer, L G W, additional, Tersteeg, J H A, additional, Brown, K J, additional, Pais, B, additional, Woodhead, P, additional, and Lagendijk, J J W, additional

Published
2017
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19. 761P - A national comparative effectiveness study to assess definitive chemoradiation regimens in proximal oesophageal squamous cell cancer

Author

de Vos-Geelen, J., Hoebers, F.J.P., Geurts, S.M.E., Hoeben, A., de Greef, B.T.A., Voncken, F.E.M., Bogers, J.A., Braam, P.M., Muijs, C.T., de Jong, M.A., Kasperts, N., Rozema, T., Jeene, P.M., Blom, G.J., Hulshof, M., van Laarhoven, H.W.M., Grabsch, H.I., Lemmens, V E P P, Tjan-Heijnen, V.C.G., and Nieuwenhuijzen, G.A.P.

Published
2019
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27. Improvement of Target Definition for Laryngeal and Hypopharyngeal Cancer on Computed Tomography, Magnetic Resonance Imaging, and 18-FDG Positron Emission Tomography Validated by Histopathology

Author

Ligtenberg, H., primary, Jager, E.A., additional, Caldas Magalhaes, J., additional, Schakel, T., additional, Kasperts, N., additional, Pameijer, F.A., additional, Terhaard, C., additional, Janssen, L.M., additional, Willems, S.M., additional, Raaijmakers, C.P., additional, and Philippens, M., additional

Published
2016
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28. Sparing the surgical area with stereotactic body radiotherapy for combined treatment of spinal metastases: a treatment planning study.

Author

Versteeg, A. L., Hes, J., van der Velden, J. M., Eppinga, W., Kasperts, N., Verkooijen, H. M., van Vulpen, M., Oner, F. C., Seravalli, E., and Verlaan, J. J.

Subjects
METASTASIS, RADIATION doses, RADIOSURGERY, SPINAL tumors
Abstract

Introduction: Decreasing the radiation dose in the surgical area is important to lower the risk of wound complications when surgery and radiotherapy are combined for the treatment of spinal metastases. The purpose of this study was to compare the radiation dose in the surgical area for spinal metastases between single fraction external beam radiotherapy (EBRT), single fraction stereotactic body radiotherapy (SBRT) and single fraction SBRT with active sparing (SBRT-AS) of the posterior surgical area. Methods: Radiotherapy treatment plans for EBRT, SBRT and SBRT-AS of the posterior surgical area were created for 13 patients with spinal metastases. A single fraction of 8Gy was prescribed to the spinal metastasis in the EBRT plan. For the SBRT treatment plans, a single fraction of 18Gy was prescribed to the metastasis and 8Gy to the rest of the vertebral body. For the SBRT plan with active sparing the dose in the designated surgical area was minimized without compromising the dose to the organs at risk. Results: The median dose in the surgical area was 2.6Gy (1.6-5.3Gy) in the SBRT plan with active sparing of the surgical area compared to a median dose of 3.7Gy (1.6-6.3Gy) in the SBRT plan without sparing and 6.5Gy (3.5-9.1Gy) in the EBRT plans (p < .001). The radiation doses to the spinal metastases and organs at risk were not significantly different between the SBRT plan with and without sparing the surgical area. Conclusions: The radiation dose to the surgical area is significantly decreased with the use of SBRT compared to EBRT. Active sparing of the surgical area further decreased the mean radiation dose in the surgical area without compromising the dose to the spinal metastasis and the organs at risk. [ABSTRACT FROM AUTHOR]

Published
2019
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34. OC-0068: Comparison of GTV delineations on CT, MRI and FDG-PET of laryngeal and hypopharyngeal carcinoma with histopathology

Author

Ligtenberg, H., primary, Jager, E.A., additional, Caldas-Magalhaes, J., additional, Schakel, T., additional, Willems, S.M., additional, Kooij, N., additional, Terhaard, C.H.J., additional, Pameijer, F.A., additional, Kasperts, N., additional, Janssen, L.M., additional, Raaijmakers, C.P.J., additional, and Philippens, M.E.P., additional

Published
2015
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