1,010 results on '"Kassiou, Michael"'
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2. Correction: Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA
3. Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA
4. iPSC-derived PSEN2 (N141I) astrocytes and microglia exhibit a primed inflammatory phenotype
5. P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes
6. Contributors
7. An investigation on linker modifications of cyanoguanidine‐based P2X7 receptor antagonists
8. P2X7-receptor binding in new-onset and secondary progressive MS – a [11C]SMW139 PET study
9. Tracer development for PET imaging of proteinopathies
10. Novel plasma protein binding analysis method for a PET tracer and its radiometabolites: A case study with [11C]SMW139 to explain the high uptake of radiometabolites in mouse brain
11. Strategies for targeting the P2Y12 receptor in the central nervous system
12. Unlocking therapeutic potential: the role of adamantane in drug discovery.
13. Structure–Activity Relationships, Deuteration, and Fluorination of Synthetic Cannabinoid Receptor Agonists Related to AKB48, 5F-AKB-48, and AFUBIATA.
14. Quantification of the purinergic P2X7 receptor with [11C]SMW139 improves through correction for brain-penetrating radiometabolites
15. Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia
16. Brain 11β-Hydroxysteroid Dehydrogenase Type 1 Occupancy by Xanamem™ Assessed by PET in Alzheimer’s Disease and Cognitively Normal Individuals
17. TSPO PET Imaging as a Biomarker of Neuroinflammation in Neurodegenerative Disorders
18. Measuring Affinity of Ligands to the Oxytocin Receptor Using Radioligand Binding
19. The discovery of a potent and selective pyrazolo-[2,3-e]-[1,2,4]-triazine cannabinoid type 2 receptor agonist
20. Tricyclic heterocycles display diverse sensitivity to the A147T TSPO polymorphism
21. Fragment-based drug discovery for disorders of the central nervous system: designing better drugs piece by piece.
22. Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA.
23. A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity
24. Development and evaluation of novel TSPO PET tracers with low binding sensitivity to human single nucleotide polymorphism rs6971
25. Strategies to develop selective CB2 receptor agonists from indole carboxamide synthetic cannabinoids
26. Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer
27. The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study
28. Neuroinflammation in frontotemporal dementia
29. Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells
30. High-Throughput Measure of Mitochondrial Superoxide Levels as a Marker of Coronary Artery Disease to Accelerate Drug Translation in Patient-Derived Endothelial Cells Using Opera Phenix ® Technology.
31. Synthesis and Preclinical Evaluation of Fluorinated 5-Azaindoles as CB2 PET Radioligands
32. Three‐dimensional bioprinting of stem cell‐derived central nervous system cells enables astrocyte growth, vasculogenesis, and enhances neural differentiation/function
33. Late-stage Functionalization for Improving Drug-like Molecular Properties
34. The role of polycyclic frameworks in modulating P2X7 receptor function
35. New-generation azaindole-adamantyl-derived synthetic cannabinoids
36. Structure-metabolism relationships of valine and tert-leucine-derived synthetic cannabinoid receptor agonists: a systematic comparison of the in vitro phase I metabolism using pooled human liver microsomes and high-resolution mass spectrometry
37. PET imaging of P2X7R in the experimental autoimmune encephalomyelitis model of multiple sclerosis using [11C]SMW139
38. An update on late-stage functionalization in today’s drug discovery
39. Mouse models of frontotemporal dementia: A comparison of phenotypes with clinical symptomatology
40. Derivatives of the pyrazolo[1,5-a]pyrimidine acetamide DPA-713 as translocator protein (TSPO) ligands and pro-apoptotic agents in human glioblastoma
41. Altered serum protein levels in frontotemporal dementia and amyotrophic lateral sclerosis indicate calcium and immunity dysregulation
42. Anaesthetic-dependent changes in gene expression following acute and chronic exposure in the rodent brain
43. P-102 - Development and evaluation of novel TSPO PET tracers with low binding sensitivity to human single nucleotide polymorphism rs6971
44. Perphenazine–Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid
45. iPSC-Derived PSEN2 (N141I) Astrocytes and Microglia Exhibit a Primed Inflammatory Phenotype
46. Investigating P2×7R‐mediated inflammatory signalling in Alzheimer’s disease
47. P2X7 in Bipolar and Depressive Disorders
48. Imaging glial activation in patients with post-treatment Lyme disease symptoms: a pilot study using [11C]DPA-713 PET
49. In vivo assessment of neuroinflammation in progressive multiple sclerosis: a proof of concept study with [18F]DPA714 PET
50. Structure–activity relationship studies of SEN12333 analogues: Determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs
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