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We conduct the first study of how the relative quenching probability of galaxies depends on environment over the redshift range $0.5 < z < 3$, using data from the UKIDSS Ultra-Deep Survey. By constructing the stellar mass functions for quiescent and post-starburst (PSB) galaxies in high, medium and low density environments to $z = 3$, we find an excess of quenched galaxies in dense environments out to at least $z \sim 2$. Using the growth rate in the number of quenched galaxies, combined with the star-forming galaxy mass function, we calculate the probability that a given star-forming galaxy is quenched per unit time. We find a significantly higher quenching rate in dense environments (at a given stellar mass) at all redshifts. Massive galaxies (M$_* > 10^{10.7}$ M$_{\odot}$) are on average 1.7 $\pm$ 0.2 times more likely to quench per Gyr in the densest third of environments compared to the sparsest third. Finally, we compare the quiescent galaxy growth rate to the rate at which galaxies pass through a PSB phase. Assuming a visibility timescale of 500 Myr, we find that the PSB route can explain $\sim$ 50\% of the growth in the quiescent population at high stellar mass (M$_* > 10^{10.7}$ M$_{\odot}$) in the redshift range $0.5 < z < 3$, and potentially all of the growth at lower stellar masses., 12 pages, 8 figures. Accepted for publication in MNRAS

Post-starburst galaxies (PSBs) are transition galaxies showing evidence of recent rapid star formation quenching. To understand the role of galaxy mergers in triggering quenching, we investigate the incidence of PSBs and resolved PSB properties in post-merger galaxies using both SDSS single-fiber spectra and MaNGA resolved IFU spectra. We find post-mergers have a PSB excess of 10 - 20 times that relative to their control galaxies using single-fiber PSB diagnostics. A similar excess of ~ 19 times is also found in the fraction of central (C)PSBs and ring-like (R)PSBs in post-mergers using the resolved PSB diagnostic. However, 60% of the CPSBs + RPSBs in both post-mergers and control galaxies are missed by the single-fiber data. By visually inspecting the resolved PSB distribution, we find that the fraction of outside-in quenching is 7 times higher than inside-out quenching in PSBs in post-mergers while PSBs in control galaxies do not show large differences in these quenching directions. In addition, we find a marginal deficit of HI gas in PSBs relative to non-PSBs in post-mergers using the MaNGA-HI data. The excesses of PSBs in post-mergers suggest that mergers play an important role in triggering quenching. Resolved IFU spectra are important to recover the PSBs missed by single-fiber spectra. The excess of outside-in quenching relative to inside-out quenching in post-mergers suggests that AGN are not the dominant quenching mechanism in these galaxies, but that processes from the disk (gas inflows/consumption and stellar feedback) play a more important role., Comment: Accepted in MNRAS on May 12 2023, 19 pages, 15 figures, 4 tables

We present star formation rates based on cold and ionized gas measurements of Mrk 266 (NGC 5256), a system composed of two colliding gas-rich galaxies, each hosting an active galactic nucleus. Using $^{12}$CO (1-0) observations with the Combined Array for Research in Millimeter-Wave Astronomy (CARMA), we find a total H$_2$ mass in the central region of $1.1\pm0.3\times10^{10}$ $M_\odot$ which leads to a possible future star formation rate of $25\pm10 M_\odot$ yr$^{-1}$. With the Fourier Transform Spectrograph (SITELLE) on the Canada-France-Hawaii Telescope, we measure an integrated H$\alpha$ luminosity and estimate a present-day star formation rate of $15\pm2 M_\odot$ yr$^{-1}$ in the core of the system (avoiding the two active nuclei). These results confirm that Mrk 266 is an intermediate stage merger with a relatively high recent star formation rate and enough molecular gas to sustain it for a few hundred million years. Inflowing gas associated with the merger may have triggered both the starburst episode and two AGN but the two galaxy components differ: the region around the SW nucleus appears to be more active than the NE nucleus, which seems relatively quiet. We speculate that this difference may originate in the properties of the interstellar medium in the two systems., Comment: 11 pages, 7 figures, 1 table, accepted for publication in Monthly Notices of the Royal Astronomical Society (MNRAS)

The molecular gas in galaxies traces both the fuel for star formation and the processes that can enhance or suppress star formation. Observations of the molecular gas state can thus point to when and why galaxies stop forming stars. In this study, we present ALMA observations of the molecular gas in galaxies evolving through the post-starburst phase. These galaxies have low current star formation rates, regardless of the SFR tracer used, with recent starbursts ending within the last 600 Myr. We present CO (3-2) observations for three post-starburst galaxies, and dense gas HCN/HCO+/HNC (1-0) observations for six (four new) post-starburst galaxies. The post-starbursts have low excitation traced by the CO spectral line energy distribution (SLED) up to CO (3-2), more similar to early-type than starburst galaxies. The low excitation indicates that lower density rather than high temperatures may suppress star formation during the post-starburst phase. One galaxy displays a blueshifted outflow traced by CO (3-2). MaNGA observations show that the ionized gas velocity is disturbed relative to the stellar velocity field, with a blueshifted component aligned with the molecular gas outflow, suggestive of a multiphase outflow. Low ratios of HCO+/CO, indicating low fractions of dense molecular gas relative to the total molecular gas, are seen throughout post-starburst phase, except for the youngest post-starburst galaxy considered here. These observations indicate that the impact of any feedback or quenching processes may be limited to low excitation and weak outflows in the cold molecular gas during the post-starburst phase., 33 pages, 24 figures, 4 tables, ApJ in press

