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1. The burden of heat-related mortality attributable to recent human-induced climate change

Author

Vicedo-Cabrera, A. M., Scovronick, N., Sera, F., Royé, D., Schneider, R., Tobias, A., Astrom, C., Guo, Y., Honda, Y., Hondula, D. M., Abrutzky, R., Tong, S., Coelho, M. de Sousa Zanotti Stagliorio, Saldiva, P. H. Nascimento, Lavigne, E., Correa, P. Matus, Ortega, N. Valdes, Kan, H., Osorio, S., Kyselý, J., Urban, A., Orru, H., Indermitte, E., Jaakkola, J. J. K., Ryti, N., Pascal, M., Schneider, A., Katsouyanni, K., Samoli, E., Mayvaneh, F., Entezari, A., Goodman, P., Zeka, A., Michelozzi, P., de’Donato, F., Hashizume, M., Alahmad, B., Diaz, M. Hurtado, Valencia, C. De La Cruz, Overcenco, A., Houthuijs, D., Ameling, C., Rao, S., Di Ruscio, F., Carrasco-Escobar, G., Seposo, X., Silva, S., Madureira, J., Holobaca, I. H., Fratianni, S., Acquaotta, F., Kim, H., Lee, W., Iniguez, C., Forsberg, B., Ragettli, M. S., Guo, Y. L. L., Chen, B. Y., Li, S., Armstrong, B., Aleman, A., Zanobetti, A., Schwartz, J., Dang, T. N., Dung, D. V., Gillett, N., Haines, A., Mengel, M., Huber, V., and Gasparrini, A.

Published
2021
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4. ABSTRACT ONLY - MEDICATION USE AND TRANSPORTATION NOISE EXPOSURE

Author

FLOUD, S, primary, HANSELL, A, additional, BLANGIARDO, M, additional, JARUP, L, additional, VIGNA-TAGLIANTI, F, additional, MATHIS, F, additional, HOUTHUIJS, D, additional, BREUGELMANS, O, additional, BABISCH, W, additional, KATSOUYANNI, K, additional, HARALABIDIS, A, additional, PERSHAGEN, G, additional, BLUHM, G, additional, PISANI, S, additional, LOCALE, AS, additional, and ANTONIOTTI, MC, additional

Published
2023
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7. Long-term air pollution exposure and malignant intracranial tumours of the central nervous system: a pooled analysis of six European cohorts

Author

Hvidtfeldt, UA, Chen, J, Rodopoulou, S, Strak, M, De Hoogh, K, Andersen, ZJ, Bellander, T, Brandt, J, Fecht, D, Forastiere, F, Gulliver, J, Hertel, O, Hoffmann, B, Katsouyanni, K, Ketzel, M, Leander, K, Magnusson, PKE, Nagel, G, Pershagen, G, Rizzuto, D, Samoli, E, So, R, Stafoggia, M, Tjønneland, A, Weinmayr, G, Wolf, K, Zhang, J, Zitt, E, Brunekreef, B, Hoek, G, and Raaschou-Nielsen, O

Abstract

BACKGROUND: Risk factors for malignant tumours of the central nervous system (CNS) are largely unknown. METHODS: We pooled six European cohorts (N = 302,493) and assessed the association between residential exposure to nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) and malignant intracranial CNS tumours defined according to the International Classification of Diseases ICD-9/ICD-10 codes 192.1/C70.0, 191.0-191.9/C71.0-C71.9, 192.0/C72.2-C72.5. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. RESULTS: During 5,497,514 person-years of follow-up (average 18.2 years), we observed 623 malignant CNS tumours. The results of the fully adjusted linear analyses showed a hazard ratio (95% confidence interval) of 1.07 (0.95, 1.21) per 10 μg/m³ NO2, 1.17 (0.96, 1.41) per 5 μg/m³ PM2.5, 1.10 (0.97, 1.25) per 0.5 10-5m-1 BC, and 0.99 (0.84, 1.17) per 10 μg/m³ O3. CONCLUSIONS: We observed indications of an association between exposure to NO2, PM2.5, and BC and tumours of the CNS. The PM elements were not consistently associated with CNS tumour incidence.

Published
2023

8. Particulate matter air pollution components and risk for lung cancer

Author

Raaschou-Nielsen, O., Beelen, R., Wang, M., Hoek, G., Andersen, Z.J., Hoffmann, B., Stafoggia, M., Samoli, E., Weinmayr, G., Dimakopoulou, K., Nieuwenhuijsen, M., Xun, W.W., Fischer, P., Eriksen, K.T., Sørensen, M., Tjønneland, A., Ricceri, F., de Hoogh, K., Key, T., Eeftens, M., Peeters, P.H., Bueno-de-Mesquita, H.B., Meliefste, K., Oftedal, B., Schwarze, P.E., Nafstad, P., Galassi, C., Migliore, E., Ranzi, A., Cesaroni, G., Badaloni, C., Forastiere, F., Penell, J., De Faire, U., Korek, M., Pedersen, N., Östenson, C.-G., Pershagen, G., Fratiglioni, L., Concin, H., Nagel, G., Jaensch, A., Ineichen, A., Naccarati, A., Katsoulis, M., Trichpoulou, A., Keuken, M., Jedynska, A., Kooter, I.M., Kukkonen, J., Brunekreef, B., Sokhi, R.S., Katsouyanni, K., and Vineis, P.

Published
2016
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9. Excess mortality attributed to heat and cold: a health impact assessment study in 854 cities in Europe

Author

Masselot, P. Mistry, M. Vanoli, J. Schneider, R. Iungman, T. Garcia-Leon, D. Ciscar, J.-C. Feyen, L. Orru, H. Urban, A. Breitner, S. Huber, V. Schneider, A. Samoli, E. Stafoggia, M. de'Donato, F. Rao, S. Armstrong, B. Nieuwenhuijsen, M. Vicedo-Cabrera, A.M. Gasparrini, A. Achilleos, S. Kyselý, J. Indermitte, E. Jaakkola, J.J.K. Ryti, N. Pascal, M. Katsouyanni, K. Analitis, A. Goodman, P. Zeka, A. Michelozzi, P. Houthuijs, D. Ameling, C. das Neves Pereira da Silva, S. Madureira, J. Holobaca, I.-H. Tobias, A. Íñiguez, C. Forsberg, B. Åström, C. Ragettli, M.S. Surname, F.N. Zafeiratou, S. Vazquez Fernandez, L. Monteiro, A. Rai, M. Zhang, S. Aunan, K. MCC Collaborative Research Network EXHAUSTION project and Masselot, P. Mistry, M. Vanoli, J. Schneider, R. Iungman, T. Garcia-Leon, D. Ciscar, J.-C. Feyen, L. Orru, H. Urban, A. Breitner, S. Huber, V. Schneider, A. Samoli, E. Stafoggia, M. de'Donato, F. Rao, S. Armstrong, B. Nieuwenhuijsen, M. Vicedo-Cabrera, A.M. Gasparrini, A. Achilleos, S. Kyselý, J. Indermitte, E. Jaakkola, J.J.K. Ryti, N. Pascal, M. Katsouyanni, K. Analitis, A. Goodman, P. Zeka, A. Michelozzi, P. Houthuijs, D. Ameling, C. das Neves Pereira da Silva, S. Madureira, J. Holobaca, I.-H. Tobias, A. Íñiguez, C. Forsberg, B. Åström, C. Ragettli, M.S. Surname, F.N. Zafeiratou, S. Vazquez Fernandez, L. Monteiro, A. Rai, M. Zhang, S. Aunan, K. MCC Collaborative Research Network EXHAUSTION project

Abstract

Background: Heat and cold are established environmental risk factors for human health. However, mapping the related health burden is a difficult task due to the complexity of the associations and the differences in vulnerability and demographic distributions. In this study, we did a comprehensive mortality impact assessment due to heat and cold in European urban areas, considering geographical differences and age-specific risks. Methods: We included urban areas across Europe between Jan 1, 2000, and Dec 12, 2019, using the Urban Audit dataset of Eurostat and adults aged 20 years and older living in these areas. Data were extracted from Eurostat, the Multi-country Multi-city Collaborative Research Network, Moderate Resolution Imaging Spectroradiometer, and Copernicus. We applied a three-stage method to estimate risks of temperature continuously across the age and space dimensions, identifying patterns of vulnerability on the basis of city-specific characteristics and demographic structures. These risks were used to derive minimum mortality temperatures and related percentiles and raw and standardised excess mortality rates for heat and cold aggregated at various geographical levels. Findings: Across the 854 urban areas in Europe, we estimated an annual excess of 203 620 (empirical 95% CI 180 882–224 613) deaths attributed to cold and 20 173 (17 261–22 934) attributed to heat. These corresponded to age-standardised rates of 129 (empirical 95% CI 114–142) and 13 (11–14) deaths per 100 000 person-years. Results differed across Europe and age groups, with the highest effects in eastern European cities for both cold and heat. Interpretation: Maps of mortality risks and excess deaths indicate geographical differences, such as a north–south gradient and increased vulnerability in eastern Europe, as well as local variations due to urban characteristics. The modelling framework and results are crucial for the design of national and local health and climate policies and for pr

Published
2023

10. Heat-related cardiorespiratory mortality: Effect modification by air pollution across 482 cities from 24 countries

Author

Rai, M. Stafoggia, M. de'Donato, F. Scortichini, M. Zafeiratou, S. Vazquez Fernandez, L. Zhang, S. Katsouyanni, K. Samoli, E. Rao, S. Lavigne, E. Guo, Y. Kan, H. Osorio, S. Kyselý, J. Urban, A. Orru, H. Maasikmets, M. Jaakkola, J.J.K. Ryti, N. Pascal, M. Hashizume, M. Fook Sheng Ng, C. Alahmad, B. Hurtado Diaz, M. De la Cruz Valencia, C. Nunes, B. Madureira, J. Scovronick, N. Garland, R.M. Kim, H. Lee, W. Tobias, A. Íñiguez, C. Forsberg, B. Åström, C. Maria Vicedo-Cabrera, A. Ragettli, M.S. Leon Guo, Y.-L. Pan, S.-C. Li, S. Gasparrini, A. Sera, F. Masselot, P. Schwartz, J. Zanobetti, A. Bell, M.L. Schneider, A. Breitner, S. and Rai, M. Stafoggia, M. de'Donato, F. Scortichini, M. Zafeiratou, S. Vazquez Fernandez, L. Zhang, S. Katsouyanni, K. Samoli, E. Rao, S. Lavigne, E. Guo, Y. Kan, H. Osorio, S. Kyselý, J. Urban, A. Orru, H. Maasikmets, M. Jaakkola, J.J.K. Ryti, N. Pascal, M. Hashizume, M. Fook Sheng Ng, C. Alahmad, B. Hurtado Diaz, M. De la Cruz Valencia, C. Nunes, B. Madureira, J. Scovronick, N. Garland, R.M. Kim, H. Lee, W. Tobias, A. Íñiguez, C. Forsberg, B. Åström, C. Maria Vicedo-Cabrera, A. Ragettli, M.S. Leon Guo, Y.-L. Pan, S.-C. Li, S. Gasparrini, A. Sera, F. Masselot, P. Schwartz, J. Zanobetti, A. Bell, M.L. Schneider, A. Breitner, S.

