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2. Allergen skin test responses in broad U.S. asthma population in those with and without rhinitis.

Author

Katial, John M., Hoyte, Flavia C. L., Khatiwada, Aastha, and Katial, Rohit K.

Subjects
ASTHMATICS, SKIN tests, ASTHMA, RHINITIS, ALLERGENS, SEASONAL variations of diseases, IMMUNOGLOBULIN E, ATOPY
Abstract

Background: Asthma and allergic rhinitis are pathologically interlinked conditions. Despite skin testing (ST) being pivotal for evaluating allergic sensitization, U.S. data that date back to 1960s on ST reactivity patterns in subjects with asthma remain sparse. Objective: The purpose of this study was to elucidate seasonal, perennial ST responses, and their relationship with asthma severity, early versus late onset disease, and immunoglobulin E (IgE) levels. Methods: Five hundred patients with asthma were randomly selected from the National Jewish Health electronic medical record over a 3-year span. Demographic, clinical, and allergen ST reactivity data for a battery of seasonal and perennial allergens were procured, including total IgE levels, asthma onset, and severity, by using t-tests, x² tests, and Analysis of Variance (ANOVA), patterns of reactivity were assessed for overall, seasonal, and perennial allergens in relation to IgE levels, asthma onset, and severity. Results: Of the 500 patients, 398 were analyzed. 63.3% were women, 50.1% had adult-onset asthma, and 86.1% had rhinitis; 75.3% tested positive to one or more allergens, with men demonstrating higher overall (p = 0.039) and perennial (p = 0.035) sensitization. ST reactivity varied based on the presence of rhinitis for seasonal (p = 0.028) but not perennial (p = 0.733) allergens. Asthma severity was not significantly associated with ST reactivity (p > 0.10). ST positivity for perennial (p < 0.001) but not seasonal (p = 0.128) allergens was higher in childhood-onset asthma versus adult-onset asthma despite both groups having a large percentage of reactors. Elevated IgE levels correlated with ST reactivity (p < 0.01). Conclusion: Our study represents a unique comprehensive evaluation of ST reactivity in a U.S. asthma population, which is lacking in the literature, when factoring in asthma onset, severity, and IgE levels. Our findings underscore the importance of allergen sensitization in asthma, regardless of severity, concurrent rhinitis symptoms, or asthma onset, which challenge some of the prevailing assumptions about the relationship between allergen sensitization and asthma onset. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Adult Asthma

Author

Hoyte, Flavia CL, primary, Choo, Eugene M, additional, and Katial, Rohit K, additional

Published
2021
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9. Association Between Elevated Blood Eosinophils and Chronic Kidney Disease Progression: Analyses of a Large United States Electronic Health Records Database.

Author

Kielar, Danuta, Jones, Andrew M, Wang, Xia, Stirnadel-Farrant, Heide, Katial, Rohit K, Bansal, Abhinav, Garg, Manu, Sharma, Chandrakant, Thakar, Shubhankar, and Ye, Qin

Subjects
ELECTRONIC health records, CHRONIC kidney failure, DATABASES, EOSINOPHILS, DISEASE risk factors
Abstract

Objective of this study was to assess the relationship between blood eosinophil counts (bEOS) and CKD progression, adjusting for clinical and demographic features as well as known risk factors for CKD stages 3– 4. The primary outcomes were CKD progression and all-cause mortality.Results: We found that high eosinophilic levels (bEOS ≥ 300 cells/μL) were associated with CKD progression from stage 3 to stages 4 or 5 (hazard ratio [HR] ranging from 1.30 to 1.50) and from stages 4 to 5 (HR ranging from 1.28 to 1.50). Among patients with CKD progression, those with blood eosinophils ≥ 300 cells/μL appeared to have a relatively lower eGFR, higher all-cause mortality, and reduced time to CKD progression and death than those with < 300 cells/μL. Factors including sex, race, hypertension, anemia, and treatments for cardiovascular and hematopoietic drugs were associated with CKD progression.Conclusion: Elevated eosinophils may increase the risk for CKD progression. Larger studies are needed to assess whether the risk of mortality is increased among patients with elevated eosinophils. [ABSTRACT FROM AUTHOR]

Published
2023
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17. List of Contributors

Author

Bacharier, Leonard B., primary, Barberis, Nicole, additional, Burckart, Gilbert J., additional, Busse, William W., additional, Carr, Tara F., additional, Castro, Mario, additional, Chung, Kian Fan, additional, Cicutto, Lisa, additional, Elie, Marc, additional, Fitzpatrick, Anne M., additional, Federico, Monica J., additional, Gaefke, Claudia L., additional, Green, Dionna, additional, Haahtela, Tari, additional, Hall, Chase, additional, Hoch, Heather, additional, Holguin, Fernando, additional, Huang, Yvonne J., additional, Johnston, Katherine, additional, Katial, Rohit K., additional, Liu, Andrew H., additional, Malka, Jonathan, additional, Nkrumah-Elie, Yasmeen, additional, Ortega, Victor E., additional, Pennington, Emily J., additional, Permaul, Perdita, additional, Phipatanakul, Wanda, additional, Reisdorph, Nichole, additional, Sears, Malcolm R., additional, Sood, Shweta, additional, Selroos, Olof, additional, Spahn, Joseph D., additional, Stokes, Jeffrey R., additional, Subbarao, Padmaja, additional, Szefler, Stanley J., additional, Wang, Eileen, additional, and Wechsler, Michael E., additional