Glycophorins are the most abundant sialoglycoproteins on the surface of human erythrocyte membranes. Genetic variation in glycophorin region of human chromosome 4 (containing GYPA, GYPB, and GYPE genes) is of interest because the gene products serve as receptors for pathogens of major public health interest, including Plasmodium sp., Babesia sp., Influenza virus, Vibrio cholerae El Tor Hemolysin, and Escherichia coli. A large structural rearrangement and hybrid glycophorin variant, known as Dantu, which was identified in East African populations, has been linked with a 40% reduction in risk for severe malaria. Apart from Dantu, other large structural variants exist, with the most common being deletion of the whole GYPB gene and its surrounding region, resulting in multiple different deletion forms. In West Africa particularly, these deletions are estimated to account for between 5 and 15% of the variation in different populations, mostly attributed to the forms known as DEL1 and DEL2. Due to the lack of specific variant assays, little is known of the distribution of these variants. Here, we report a modification of a previous GYPB DEL1 assay and the development of a novel GYPB DEL2 assay as high-throughput PCR-RFLP assays, as well as the identification of the crossover/breakpoint for GYPB DEL2. Using 393 samples from three study sites in Ghana as well as samples from HapMap and 1000 G projects for validation, we show that our assays are sensitive and reliable for genotyping GYPB DEL1 and DEL2. To the best of our knowledge, this is the first report of such high-throughput genotyping assays by PCR-RFLP for identifying specific GYPB deletion types in populations. These assays will enable better identification of GYPB deletions for large genetic association studies and functional experiments to understand the role of this gene cluster region in susceptibility to malaria and other diseases.

We present the star formation histories of 39 galaxies with high quality rest-frame optical spectra at 0.5, Comment: 24 pages, 16 figures, MNRAS accepted 06/03/2020

We present an analysis of 10 ks snapshot Chandra observations of 12 shocked post-starburst galaxies, which provide a window into the unresolved question of active galactic nuclei (AGN) activity in post-starburst galaxies and its role in the transition of galaxies from actively star forming to quiescence. While 7/12 galaxies have statistically significant detections (with 2 more marginal detections), the brightest only obtained 10 photons. Given the wide variety of hardness ratios in this sample, we chose to pursue a forward modeling approach to constrain the intrinsic luminosity and obscuration of these galaxies rather than stacking. We constrain intrinsic luminosity of obscured power-laws based on the total number of counts and spectral shape, itself mostly set by the obscuration, with hardness ratios consistent with the data. We also tested thermal models. While all the galaxies have power-law models consistent with their observations, a third of the galaxies are better fit as an obscured power-law and another third are better fit as thermal emission. If these post-starburst galaxies, early in their transition, contain AGN, then these are mostly confined to a lower obscuration ($n_H \leq10^{23}$ cm$^{-2}$) and lower luminosity ($L_{2-10~ \rm keV}\leq10^{42}$erg s$^{-1}$). Two galaxies, however, are clearly best fit as significantly obscured AGN. At least half of this sample show evidence of at least low luminosity AGN activity, though none could radiatively drive out the remaining molecular gas reservoirs. Therefore, these AGN are more likely along for the ride, having been fed gas by the same processes driving the transition., Comment: 16 pages, 6 figures, 3 tables, accepted for publication in ApJ

Background: The -α3.7I-thalassaemia deletion is very common throughout Africa because it protects against malaria. When undertaking studies to investigate human genetic adaptations to malaria or other diseases, it is important to account for any confounding effects of α-thalassaemia to rule out spurious associations. Methods: In this study, we have used direct α-thalassaemia genotyping to understand why GWAS data from a large malaria association study in Kilifi Kenya did not identify the α-thalassaemia signal. We then explored the potential use of a number of new approaches to using GWAS data for imputing α-thalassaemia as an alternative to direct genotyping by PCR. Results: We found very low linkage-disequilibrium of the directly typed data with the GWAS SNP markers around α-thalassaemia and across the haemoglobin-alpha (HBA) gene region, which along with a complex haplotype structure, could explain the lack of an association signal from the GWAS SNP data. Some indirect typing methods gave results that were in broad agreement with those derived from direct genotyping and could identify an association signal, but none were sufficiently accurate to allow correct interpretation compared with direct typing, leading to confusing or erroneous results. Conclusions: We conclude that going forwards, direct typing methods such as PCR will still be required to account for α-thalassaemia in GWAS studies.

We present a multiwavelength study of IC 860, a nearby post-starburst galaxy at the early stage of transitioning from blue and star-forming to red and quiescent. Optical images reveal a galaxy-wide, dusty outflow originating from a compact core. We find evidence for a multiphase outflow in the molecular and neutral gas phase from the CO position-velocity diagram and NaD absorption features. We constrain the neutral mass outflow rate to be ~0.5 M$_{\odot}/$yr, and the total hydrogen mass outflow rate to be ~12 M$_{\odot}$/yr. Neither outflow component seems able to escape the galaxy. We also find evidence for a recent merger in the optical images, CO spatial distribution, and kinematics, and evidence for a buried AGN in the optical emission line ratios, mid-IR properties, and radio spectral shape. The depletion time of the molecular gas reservoir under the current star formation rate is ~7 Gyr, indicating that the galaxy could stay at the intermediate stage between the blue and red sequence for a long time. Thus the timescales for a significant decline in star formation rate ("quenching") and gas depletion are not necessarily the same. Our analysis supports the quenching picture where outflows help suppress star formation by disturbing rather than expelling the gas and shed light on possible ongoing activities in similar quenching galaxies., Comment: 31 pages, 15 figures, accepted for publication in The Astrophysical Journal. Online material will be available from the publisher