Abstract

Background: Evidence on the potential interactive effects of heat and ambient air pollution on cause-specific mortality is inconclusive and limited to selected locations. Objectives: We investigated the effects of heat on cardiovascular and respiratory mortality and its modification by air pollution during summer months (six consecutive hottest months) in 482 locations across 24 countries. Methods: Location-specific daily death counts and exposure data (e.g., particulate matter with diameters ≤ 2.5 µm [PM2.5]) were obtained from 2000 to 2018. We used location-specific confounder-adjusted Quasi-Poisson regression with a tensor product between air temperature and the air pollutant. We extracted heat effects at low, medium, and high levels of pollutants, defined as the 5th, 50th, and 95th percentile of the location-specific pollutant concentrations. Country-specific and overall estimates were derived using a random-effects multilevel meta-analytical model. Results: Heat was associated with increased cardiorespiratory mortality. Moreover, the heat effects were modified by elevated levels of all air pollutants in most locations, with stronger effects for respiratory than cardiovascular mortality. For example, the percent increase in respiratory mortality per increase in the 2-day average summer temperature from the 75th to the 99th percentile was 7.7% (95% Confidence Interval [CI] 7.6–7.7), 11.3% (95%CI 11.2–11.3), and 14.3% (95% CI 14.1–14.5) at low, medium, and high levels of PM2.5, respectively. Similarly, cardiovascular mortality increased by 1.6 (95%CI 1.5–1.6), 5.1 (95%CI 5.1–5.2), and 8.7 (95%CI 8.7–8.8) at low, medium, and high levels of O3, respectively. Discussion: We observed considerable modification of the heat effects on cardiovascular and respiratory mortality by elevated levels of air pollutants. Therefore, mitigation measures following the new WHO Air Quality Guidelines are crucial to enhance better health and promote sustainable development. © 2023

Published
2023

11. Should We Adjust for Season in Time-Series Studies of the Short-Term Association between Temperature and Mortality?

Author

Madaniyazi, L. Tobías, A. Vicedo-Cabrera, A.M. Jaakkola, J.J.K. Honda, Y. Guo, Y. Schwartz, J. Zanobetti, A. Bell, M.L. Armstrong, B. Campbell, M.J. Katsouyanni, K. Haines, A. Ebi, K.L. Gasparrini, A. Hashizume, M. and Madaniyazi, L. Tobías, A. Vicedo-Cabrera, A.M. Jaakkola, J.J.K. Honda, Y. Guo, Y. Schwartz, J. Zanobetti, A. Bell, M.L. Armstrong, B. Campbell, M.J. Katsouyanni, K. Haines, A. Ebi, K.L. Gasparrini, A. Hashizume, M.

Published
2023

12. Associations between exposure to blue spaces and natural and cause-specific mortality in Greece: An ecological study

Author

Kasdagli, M.-I. Katsouyanni, K. de Hoogh, K. Zafeiratou, S. Dimakopoulou, K. Samoli, E. and Kasdagli, M.-I. Katsouyanni, K. de Hoogh, K. Zafeiratou, S. Dimakopoulou, K. Samoli, E.

Abstract

Background: A growing body of evidence suggests that exposure to natural environments, such as green space, may have a beneficial role in health. However, there is limited evidence regarding the effects of exposure to blue spaces and mortality. We investigated the association of exposure to blue spaces with natural and cause-specific mortality in Greece using an ecological study design Methods: Mortality and socioeconomic data were obtained from 1,035 municipal units (MUs) from the 2011 census data. To define exposure to “blue” we used a rate of the land cover categories related to blue space from the COoRdination and INformation on the Environmental (CORINE) 2012 map per 10,000 persons in the municipal unit. We further assessed the exposure to blue space in the MUs that are located in the coastline of Greece using the distance to the coast as a proxy for proximity to blue space. the Annual PM2.5, NO2, BC and O3 concentrations for 2010 were predicted by land use regression models while the normalized difference vegetation index was used to assess greenness. We applied single and two exposure Poisson regression models accounting for spatial autocorrelation and adjusting for unemployment and lung cancer mortality rates, percentages of the population aged 25–64 with upper secondary or tertiary education attainment and of those born in Greece, and urbanicity. The analysis was conducted for the whole country and separately by varying geographical definitions. Results: An interquartile range (IQR) increase of blue space per 10,000 persons was associated with decreased risk in natural mortality (Relative Risk (RR): 0.98 (95% confidence interval (CI): 0.98, 0.99), as well as in mortality due to cardiovascular causes, respiratory causes and diseases of the nervous system 0.98 (95% CI: 0.97, 0.99); 0.97 (95% CI: 0.95, 0.99); 0.94 (95% CI: 0.88, 1.00) respectively). We estimated protective associations for ischemic heart disease (IHD) mortality (RR = 0.98, 95% CI: 0.97, 1.00 p

Published
2023

13. Corrigendum to “Effect modification of greenness on the association between heat and mortality: A multi-city multi-country study” (eBioMedicine (2022) 84, (S2352396422004339), (10.1016/j.ebiom.2022.104251))

Author

Choi, H.M. Lee, W. Roye, D. Heo, S. Urban, A. Entezari, A. Vicedo-Cabrera, A.M. Zanobetti, A. Gasparrini, A. Analitis, A. Tobias, A. Armstrong, B. Forsberg, B. Íñiguez, C. Åström, C. Sheng Ng, C.F. Indermitte, E. Lavigne, E. Mayvaneh, F. Acquaotta, F. Sera, F. Orru, H. Kim, H. Kyselý, J. Madueira, J. Schwartz, J. Jaakkola, J.J.K. Katsouyanni, K. Diaz, M.H. Ragettli, M.S. Hashizume, M. Pascal, M. Ryti, N. Scovronick, N. Osorio, S. Tong, S. Seposo, X. Honda, Y. Kim, Y. Guo, Y.-L. Guo, Y. Bell, M.L. and Choi, H.M. Lee, W. Roye, D. Heo, S. Urban, A. Entezari, A. Vicedo-Cabrera, A.M. Zanobetti, A. Gasparrini, A. Analitis, A. Tobias, A. Armstrong, B. Forsberg, B. Íñiguez, C. Åström, C. Sheng Ng, C.F. Indermitte, E. Lavigne, E. Mayvaneh, F. Acquaotta, F. Sera, F. Orru, H. Kim, H. Kyselý, J. Madueira, J. Schwartz, J. Jaakkola, J.J.K. Katsouyanni, K. Diaz, M.H. Ragettli, M.S. Hashizume, M. Pascal, M. Ryti, N. Scovronick, N. Osorio, S. Tong, S. Seposo, X. Honda, Y. Kim, Y. Guo, Y.-L. Guo, Y. Bell, M.L.

Abstract

The authors would like to acknowledge the participation of 4 additional authors to this article. They contributed to the processing of the Japanese dataset used in the study. The corrected authorship, the corrected Acknowledgements and the corrected Contributors and Declaration of interests sections are presented below. H.M.C. and W.L. performed data analysis. W.L., D.R., A.U., A.E., A.M.V., A.Z., A.G., A.Z., A.T., B.A., B.F., C.Í., C.Å., C.F.S.N., E.I., E.L., F.M., F.A., F.S., H.O. H.K., J.K., J.M., J.S., J.J., K.K., M.H.D., M.S.R., M.H., M.P., N.R., N.S., S.O., S.T., X.S., Y.H., Y.K., YL.G., Y.G., and M.L.B. provided essential data resources. H.M.C. drafted the first version. H.M.C. and M.L.B. performed writing and editing the manuscript. H.M.C., W.L., A.U., A.G., A.T., B.A., E.L., F.S., S.T., and M.L.B. conducted reviewing. H.M.C. and D.R. have developed the figures. All authors have read and acknowledged the final manuscript. © 2022 The Author(s)

Published
2023

14. Prevalence of rheumatoid arthritis in Greece: results from the national health examination survey EMENO

Author

Venetsanopoulou, A.I. Kalpourtzi, N. Alamanos, Y. Gavana, M. Vantarakis, A. Hadjichristodoulou, C. Mouchtouri, V.A. Chlouverakis, G. Trypsianis, G. Drosos, A.A. Touloumi, G. Voulgari, P.V. Alamanos, Y. Benos, A. Chlouverakis, G. Hadjichristodoulou, C. Karakatsani, A. Stergiou, G. Touloumi, G. Trypsianis, G. Vantarakis, A. Voulgari, P.V. Karakosta, A. Pantazis, N. Vourli, G. Kalpourtzi, N. Katsouyanni, K. Kantzanou, M. Chrysochoou, X. Gavana, M. Haidich, B. Hadjichristodoulou, C. Rachiotis, G. Nikolakopoulos, I. Koustenis, P. Makrilakis, K. Liatis, S. the EMENO study group and Venetsanopoulou, A.I. Kalpourtzi, N. Alamanos, Y. Gavana, M. Vantarakis, A. Hadjichristodoulou, C. Mouchtouri, V.A. Chlouverakis, G. Trypsianis, G. Drosos, A.A. Touloumi, G. Voulgari, P.V. Alamanos, Y. Benos, A. Chlouverakis, G. Hadjichristodoulou, C. Karakatsani, A. Stergiou, G. Touloumi, G. Trypsianis, G. Vantarakis, A. Voulgari, P.V. Karakosta, A. Pantazis, N. Vourli, G. Kalpourtzi, N. Katsouyanni, K. Kantzanou, M. Chrysochoou, X. Gavana, M. Haidich, B. Hadjichristodoulou, C. Rachiotis, G. Nikolakopoulos, I. Koustenis, P. Makrilakis, K. Liatis, S. the EMENO study group

