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8. Estimates of protection levels against SARS-CoV-2 infection and severe COVID-19 in Germany before the 2022/2023 winter season: the IMMUNEBRIDGE project

Author

Lange, Berit, Jaeger, Veronika K., Harries, Manuela, Rücker, Viktoria, Streeck, Hendrik, Blaschke, Sabine, Petersmann, Astrid, Toepfner, Nicole, Nauck, Matthias, Hassenstein, Max J., Dreier, Maren, von Holt, Isabell, Budde, Axel, Bartz, Antonia, Ortmann, Julia, Kurosinski, Marc-André, Berner, Reinhard, Borsche, Max, Brandhorst, Gunnar, Brinkmann, Melanie, Budde, Kathrin, Deckena, Marek, Engels, Geraldine, Fenzlaff, Marc, Härtel, Christoph, Hovardovska, Olga, Katalinic, Alexander, Kehl, Katja, Kohls, Mirjam, Krüger, Stefan, Lieb, Wolfgang, Meyer-Schlinkmann, Kristin M., Pischon, Tobias, Rosenkranz, Daniel, Rübsamen, Nicole, Rupp, Jan, Schäfer, Christian, Schattschneider, Mario, Schlegtendal, Anne, Schlinkert, Simon, Schmidbauer, Lena, Schulze-Wundling, Kai, Störk, Stefan, Tiemann, Carsten, Völzke, Henry, Winter, Theresa, Klein, Christine, Liese, Johannes, Brinkmann, Folke, Ottensmeyer, Patrick F., Reese, Jens-Peter, Heuschmann, Peter, and Karch, André

Published
2024
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12. Long-term survival for lymphoid neoplasms and national health expenditure (EUROCARE-6): a retrospective, population-based study

Author

Hackl, Monika, Van Eycken, Elizabeth, Van Damme, Nancy, Valerianova, Zdravka, Sekerija, Mario, Scoutellas, Vasos, Demetriou, Anna, Dušek, Ladislav, Krejici, Denisa, Storm, Hans, Mägi, Margit, Innos, Kaire, Pitkäniemi, Janne, Velten, Michel, Troussard, Xavier, Bouvier, Anne-Marie, Jooste, Valerie, Guizard, Anne-Valérie, Launoy, Guy, Dabakuyo Yonli, Sandrine, Maynadié, Marc, Woronoff, Anne-Sophie, Nousbaum, Jean-Baptiste, Coureau, Gaëlle, Monnereau, Alain, Baldi, Isabelle, Hammas, Karima, Tretarre, Brigitte, Colonna, Marc, Plouvier, Sandrine, D'Almeida, Tania, Molinié, Florence, Cowppli-Bony, Anne, Bara, Simona, Debreuve, Adeline, Defossez, Gautier, Lapôtre-Ledoux, Bénédicte, Grosclaude, Pascale, Daubisse-Marliac, Laetitia, Luttmann, Sabine, Eberle, Andrea, Stabenow, Roland, Nennecke, Alice, Kieschke, Joachim, Zeissig, Sylke, Holleczek, Bernd, Katalinic, Alexander, Birgisson, Helgi, Murray, Deirdre, Walsh, Paul M, Mazzoleni, Guido, Vittadello, Fabio, Cuccaro, Francesco, Galasso, Rocco, Sampietro, Giuseppe, Rosso, Stefano, Gasparotti, Cinzia, Maifredi, Giovanni, Ferrante, Margherita, Ragusa, Rosalia, Sutera Sardo, Antonella, Gambino, Maria Letizia, Lanzoni, Monica, Ballotari, Paola, Giacomazzi, Erica, Ferretti, Stefano, Caldarella, Adele, Manneschi, Gianfranco, Gatta, Gemma, Sant, Milena, Baili, Paolo, Berrino, Franco, Botta, Laura, Trama, Annalisa, Lillini, Roberto, Bernasconi, Alice, Bonfarnuzzo, Simone, Vener, Claudia, Didonè, Fabio, Lasalvia, Paolo, Buratti, Lucia, Tagliabue, Giovanna, Serraino, Diego, Dal Maso, Luigino, Capocaccia, Riccardo, De Angelis, Roberta, Demuru, Elena, Cerza, Francesco, Di Mari, Fabrizio, Di Benedetto, Corrado, Rossi, Silvia, Santaquilani, Mariano, Venanzi, Serenella, Tallon, Marco, Boni, Luca, Iacovacci, Silvia, Gennaro, Valerio, Russo, Antonio Giampiero, Gervasi, Federico, Spagnoli, Gianbattista, Cavalieri d'Oro, Luca, Fusco, Mario, Vitale, Maria Francesca, Usala, Mario, Mazzucco, Walter, Michiara, Maria, Chiranda, Giorgio, Cascone, Giuseppe, Rollo, Concetta Patrizia, Mangone, Lucia, Falcini, Fabio, Cavallo, Rossella, Piras, Daniela, Madeddu, Anselmo, Bella, Francesca, Fanetti, Anna Clara, Minerba, Sante, Candela, Giuseppina, Scuderi, Tiziana, Rizzello, Roberto Vito, Stracci, Fabrizio, Rugge, Massimo, Brustolin, Angelita, Pildava, Santa, Smailyte, Giedre, Azzopardi, Miriam, Johannesen, Tom Børge, Didkowska, Joanna, Wojciechowska, Urszula, Bielska-Lasota, Magdalena, Pais, Ana, Bento, Maria José, Ferreira, Ana Maia, Lourenço, António, Safaei Diba, Chakameh, Zadnik, Vesna, Zagar, Tina, Sánchez-Contador Escudero, Carmen, Franch Sureda, Paula, Lopez de Munain, Arantza, De-La-Cruz, Marta, Rojas, María Dolores, Aleman, Araceli, Vizcaino, Ana, Marcos-Gragera, Rafael, Sanvisens, Arantza, Sanchez, Maria Josè, Chirlaque Lopez, Maria Dolores, Sanchez-Gil, Antonia, Guevara, Marcela, Ardanaz, Eva, Galceran, Jaume, Carulla, Maria, Bergeron, Yvan, Bouchardy, Christine, Mohsen Mousavi, Seyed, Went, Philip, Blum, Marcel, Bordoni, Andrea, Visser, Otto, Stevens, Sarah, Broggio, John, Bennett, Damien, Gavin, Anna, Morrison, David, Huws, Dyfed Wyn, Paapsi, Keiu, Mousavi, Seyed Mohsen, and Sánchez, Maria-Jose