Since its installation on the Hubble Space Telescope in 2009, the Cosmic Origins Spectrograph (COS) has obtained thousands of spectra in the ultraviolet. Most of these observations have used the far ultraviolet (FUV) channel. The microchannel plates in the FUV detector are subject to gain sag, resulting in a loss of sensitivity as a function of time, so the spectra are regularly repositioned to mitigate this effect. The original operations concept allowed space for spectra to be placed at five separate Lifetime Positions (LPs) on the detector, and the last of these will become operational in October 2021. Recent investigations into extending the operations of COS beyond 2025 have led to the realization that the instrument is capable of supporting additional LPs if operational changes are adopted. As a result, we have begun planning for taking data at LP6, which will use an area on the detector originally thought to be unavailable, beginning in 2022. Exploratory work for this effort began in late 2020, and additional characterization and calibration will continue over the next year. Here we discuss our plans for operating COS at LP6 and beyond.

Author(s): Jacob, Christopher G; Thuy-Nhien, Nguyen; Mayxay, Mayfong; Maude, Richard J; Quang, Huynh Hong; Hongvanthong, Bouasy; Vanisaveth, Viengxay; Ngo Duc, Thang; Rekol, Huy; van der Pluijm, Rob; von Seidlein, Lorenz; Fairhurst, Rick; Nosten, Francois; Hossain, Md Amir; Park, Naomi; Goodwin, Scott; Ringwald, Pascal; Chindavongsa, Keobouphaphone; Newton, Paul; Ashley, Elizabeth; Phalivong, Sonexay; Maude, Rapeephan; Leang, Rithea; Huch, Cheah; Dong, Le Thanh; Nguyen, Kim-Tuyen; Nhat, Tran Minh; Hien, Tran Tinh; Nguyen, Hoa; Zdrojewski, Nicole; Canavati, Sara; Sayeed, Abdullah Abu; Uddin, Didar; Buckee, Caroline; Fanello, Caterina I; Onyamboko, Marie; Peto, Thomas; Tripura, Rupam; Amaratunga, Chanaki; Myint Thu, Aung; Delmas, Gilles; Landier, Jordi; Parker, Daniel M; Chau, Nguyen Hoang; Lek, Dysoley; Suon, Seila; Callery, James; Jittamala, Podjanee; Hanboonkunupakarn, Borimas; Pukrittayakamee, Sasithon; Phyo, Aung Pyae; Smithuis, Frank; Lin, Khin; Thant, Myo; Hlaing, Tin Maung; Satpathi, Parthasarathi; Satpathi, Sanghamitra; Behera, Prativa K; Tripura, Amar; Baidya, Subrata; Valecha, Neena; Anvikar, Anupkumar R; Ul Islam, Akhter; Faiz, Abul; Kunasol, Chanon; Drury, Eleanor; Kekre, Mihir; Ali, Mozam; Love, Katie; Rajatileka, Shavanthi; Jeffreys, Anna E; Rowlands, Kate; Hubbart, Christina S; Dhorda, Mehul; Vongpromek, Ranitha; Kotanan, Namfon; Wongnak, Phrutsamon; Almagro Garcia, Jacob; Pearson, Richard D; Ariani, Cristina V; Chookajorn, Thanat; Malangone, Cinzia; Nguyen, T; Stalker, Jim; Jeffery, Ben | Abstract: BackgroundNational Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale surveillance projects by integrating simple sample collection procedures in routine public health procedures.MethodsSamples from symptomatic patients are processed by SpotMalaria, a high-throughput system that produces a comprehensive set of genotypes comprising several drug resistance markers, species markers and a genomic barcode. GenRe-Mekong delivers Genetic Report Cards, a compendium of genotypes and phenotype predictions used to map prevalence of resistance to multiple drugs.ResultsGenRe-Mekong has worked with NMCPs and research projects in eight countries, processing 9623 samples from clinical cases. Monitoring resistance markers has been valuable for tracking the rapid spread of parasites resistant to the dihydroartemisinin-piperaquine combination therapy. In Vietnam and Laos, GenRe-Mekong data have provided novel knowledge about the spread of these resistant strains into previously unaffected provinces, informing decision-making by NMCPs.ConclusionsGenRe-Mekong provides detailed knowledge about drug resistance at a local level, and facilitates data sharing at a regional level, enabling cross-border resistance monitoring and providing the public health community with valuable insights. The project provides a rich open data resource to benefit the entire malaria community.FundingThe GenRe-Mekong project is funded by the Bill and Melinda Gates Foundation (OPP11188166, OPP1204268). Genotyping and sequencing were funded by the Wellcome Trust (098051, 206194, 203141, 090770, 204911, 106698/B/14/Z) and Medical Research Council (G0600718). A proportion of samples were collected with the support of the UK Department for International Development (201900, M006212), and Intramural Research Program of the National Institute of Allergy and Infectious Diseases.