Abstract

Rheumatoid arthritis (RA) is considered the most common form of autoimmune arthritis. The disease’s prevalence is around 0.5–1% worldwide, but it seems to vary among different populations. The aim of this study was to estimate the prevalence of self-reported diagnosed RA in the general adult population in Greece. The data were derived from the Greek Health Examination Survey EMENO, a population-based survey performed between 2013 and 2016. Of the 6006 participants (response rate 72%), 5884 were eligible for this study. Prevalence estimates were calculated according to the study design. Prevalence of self-reported RA was estimated to be overall 0.5% (95% CI 0.4–0.7) being approximately three times higher in women than in men (0.7% vs 0.2%, p value = 0.004). A decrease in the prevalence of RA was observed in urban areas of the country. In contrast, higher disease rates were reported in individuals with lower socioeconomic status. Multivariable regression analysis showed that gender, age, and income were related to the occurrence of the disease. Osteoporosis and thyroid disease were the two comorbidities observed at statistically significant higher rates in individuals with self-reported RA. The prevalence of self-reported RA in Greece is similar to that reported in other European countries. Gender, age, and income are the main factors related to the disease’s prevalence in Greece. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Published
2023

15. Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort

Author

Hvidtfeldt, U.A. Chen, J. Rodopoulou, S. Strak, M. de Hoogh, K. Andersen, Z.J. Bellander, T. Brandt, J. Fecht, D. Forastiere, F. Gulliver, J. Hertel, O. Hoffmann, B.H. Katsouyanni, K. Ketzel, M. Brynedal, B. Leander, K. Ljungman, P.L.S. Magnusson, P.K.E. Nagel, G. Pershagen, G. Rizzuto, D. Boutron-Ruault, M.-C. Samoli, E. So, R. Stafoggia, M. Tjønneland, A. Vermeulen, R. Verschuren, W.M.M. Weinmayr, G. Wolf, K. Zhang, J. Zitt, E. Brunekreef, B. Hoek, G. Raaschou-Nielsen, O. and Hvidtfeldt, U.A. Chen, J. Rodopoulou, S. Strak, M. de Hoogh, K. Andersen, Z.J. Bellander, T. Brandt, J. Fecht, D. Forastiere, F. Gulliver, J. Hertel, O. Hoffmann, B.H. Katsouyanni, K. Ketzel, M. Brynedal, B. Leander, K. Ljungman, P.L.S. Magnusson, P.K.E. Nagel, G. Pershagen, G. Rizzuto, D. Boutron-Ruault, M.-C. Samoli, E. So, R. Stafoggia, M. Tjønneland, A. Vermeulen, R. Verschuren, W.M.M. Weinmayr, G. Wolf, K. Zhang, J. Zitt, E. Brunekreef, B. Hoek, G. Raaschou-Nielsen, O.

Published
2023

16. Long-term exposure to elemental components of fine particulate matter and all-natural and cause-specific mortality in a Danish nationwide administrative cohort study

Author

So, R. Chen, J. Stafoggia, M. de Hoogh, K. Katsouyanni, K. Vienneau, D. Samoli, E. Rodopoulou, S. Loft, S. Lim, Y.-H. Westendorp, R.G.J. Amini, H. Cole-Hunter, T. Bergmann, M. Shahri, S.M.T. Zhang, J. Maric, M. Mortensen, L.H. Bauwelinck, M. Klompmaker, J.O. Atkinson, R.W. Janssen, N.A.H. Oftedal, B. Renzi, M. Forastiere, F. Strak, M. Brunekreef, B. Hoek, G. Andersen, Z.J. and So, R. Chen, J. Stafoggia, M. de Hoogh, K. Katsouyanni, K. Vienneau, D. Samoli, E. Rodopoulou, S. Loft, S. Lim, Y.-H. Westendorp, R.G.J. Amini, H. Cole-Hunter, T. Bergmann, M. Shahri, S.M.T. Zhang, J. Maric, M. Mortensen, L.H. Bauwelinck, M. Klompmaker, J.O. Atkinson, R.W. Janssen, N.A.H. Oftedal, B. Renzi, M. Forastiere, F. Strak, M. Brunekreef, B. Hoek, G. Andersen, Z.J.

Abstract

Background: Fine particulate matter (PM2.5) is a well-recognized risk factor for premature death. However, evidence on which PM2.5 components are most relevant is unclear. Methods: We evaluated the associations between mortality and long-term exposure to eight PM2.5 elemental components [copper (Cu), iron (Fe), zinc (Zn), sulfur (S), nickel (Ni), vanadium (V), silicon (Si), and potassium (K)]. Studied outcomes included death from diabetes, chronic kidney disease (CKD), dementia, and psychiatric disorders as well as all-natural causes, cardiovascular disease (CVD), respiratory diseases (RD), and lung cancer. We followed all residents in Denmark (aged ≥30 years) from January 1, 2000 to December 31, 2017. We used European-wide land-use regression models at a 100 × 100 m scale to estimate the residential annual mean levels of exposure to PM2.5 components. The models were developed with supervised linear regression (SLR) and random forest (RF). The associations were evaluated by Cox proportional hazard models adjusting for individual- and area-level socioeconomic factors and total PM2.5 mass. Results: Of 3,081,244 individuals, we observed 803,373 death from natural causes during follow-up. We found significant positive associations between all-natural mortality with Si and K from both exposure modeling approaches (hazard ratios; 95% confidence intervals per interquartile range increase): SLR-Si (1.04; 1.03–1.05), RF-Si (1.01; 1.00–1.02), SLR-K (1.03; 1.02–1.04), and RF-K (1.06; 1.05–1.07). Strong associations of K and Si were detected with most causes of mortality except CKD and K, and diabetes and Si (the strongest associations for psychiatric disorders mortality). In addition, Fe was relevant for mortality from RD, lung cancer, CKD, and psychiatric disorders; Zn with mortality from CKD, RD, and lung cancer, and; Ni and V with lung cancer mortality. Conclusions: We present novel results of the relevance of different PM2.5 components for different causes of death, with K

Published
2023

17. Clean Air in Europe for All: Taking Stock of the Proposed Revision to the Ambient Air Quality Directives. A Joint ERS, HEI, and ISEE Workshop Report

Author

Turner, M.C., Andersen, Z.J., Neira, M., Krzyzanowski, M., Malmqvist, E., Ortiz, A.G., Kiesewetter, G., Katsouyanni, K., Brunekreef, B., Melén, E., Ljungman, P., Tolotto, M., Forastiere, F., Dendale, P., Price, R., Bakke, O., Reichert, S., Hoek, G., Pershagen, G., Peters, A., Querol, X., Gerometta, A., Samoli, E., Markevych, I., Basthiste, R., Khreis, H., Pant, P., Nieuwenhuijsen, M., Sacks, J.D., Hansen, K., Lymes, T., Stauffer, A., Fuller, G.W., Boogaard, H., Hoffmann, B., Turner, M.C., Andersen, Z.J., Neira, M., Krzyzanowski, M., Malmqvist, E., Ortiz, A.G., Kiesewetter, G., Katsouyanni, K., Brunekreef, B., Melén, E., Ljungman, P., Tolotto, M., Forastiere, F., Dendale, P., Price, R., Bakke, O., Reichert, S., Hoek, G., Pershagen, G., Peters, A., Querol, X., Gerometta, A., Samoli, E., Markevych, I., Basthiste, R., Khreis, H., Pant, P., Nieuwenhuijsen, M., Sacks, J.D., Hansen, K., Lymes, T., Stauffer, A., Fuller, G.W., Boogaard, H., and Hoffmann, B.

Published
2023
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18. Investigating links between air pollution, COVID-19 and lower respiratory infectious diseases – A review

Author

Walton, H, Evangelopoulos, D, Kasdagli, M-I, Selley, L, Dajnak, D, and Katsouyanni, K

Subjects
General Earth and Planetary Sciences, General Environmental Science
Abstract

Background/aim Hundreds of air pollution and COVID-19 papers have been published in a short time varying widely in quality. The Greater London Authority commissioned a comprehensive overview of the most credible evidence for the links between air pollution and COVID-19 and other lung infections. Methods Building on the Brunekreef et al (2021) review, a literature search was performed from November 2020 – May 2021, classifying the evidence by exposure, the potential mechanism and the health outcome. Studies on hospital admissions for lower respiratory infections were reviewed from 2011 Results Long-term exposure increased the risk of hospitalization in people already infected with COVID-19 in two good-quality cohort studies with individual data, perhaps due to respiratory and cardiovascular disease from air pollution increasing vulnerability to COVID-19 adverse outcomes. Mortality results were conflicting. Inconsistent results were found for long-term exposure and COVID-19 cases in ecological studies. Studies on short-term exposure were unclear and hard to evaluate. Several studies demonstrated that inhaled pollutant increased expression of the ACE2 receptor and other host susceptibility genes in both alveolar epithelial cells and macrophages. Susceptibility to infection by SARS-CoV-2 can be inferred from these results but only one study used SARS-CoV-2 directly. Several studies from 2011-2021 showed a link between air pollution and hospital admissions for lung infections although the studies were spread across different age groups and disease definitions. Particulate matter does not appear to play any important part in transporting COVID-19 in the environment, as had been suggested by some earlier studies. Conclusions The publication of cohort studies with individual data in this time period is an important step forward. Results are suggestive for long-term exposure and hospital admissions for COVID-19 and some toxicological effects are plausible but further research will be necessary to strengthen these emerging findings. Keywords Air pollution, COVID-19, lower respiratory infections.