Published
2024
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16. Complete cancer prevalence in Europe in 2020 by disease duration and country (EUROCARE-6): a population-based study

Author

Hackl, Monika, Van Eycken, Elizabeth, Van Damme, Nancy, Valerianova, Zdravka, Sekerija, Mario, Scoutellas, Vasos, Demetriou, Anna, Dušek, Ladislav, Krejici, Denisa, Storm, Hans, Mägi, Margit, Innos, Kaire, Pitkäniemi, Janne, Velten, Michel, Troussard, Xavier, Bouvier, Anne-Marie, Jooste, Valerie, Guizard, Anne-Valérie, Launoy, Guy, Dabakuyo Yonli, Sandrine, Maynadié, Marc, Woronoff, Anne-Sophie, Nousbaum, Jean-Baptiste, Coureau, Gaëlle, Monnereau, Alain, Baldi, Isabelle, Hammas, Karima, Tretarre, Brigitte, Colonna, Marc, Plouvier, Sandrine, D'Almeida, Tania, Molinié, Florence, Cowppli-Bony, Anne, Bara, Simona, Debreuve, Adeline, Defossez, Gautier, Lapôtre-Ledoux, Bénédicte, Grosclaude, Pascale, Daubisse-Marliac, Laetitia, Luttmann, Sabine, Stabenow, Roland, Nennecke, Alice, Kieschke, Joachim, Zeissig, Sylke, Holleczek, Bernd, Katalinic, Alexander, Birgisson, Helgi, Murray, Deirdre, Walsh, Paul M., Mazzoleni, Guido, Vittadello, Fabio, Cuccaro, Francesco, Galasso, Rocco, Sampietro, Giuseppe, Rosso, Stefano, Gasparotti, Cinzia, Maifredi, Giovanni, Ferrante, Margherita, Ragusa, Rosalia, Sutera Sardo, Antonella, Gambino, Maria Letizia, Lanzoni, Monica, Ballotari, Paola, Giacomazzi, Erica, Ferretti, Stefano, Caldarella, Adele, Manneschi, Gianfranco, Gatta, Gemma, Sant, Milena, Baili, Paolo, Berrino, Franco, Botta, Laura, Trama, Annalisa, Lillini, Roberto, Bernasconi, Alice, Bonfarnuzzo, Simone, Vener, Claudia, Didonè, Fabio, Lasalvia, Paolo, Buratti, Lucia, Tagliabue, Giovanna, Serraino, Diego, Dal Maso, Luigino, Capocaccia, Riccardo, De Angelis, Roberta, Demuru, Elena, Di Benedetto, Corrado, Rossi, Silvia, Santaquilani, Mariano, Venanzi, Serenella, Tallon, Marco, Boni, Luca, Iacovacci, Silvia, Gennaro, Valerio, Russo, Antonio Giampiero, Gervasi, Federico, Spagnoli, Gianbattista, Cavalieri d'Oro, Luca, Fusco, Mario, Vitale, Maria Francesca, Usala, Mario, Mazzucco, Walter, Michiara, Maria, Chiranda, Giorgio, Cascone, Giuseppe, Giurdanella, Maria Concetta, Mangone, Lucia, Falcini, Fabio, Cavallo, Rossella, Piras, Daniela, Madeddu, Anselmo, Bella, Francesca, Fanetti, Anna Clara, Minerba, Sante, Candela, Giuseppina, Scuderi, Tiziana, Rizzello, Roberto Vito, Stracci, Fabrizio, Rugge, Massimo, Brustolin, Angelita, Pildava, Santa, Smailyte, Giedre, Azzopardi, Miriam, Johannesen, Tom Børge, Didkowska, Joanna, Wojciechowska, Urszula, Bielska-Lasota, Magdalena, Pais, Ana, Bento, Maria José, Calisto, Rita, Lourenço, António, Safaei Diba, Chakameh, Zadnik, Vesna, Zagar, Tina, Sánchez-Contador Escudero, Carmen, Franch Sureda, Paula, Lopez de Munain, Arantza, De-La-Cruz, Marta, Rojas, Marìa Dolores, Aleman, Araceli, Vizcaino, Ana, Marcos-Gragera, Rafael, Sanvisens, Arantza, Sanchez, Maria Josè, Chirlaque Lopez, Maria Dolores, Sanchez-Gil, Antonia, Guevara, Marcela, Ardanaz, Eva, Galceran, Jaume, Carulla, Maria, Bergeron, Yvan, Bouchardy, Christine, Mohsen Mousavi, Seyed, Went, Philip, Blum, Marcel, Bordoni, Andrea, Visser, Otto, Stevens, Sarah, Broggio, John, Bennett, Damien, Gavin, Anna, Morrison, David, Huws, Dyfed Wyn, Ventura, Leonardo, Paapsi, Keiu, Randi, Giorgia, Bettio, Manola, and Guzzinati, Stefano