Post-starburst galaxies, identified by their unusually strong Balmer absorption lines and weaker than average emission lines, have traditionally been selected based on their central stellar populations. Here we identify 360 galaxies with post-starburst regions from the MaNGA integral field survey and classify these galaxies into three types: 31 galaxies with central post-starburst regions (CPSB), 37 galaxies with off-center ring-like post-starburst regions (RPSB) and 292 galaxies with irregular post-starburst regions (IPSB). Focussing on the CPSB and RPSB samples, and comparing their radial gradients in D$_n$4000, H$\delta_{\rm A}$ and W(H$\alpha$) to control samples, we find that while the CPSBs have suppressed star formation throughout their bulge and disk, and clear evidence of rapid decline of star formation in the central regions, the RPSBs only show clear evidence of recently rapidly suppressed star formation in their outer regions and an ongoing central starburst. The radial profiles in mass-weighted age and stellar $v/\sigma$ indicate that CPSBs and RPSBs are not simply different evolutionary stages of the same event, rather that CPSB galaxies are caused by a significant disruptive event, while RPSB galaxies are caused by disruption of gas fuelling to the outer regions. Compared to the control samples, both CPSB and RPSB galaxies show a higher fraction of interactions/mergers, misaligned gas or bars that might be the cause of the gas inflows and subsequent quenching., Comment: 17 pages, 10 figures

How do galaxies transform from blue, star-forming spirals to red, quiescent early-type galaxies? To answer this question, we analyzed a set of 26 gas-rich, shocked post-starburst galaxies with Hubble Space Telescope (HST) imaging in B, I, and H bands, and Sloan Digital Sky Survey (SDSS) i-band imaging of similar depth but lower resolution. We found that post-starbursts in our sample have intermediate morphologies between disk- and bulge-dominated (S\'ersic n$=1.7^{+0.3}_{-0.0}$) and have red bulges, likely due to dust obscuration in the cores. Majority of galaxies in our sample are more morphologically disturbed than regular galaxies (88%, corresponding to >3$\sigma$ significance) when observed with HST, with asymmetry and S\'ersic residual flux fraction being the most successful measures of disturbance. Most disturbances are undetected at the lower resolution of SDSS imaging. Although ~27% galaxies are clear merger remnants, we found that disturbances in another ~30% of the sample are internal, caused by small-scale perturbations or dust substructures rather than tidal features, and require high-resolution imaging to detect. We found a 2.8$\sigma$ evidence that asymmetry features fade on timescales ~200 Myr, and may vanish entirely after ~750 Myr, so we do not rule out a possible merger origin of all post-starbursts given that asymmetric features may have already faded. This work highlights the importance of small-scale disturbances, detected only in high-resolution imaging, in understanding structural evolution of transitioning galaxies., Comment: 31 pages, 19 figures, 2 figure sets, 1 machine-readable table; accepted to ApJ

We present the first study of the large-scale clustering of post-starburst (PSB) galaxies in the high redshift Universe ($0.510^{14}$M$_{\odot}$), suggesting they are likely to be infalling satellite galaxies in cluster-like environments. High-mass PSB galaxies are more weakly clustered at low redshifts, but they reside in higher mass haloes with increasing look-back time, suggesting strong redshift-dependent halo downsizing. These key results are consistent with previous results suggesting that two main channels are responsible for the rapid quenching of galaxies. While high-redshift ($z>1$) galaxies appear to be quenched by secular feedback mechanisms, processes associated with dense environments are likely to be the key driver of rapid quenching in the low-redshift Universe ($z, Comment: 19 pages, 9 figures, 3 tables; accepted for publication in MNRAS. Comments/questions welcome: please send queries to aaron.wilkinson91@gmail.com

Host genetic factors can confer resistance against malaria, raising the question of whether this has led to evolutionary adaptation of parasite populations. In this study we investigated the correlation between host and parasite genetic variation in 4,171 Gambian and Kenya children ascertained with severe malaria due to Plasmodium falciparum. We identified a strong association between sickle haemoglobin (HbS) in the host and variation in three regions of the parasite genome, including nonsynonymous variants in the acyl-CoA synthetase family member PfACS8 on chromosome 2, in a second region of chromosome 2, and in a region containing structural variation on chromosome 11. The HbS-associated parasite alleles are in strong linkage disequilibrium and have frequencies which covary with the frequency of HbS across populations, in particular being much more common in Africa than other parts of the world. The estimated protective effect of HbS against severe malaria, as determined by comparison of cases with population controls, varies greatly according to the parasite genotype at these three loci. These findings open up a new avenue of enquiry into the biological and epidemiological significance of the HbS-associated polymorphisms in the parasite genome, and the evolutionary forces that have led to their high frequency and strong linkage disequilibrium in African P. falciparum populations.

Vector population control using insecticides is a key element of current strategies to prevent malaria transmission in Africa. The introduction of effective insecticides, such as the organophosphate pirimiphos-methyl, is essential to overcome the recurrent emergence of resistance driven by the highly diverse Anopheles genomes. Here, we use a population genomic approach to investigate the basis of pirimiphos-methyl resistance in the major malaria vectors Anopheles gambiae and A. coluzzii. A combination of copy number variation and a single non-synonymous substitution in the acetylcholinesterase gene, Ace1, provides the key resistance diagnostic in an A. coluzzii population from Côte d’Ivoire that we used for sequence-based association mapping, with replication in other West African populations. The Ace1 substitution and duplications occur on a unique resistance haplotype that evolved in A. gambiae and introgressed into A. coluzzii, and is now common in West Africa primarily due to selection imposed by other organophosphate or carbamate insecticides. Our findings highlight the predictive value of this complex resistance haplotype for phenotypic resistance and clarify its evolutionary history, providing tools to for molecular surveillance of the current and future effectiveness of pirimiphos-methyl based interventions., Author summary Control of mosquito populations via insecticidal tools or interventions is a mainstay of campaigns to reduce malaria transmission. However, especially in sub-Saharan Africa, continued insecticidal selection pressure on the most important species of Anopheles malaria mosquitoes has favoured the evolutionary selection of increasingly effective resistance mechanisms. We investigate the genetic basis of resistance to the organophosphate pirimiphos-methyl, the dominant insecticide now used for indoor residual spraying campaigns in Africa. Genome-wide association analysis of a population from Cote d’Ivoire showed that resistant specimens share a unique combination of mutations in one gene, the acetylcholinesterase enzyme, which constitute the prime cause of pirimiphos-methyl resistance. Further testing of these mutations in diagnostic assays involving two major malaria vectors, A. coluzzii and A. gambiae, validate their use as informative predictors of pirimiphos-methyl resistance. Using data from a large collection of whole genome sequenced specimens from a broader range of locations (Burkina-Faso, Côte d’Ivoire, Ghana, and Guinea), our evolutionary analyses demonstrate that these mutations emerged in A. gambiae and transferred into A. coluzzii by inter-specific hybridisation. Our results show how resistance mechanisms in key malaria vectors have developed and spread, and provide validated tools for molecular surveillance to inform public health campaigns.