Published
2022
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24. Coarse Particulate Air Pollution and Daily Mortality: A Global Study in 205 Cities

Author

Liu, C. Cai, J. Chen, R. Sera, F. Guo, Y. Tong, S. Li, S. Lavigne, E. Correa, P.M. Ortega, N.V. Orru, H. Maasikmets, M. Jaakkola, J.J.K. Ryti, N. Breitner, S. Schneider, A. Katsouyanni, K. Samoli, E. Hashizume, M. Honda, Y. Ng, C.F.S. Diaz, M.H. la Cruz Valencia, C. Rao, S. Palomares, A.D.-L. Pereira da Silva, S. Madureira, J. Holobâc, I.H. Fratianni, S. Scovronick, N. Garland, R.M. Tobias, A. Íñiguez, C. Forsberg, B. Åström, C. Vicedo-Cabrera, A.M. Ragettli, M.S. Guo, Y.-L.L. Pan, S.-C. Milojevic, A. Bell, M.L. Zanobetti, A. Schwartz, J. Gasparrini, A. Kan, H. and Liu, C. Cai, J. Chen, R. Sera, F. Guo, Y. Tong, S. Li, S. Lavigne, E. Correa, P.M. Ortega, N.V. Orru, H. Maasikmets, M. Jaakkola, J.J.K. Ryti, N. Breitner, S. Schneider, A. Katsouyanni, K. Samoli, E. Hashizume, M. Honda, Y. Ng, C.F.S. Diaz, M.H. la Cruz Valencia, C. Rao, S. Palomares, A.D.-L. Pereira da Silva, S. Madureira, J. Holobâc, I.H. Fratianni, S. Scovronick, N. Garland, R.M. Tobias, A. Íñiguez, C. Forsberg, B. Åström, C. Vicedo-Cabrera, A.M. Ragettli, M.S. Guo, Y.-L.L. Pan, S.-C. Milojevic, A. Bell, M.L. Zanobetti, A. Schwartz, J. Gasparrini, A. Kan, H.

Published
2022

25. Exposure to surrounding greenness and natural-cause and cause-specific mortality in the ELAPSE pooled cohort

Author

Bereziartua, A. Chen, J. de Hoogh, K. Rodopoulou, S. Andersen, Z.J. Bellander, T. Brandt, J. Fecht, D. Forastiere, F. Gulliver, J. Hertel, O. Hoffmann, B. Arthur Hvidtfeldt, U. Verschuren, W.M.M. Jöckel, K.-H. Jørgensen, J.T. Katsouyanni, K. Ketzel, M. Hjertager Krog, N. Brynedal, B. Leander, K. Liu, S. Ljungman, P. Faure, E. Magnusson, P.K.E. Nagel, G. Pershagen, G. Peters, A. Raaschou-Nielsen, O. Renzi, M. Rizzuto, D. Samoli, E. van der Schouw, Y.T. Schramm, S. Severi, G. Stafoggia, M. Strak, M. Sørensen, M. Tjønneland, A. Weinmayr, G. Wolf, K. Zitt, E. Brunekreef, B. Hoek, G. and Bereziartua, A. Chen, J. de Hoogh, K. Rodopoulou, S. Andersen, Z.J. Bellander, T. Brandt, J. Fecht, D. Forastiere, F. Gulliver, J. Hertel, O. Hoffmann, B. Arthur Hvidtfeldt, U. Verschuren, W.M.M. Jöckel, K.-H. Jørgensen, J.T. Katsouyanni, K. Ketzel, M. Hjertager Krog, N. Brynedal, B. Leander, K. Liu, S. Ljungman, P. Faure, E. Magnusson, P.K.E. Nagel, G. Pershagen, G. Peters, A. Raaschou-Nielsen, O. Renzi, M. Rizzuto, D. Samoli, E. van der Schouw, Y.T. Schramm, S. Severi, G. Stafoggia, M. Strak, M. Sørensen, M. Tjønneland, A. Weinmayr, G. Wolf, K. Zitt, E. Brunekreef, B. Hoek, G.

Abstract

Background: The majority of studies have shown higher greenness exposure associated with reduced mortality risks, but few controlled for spatially correlated air pollution and traffic noise exposures. We aim to address this research gap in the ELAPSE pooled cohort. Methods: Mean Normalized Difference Vegetation Index (NDVI) in a 300-m grid cell and 1-km radius were assigned to participants’ baseline home addresses as a measure of surrounding greenness exposure. We used Cox proportional hazards models to estimate the association of NDVI exposure with natural-cause and cause-specific mortality, adjusting for a number of potential confounders including socioeconomic status and lifestyle factors at individual and area-levels. We further assessed the associations between greenness exposure and mortality after adjusting for fine particulate matter (PM2.5), nitrogen dioxide (NO2) and road traffic noise. Results: The pooled study population comprised 327,388 individuals who experienced 47,179 natural-cause deaths during 6,374,370 person-years of follow-up. The mean NDVI in the pooled cohort was 0.33 (SD 0.1) and 0.34 (SD 0.1) in the 300-m grid and 1-km buffer. In the main fully adjusted model, 0.1 unit increment of NDVI inside 300-m grid was associated with 5% lower risk of natural-cause mortality (Hazard Ratio (HR) 0.95 (95% CI: 0.94, 0.96)). The associations attenuated after adjustment for air pollution [HR (95% CI): 0.97 (0.96, 0.98) adjusted for PM2.5; 0.98 (0.96, 0.99) adjusted for NO2]. Additional adjustment for traffic noise hardly affected the associations. Consistent results were observed for NDVI within 1-km buffer. After adjustment for air pollution, NDVI was inversely associated with diabetes, respiratory and lung cancer mortality, yet with wider 95% confidence intervals. No association with cardiovascular mortality was found. Conclusions: We found a significant inverse association between surrounding greenness and natural-cause mortality, which remained after a

Published
2022

26. Long-Term Exposure to Source-Specific Fine Particles and Mortality-A Pooled Analysis of 14 European Cohorts within the ELAPSE Project

Author

Chen, J. Hoek, G. De Hoogh, K. Rodopoulou, S. Andersen, Z.J. Bellander, T. Brandt, Jø. Fecht, D. Forastiere, F. Gulliver, J. Hertel, O. Hoffmann, B. Hvidtfeldt, U.A. Verschuren, W.M.M. Jöckel, K.-H. Jørgensen, J.T. Katsouyanni, K. Ketzel, M. Méndez, D.Y. Leander, K. Liu, S. Ljungman, P. Faure, E. Magnusson, P.K.E. Nagel, G. Pershagen, G. Peters, A. Raaschou-Nielsen, O. Rizzuto, D. Samoli, E. Van Der Schouw, Y.T. Schramm, S. Severi, G. Stafoggia, M. Strak, M. Sørensen, M. Tjønneland, A. Weinmayr, G. Wolf, K. Zitt, E. Brunekreef, B. Thurston, G.D. and Chen, J. Hoek, G. De Hoogh, K. Rodopoulou, S. Andersen, Z.J. Bellander, T. Brandt, Jø. Fecht, D. Forastiere, F. Gulliver, J. Hertel, O. Hoffmann, B. Hvidtfeldt, U.A. Verschuren, W.M.M. Jöckel, K.-H. Jørgensen, J.T. Katsouyanni, K. Ketzel, M. Méndez, D.Y. Leander, K. Liu, S. Ljungman, P. Faure, E. Magnusson, P.K.E. Nagel, G. Pershagen, G. Peters, A. Raaschou-Nielsen, O. Rizzuto, D. Samoli, E. Van Der Schouw, Y.T. Schramm, S. Severi, G. Stafoggia, M. Strak, M. Sørensen, M. Tjønneland, A. Weinmayr, G. Wolf, K. Zitt, E. Brunekreef, B. Thurston, G.D.

Published
2022

27. Long term exposure to air pollution and kidney parenchyma cancer – Effects of low-level air pollution: a Study in Europe (ELAPSE)

Author

Hvidtfeldt, U.A. Taj, T. Chen, J. Rodopoulou, S. Strak, M. de Hoogh, K. Andersen, Z.J. Bellander, T. Brandt, J. Fecht, D. Forastiere, F. Gulliver, J. Hertel, O. Hoffmann, B. Jørgensen, J.T. Katsouyanni, K. Ketzel, M. Lager, A. Leander, K. Ljungman, P. Magnusson, P.K.E. Nagel, G. Pershagen, G. Rizzuto, D. Samoli, E. So, R. Stafoggia, M. Tjønneland, A. Vermeulen, R. Weinmayr, G. Wolf, K. Zhang, J. Zitt, E. Brunekreef, B. Hoek, G. Raaschou-Nielsen, O. and Hvidtfeldt, U.A. Taj, T. Chen, J. Rodopoulou, S. Strak, M. de Hoogh, K. Andersen, Z.J. Bellander, T. Brandt, J. Fecht, D. Forastiere, F. Gulliver, J. Hertel, O. Hoffmann, B. Jørgensen, J.T. Katsouyanni, K. Ketzel, M. Lager, A. Leander, K. Ljungman, P. Magnusson, P.K.E. Nagel, G. Pershagen, G. Rizzuto, D. Samoli, E. So, R. Stafoggia, M. Tjønneland, A. Vermeulen, R. Weinmayr, G. Wolf, K. Zhang, J. Zitt, E. Brunekreef, B. Hoek, G. Raaschou-Nielsen, O.