Published
2024
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18. Survival of endometrial cancer patients in Germany in the early 21st century: a period analysis by age, histology, and stage

Author

Chen Tianhui, Jansen Lina, Gondos Adam, Ressing Meike, Holleczek Bernd, Katalinic Alexander, and Brenner Hermann

Subjects
Endometrial cancer, Survival, Germany, Cancer registries, Population based, Period analysis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Population-based studies on endometrial cancer providing survival estimates by age, histology, and stage have been sparse. We aimed to derive most up-to-date and detailed survival estimates for endometrial cancer patients in Germany. Methods We used a pooled German national dataset including data from 11 cancer registries covering a population of 33 million people. 30,906 patients diagnosed with endometrial cancer in 1997-2006 were included. Period analysis was performed to calculate 5-year relative survival (RS) in 2002-2006. Trends in survival between 2002 and 2006 were examined using model-based period analysis. Age-adjustment was performed using five age groups (15-44, 45-54, 55-64, 65-74, and 75+ years). Results Overall, age-adjusted 5-year relative survival in 2002-2006 was 81%. A moderate age gradient was observed, with 5-year RS decreasing from 90% in the age group 15-49 years to 75% in the age group 70+ years. Furthermore prognosis varied strongly by histologic subtypes and stage, with age-adjusted 5-year RS ranging from 43% (for sarcoma) to 94% (for squamous metaplasia), and reaching 91% for localized, 51% for regional, and 20% for distant stage. Except for age group 65-74 years, no significant improvement in survival was seen during the recent 5-year period under investigation. Conclusion In this comprehensive population-based survival analysis of patients with endometrial cancer from Germany, prognosis of endometrial cancer moderately varied by age, and strongly varied by histology and stage. While prognosis is rather good overall, further improvement in 5-year relative survival of endometrial cancer patients has been stagnating in the early 21st century.

Published
2012
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19. Imputation of missing values of tumour stage in population-based cancer registration

Author

Katalinic Alexander, Waldmann Annika, and Eisemann Nora

Subjects
Medicine (General), R5-920
Abstract

Abstract Background Missing data on tumour stage information is a common problem in population-based cancer registries. Statistical analyses on the level of tumour stage may be biased, if no adequate method for handling of missing data is applied. In order to determine a useful way to treat missing data on tumour stage, we examined different imputation models for multiple imputation with chained equations for analysing the stage-specific numbers of cases of malignant melanoma and female breast cancer. Methods This analysis was based on the malignant melanoma data set and the female breast cancer data set of the cancer registry Schleswig-Holstein, Germany. The cases with complete tumour stage information were extracted and their stage information partly removed according to a MAR missingness-pattern, resulting in five simulated data sets for each cancer entity. The missing tumour stage values were then treated with multiple imputation with chained equations, using polytomous regression, predictive mean matching, random forests and proportional sampling as imputation models. The estimated tumour stages, stage-specific numbers of cases and survival curves after multiple imputation were compared to the observed ones. Results The amount of missing values for malignant melanoma was too high to estimate a reasonable number of cases for each UICC stage. However, multiple imputation of missing stage values led to stage-specific numbers of cases of T-stage for malignant melanoma as well as T- and UICC-stage for breast cancer close to the observed numbers of cases. The observed tumour stages on the individual level, the stage-specific numbers of cases and the observed survival curves were best met with polytomous regression or predictive mean matching but not with random forest or proportional sampling as imputation models. Conclusions This limited simulation study indicates that multiple imputation with chained equations is an appropriate technique for dealing with missing information on tumour stage in population-based cancer registries, if the amount of unstaged cases is on a reasonable level.