Post-starburst (PSB), or 'E+A', galaxies represent a rapid transitional phase between major, gas-rich mergers and gas-poor, quiescent early-type galaxies. Surprisingly, many PSBs have been shown to host a significant interstellar medium (ISM), despite theoretical predictions that the majority of star-forming gas should be expelled in AGN- or starburst-driven outflows. To-date, the resolved properties of this surviving ISM have remained unknown. We present high resolution ALMA continuum and CO(2$-$1) observations in six gas- and dust-rich PSBs, revealing for the first time the spatial and kinematic structure of their ISM on sub-kpc scales. We find extremely compact molecular reservoirs, with dust and gas surface densities rivaling those found in (ultra-)luminous infrared galaxies. We observe spatial and kinematic disturbances in all sources, with some also displaying disk-like kinematics. Estimates of the internal turbulent pressure in the gas exceed those of normal star-forming disks by at least 2 orders of magnitude, and rival the turbulent gas found in local interacting galaxies, such as the Antennae. Though the source of this high turbulent pressure remains uncertain, we suggest that the high incidence of tidal disruption events (TDEs) in PSBs could play a role. The star formation in these PSBs' turbulent central molecular reservoirs is suppressed, forming stars only 10% as efficiently as starburst galaxies with similar gas surface densities. "The fall" of star formation in these galaxies was not precipitated by complete gas expulsion or redistribution. Rather, this high-resolution view of PSBs' ISM indicates that star formation in their remaining compact gas reservoirs is suppressed by significant turbulent heating., Comment: 19 pages, 9 figures, 3 tables; Accepted for publication in ApJ

This paper documents the 16th data release (DR16) from the Sloan Digital Sky Surveys (SDSS), the fourth and penultimate from the fourth phase (SDSS-IV). This is the first release of data from the Southern Hemisphere survey of the Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2); new data from APOGEE-2 North are also included. DR16 is also notable as the final data release for the main cosmological program of the Extended Baryon Oscillation Spectroscopic Survey (eBOSS), and all raw and reduced spectra from that project are released here. DR16 also includes all the data from the Time Domain Spectroscopic Survey and new data from the SPectroscopic IDentification of ERosita Survey programs, both of which were co-observed on eBOSS plates. DR16 has no new data from the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey (or the MaNGA Stellar Library "MaStar"). We also preview future SDSS-V operations (due to start in 2020), and summarize plans for the final SDSS-IV data release (DR17)., Funding for the Sloan Digital Sky Survey IV has been provided by the Alfred P. Sloan Foundation, the U.S. Department of Energy Office of Science, and the Participating Institutions. SDSS-IV acknowledges support and resources from the Center for High-Performance Computing at the University of Utah. The SDSS website is www.sdss.org.

The large Integral Field Spectroscopy surveys have allowed the classification of ionizing sources of emission lines on sub-kiloparsec scales. In this work, we define two non-parametric parameters, quiescence (F q ) and its concentration (C q ), to quantify the strength and the spatial distribution of the quenched areas, respectively, traced by the LI(N)ER regions with low EW(Hα). With these two measurements, we classify MaNGA galaxies into inside-out and outside-in quenching types according to their locations on the F q versus C q plane and we measure the fraction of inside-out (outside-in) quenching galaxies as a function of halo mass. We find that the fraction of galaxies showing inside-out quenching increases with halo mass, irrespective of stellar mass or galaxy type (satellites versus centrals). In addition, high-stellar-mass galaxies exhibit a greater fraction of inside-out quenching compared to low-stellar-mass ones in all environments. In contrast, the fraction of outside-in quenching does not depend on halo mass. Our results suggest that morphological quenching may be responsible for the inside-out quenching seen in all environments. On the other hand, the flat dependence of the outside-in quenching on halo mass could be a mixed result of ram pressure stripping and galaxy mergers. Nevertheless, for a given environment and stellar mass, the fraction of inside-out quenching is systematically greater than that of outside-in quenching, suggesting that inside-out quenching is the dominant quenching mode in all environments.