Published
2022

28. Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study

Author

Andersen, Z.J. Zhang, J. Jørgensen, J.T. Samoli, E. Liu, S. Chen, J. Strak, M. Wolf, K. Weinmayr, G. Rodopolou, S. Remfry, E. de Hoogh, K. Bellander, T. Brandt, J. Concin, H. Zitt, E. Fecht, D. Forastiere, F. Gulliver, J. Hoffmann, B. Hvidtfeldt, U.A. Monique Verschuren, W.M. Jöckel, K.-H. So, R. Cole-Hunter, T. Mehta, A.J. Mortensen, L.H. Ketzel, M. Lager, A. Leander, K. Ljungman, P. Severi, G. Boutron-Ruault, M.-C. Magnusson, P.K.E. Nagel, G. Pershagen, G. Peters, A. Rizzuto, D. van der Schouw, Y.T. Schramm, S. Stafoggia, M. Katsouyanni, K. Brunekreef, B. Hoek, G. Lim, Y.-H. and Andersen, Z.J. Zhang, J. Jørgensen, J.T. Samoli, E. Liu, S. Chen, J. Strak, M. Wolf, K. Weinmayr, G. Rodopolou, S. Remfry, E. de Hoogh, K. Bellander, T. Brandt, J. Concin, H. Zitt, E. Fecht, D. Forastiere, F. Gulliver, J. Hoffmann, B. Hvidtfeldt, U.A. Monique Verschuren, W.M. Jöckel, K.-H. So, R. Cole-Hunter, T. Mehta, A.J. Mortensen, L.H. Ketzel, M. Lager, A. Leander, K. Ljungman, P. Severi, G. Boutron-Ruault, M.-C. Magnusson, P.K.E. Nagel, G. Pershagen, G. Peters, A. Rizzuto, D. van der Schouw, Y.T. Schramm, S. Stafoggia, M. Katsouyanni, K. Brunekreef, B. Hoek, G. Lim, Y.-H.

Abstract

Ambient air pollution is an established risk factor for premature mortality from chronic cardiovascular, respiratory and metabolic diseases, while evidence on neurodegenerative diseases and psychiatric disorders remains limited. We examined the association between long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in seven European cohorts. Within the multicenter project ‘Effects of Low-Level Air Pollution: A Study in Europe’ (ELAPSE), we pooled data from seven European cohorts from six countries. Based on the residential addresses, annual mean levels of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), ozone (O3), and 8 PM2.5 components were estimated using Europe-wide hybrid land-use regression models. We applied stratified Cox proportional hazard models to investigate the associations between air pollution and mortality from dementia, psychiatric disorders, and suicide. Of 271,720 participants, 900 died from dementia, 241 from psychiatric disorders, and 164 from suicide, during a mean follow-up of 19.7 years. In fully adjusted models, we observed positive associations of NO2 (hazard ratio [HR] = 1.38; 95 % confidence interval [CI]: 1.13, 1.70 per 10 µg/m3), PM2.5 (HR = 1.29; 95 % CI: 0.98, 1.71 per 5 µg/m3), and BC (HR = 1.37; 95 % CI: 1.11, 1.69 per 0.5 × 10−5/m) with psychiatric disorders mortality, as well as with suicide (NO2: HR = 1.13 [95 % CI: 0.92, 1.38]; PM2.5: HR = 1.19 [95 % CI: 0.76, 1.87]; BC: HR = 1.08 [95 % CI: 0.87, 1.35]), and no association with dementia mortality. We did not detect any positive associations of O3 and 8 PM2.5 components with any of the three mortality outcomes. Long-term exposure to NO2, PM2.5, and BC may lead to premature mortality from psychiatric disorders and suicide. © 2022

Published
2022

29. Author Correction: Comparison of weather station and climate reanalysis data for modelling temperature-related mortality (Scientific Reports, (2022), 12, 1, (5178), 10.1038/s41598-022-09049-4)

Author

Mistry, M.N. Schneider, R. Masselot, P. Royé, D. Armstrong, B. Kyselý, J. Orru, H. Sera, F. Tong, S. Lavigne, É. Urban, A. Madureira, J. García-León, D. Ibarreta, D. Ciscar, J.-C. Feyen, L. de Schrijver, E. de Sousa Zanotti Stagliorio Coelho, M. Pascal, M. Tobias, A. Alahmad, B. Abrutzky, R. Saldiva, P.H.N. Correa, P.M. Orteg, N.V. Kan, H. Osorio, S. Indermitte, E. Jaakkola, J.J.K. Ryti, N. Schneider, A. Huber, V. Katsouyanni, K. Analitis, A. Entezari, A. Mayvaneh, F. Michelozzi, P. de’Donato, F. Hashizume, M. Kim, Y. Diaz, M.H. De la Cruz Valencia, C. Overcenco, A. Houthuijs, D. Ameling, C. Rao, S. Seposo, X. Nunes, B. Holobaca, I.-H. Kim, H. Lee, W. Íñiguez, C. Forsberg, B. Åström, C. Ragettli, M.S. Guo, Y.-L.L. Chen, B.-Y. Colistro, V. Zanobetti, A. Schwartz, J. Dang, T.N. Van Dung, D. Guo, Y. Vicedo-Cabrera, A.M. Gasparrini, A. Multi-Country Multi-City (MCC) Collaborative Research Network and Mistry, M.N. Schneider, R. Masselot, P. Royé, D. Armstrong, B. Kyselý, J. Orru, H. Sera, F. Tong, S. Lavigne, É. Urban, A. Madureira, J. García-León, D. Ibarreta, D. Ciscar, J.-C. Feyen, L. de Schrijver, E. de Sousa Zanotti Stagliorio Coelho, M. Pascal, M. Tobias, A. Alahmad, B. Abrutzky, R. Saldiva, P.H.N. Correa, P.M. Orteg, N.V. Kan, H. Osorio, S. Indermitte, E. Jaakkola, J.J.K. Ryti, N. Schneider, A. Huber, V. Katsouyanni, K. Analitis, A. Entezari, A. Mayvaneh, F. Michelozzi, P. de’Donato, F. Hashizume, M. Kim, Y. Diaz, M.H. De la Cruz Valencia, C. Overcenco, A. Houthuijs, D. Ameling, C. Rao, S. Seposo, X. Nunes, B. Holobaca, I.-H. Kim, H. Lee, W. Íñiguez, C. Forsberg, B. Åström, C. Ragettli, M.S. Guo, Y.-L.L. Chen, B.-Y. Colistro, V. Zanobetti, A. Schwartz, J. Dang, T.N. Van Dung, D. Guo, Y. Vicedo-Cabrera, A.M. Gasparrini, A. Multi-Country Multi-City (MCC) Collaborative Research Network

Abstract

The original version of this Article contained an error in Affiliation 25, which was incorrectly given as ‘Faculty of Medicine ArqFuturo INSPER, University of São Paulo, São Paulo, Brazil’. The correct affiliation is listed below. Faculty of Medicine, University of São Paulo, São Paulo, Brazil The original Article has been corrected. © The Author(s) 2022.

Published
2022

30. Long-term exposure to air pollution and mortality in a Danish nationwide administrative cohort study: Beyond mortality from cardiopulmonary disease and lung cancer

Author

So, R. Andersen, Z.J. Chen, J. Stafoggia, M. de Hoogh, K. Katsouyanni, K. Vienneau, D. Rodopoulou, S. Samoli, E. Lim, Y.-H. Jørgensen, J.T. Amini, H. Cole-Hunter, T. Mahmood Taghavi Shahri, S. Maric, M. Bergmann, M. Liu, S. Azam, S. Loft, S. Westendorp, R.G.J. Mortensen, L.H. Bauwelinck, M. Klompmaker, J.O. Atkinson, R. Janssen, N.A.H. Oftedal, B. Renzi, M. Forastiere, F. Strak, M. Thygesen, L.C. Brunekreef, B. Hoek, G. Mehta, A.J. and So, R. Andersen, Z.J. Chen, J. Stafoggia, M. de Hoogh, K. Katsouyanni, K. Vienneau, D. Rodopoulou, S. Samoli, E. Lim, Y.-H. Jørgensen, J.T. Amini, H. Cole-Hunter, T. Mahmood Taghavi Shahri, S. Maric, M. Bergmann, M. Liu, S. Azam, S. Loft, S. Westendorp, R.G.J. Mortensen, L.H. Bauwelinck, M. Klompmaker, J.O. Atkinson, R. Janssen, N.A.H. Oftedal, B. Renzi, M. Forastiere, F. Strak, M. Thygesen, L.C. Brunekreef, B. Hoek, G. Mehta, A.J.

Abstract

Background: The association between long-term exposure to air pollution and mortality from cardiorespiratory diseases is well established, yet the evidence for other diseases remains limited. Objectives: To examine the associations of long-term exposure to air pollution with mortality from diabetes, dementia, psychiatric disorders, chronic kidney disease (CKD), asthma, acute lower respiratory infection (ALRI), as well as mortality from all-natural and cardiorespiratory causes in the Danish nationwide administrative cohort. Methods: We followed all residents aged ≥ 30 years (3,083,227) in Denmark from 1 January 2000 until 31 December 2017. Annual mean concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), and ozone (warm season) were estimated using European-wide hybrid land-use regression models (100 m × 100 m) and assigned to baseline residential addresses. We used Cox proportional hazard models to evaluate the association between air pollution and mortality, accounting for demographic and socioeconomic factors. We additionally applied indirect adjustment for smoking and body mass index (BMI). Results: During 47,023,454 person-years of follow-up, 803,881 people died from natural causes. Long-term exposure to PM2.5 (mean: 12.4 µg/m3), NO2 (20.3 µg/m3), and/or BC (1.0 × 10-5/m) was statistically significantly associated with all studied mortality outcomes except CKD. A 5 µg/m3 increase in PM2.5 was associated with higher mortality from all-natural causes (hazard ratio 1.11; 95% confidence interval 1.09–1.13), cardiovascular disease (1.09; 1.07–1.12), respiratory disease (1.11; 1.07–1.15), lung cancer (1.19; 1.15–1.24), diabetes (1.10; 1.04–1.16), dementia (1.05; 1.00–1.10), psychiatric disorders (1.38; 1.27–1.50), asthma (1.13; 0.94–1.36), and ALRI (1.14; 1.09–1.20). Associations with long-term exposure to ozone (mean: 80.2 µg/m3) were generally negative but became significantly positive for several endpoints in two-pollutant mo

