1. Feeding blueberry diets inhibits angiotensin II-converting enzyme (ACE) activity in spontaneously hypertensive stroke-prone rats
- Author
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Katherine BallemK. Ballem, Jennifer M. EganJ.M. Egan, Waylon WisemanW. Wiseman, Jennifer E. Slemmer, Kevin S. Shaughnessy, Katherine Gottschall-Pass, and Marva I. Sweeney
- Subjects
Male ,medicine.medical_specialty ,Physiology ,Flavonoid ,Blueberry Plants ,Peptide hormone ,Peptidyl-Dipeptidase A ,Rats, Inbred WKY ,Food-Drug Interactions ,Random Allocation ,Physiology (medical) ,Internal medicine ,Rats, Inbred SHR ,Renin–angiotensin system ,medicine ,Animals ,Protease Inhibitors ,Stroke ,Antihypertensive Agents ,Pharmacology ,chemistry.chemical_classification ,biology ,business.industry ,Angiotensin-converting enzyme ,General Medicine ,medicine.disease ,Angiotensin II ,Diet ,Rats ,Endocrinology ,Enzyme ,Blood pressure ,chemistry ,biology.protein ,Angiotensin-Converting Enzyme 2 ,business - Abstract
Feeding flavonoid-rich blueberries to spontaneously hypertensive stroke-prone rats (SHRSP) lowers blood pressure. To determine whether this is due to inhibition of angiotensin-converting enzyme (ACE) activity, as seen with other flavanoid-rich foods, we fed blueberries to SHRSP and normotensive rats and analyzed ACE activity in blood and tissues. After 2 weeks on a control diet, the hypertensive rats showed 56% higher levels of ACE activity in blood as compared with the normotensive rats (p
- Published
- 2010