One key problem in astrophysics is understanding how and why galaxies switch off their star formation, building the quiescent population that we observe in the local Universe. From the GAMA and VIPERS surveys, we use spectroscopic indices to select quiescent and candidate transition galaxies. We identify potentially rapidly transitioning post-starburst galaxies, and slower transitioning green-valley galaxies. Over the last 8 Gyrs the quiescent population has grown more slowly in number density at high masses (M$_*>10^{11}$M$_\odot$) than at intermediate masses (M$_*>10^{10.6}$M$_\odot$). There is evolution in both the post-starburst and green valley stellar mass functions, consistent with higher mass galaxies quenching at earlier cosmic times. At intermediate masses (M$_*>10^{10.6}$M$_\odot$) we find a green valley transition timescale of 2.6 Gyr. Alternatively, at $z\sim0.7$ the entire growth rate could be explained by fast-quenching post-starburst galaxies, with a visibility timescale of 0.5 Gyr. At lower redshift, the number density of post-starbursts is so low that an unphysically short visibility window would be required for them to contribute significantly to the quiescent population growth. The importance of the fast-quenching route may rapidly diminish at $z10^{11}$M$_\odot$), there is tension between the large number of candidate transition galaxies compared to the slow growth of the quiescent population. This could be resolved if not all high mass post-starburst and green-valley galaxies are transitioning from star-forming to quiescent, for example if they rejuvenate out of the quiescent population following the accretion of gas and triggering of star formation, or if they fail to completely quench their star formation., Comment: 19 pages, 11 figures, 3 tables. Accepted for publication in MNRAS. Updated to match published version

The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease(1). To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.

The origin of the star forming main sequence ( i.e., the relation between star formation rate and stellar mass, globally or on kpc-scales; hereafter SFMS) remains a hotly debated topic in galaxy evolution. Using the ALMA-MaNGA QUEnching and STar formation (ALMaQUEST) survey, we show that for star forming spaxels in the main sequence galaxies, the three local quantities, star-formation rate surface density (\sigsfr), stellar mass surface density (\sigsm), and the \h2~mass surface density (\sigh2), are strongly correlated with one another and form a 3D linear (in log) relation with dispersion. In addition to the two well known scaling relations, the resolved SFMS (\sigsfr~ vs. \sigsm) and the Schmidt-Kennicutt relation (\sigsfr~ vs. \sigh2; SK relation), there is a third scaling relation between \sigh2~ and \sigsm, which we refer to as the `molecular gas main sequence' (MGMS). The latter indicates that either the local gas mass traces the gravitational potential set by the local stellar mass or both quantities follow the underlying total mass distributions. The scatter of the resolved SFMS ($\sigma \sim 0.25$ dex) is the largest compared to those of the SK and MGMS relations ($\sigma \sim$ 0.2 dex). A Pearson correlation test also indicates that the SK and MGMS relations are more strongly correlated than the resolved SFMS. Our result suggests a scenario in which the resolved SFMS is the least physically fundamental and is the consequence of the combination of the SK and the MGMS relations., Comment: 4 figures, 1 table, accepted by ApJL

We present the HI-MaNGA programme of HI follow-up for the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey. MaNGA, which is part of the Fourth phase of the Sloan Digital Sky Surveys (SDSS-IV), is in the process of obtaining integral field unit (IFU) spectroscopy for a sample of ~10,000 nearby galaxies. We give an overview of the HI 21cm radio follow-up observing plans and progress and present data for the first 331 galaxies observed in the 2016 observing season at the Robert C. Bryd Green Bank Telescope (GBT). We also provide a cross match of the current MaNGA (DR15) sample with publicly available HI data from the Arecibo Legacy Fast Arecibo L-band Feed Array (ALFALFA) survey. The addition of HI data to the MaNGA data set will strengthen the survey's ability to address several of its key science goals that relate to the gas content of galaxies, while also increasing the legacy of this survey for all extragalactic science., 11 pages, 7 figures. MNRAS accepted version

We present a method of fitting optical spectra of galaxies using a basis set of six vectors obtained from principal component analysis (PCA) of a library of synthetic spectra of 40000 star formation histories (SFHs). Using this library, we provide estimates of resolved effective stellar mass-to-light ratio ($\log \Upsilon^*$) for thousands of galaxies from the SDSS-IV/MaNGA integral-field spectroscopic survey. Using a testing framework built on additional synthetic SFHs, we show that the estimates of stellar mass-to-light ratio are reliable (as are their uncertainties) at a variety of signal-to-noise ratios, stellar metallicities, and dust attenuation conditions. Finally, we describe the future release of the resolved stellar mass-to-light ratios as a SDSS-IV/MaNGA Value-Added Catalog (VAC) and provide a link to the software used to conduct this analysis.

We conducted a genome-wide association study of host resistance to severePlasmodium falciparummalaria in over 17,000 individuals from 11 malaria-endemic countries, undertaking a wide ranging analysis which identifies five replicable associations with genome-wide levels of evidence. Our findings include a newly implicated variant on chromosome 6 associated with risk of cerebral malaria, and the discovery of an erythroid-specific transcription start site underlying the association inATP2B4. Previously reported HLA associations cannot be replicated in this dataset. We estimate substantial heritability of severe malaria (h2~ 23%), of which around 10% is explained by the currently identified associations. Our dataset will provide a major building block for future research on the genetic determinants of disease in these diverse human populations.