Published
2022

31. Global, regional, and national burden of mortality associated with short-term temperature variability from 2000–19: a three-stage modelling study

Author

Wu, Y. Li, S. Zhao, Q. Wen, B. Gasparrini, A. Tong, S. Overcenco, A. Urban, A. Schneider, A. Entezari, A. Vicedo-Cabrera, A.M. Zanobetti, A. Analitis, A. Zeka, A. Tobias, A. Nunes, B. Alahmad, B. Armstrong, B. Forsberg, B. Pan, S.-C. Íñiguez, C. Ameling, C. De la Cruz Valencia, C. Åström, C. Houthuijs, D. Van Dung, D. Royé, D. Indermitte, E. Lavigne, E. Mayvaneh, F. Acquaotta, F. de'Donato, F. Rao, S. Sera, F. Carrasco-Escobar, G. Kan, H. Orru, H. Kim, H. Holobaca, I.-H. Kyselý, J. Madureira, J. Schwartz, J. Jaakkola, J.J.K. Katsouyanni, K. Hurtado Diaz, M. Ragettli, M.S. Hashizume, M. Pascal, M. de Sousa Zanotti Stagliorio Coélho, M. Ortega, N.V. Ryti, N. Scovronick, N. Michelozzi, P. Correa, P.M. Goodman, P. Nascimento Saldiva, P.H. Abrutzky, R. Osorio, S. Dang, T.N. Colistro, V. Huber, V. Lee, W. Seposo, X. Honda, Y. Guo, Y.L. Bell, M.L. Guo, Y. and Wu, Y. Li, S. Zhao, Q. Wen, B. Gasparrini, A. Tong, S. Overcenco, A. Urban, A. Schneider, A. Entezari, A. Vicedo-Cabrera, A.M. Zanobetti, A. Analitis, A. Zeka, A. Tobias, A. Nunes, B. Alahmad, B. Armstrong, B. Forsberg, B. Pan, S.-C. Íñiguez, C. Ameling, C. De la Cruz Valencia, C. Åström, C. Houthuijs, D. Van Dung, D. Royé, D. Indermitte, E. Lavigne, E. Mayvaneh, F. Acquaotta, F. de'Donato, F. Rao, S. Sera, F. Carrasco-Escobar, G. Kan, H. Orru, H. Kim, H. Holobaca, I.-H. Kyselý, J. Madureira, J. Schwartz, J. Jaakkola, J.J.K. Katsouyanni, K. Hurtado Diaz, M. Ragettli, M.S. Hashizume, M. Pascal, M. de Sousa Zanotti Stagliorio Coélho, M. Ortega, N.V. Ryti, N. Scovronick, N. Michelozzi, P. Correa, P.M. Goodman, P. Nascimento Saldiva, P.H. Abrutzky, R. Osorio, S. Dang, T.N. Colistro, V. Huber, V. Lee, W. Seposo, X. Honda, Y. Guo, Y.L. Bell, M.L. Guo, Y.

Abstract

Background: Increased mortality risk is associated with short-term temperature variability. However, to our knowledge, there has been no comprehensive assessment of the temperature variability-related mortality burden worldwide. In this study, using data from the MCC Collaborative Research Network, we first explored the association between temperature variability and mortality across 43 countries or regions. Then, to provide a more comprehensive picture of the global burden of mortality associated with temperature variability, global gridded temperature data with a resolution of 0·5° × 0·5° were used to assess the temperature variability-related mortality burden at the global, regional, and national levels. Furthermore, temporal trends in temperature variability-related mortality burden were also explored from 2000–19. Methods: In this modelling study, we applied a three-stage meta-analytical approach to assess the global temperature variability-related mortality burden at a spatial resolution of 0·5° × 0·5° from 2000–19. Temperature variability was calculated as the SD of the average of the same and previous days’ minimum and maximum temperatures. We first obtained location-specific temperature variability related-mortality associations based on a daily time series of 750 locations from the Multi-country Multi-city Collaborative Research Network. We subsequently constructed a multivariable meta-regression model with five predictors to estimate grid-specific temperature variability related-mortality associations across the globe. Finally, percentage excess in mortality and excess mortality rate were calculated to quantify the temperature variability-related mortality burden and to further explore its temporal trend over two decades. Findings: An increasing trend in temperature variability was identified at the global level from 2000 to 2019. Globally, 1 753 392 deaths (95% CI 1 159 901–2 357 718) were associated with temperature variability per year, accounting for

Published
2022

32. Fluctuating temperature modifies heat-mortality association around the globe

Author

Wu, Y. Wen, B. Li, S. Gasparrini, A. Tong, S. Overcenco, A. Urban, A. Schneider, A. Entezari, A. Vicedo-Cabrera, A.M. Zanobetti, A. Analitis, A. Zeka, A. Tobias, A. Alahmad, B. Armstrong, B. Forsberg, B. Íñiguez, C. Ameling, C. De la Cruz Valencia, C. Åström, C. Houthuijs, D. Van Dung, D. Royé, D. Indermitte, E. Lavigne, E. Mayvaneh, F. Acquaotta, F. de'Donato, F. Sera, F. Carrasco-Escobar, G. Kan, H. Orru, H. Kim, H. Holobaca, I.-H. Kyselý, J. Madureira, J. Schwartz, J. Katsouyanni, K. Hurtado-Diaz, M. Ragettli, M.S. Hashizume, M. Pascal, M. de Sousa Zanotti Stagliorio Coélho, M. Scovronick, N. Michelozzi, P. Goodman, P. Nascimento Saldiva, P.H. Abrutzky, R. Osorio, S. Dang, T.N. Colistro, V. Huber, V. Lee, W. Seposo, X. Honda, Y. Bell, M.L. Guo, Y. and Wu, Y. Wen, B. Li, S. Gasparrini, A. Tong, S. Overcenco, A. Urban, A. Schneider, A. Entezari, A. Vicedo-Cabrera, A.M. Zanobetti, A. Analitis, A. Zeka, A. Tobias, A. Alahmad, B. Armstrong, B. Forsberg, B. Íñiguez, C. Ameling, C. De la Cruz Valencia, C. Åström, C. Houthuijs, D. Van Dung, D. Royé, D. Indermitte, E. Lavigne, E. Mayvaneh, F. Acquaotta, F. de'Donato, F. Sera, F. Carrasco-Escobar, G. Kan, H. Orru, H. Kim, H. Holobaca, I.-H. Kyselý, J. Madureira, J. Schwartz, J. Katsouyanni, K. Hurtado-Diaz, M. Ragettli, M.S. Hashizume, M. Pascal, M. de Sousa Zanotti Stagliorio Coélho, M. Scovronick, N. Michelozzi, P. Goodman, P. Nascimento Saldiva, P.H. Abrutzky, R. Osorio, S. Dang, T.N. Colistro, V. Huber, V. Lee, W. Seposo, X. Honda, Y. Bell, M.L. Guo, Y.

Abstract

Studies have investigated the effects of heat and temperature variability (TV) on mortality. However, few assessed whether TV modifies the heat-mortality association. Data on daily temperature and mortality in the warm season were collected from 717 locations across 36 countries. TV was calculated as the standard deviation of the average of the same and previous days’ minimum and maximum temperatures. We used location-specific quasi-Poisson regression models with an interaction term between the cross-basis term for mean temperature and quartiles of TV to obtain heat-mortality associations under each quartile of TV, and then pooled estimates at the country, regional, and global levels. Results show the increased risk in heat-related mortality with increments in TV, accounting for 0.70% (95% confidence interval [CI]: −0.33 to 1.69), 1.34% (95% CI: −0.14 to 2.73), 1.99% (95% CI: 0.29–3.57), and 2.73% (95% CI: 0.76–4.50) of total deaths for Q1–Q4 (first quartile–fourth quartile) of TV. The modification effects of TV varied geographically. Central Europe had the highest attributable fractions (AFs), corresponding to 7.68% (95% CI: 5.25–9.89) of total deaths for Q4 of TV, while the lowest AFs were observed in North America, with the values for Q4 of 1.74% (95% CI: −0.09 to 3.39). TV had a significant modification effect on the heat-mortality association, causing a higher heat-related mortality burden with increments of TV. Implementing targeted strategies against heat exposure and fluctuant temperatures simultaneously would benefit public health. © 2022 The Author(s)

Published
2022

34. Global mortality burden attributable to non-optimal temperatures

Author

Vicedo-Cabrera, A.M. Tobias, A. Jaakkola, J.J.K. Honda, Y. Hashizume, M. Guo, Y. Schwartz, J. Zanobetti, A. Bell, M.L. Armstrong, B. Katsouyanni, K. Haines, A. Ebi, K.L. Gasparrini, A. and Vicedo-Cabrera, A.M. Tobias, A. Jaakkola, J.J.K. Honda, Y. Hashizume, M. Guo, Y. Schwartz, J. Zanobetti, A. Bell, M.L. Armstrong, B. Katsouyanni, K. Haines, A. Ebi, K.L. Gasparrini, A.

Published
2022

35. Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people: results from seven large European cohorts within the ELAPSE project

Author

Stafoggia, M. Oftedal, B. Chen, J. Rodopoulou, S. Renzi, M. Atkinson, R.W. Bauwelinck, M. Klompmaker, J.O. Mehta, A. Vienneau, D. Andersen, Z.J. Bellander, T. Brandt, J. Cesaroni, G. de Hoogh, K. Fecht, D. Gulliver, J. Hertel, O. Hoffmann, B. Hvidtfeldt, U.A. Jöckel, K.-H. Jørgensen, J.T. Katsouyanni, K. Ketzel, M. Kristoffersen, D.T. Lager, A. Leander, K. Liu, S. Ljungman, P.L.S. Nagel, G. Pershagen, G. Peters, A. Raaschou-Nielsen, O. Rizzuto, D. Schramm, S. Schwarze, P.E. Severi, G. Sigsgaard, T. Strak, M. van der Schouw, Y.T. Verschuren, M. Weinmayr, G. Wolf, K. Zitt, E. Samoli, E. Forastiere, F. Brunekreef, B. Hoek, G. Janssen, N.A.H. and Stafoggia, M. Oftedal, B. Chen, J. Rodopoulou, S. Renzi, M. Atkinson, R.W. Bauwelinck, M. Klompmaker, J.O. Mehta, A. Vienneau, D. Andersen, Z.J. Bellander, T. Brandt, J. Cesaroni, G. de Hoogh, K. Fecht, D. Gulliver, J. Hertel, O. Hoffmann, B. Hvidtfeldt, U.A. Jöckel, K.-H. Jørgensen, J.T. Katsouyanni, K. Ketzel, M. Kristoffersen, D.T. Lager, A. Leander, K. Liu, S. Ljungman, P.L.S. Nagel, G. Pershagen, G. Peters, A. Raaschou-Nielsen, O. Rizzuto, D. Schramm, S. Schwarze, P.E. Severi, G. Sigsgaard, T. Strak, M. van der Schouw, Y.T. Verschuren, M. Weinmayr, G. Wolf, K. Zitt, E. Samoli, E. Forastiere, F. Brunekreef, B. Hoek, G. Janssen, N.A.H.