Published
2011
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20. Measuring prostate-specific quality of life in prostate cancer patients scheduled for radiotherapy or radical prostatectomy and reference men in Germany and Canada using the Patient Oriented Prostate Utility Scale-Psychometric (PORPUS-P)

Author

Kuechler Thomas, Krahn Murray, Bremner Karen, Rohde Volker, Waldmann Annika, and Katalinic Alexander

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The PORPUS-P is a short questionnaire for measuring prostate-specific quality of life (QoL), which was designed in Canada for use in prostate cancer (PC) patients. We aimed to generate a German version and compare PORPUS-P scores of German reference men from the general population, and German and Canadian patients with newly diagnosed PC who were scheduled to receive radical prostatectomy (RP) or radiotherapy (RT). Methods The study sample consisted of 988 reference men, 121 German and 66 Canadian PC patients scheduled for RT, and 371 German and 68 Canadian PC patients scheduled for RP. All men completed the PORPUS-P (German postal questionnaire, Canada personal interview). Data were gathered from PC patients before the start of therapy. Results Canadian patients were better educated than the German patients, and fewer were retired. Patients scheduled to receive RT were older and more were retired. German RT patients had lower D'Amico risk scores and pre-treatment Gleason scores than RP patients, and Canadian RT patients had higher pre-treatment PSA than RP patients. Urinary and sexual dysfunction were seen in PC patients (especially RT patients), but were also common in the German reference men. Crude mean PORPUS-P scores differed statistically significant between German RT and RP and Canadian RP and RT patients, with RT patients having higher QoL scores. The differences in age-adjusted mean PORPUS-P scores between reference men and RP patients were not clinically significant, while RT patients had (clinically) significantly lower scores than the reference men. Conclusion The German translation of the PORPUS-P appears to be a short and feasible tool for assessing prostate-specific QoL. Although we found a similar response pattern, Canadian and German PC patients scheduled to receive RT or RP rated their pre-treatment quality of life on different levels, which reveals the need for national reference data. Problems in several QoL domains exist before treatment, and differ between PC patients scheduled for RT and RP.

Published
2009
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21. The population-based oncological health care study OVIS – recruitment of the patients and analysis of the non-participants

Author

Raspe Heiner, Waldmann Annika, Pritzkuleit Ron, and Katalinic Alexander

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The ageing of the population is expected to bring an enormous growth in demand for oncological health care. In order to anticipate and respond to future trends, cancer care needs to be critically evaluated. The present study explores the possibility of conducting representative and population-based research on cancer care on the basis of data drawn from the Cancer Registry. Methods A population-based state-wide cohort study (OVIS) has been carried out in Schleswig-Holstein, Germany. All patients with malignant melanoma, breast, or prostate cancer were identified in the Cancer Registry. Epidemiological data were obtained for all the patients and screened for study eligibility. A postal questionnaire requesting information on diagnosis, therapy, QoL and aftercare was sent to eligible patients. Results A total of 11,489 persons diagnosed with the cancer types of interest in the period from January 2002 to July 2004 were registered in the Cancer Registry. Of the 5,354 (47%) patients who gave consent for research, 4,285 (80% of consenters) completed the questionnaire. In terms of relevant epidemiological variables, participants with melanoma were not found to be different from non-participants with the same diagnosis. However, participants with breast or prostate cancer were slightly younger and had smaller tumours than patients who did not participate in our study. Conclusion Population-based cancer registry data proved to be an invaluable resource for both patient recruitment and non-participant analysis. It can help improve our understanding of the strength and nature of differences between participants and non-respondents. Despite minor differences observed in breast and prostate cancer, the OVIS-sample seems to represent the source population adequately.

Published
2008
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27. Long-term survival and cure fraction estimates for childhood cancer in Europe (EUROCARE-6): results from a population-based study