Unresolved gas and dust observations show a surprising diversity in the amount of interstellar matter in early-type galaxies. Using ALMA observations we resolve the ISM in z$\sim$0.05 early-type galaxies. From a large sample of early-type galaxies detected in the Herschel Astrophysical Terahertz Large Area Survey (H-ATLAS) we selected five of the dustiest cases, with dust masses M$_d\sim$several$\times10^7$M$_\odot$, with the aim of mapping their submillimetre continuum and $^{12}$CO(2-1) line emission distributions. These observations reveal molecular gas disks. There is a lack of associated, extended continuum emission in these ALMA observations, most likely because it is resolved out or surface brightness limited, if the dust distribution is as extended as the CO gas. However, two galaxies have central continuum ALMA detections. An additional, slightly offset, continuum source is revealed in one case, which may have contributed to confusion in the Herschel fluxes. Serendipitous continuum detections further away in the ALMA field are found in another case. Large and massive rotating molecular gas disks are mapped in three of our targets, reaching a few$\times10^{9}$M$_\odot$. One of these shows evidence of kinematic deviations from a pure rotating disc. The fields of our two remaining targets contain only smaller, weak CO sources, slightly offset from the optical galaxy centres. These may be companion galaxies seen in ALMA observations, or background objects. These heterogeneous findings in a small sample of dusty early-type galaxies reveal the need for more such high spatial resolution studies, to understand statistically how dust and gas are related in early-type galaxies., Comment: 15 pages, 10 figures, 3 tables, accepted for publication in MNRAS

An important aspect of quenching star formation is the removal of the cold interstellar medium (ISM; non-ionised gas and dust) from a galaxy. In addition, dust grains can be destroyed in a hot or turbulent medium. The adopted timescale of dust removal usually relies on uncertain theoretical estimates. It is tricky to track the dust removal, because usually dust is constantly replenished by consecutive generations of stars. Our objective is to measure observationally the timescale of dust removal. We here explore an approach to select galaxies which do have detectable amounts of dust and cold ISM but exhibit a low current dust production rate. Any decrease of the dust and gas content as a function of the age of such galaxies therefore must be attributed to processes governing the ISM removal. We used a sample of galaxies detected by Herschel in the far-infrared with visually assigned early-type morphology or spirals with red colours. We also obtained JCMT/SCUBA-2 observations for five of them. We discovered an exponential decline of the dust-to-stellar mass ratio with age, which we interpret as an evolutionary trend of dust removal from these galaxies. For the first time we directly measure the dust removal timescale in such galaxies to be tau=(2.5+-0.4) Gyr (the corresponding half-life time is (1.75+-0.25) Gyr). This quantity may be used in models in which it must be assumed a priori and cannot be derived. Any process which removes dust in these galaxies, such as dust grain destruction, cannot happen on shorter timescales. The timescale is comparable to the quenching timescales found in simulations for galaxies with similar stellar masses. The dust is likely of internal, not external origin. It was either formed in the past directly by supernovae, or from seeds produced by SNe and with grain growth in the ISM contributing substantially to the dust mass accumulation., Comment: Astronomy & Astrophysics, accepted; 13 pages, 9 figures, 1 table

We investigate the prevalence of galactic-scale outflows in post-starburst (PSB) galaxies at high redshift ($1 < z < 1.4$), using the deep optical spectra available in the UKIDSS Ultra Deep Survey (UDS). We use a sample of $\sim40$ spectroscopically confirmed PSBs, recently identified in the UDS field, and perform a stacking analysis in order to analyse the structure of strong interstellar absorption features such as Mg ii ($\lambda2800$ Ang.). We find that for massive ($M_* > 10^{10}\rm\,M_{\odot}$) PSBs at $z > 1$, there is clear evidence for a strong blue-shifted component to the Mg ii absorption feature, indicative of high-velocity outflows ($v_{\rm out}\sim1150\pm160\rm\,km\,s^{-1}$) in the interstellar medium. We conclude that such outflows are typical in massive PSBs at this epoch, and potentially represent the residual signature of a feedback process that quenched these galaxies. Using full spectral fitting, we also obtain a typical stellar velocity dispersion $��_*$ for these PSBs of $\sim200\rm\,km\,s^{-1}$, which confirms they are intrinsically massive in nature (dynamical mass $M_{\rm d}\sim10^{11}\rm\,M_{\odot}$). Given that these high-$z$ PSBs are also exceptionally compact ($r_{\rm e}\sim1$--$2\rm\,kpc$) and spheroidal (Sersic index $n\sim3$), we propose that the outflowing winds may have been launched during a recent compaction event (e.g. major merger or disc collapse) that triggered either a centralised starburst or active galactic nuclei (AGN) activity. Finally, we find no evidence for AGN signatures in the optical spectra of these PSBs, suggesting they were either quenched by stellar feedback from the starburst itself, or that if AGN feedback is responsible, the AGN episode that triggered quenching does not linger into the post-starburst phase., 13 pages, 6 figures, accepted for publication in MNRAS

Over half of disk galaxies are barred, yet the mechanisms for bar formation and the life-time of bar buckling remain poorly understood. In simulations, a thin bar undergoes a rapid (, 22 pages, 12 figures. Accepted for publication in ApJ

We combine Herschel/SPIRE sub-millimeter (submm) observations with existing multi-wavelength data to investigate the characteristics of low redshift, optically red galaxies detected in submm bands. We select a sample of galaxies in the redshift range 0.01$\leq$z$\leq$0.2, having >5$\sigma$ detections in the SPIRE 250 micron submm waveband. Sources are then divided into two sub-samples of $red$ and $blue$ galaxies, based on their UV-optical colours. Galaxies in the $red$ sample account for $\approx$4.2 per cent of the total number of sources with stellar masses M$_{*}\gtrsim$10$^{10}$ Solar-mass. Following visual classification of the $red$ galaxies, we find that $\gtrsim$30 per cent of them are early-type galaxies and $\gtrsim$40 per cent are spirals. The colour of the $red$-spiral galaxies could be the result of their highly inclined orientation and/or a strong contribution of the old stellar population. It is found that irrespective of their morphological types, $red$ and $blue$ sources occupy environments with more or less similar densities (i.e., the $\Sigma_5$ parameter). From the analysis of the spectral energy distributions (SEDs) of galaxies in our samples based on MAGPHYS, we find that galaxies in the $red$ sample (of any morphological type) have dust masses similar to those in the $blue$ sample (i.e. normal spiral/star-forming systems). However, in comparison to the $red$-spirals and in particular $blue$ systems, $red$-ellipticals have lower mean dust-to-stellar mass ratios. Besides galaxies in the $red$-elliptical sample have much lower mean star-formation/specific-star-formation rates in contrast to their counterparts in the $blue$ sample. Our results support a scenario where dust in early-type systems is likely to be of an external origin., Comment: Accepted for publication in MNRAS - Paper without gallery of galaxy post-stamp images (in appendix). Full paper with appendix is available here: http://www.ast.cam.ac.uk/~adariush/hatlas_alidariush_20151125.pdf