Published
2022

36. Long-term exposure to fine particle elemental components and mortality in Europe: Results from six European administrative cohorts within the ELAPSE project

Author

Rodopoulou, S. Stafoggia, M. Chen, J. de Hoogh, K. Bauwelinck, M. Mehta, A.J. Klompmaker, J.O. Oftedal, B. Vienneau, D. Janssen, N.A.H. Strak, M. Andersen, Z.J. Renzi, M. Cesaroni, G. Nordheim, C.F. Bekkevold, T. Atkinson, R. Forastiere, F. Katsouyanni, K. Brunekreef, B. Samoli, E. Hoek, G. and Rodopoulou, S. Stafoggia, M. Chen, J. de Hoogh, K. Bauwelinck, M. Mehta, A.J. Klompmaker, J.O. Oftedal, B. Vienneau, D. Janssen, N.A.H. Strak, M. Andersen, Z.J. Renzi, M. Cesaroni, G. Nordheim, C.F. Bekkevold, T. Atkinson, R. Forastiere, F. Katsouyanni, K. Brunekreef, B. Samoli, E. Hoek, G.

Abstract

Evidence for the association between long-term exposure to ambient particulate matter components and mortality from natural causes is sparse and inconsistent. We evaluated this association in six large administrative cohorts in the framework of the Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE) project. We analyzed data from country-wide administrative cohorts in Norway, Denmark, the Netherlands, Belgium, Switzerland and in Rome (Italy). Annual 2010 mean concentrations of copper (Cu), iron (Fe), potassium (K), nickel (Ni), sulfur (S), silicon (Si), vanadium (V) and zinc (Zn) in fine particulate matter (PM2.5) were estimated using 100 × 100 m Europe-wide hybrid land use regression models assigned to the participants' residential addresses. We applied cohort-specific Cox proportional hazard models controlling for area- and individual-level covariates to evaluate associations with natural mortality. Two pollutant models adjusting for PM2.5 total mass or nitrogen dioxide (NO2) were also applied. We pooled cohort-specific estimates using a random effects meta-analysis. We included almost 27 million participants contributing more than 240 million person-years. All components except Zn were significantly associated with natural mortality [pooled Hazard Ratios (HRs) (95% CI): 1.037 (1.014, 1.060) per 5 ng/m3 Cu; 1.069 (1.031, 1.108) per 100 ng/m3 Fe; 1.039 (1.018, 1.062) per 50 ng/m3 K; 1.024 (1.006, 1.043) per 1 ng/m3 Ni; 1.036 (1.016, 1.057) per 200 ng/m3 S; 1.152 (1.048, 1.266) per 100 ng/m3 Si; 1.020 (1.006, 1.034) per 2 ng/m3 V]. Only K and Si were robust to PM2.5 or NO2 adjustment [pooled HRs (95% CI) per 50 ng/m3 in K: 1.025 (1.008, 1.044), 1.020 (0.999, 1.042) and per 100 ng/m3 in Si: 1.121 (1.039, 1.209), 1.068 (1.022, 1.117) adjusted for PM2.5 and NO2 correspondingly]. Our findings indicate an association of natural mortality with most components, which was reduced after adjustment for PM2.5 and especially NO2. © 2021

Published
2022

37. Variability in the association between long-term exposure to ambient air pollution and mortality by exposure assessment method and covariate adjustment: A census-based country-wide cohort study

Author

Bauwelinck, M. Chen, J. de Hoogh, K. Katsouyanni, K. Rodopoulou, S. Samoli, E. Andersen, Z.J. Atkinson, R. Casas, L. Deboosere, P. Demoury, C. Janssen, N. Klompmaker, J.O. Lefebvre, W. Mehta, A.J. Nawrot, T.S. Oftedal, B. Renzi, M. Stafoggia, M. Strak, M. Vandenheede, H. Vanpoucke, C. Van Nieuwenhuyse, A. Vienneau, D. Brunekreef, B. Hoek, G. and Bauwelinck, M. Chen, J. de Hoogh, K. Katsouyanni, K. Rodopoulou, S. Samoli, E. Andersen, Z.J. Atkinson, R. Casas, L. Deboosere, P. Demoury, C. Janssen, N. Klompmaker, J.O. Lefebvre, W. Mehta, A.J. Nawrot, T.S. Oftedal, B. Renzi, M. Stafoggia, M. Strak, M. Vandenheede, H. Vanpoucke, C. Van Nieuwenhuyse, A. Vienneau, D. Brunekreef, B. Hoek, G.

Published
2022

38. Investigating the association between long-term exposure to air pollution and greenness with mortality from neurological, cardio-metabolic and chronic obstructive pulmonary diseases in Greece

Author

Kasdagli, M.-I. Katsouyanni, K. de Hoogh, K. Lagiou, P. Samoli, E. and Kasdagli, M.-I. Katsouyanni, K. de Hoogh, K. Lagiou, P. Samoli, E.

Abstract

Long-term exposure to air pollution has been associated with increased natural-cause mortality, but the evidence on diagnoses-specific mortality outcomes is limited. Few studies have examined the potential synergistic effects of exposure to pollutants and greenness. We investigated the association between exposure to air pollution and greenness with nervous system related mortality, cardiometabolic and chronic obstructive pulmonary diseases (COPD) mortality in Greece, using an ecological study design. We collected socioeconomic and mortality data for 1035 municipal units from the 2011 Census. Annual PM2.5, NO2, BC and O3 concentrations for 2010 were predicted at 100 × 100 m grids by hybrid land use regression models. The normalized difference vegetation index (NDVI) was used for greenness. We applied single and two-exposure Poisson regression models on standardized mortality rates accounting for spatial autocorrelation. We assessed interactions between pollutants and greenness. An interquartile range increase in PM2.5, NO2 and BC was associated with increased risk in mortality from diseases of the nervous system (relative risk (RR): 1.14, 95% confidence interval (CI): 1.01, 1.28); 1.03 (95% CI: 0.99, 1.07); 1.05 (95% CI: 1.00, 1.10) respectively) and from cerebrovascular disease (RR: 1.14, 95% CI: 1.10, 1.18); 1.02 (95% CI: 1.01, 1.04); 1.02 (95% CI: 1.00, 1.04) respectively). PM2.5 was associated with ischemic heart disease mortality (RR: 1.05, 95% CI: 1.01, 1.10). We estimated inverse associations for all outcomes with O3 and for mortality from diseases of the nervous system or COPD with greenness. Estimates were mostly robust to co-exposure adjustment. Interactions were identified between NDVI and O3 or PM2.5 on mortality from the diseases of the nervous system, with higher effect estimates in greener areas. Our findings support the adverse effects of air pollution and the beneficial role of greenness on cardiovascular and nervous system related mortality. Furthe

Published
2022

39. Differential mortality risks associated with PM2.5 components:a multi-country, multi-city study

Author

Masselot, P. (Pierre), Sera, F. (Francesco), Schneider, R. (Rochelle), Kan, H. (Haidong), Lavigne, É. (Éric), Stafoggia, M. (Massimo), Tobias, A. (Aurelio), Chen, H. (Hong), Burnett, R. T. (Richard T.), Schwartz, J. (Joel), Zanobetti, A. (Antonella), Bell, M. L. (Michelle L.), Chen, B.-Y. (Bing-Yu), Guo, Y. L. (Yue-Liang Leon), Ragettli, M. S. (Martina S.), Vicedo-Cabrera, A. M. (Ana Maria), Åström, C. (Christofer), Forsberg, B. (Bertil), Íñiguez, C. (Carmen), Garland, R. M. (Rebecca M.), Scovronick, N. (Noah), Madureira, J. (Joana), Nunes, B. (Baltazar), De la Cruz Valencia, C. (César), Hurtado Diaz, M. (Magali), Honda, Y. (Yasushi), Hashizume, M. (Masahiro), Fook Cheng Ng, C. (Chris), Samoli, E. (Evangelia), Katsouyanni, K. (Klea), Schneider, A. (Alexandra), Breitner, S. (Susanne), Ryti, N. R. (Niilo R.I.), Jaakkola, J. J. (Jouni J.K.), Maasikmets, M. (Marek), Orru, H. (Hans), Guo, Y. (Yuming), Valdés Ortega, N. (Nicolás), Matus Correa, P. (Patricia), Tong, S. (Shilu), Gasparrini, A. (Antonio), Masselot, P. (Pierre), Sera, F. (Francesco), Schneider, R. (Rochelle), Kan, H. (Haidong), Lavigne, É. (Éric), Stafoggia, M. (Massimo), Tobias, A. (Aurelio), Chen, H. (Hong), Burnett, R. T. (Richard T.), Schwartz, J. (Joel), Zanobetti, A. (Antonella), Bell, M. L. (Michelle L.), Chen, B.-Y. (Bing-Yu), Guo, Y. L. (Yue-Liang Leon), Ragettli, M. S. (Martina S.), Vicedo-Cabrera, A. M. (Ana Maria), Åström, C. (Christofer), Forsberg, B. (Bertil), Íñiguez, C. (Carmen), Garland, R. M. (Rebecca M.), Scovronick, N. (Noah), Madureira, J. (Joana), Nunes, B. (Baltazar), De la Cruz Valencia, C. (César), Hurtado Diaz, M. (Magali), Honda, Y. (Yasushi), Hashizume, M. (Masahiro), Fook Cheng Ng, C. (Chris), Samoli, E. (Evangelia), Katsouyanni, K. (Klea), Schneider, A. (Alexandra), Breitner, S. (Susanne), Ryti, N. R. (Niilo R.I.), Jaakkola, J. J. (Jouni J.K.), Maasikmets, M. (Marek), Orru, H. (Hans), Guo, Y. (Yuming), Valdés Ortega, N. (Nicolás), Matus Correa, P. (Patricia), Tong, S. (Shilu), and Gasparrini, A. (Antonio)