Author

Hackl, Monika, Van Eycken, Elizabeth, Van Damme, Nancy, Valerianova, Zdravka, Sekerija, Mario, Scoutellas, Vasos, Demetriou, Anna, Dušek, Ladislav, Krejci, Denisa, Storm, Hans, Mägi, Margit, Innos, Kaire, Paapsi, Keiu, Malila, Nea, Pitkäniemi, Janne, Jooste, Valerie, Clavel, Jacqueline, Poulalhon, Claire, Lacour, Brigitte, Desandes, Emmanuel, Monnereau, Alain, Erdmann, Friederike, Spix, Claudia, Katalinic, Alexander, Petridou, Eleni, Markozannes, Georgios, Garami, Miklos, Birgisson, Helgi, Murray, Deirdre, Walsh, Paul M, Mazzoleni, Guido, Vittadello, Fabio, Cuccaro, Francesco, Galasso, Rocco, Sampietro, Giuseppe, Rosso, Stefano, Gasparotto, Cinzia, Maifredi, Giovanni, Ferrante, Margherita, Torrisi, Antonina, Sutera Sardo, Antonella, Gambino, Maria Letizia, Lanzoni, Monica, Ballotari, Paola, Giacomazzi, Erica, Ferretti, Stefano, Caldarella, Adele, Manneschi, Gianfranco, Gatta, Gemma, Sant, Milena, Baili, Paolo, Berrino, Franco, Botta, Laura, Trama, Annalisa, Lillini, Roberto, Bernasconi, Alice, Bonfarnuzzo, Simone, Vener, Claudia, Didonè, Fabio, Lasalvia, Paolo, Del Monego, Giulia, Buratti, Lucia, Serraino, Diego, Taborelli, Martina, Capocaccia, Riccardo, De Angelis, Roberta, Demuru, Elena, Di Benedetto, Corrado, Rossi, Silvia, Santaquilani, Mariano, Venanzi, Serenella, Tallon, Marco, Boni, Luca, Iacovacci, Silvia, Russo, Antonio Giampiero, Gervasi, Federico, Spagnoli, Gianbattista, Cavalieri d'Oro, Luca, Fusco, Mario, Vitale, Maria Francesca, Usala, Mario, Vitale, Francesco, Michiara, Maria, Chiranda, Giorgio, Sacerdote, Carlotta, Maule, Milena, Cascone, Giuseppe, Spata, Eugenia, Mangone, Lucia, Falcini, Fabio, Cavallo, Rossella, Piras, Daniela, Dinaro, Ylenia, Castaing, Marine, Fanetti, Anna Clara, Minerba, Sante, Candela, Giuseppina, Scuderi, Tiziana, Rizzello, Roberto Vito, Stracci, Fabrizio, Tagliabue, Giovanna, Rugge, Massimo, Brustolin, Angelita, Pildava, Santa, Smailyte, Giedre, Azzopardi, Miriam, Johannesen, Tom Børge, Didkowska, Joanna, Wojciechowska, Urszula, Bielska-Lasota, Magdalena, Pais, Ana, Ferreira, Ana Maria, Bento, Maria José, Miranda, Ana, Safaei Diba, Chakameh, Zadnik, Vesna, Zagar, Tina, Sánchez-Contador Escudero, Carmen, Franch Sureda, Paula, Lopez de Munain, Arantza, De-La-Cruz, Marta, Rojas, Marìa Dolores, Aleman, Araceli, Vizcaino, Ana, Almela, Fernando, Marcos-Gragera, Rafael, Sanvisens, Arantza, Sanchez, Maria Josè, Chirlaque, Maria Dolores, Sanchez-Gil, Antonia, Guevara, Marcela, Ardanaz, Eva, Cañete-Nieto, Adela, Peris-Bonet, Rafael, Galceran, Jaume, Carulla, Maria, Kuehni, Claudia, Redmond, Shelagh, Visser, Otto, Karim-Kos, Henrike, Stevens, Sarah, Stiller, Charles, Gavin, Anna, Morrison, David, Huws, Dyfed Wyn, Cañete, Adela, Dal Maso, Luigino, and Mihor, Ana

Published
2022
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29. Impact of COVID-19 crisis on medical care of patients with metastasized uro-oncologic disease under systemic cancer therapy: a multicenter study in German university hospitals

Author

Struck, Julian P., Schnoor, Maike, Schulze, Andrea, Hupe, Marie C., Ozimek, Tomasz, Oppolzer, Immanuel A., Schnabel, Marco J., Burger, Maximilian, Darr, Christopher, Gruenwald, Viktor, Hadaschik, Boris, Weinke, Maximilian, Kuebler, Hubert, Klockenbusch, Jonas C., Grabbert, Markus T., Gratzke, Christian, Kramer, Mario W., Katalinic, Alexander, and Merseburger, Axel S.

Published
2022
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32. Protocol of the Luebeck longitudinal investigation of SARS-CoV-2 infection (ELISA) study – a prospective population-based cohort study

Author

Balck, Alexander, Föh, Bandik, Borsche, Max, Rahmöller, Johann, Vollstedt, Eva-Juliane, Waldeck, Frederike, Käding, Nadja, Twesten, Christoph, Mischnik, Alexander, Gillessen-Kaesbach, Gabriele, Ehlers, Marc, Sina, Christian, Taube, Stefan, Busch, Hauke, Rupp, Jan, Katalinic, Alexander, and Klein, Christine

Published
2022
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33. Water and Soil Pollution: Ecological Environmental Study Methodologies Useful for Public Health Projects. A Literature Review

Author

Lillini, Roberto, Tittarelli, Andrea, Bertoldi, Martina, Ritchie, David, Katalinic, Alexander, Pritzkuleit, Ron, Launoy, Guy, Launay, Ludivine, Guillaume, Elodie, Žagar, Tina, Modonesi, Carlo, Meneghini, Elisabetta, Amati, Camilla, Di Salvo, Francesca, Contiero, Paolo, Borgini, Alessandro, Baili, Paolo, de Voogt, Pim, Series Editor, Cavieres, María Fernanda, Associate Editor, Knaak, James B., Associate Editor, van Wezel, Annemarie P., Associate Editor, Tjeerdema, Ronald S., Associate Editor, and Vighi, Marco, Associate Editor

Published
2021
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34. Effectiveness of structured, multidisciplinary long-term care for pediatric cancer survivors: protocol of the multicenter, randomized-controlled AELKI study.

