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Kefale Getie,1 Gebreslassie Kahsay,1 Alemu Kassaw,1 Gidey Gomera,1 Abayneh Alamer,1 Tesfay Hailu2 1Department of Physiotherapy, School of Medicine, College of Health Sciences, Mekelle University, Mekelle, Ethiopia; 2School of Public Health, College of Health Sciences, Mekelle University, Mekelle, EthiopiaCorrespondence: Kefale GetieMekelle University, PO Box 1871, Mekelle, EthiopiaTel +251 962543230Email kefegete@gmail.comBackground: Ankle–foot pain is a significant public health problem in nurse professionals and has great burdens to the individuals, healthcare systems, and community at large. However, there is limited evidence on the prevalence of ankle–foot pain and its associated factors among nurses in Ethiopia. Thus, the finding of this study will help to address health problems resulting from ankle–foot pain among nurses.Purpose: The aim of this study was to determine the prevalence and associated factors of ankle–s–foot pain among nurse working in Ayder Comprehensive Specialized Hospital, Tigray, Ethiopia.Patients and Methods: An institutional-based cross-sectional study was conducted on a total of 366 nurses, and a simple random sampling technique was used to recruit study participants. Data were collected by using a self-administered adapted standardized Nordic questionnaire. Descriptive statistics and a bivariate logistic regression model were done to identify factors associated with ankle–foot pain. Those variables with a P-value less than 0.05 with 95% CI in multivariate model were taken as statistically significant. Finally, AOR with 95% confidence interval at a P-value of < 0.05 was reported.Results: The prevalence of self-reported ankle–foot pain among nurses was 43.7% (95% CI=38.5– 49.1). Older age (AOR=7.669, 95% CI=2.316− 25.390), low shoe comfort (AOR=4.215, 95% CI=2.031– 8.745), multiple foot conditions (AOR=6.102 95% CI=1.959– 19