Abstract

Background: The association between fine particulate matter (PM2.5) and mortality widely differs between as well as within countries. Differences in PM2.5 composition can play a role in modifying the effect estimates, but there is little evidence about which components have higher impacts on mortality. Methods: We applied a 2-stage analysis on data collected from 210 locations in 16 countries. In the first stage, we estimated location-specific relative risks (RR) for mortality associated with daily total PM2.5 through time series regression analysis. We then pooled these estimates in a meta-regression model that included city-specific logratio-transformed proportions of seven PM2.5 components as well as meta-predictors derived from city-specific socio-economic and environmental indicators. Results: We found associations between RR and several PM2.5 components. Increasing the ammonium (NH₄⁺) proportion from 1% to 22%, while keeping a relative average proportion of other components, increased the RR from 1.0063 (95% confidence interval [95% CI] = 1.0030, 1.0097) to 1.0102 (95% CI = 1.0070, 1.0135). Conversely, an increase in nitrate (NO₃⁻) from 1% to 71% resulted in a reduced RR, from 1.0100 (95% CI = 1.0067, 1.0133) to 1.0037 (95% CI = 0.9998, 1.0077). Differences in composition explained a substantial part of the heterogeneity in PM2.5 risk. Conclusions: These findings contribute to the identification of more hazardous emission sources. Further work is needed to understand the health impacts of PM2.5 components and sources given the overlapping sources and correlations among many components.

Published
2022

40. Global, regional, and national burden of mortality associated with short-term temperature variability from 2000–19:a three-stage modelling study

Author

Wu, Y. (Yao), Li, S. (Shanshan), Zhao, Q. (Qi), Wen, B. (Bo), Gasparrini, A. (Antonio), Tong, S. (Shilu), Overcenco, A. (Ala), Urban, A. (Ales), Schneider, A. (Alexandra), Entezari, A. (Alireza), Vicedo-Cabrera, A. M. (Ana Maria), Zanobetti, A. (Antonella), Analitis, A. (Antonis), Zeka, A. (Ariana), Tobias, A. (Aurelio), Nunes, B. (Baltazar), Alahmad, B. (Barrak), Armstrong, B. (Ben), Forsberg, B. (Bertil), Pan, S.-C. (Shih-Chun), Iniguez, C. (Carmen), Ameling, C. (Caroline), De la Cruz Valencia, C. (Cesar), Astrom, C. (Christofer), Houthuijs, D. (Danny), Roye, D. (Dominic), Indermitte, E. (Ene), Lavigne, E. (Eric), Mayvaneh, F. (Fatemeh), Acquaotta, F. (Fiorella), De'Donato, F. (Francesca), Rao, S. (Shilpa), Sera, F. (Francesco), Carrasco-Escobar, G. (Gabriel), Kan, H. (Haidong), Orru, H. (Hans), Kim, H. (Ho), Holobaca, I.-H. (Iulian-Horia), Kysely, J. (Jan), Madureira, J. (Joana), Schwartz, J. (Joel), Jaakkola, J. J. (Jouni J. K.), Katsouyanni, K. (Klea), Diaz, M. H. (Magali Hurtado), Ragettli, M. S. (Martina S.), Hashizume, M. (Masahiro), Pascal, M. (Mathilde), Zanotti Stagliorio Coelho, M. d. (Micheline de Sousa), Ortega, N. V. (Nicolas Valdes), Ryti, N. (Niilo), Scovronick, N. (Noah), Michelozzi, P. (Paola), Correa, P. M. (Patricia Matus), Goodman, P. (Patrick), Nascimento Saldiva, P. H. (Paulo Hilario), Abrutzky, R. (Rosana), Osorio, S. (Samuel), Colistro, V. (Valentina), Huber, V. (Veronika), Lee, W. (Whanhee), Seposo, X. (Xerxes), Honda, Y. (Yasushi), Guo, Y. L. (Yue Leon), Bell, M. L. (Michelle L.), Guo, Y. (Yuming), Wu, Y. (Yao), Li, S. (Shanshan), Zhao, Q. (Qi), Wen, B. (Bo), Gasparrini, A. (Antonio), Tong, S. (Shilu), Overcenco, A. (Ala), Urban, A. (Ales), Schneider, A. (Alexandra), Entezari, A. (Alireza), Vicedo-Cabrera, A. M. (Ana Maria), Zanobetti, A. (Antonella), Analitis, A. (Antonis), Zeka, A. (Ariana), Tobias, A. (Aurelio), Nunes, B. (Baltazar), Alahmad, B. (Barrak), Armstrong, B. (Ben), Forsberg, B. (Bertil), Pan, S.-C. (Shih-Chun), Iniguez, C. (Carmen), Ameling, C. (Caroline), De la Cruz Valencia, C. (Cesar), Astrom, C. (Christofer), Houthuijs, D. (Danny), Roye, D. (Dominic), Indermitte, E. (Ene), Lavigne, E. (Eric), Mayvaneh, F. (Fatemeh), Acquaotta, F. (Fiorella), De'Donato, F. (Francesca), Rao, S. (Shilpa), Sera, F. (Francesco), Carrasco-Escobar, G. (Gabriel), Kan, H. (Haidong), Orru, H. (Hans), Kim, H. (Ho), Holobaca, I.-H. (Iulian-Horia), Kysely, J. (Jan), Madureira, J. (Joana), Schwartz, J. (Joel), Jaakkola, J. J. (Jouni J. K.), Katsouyanni, K. (Klea), Diaz, M. H. (Magali Hurtado), Ragettli, M. S. (Martina S.), Hashizume, M. (Masahiro), Pascal, M. (Mathilde), Zanotti Stagliorio Coelho, M. d. (Micheline de Sousa), Ortega, N. V. (Nicolas Valdes), Ryti, N. (Niilo), Scovronick, N. (Noah), Michelozzi, P. (Paola), Correa, P. M. (Patricia Matus), Goodman, P. (Patrick), Nascimento Saldiva, P. H. (Paulo Hilario), Abrutzky, R. (Rosana), Osorio, S. (Samuel), Colistro, V. (Valentina), Huber, V. (Veronika), Lee, W. (Whanhee), Seposo, X. (Xerxes), Honda, Y. (Yasushi), Guo, Y. L. (Yue Leon), Bell, M. L. (Michelle L.), and Guo, Y. (Yuming)

Abstract

Background: Increased mortality risk is associated with short-term temperature variability: However, to our knowledge, there has been no comprehensive assessment of the temperature variability-related mortality burden worldwide. In this study, using data from the MCC Collaborative Research Network, we first explored the association between temperature variability and mortality across 43 countries or regions. Then, to provide a more comprehensive picture of the global burden of mortality associated with temperature variability, global gridded temperature data with a resolution of 0·5° × 0·5° were used to assess the temperature variability-related mortality burden at the global, regional, and national levels. Furthermore, temporal trends in temperature variability-related mortality burden were also explored from 2000–19. Methods: In this modelling study, we applied a three-stage meta-analytical approach to assess the global temperature variability-related mortality burden at a spatial resolution of 0·5° × 0·5° degrees from 2000–19. Temperature variability was calculated as the SD of the average of the same and previous days’ minimum and maximum temperatures. We first obtained location-specific temperature variability related-mortality associations based on a daily time series of 750 locations from the Multi-country Multi-city Collaborative Research Network. We subsequently constructed a multivariable meta-regression model with five predictors to estimate grid-specific temperature variability related-mortality associations across the globe. Finally, percentage excess in mortality and excess mortality rate were calculated to quantify the temperature variability-related mortality burden and to further explore its temporal trend over two decades. Findings: An increasing trend in temperature variability was identified at the global level from 2000 to 2019. Globally, 1753392 deaths (95% CI 1159 901–2357 718) were associated with temperature variability per year, ac

Published
2022

48. Short-term effects of particulate matter on mortality during forest fires in Southern Europe: results of the MED-PARTICLES Project

Author

Faustini, Annunziata, Alessandrini, Ester R, Pey, Jorge, Perez, Noemi, Samoli, Evangelia, Querol, Xavier, Cadum, Ennio, Perrino, Cinzia, Ostro, Bart, Ranzi, Andrea, Sunyer, Jordi, Stafoggia, Massimo, Forastiere, Francesco, Angelini, P, Berti, G, Bisanti, L, Catrambone, M, Chiusolo, M, Davoli, M, de’ Donato, F, Demaria, M, Gandini, M, Grosa, M, Ferrari, S, Pandolfi, P, Pelosini, R, Pietrodangelo, A, Pizzi, L, Poluzzi, V, Priod, G, Randi, G, Rowinski, M, Scarinzi, C, Stivanello, E, Zauli-Sajani, S, Dimakopoulou, K, Elefteriadis, K, Katsouyanni, K, Kelessis, A, Maggos, T, Michalopoulos, N, Pateraki, S, Petrakakis, M, Rodopoulou, S, Sypsa, V, Agis, D, Alguacil, J, Artiñano, B, Barrera-Gómez, J, Basagaña, X, de la Rosa, J, Diaz, J, Fernandez, R, Jacquemin, B, Karanasiou, A, Linares, C, Sanchez, AM, Tobias, A, Bidondo, M, Declercq, C, Le Tertre, A, Lozano, P, Medina, S, Pascal, L, and Pascal, M

Published
2015
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