Author

Schmidt, Hannah, Baust, Katja, Calaminus, Gabriele, Hohls, Lisa, Tetzner, Katharina, Griech, Nicole, Haugke, Henrike, Baltus, Hannah, Elsner, Susanne, Katalinic, Alexander, Becker, Hera, Cytera, Chirine, Gebauer, Judith, Kock-Schoppenhauer, Ann-Kristin, Neumann, Anke, Denzer, Christian, Schündeln, Michael M., Faber, Jörg, Sattler, Conny, and Frühwald, Michael C.

Abstract

Background: In Germany, around 2.250 children and adolescents are diagnosed with cancer each year. Despite generally positive long-term survival rates, many patients must cope with late effects of the disease and its treatment. This highlights the need for a well-structured, long-term approach addressing both physical and mental health issues. Currently, the German healthcare system lacks such comprehensive structures. Our study aims to evaluate the effectiveness of a structured, multidisciplinary long-term approach compared to conventional "treatment as usual" (TAU). Methods: A prospective, multicenter study with ten pediatric university clinics in Germany will be conducted. The cluster-randomization takes place at the clinic level. Children and adolescents who completed their cancer treatment at least five years ago and their parents will be eligible to participate. While the control group (CG) receives TAU, the intervention group (IG) participates in a structured program. This program includes risk-based medical treatment and psychosocial interventions tailored to each patient's individual needs within a two-month timeframe. The primary outcome is the improvement of self-efficacy. Secondary outcomes are satisfaction with health care, improvement of health-related quality of life (HRQoL), reduction of mental health problems, and improvement of transition readiness. Discussion: This approach has the potential to optimize the health care for individuals who survived cancer during childhood or adolescence. It addresses the challenges of overuse, underuse, and misuse of health care resources. By considering both medical and psychosocial factors and promoting increased self-efficacy, independent from parental involvement, it may facilitate a smoother transition to adult medicine and enhance adherence to lifelong aftercare. If proven successful, this approach will contribute to the integration of multidisciplinary strategies into standard healthcare practice. Trial registration: German Clinical Trials Register DRKS00029269. Registered on December 23, 2022. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Differences in survival and recurrence of colorectal cancer by stage across population‐based European registries.

Author

Bouvier, Anne‐Marie, Jooste, Valérie, Lillini, Roberto, Marcos‐Gragera, Rafael, Katalinic, Alexander, Giorgi Rossi, Paolo, Launoy, Guy, Bouvier, Véronique, Guevara, Marcela, Ardanaz, Eva, Rapiti Aylward, Elisabetta, Innos, Kaire, Barranco, Miguel Rodríguez, Sant, Milena, Van Eycken, L, Henau, K, Grozeva, T, Valerianova, Z, Innos, K, and Mägi, M

Subjects
COLORECTAL cancer, TUMOR classification, ONCOLOGIC surgery, OVERALL survival, CANCER patients, CANCER relapse
Abstract

Recurrence after colorectal cancer resection is rarely documented in the general population while a key clinical determinant for patient survival. We identified 8785 patients with colorectal cancer diagnosed between 2010 and 2013 and clinically followed up to 2020 in 15 cancer registries from seven European countries (Bulgaria, Switzerland, Germany, Estonia, France, Italy, and Spain). We estimated world age‐standardized net survival using a flexible cumulative excess hazard model. Recurrence rates were calculated for patients with initially resected stage I, II, or III cancer in six countries, using the actuarial survival method. The proportion of nonmetastatic resected colorectal cancers varied from 58.6% to 78.5% according to countries. The overall 5‐year net survival by country ranged between 60.8% and 74.5%. The absolute difference between the 5‐year survival extremes was 12.8 points for stage II (Bulgaria vs Switzerland), 19.7 points for stage III (Bulgaria vs. Switzerland) and 14.8 points for Stage IV and unresected cases (Bulgaria vs. Switzerland or France). Five‐year cumulative rate of recurrence among resected patients with stage I–III was 17.7%. As compared to the mean of the whole cohort, the risk of developing a recurrence did not differ between countries except a lower risk in Italy for both stage I/II and stage III cancers and a higher risk in Spain for stage III. Survival after colorectal cancer differed across the concerned European countries while there were slight differences in recurrence rates. Population‐based collection of cancer recurrence information is crucial to enhance efforts for evidence‐based management of colorectal cancer follow up. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Epidemiologie des keratinozytären Hautkrebses unter besonderer Berücksichtigung des kutanen Plattenepithelkarzinoms.