Published
2018
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30. Effect of the S‐nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma

Author

Que, Loretta G., Yang, Zhonghui, Lugogo, Njira L., Katial, Rohit K., Shoemaker, Steven A., Troha, Janice M., Rodman, David M., Tighe, Robert M., and Kraft, Monica

Subjects
Adult, Male, S‐nitrosoglutathione reductase, N6022, Proof of Concept Study, Bronchial Provocation Tests, Bronchoconstrictor Agents, Placebos, Young Adult, Double-Blind Method, Forced Expiratory Volume, Humans, Pyrroles, Methacholine Chloride, Original Research, Cross-Over Studies, Middle Aged, Aldehyde Oxidoreductases, Asthma, respiratory tract diseases, Treatment Outcome, S‐nitrosoglutathione, Benzamides, S-Nitrosoglutathione, Administration, Intravenous, Female, Bronchial Hyperreactivity, mild asthma
Abstract

Rationale Patients with asthma demonstrate depletion of the endogenous bronchodilator GSNO and upregulation of GSNOR. Objectives An exploratory proof of concept clinical study of N6022 in mild asthma to determine the potential bronchoprotective effects of GSNOR inhibition. Mechanistic studies aimed to provide translational evidence of effect. Methods Fourteen mild asthma patients were treated with intravenous N6022 (5 mg) or placebo and observed for 7 days, with repeated assessments of the provocative dose of methacholine causing a 20% fall in FEV1 (methacholine PC20 FEV1), followed by a washout period and crossover treatment and observation. In vitro studies in isolated eosinophils investigated the effect of GSNO and N6022 on apoptosis. Measurements and Main Results This was a negative trial as it failed to reach its primary endpoint, which was change from baseline in methacholine PC20 FEV1 at 24 h. However, our exploratory analysis demonstrated significantly more two dose‐doubling increases in PC20 FEV1 for N6022 compared with placebo (21% vs 6%, P

Published
2018

34. Contributors

Author

Aeling, John L., primary, Arbuckle, H. Alan, additional, Bennion, Scott D., additional, Benson, Paul M., additional, Bigler, Carl F., additional, Brice, Sylvia L., additional, Brown, Mariah Ruth, additional, Burch, Joanna M., additional, Campoli, Michael R., additional, Chen, T. Minsue, additional, Corvette, Donna M., additional, Dapprich, Daniel C., additional, David-Bajar, Kathleen M., additional, Demidovich, Carl W., additional, Egnatios, Genevieve L., additional, Eubanks, Stephen W., additional, Fitzpatrick, James E., additional, Francis, Shayla, additional, Gerondale, Brian J., additional, Giandoni, Martin B., additional, Gilchrist, Heidi, additional, Golitz, Loren E., additional, Grammer-West, Nadja Y., additional, Green, Clayton B., additional, Grimwood, Ronald E., additional, Halbert, Anne R., additional, Henderson, Deborah B., additional, High, Whitney A., additional, Ince, Simone A., additional, James, William D., additional, Katial, Rohit K., additional, Keller, Richard A., additional, Klenk, Alison S., additional, Kobayashi, Todd T., additional, Li, Kehua, additional, Lowe, Lori, additional, Maier, Lisa E., additional, McGovern, Thomas W., additional, Meffert, Jeffrey J., additional, Mellette, J. Ramsey, additional, Miller, Misha D., additional, Morelli, Joseph G., additional, Muldrow, Margaret E., additional, Norton, Scott A., additional, O’Hara, Christina S., additional, Pacheco, Theresa R., additional, Patterson, James W., additional, Prado, Renata, additional, Prok, Lori D., additional, Reed, Barbara R., additional, Samlaska, Curt P., additional, Sayers, C. Paul, additional, Schleve, Milton J., additional, Schmidt, Dieter K.T., additional, Shurnas, Elizabeth R., additional, Spates, Stephen Thomas, additional, Speetzen, Larisa S., additional, Sperling, Leonard C., additional, Stewart, Leslie A., additional, Theriault, Alexandra, additional, Thompson, Paul B., additional, Travers, Jeffrey B., additional, Turiansky, George W., additional, Walsh, Patrick, additional, Warschaw, Karen E., additional, Weston, William L., additional, and Yohn, Joseph, additional

Published
2011
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37. Suggested updated approaches to patient management

Author

Katial, Rohit K., Meltzer, Eli O., Lieberman, Phil, Ratner, Paul H., Berger, William E., Kaliner, Michael A., Siegel, Charles J., Bukstein, Don A., Ciervo, Carman A., and Marple, Bradley

Published
2011

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