The morphology-density relationship states that dense cosmic environments such as galaxy clusters have an overabundance of quiescent elliptical galaxies, but it is unclear at which redshift this relationship is first established. We study the morphology of 4 clusters with $1.2

JINGLE is a new JCMT legacy survey designed to systematically study the cold interstellar medium of galaxies in the local Universe. As part of the survey we perform 850um continuum measurements with SCUBA-2 for a representative sample of 193 Herschel-selected galaxies with M*>10^9Msun, as well as integrated CO(2-1) line fluxes with RxA3m for a subset of 90 of these galaxies. The sample is selected from fields covered by the Herschel-ATLAS survey that are also targeted by the MaNGA optical integral-field spectroscopic survey. The new JCMT observations combined with the multi-wavelength ancillary data will allow for the robust characterization of the properties of dust in the nearby Universe, and the benchmarking of scaling relations between dust, gas, and global galaxy properties. In this paper we give an overview of the survey objectives and details about the sample selection and JCMT observations, present a consistent 30 band UV-to-FIR photometric catalog with derived properties, and introduce the JINGLE Main Data Release (MDR). Science highlights include the non-linearity of the relation between 850um luminosity and CO line luminosity, and the serendipitous discovery of candidate z>6 galaxies., MNRAS in press, 25 pages

Post-starburst galaxies are typically considered to be a transition population, en route to the red sequence after a recent quenching event. Despite this, recent observations have shown that these objects typically have large reservoirs of cold molecular gas. In this paper we study the star-forming gas properties of a large sample of post-starburst galaxies selected from the cosmological, hydrodynamical EAGLE simulations. These objects resemble observed high-mass post-starburst galaxies both spectroscopically and in terms of their space density, stellar mass distribution and sizes. We find that the vast majority of simulated post-starburst galaxies have significant gas reservoirs, with star-forming gas masses of ~10$^9$ M$_{\odot}$, in good agreement with those seen in observational samples. The simulation reproduces the observed time evolution of the gas fraction of the post-starburst galaxy population, with the average galaxy losing ~90 per cent of its star-forming interstellar medium in only ~600 Myr. A variety of gas consumption/loss processes are responsible for this rapid evolution, including mergers and environmental effects, while active galactic nuclei play only a secondary role. The fast evolution in the gas fraction of post-starburst galaxies is accompanied by a clear decrease in the efficiency of star formation, due to a decrease in the dense gas fraction. We predict that forthcoming ALMA observations of the gas reservoirs of low-redshift post-starburst galaxies will show that the molecular gas is typically compact and has disturbed kinematics, reflecting the disruptive nature of many of the evolutionary pathways that build up the post-starburst galaxy population., 15 pages, 17 figures, MNRAS accepted

The Herschel-ATLAS unbiased survey of cold dust in the local Universe is dominated by a surprising population of very blue (FUV-K < 3.5), dust-rich galaxies with high gas fractions (f_HI = M_HI/(M*+M_HI)>0.5)). Dubbed `Blue and Dusty Gas Rich Sources' (BADGRS) they have cold diffuse dust temperatures, and the highest dust-to-stellar mass ratios of any galaxies in the local Universe. Here, we explore the molecular ISM in a representative sample of BADGRS, using very deep CO(J_up=1,2,3) observations across the central and outer disk regions. We find very low CO brightnesses (Tp=15-30 mK), despite the bright far-infrared emission and metallicities in the range 0.5, Comment: 22 pages

Post-starburst galaxies can be identified via the presence of prominent Hydrogen Balmer absorption lines in their spectra. We present a comprehensive study of the origin of strong Balmer lines in a volume-limited sample of 189 galaxies with $0.019.5$ and projected axis ratio $b/a>0.32$. We explore their structural properties, environments, emission lines and star formation histories, and compare them to control samples of star-forming and quiescent galaxies, and simulated galaxy mergers. Excluding contaminants, in which the strong Balmer lines are most likely caused by dust-star geometry, we find evidence for three different pathways through the post-starburst phase, with most events occurring in intermediate-density environments: (1) a significant disruptive event, such as a gas-rich major merger, causing a starburst and growth of a spheroidal component, followed by quenching of the star formation (70% of post-starburst galaxies at $9.510.5$); (2) at $9.510.5$, cyclic evolution of quiescent galaxies which gradually move towards the high-mass end of the red sequence through weak starbursts, possibly as a result of a merger with a smaller gas-rich companion (40%). Our analysis suggests that AGN are `on' for $50%$ of the duration of the post-starburst phase, meaning that traditional samples of post-starburst galaxies with strict emission line cuts will be at least $50%$ incomplete due to the exclusion of narrow-line AGN., Comment: Accepted by MNRAS; 19 figures, 39 pages