Author

Nanz, Lena, Keim, Ulrike, Katalinic, Alexander, Meyer, Thomas, Garbe, Claus, and Leiter, Ulrike

Subjects
HATS
Abstract

Zusammenfassung: Die Inzidenz von keratinozytärem Hautkrebs hat in den letzten fünf Jahrzehnten in hellhäutigen Bevölkerungsgruppen weltweit rapide zugenommen. Das Plattenepithelkarzinom (SCC) macht etwa 20 % der Fälle aus und betrifft hauptsächlich ältere Menschen. Keratinozytärer Hautkrebs hat zwar eine niedrige Mortalitätsrate, ist aber mit einer hohen Morbidität verbunden, insbesondere wenn mehrere Tumoren auftreten, und stellt daher ein Problem für das Gesundheitssystem dar. Wir geben einen Überblick über die Epidemiologie von keratinozytärem Hautkrebs in Queensland, Australien, den USA und Nordeuropa und werfen einen Blick auf zukünftige Herausforderungen. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Prävention

Author

Katalinic, Alexander, primary, Elsner, Susanne, additional, and Hübner, Joachim, additional

Published
2022
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41. Autoreninnen und Autoren

Author

Ahrens, Marit, primary, Al-Batran, Salah-Eddin, additional, Armbrust, Robert, additional, Banek, Séverine, additional, Becker, Sven, additional, Bergmann, Lothar, additional, Bojunga, Jörg, additional, Brümmendorf, Tim Henrik, additional, Brunnberg, Uta, additional, Bug, Gesine, additional, Burger, Michael, additional, Chromik, Jörg, additional, Chun, Felix K.-H., additional, Czauderna, Carolin, additional, Dumoulin, Franz Ludwig, additional, Dreyling, Martin, additional, El-Balat, Ahmed, additional, Ellinger, Jörg, additional, Elsner, Susanne, additional, Enßle, Julius C., additional, Fottner, Christian, additional, Galle, Peter R., additional, Gökbuget, Nicola, additional, Götze, Thorsten Oliver, additional, Halbsguth, Teresa, additional, Höh, Benedikt, additional, Hohenberger, Peter, additional, Hübner, Joachim, additional, Hübner, Jutta, additional, Isfort, Susanne, additional, Kasper, Bernd, additional, Katalinic, Alexander, additional, Kestler, Angelika, additional, Khodamoradi, Yascha, additional, Kleemann, Johannes, additional, Kluth, Luis A., additional, Köhler, Viktoria F., additional, Kollmar, Otto, additional, Koschmieder, Steffen, additional, Lang, Fabian, additional, Makowka, Philipp, additional, Mallmann, Peter, additional, Mallmann-Gottschalk, Nina, additional, Mandel, Philipp, additional, Maurer, Gabriele, additional, Mayer, Arnulf, additional, Meissner, Markus, additional, Menge, Franka, additional, Middeke, Jan Moritz, additional, Miesbach, Wolfgang, additional, Möhler, Markus, additional, Möbus, Volker, additional, Müller, Stefan C., additional, Musholt, Thomas J., additional, Nauck, Friedemann, additional, Oellerich, Thomas, additional, Özistanbullu, Deniz, additional, Porschen, Rainer, additional, Pox, Christian, additional, Richter, Konrad Klaus, additional, Sauerbruch, Tilman, additional, Scheich, Sebastian, additional, Schetelig, . Johannes, additional, Schmidberger, Heinz, additional, Schnürch, Hans-Georg, additional, Sebastian, Martin, additional, Sehouli, Jalid, additional, Seifart, Ulf, additional, Serve, Hubert, additional, Seufferlein, Thomas, additional, Shaid, Shabnam, additional, Soysal, Savas D., additional, Steffen, Björn, additional, Steinbach, Joachim P., additional, Stratmann, Jan A., additional, Tsoukakis, Ioannis, additional, Ullrich, Evelyn, additional, Vehreschild, Janne, additional, Metzler, Ivana von, additional, Wolff, Michael von, additional, Voß, Martin, additional, Wagner, Sebastian, additional, Weber, Matthias M., additional, Wege, Henning, additional, Weis, Joachim, additional, Welte, Maria-Noemi, additional, Wenzel, Mike, additional, Wolf, Timo, additional, and Zurmeyer, David, additional

Published
2022
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49. Complete cancer prevalence in Europe in 2020 by disease duration and country (EUROCARE-6): a population-based study

Author

De Angelis, Roberta, primary, Demuru, Elena, additional, Baili, Paolo, additional, Troussard, Xavier, additional, Katalinic, Alexander, additional, Chirlaque Lopez, Maria Dolores, additional, Innos, Kaire, additional, Santaquilani, Mariano, additional, Blum, Marcel, additional, Ventura, Leonardo, additional, Paapsi, Keiu, additional, Galasso, Rocco, additional, Guevara, Marcela, additional, Randi, Giorgia, additional, Bettio, Manola, additional, Botta, Laura, additional, Guzzinati, Stefano, additional, Dal Maso, Luigino, additional, Rossi, Silvia, additional, Hackl, Monika, additional, Van Eycken, Elizabeth, additional, Van Damme, Nancy, additional, Valerianova, Zdravka, additional, Sekerija, Mario, additional, Scoutellas, Vasos, additional, Demetriou, Anna, additional, Dušek, Ladislav, additional, Krejici, Denisa, additional, Storm, Hans, additional, Mägi, Margit, additional, Pitkäniemi, Janne, additional, Velten, Michel, additional, Bouvier, Anne-Marie, additional, Jooste, Valerie, additional, Guizard, Anne-Valérie, additional, Launoy, Guy, additional, Dabakuyo Yonli, Sandrine, additional, Maynadié, Marc, additional, Woronoff, Anne-Sophie, additional, Nousbaum, Jean-Baptiste, additional, Coureau, Gaëlle, additional, Monnereau, Alain, additional, Baldi, Isabelle, additional, Hammas, Karima, additional, Tretarre, Brigitte, additional, Colonna, Marc, additional, Plouvier, Sandrine, additional, D'Almeida, Tania, additional, Molinié, Florence, additional, Cowppli-Bony, Anne, additional, Bara, Simona, additional, Debreuve, Adeline, additional, Defossez, Gautier, additional, Lapôtre-Ledoux, Bénédicte, additional, Grosclaude, Pascale, additional, Daubisse-Marliac, Laetitia, additional, Luttmann, Sabine, additional, Stabenow, Roland, additional, Nennecke, Alice, additional, Kieschke, Joachim, additional, Zeissig, Sylke, additional, Holleczek, Bernd, additional, Birgisson, Helgi, additional, Murray, Deirdre, additional, Walsh, Paul M., additional, Mazzoleni, Guido, additional, Vittadello, Fabio, additional, Cuccaro, Francesco, additional, Sampietro, Giuseppe, additional, Rosso, Stefano, additional, Gasparotti, Cinzia, additional, Maifredi, Giovanni, additional, Ferrante, Margherita, additional, Ragusa, Rosalia, additional, Sutera Sardo, Antonella, additional, Gambino, Maria Letizia, additional, Lanzoni, Monica, additional, Ballotari, Paola, additional, Giacomazzi, Erica, additional, Ferretti, Stefano, additional, Caldarella, Adele, additional, Manneschi, Gianfranco, additional, Gatta, Gemma, additional, Sant, Milena, additional, Berrino, Franco, additional, Trama, Annalisa, additional, Lillini, Roberto, additional, Bernasconi, Alice, additional, Bonfarnuzzo, Simone, additional, Vener, Claudia, additional, Didonè, Fabio, additional, Lasalvia, Paolo, additional, Buratti, Lucia, additional, Tagliabue, Giovanna, additional, Serraino, Diego, additional, Capocaccia, Riccardo, additional, De Angelis, Roberta, additional, Di Benedetto, Corrado, additional, Venanzi, Serenella, additional, Tallon, Marco, additional, Boni, Luca, additional, Iacovacci, Silvia, additional, Gennaro, Valerio, additional, Russo, Antonio Giampiero, additional, Gervasi, Federico, additional, Spagnoli, Gianbattista, additional, Cavalieri d'Oro, Luca, additional, Fusco, Mario, additional, Vitale, Maria Francesca, additional, Usala, Mario, additional, Mazzucco, Walter, additional, Michiara, Maria, additional, Chiranda, Giorgio, additional, Cascone, Giuseppe, additional, Giurdanella, Maria Concetta, additional, Mangone, Lucia, additional, Falcini, Fabio, additional, Cavallo, Rossella, additional, Piras, Daniela, additional, Madeddu, Anselmo, additional, Bella, Francesca, additional, Fanetti, Anna Clara, additional, Minerba, Sante, additional, Candela, Giuseppina, additional, Scuderi, Tiziana, additional, Rizzello, Roberto Vito, additional, Stracci, Fabrizio, additional, Rugge, Massimo, additional, Brustolin, Angelita, additional, Pildava, Santa, additional, Smailyte, Giedre, additional, Azzopardi, Miriam, additional, Johannesen, Tom Børge, additional, Didkowska, Joanna, additional, Wojciechowska, Urszula, additional, Bielska-Lasota, Magdalena, additional, Pais, Ana, additional, Bento, Maria José, additional, Calisto, Rita, additional, Lourenço, António, additional, Safaei Diba, Chakameh, additional, Zadnik, Vesna, additional, Zagar, Tina, additional, Sánchez-Contador Escudero, Carmen, additional, Franch Sureda, Paula, additional, Lopez de Munain, Arantza, additional, De-La-Cruz, Marta, additional, Rojas, Marìa Dolores, additional, Aleman, Araceli, additional, Vizcaino, Ana, additional, Marcos-Gragera, Rafael, additional, Sanvisens, Arantza, additional, Sanchez, Maria Josè, additional, Sanchez-Gil, Antonia, additional, Ardanaz, Eva, additional, Galceran, Jaume, additional, Carulla, Maria, additional, Bergeron, Yvan, additional, Bouchardy, Christine, additional, Mohsen Mousavi, Seyed, additional, Went, Philip, additional, Bordoni, Andrea, additional, Visser, Otto, additional, Stevens, Sarah, additional, Broggio, John, additional, Bennett, Damien, additional, Gavin, Anna, additional, Morrison, David, additional, and Huws, Dyfed Wyn, additional

Published
2024
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