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Your search keyword '"Katundu, Pauline"' showing total 12 results
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12 results on '"Katundu, Pauline"'

1. Six months survival and risk factors for attrition for patients detected with cryptococcal antigenemia through screening in Malawi

Author

Chisale, Master R. O., primary, Jordan, Alex, additional, Kamudumuli, Pocha S., additional, Mvula, Bernard, additional, Odo, Michael, additional, Maida, Alice, additional, Kandulu, James, additional, Chilima, Ben, additional, Sinyiza, Frank W., additional, Katundu, Pauline, additional, Lee, Hsin-yi, additional, Mtegha, Rebecca, additional, Wu, Tsung-Shu Joseph, additional, Bitirinyo, Joseph, additional, Nyirenda, Rose, additional, Kalua, Thoko, additional, Greene, Greg, additional, and Chiller, Tom, additional

Published
2023
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6. Distribution of haematological and chemical pathology values among infants in Malawi and Uganda

Author

Kumwenda, Newton I, primary, Khonje, Tiwonge, additional, Mipando, Linda, additional, Nkanaunena, Kondwani, additional, Katundu, Pauline, additional, Lubega, Irene, additional, Elbireer, Ali, additional, Bolton, Steve, additional, Bagenda, Danstan, additional, Mubiru, Michael, additional, Fowler, Mary Glenn, additional, and Taha, Taha E, additional

Published
2012
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7. Lack of Minority K65R-Resistant Viral Populations Detected After Repeated Treatment Interruptions of Tenofovir/Zidovudine and Lamivudine in a Resource-Limited Setting

Author

McCormick, Adele L, primary, Goodall, Ruth L, additional, Joyce, Aengus, additional, Ndembi, Nicaise, additional, Chirara, Mike, additional, Katundu, Pauline, additional, Walker, Sarah, additional, Yirrell, David, additional, Gilks, Charlie F, additional, and Pillay, Deenan, additional

Published
2010
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11. Haplotypic analysis of the TNFlocus by association efficiency and entropy

Author

Ackerman, Hans, Usen, Stanley, Mott, Richard, Richardson, Anna, Sisay-Joof, Fatoumatta, Katundu, Pauline, Taylor, Terrie, Ward, Ryk, Molyneux, Malcolm, Pinder, Margaret, and Kwiatkowski, Dominic P

Abstract

Background: To understand the causal basis of TNFassociations with disease, it is necessary to understand the haplotypic structure of this locus. We genotyped 12 single-nucleotide polymorphisms (SNPs) distributed over 4.3 kilobases in 296 healthy, unrelated Gambian and Malawian adults. We generated 592 high-quality haplotypes by integrating family- and population-based reconstruction methods. Results: We found 32 different haplotypes, of which 13 were shared between the two populations. Both populations were haplotypically diverse (gene diversity = 0.80, Gambia; 0.85, Malawi) and significantly differentiated (p< 10-5by exact test). More than a quarter of marker pairs showed evidence of intragenic recombination (29% Gambia; 27% Malawi). We applied two new methods of analyzing haplotypic data: association efficiency analysis (AEA), which describes the ability of each SNP to detect every other SNP in a case-control scenario; and the entropy maximization method (EMM), which selects the subset of SNPs that most effectively dissects the underlying haplotypic structure. AEA revealed that many SNPs in TNFare poor markers of each other. The EMM showed that 8 of 12 SNPs (Gambia) and 7 of 12 SNPs (Malawi) are required to describe 95% of the haplotypic diversity. Conclusions: The TNFlocus in the Gambian and Malawi sample is haplotypically diverse and has a rich history of intragenic recombination. As a consequence, a large proportion of TNFSNPs must be typed to detect a disease-modifying SNP at this locus. The most informative subset of SNPs to genotype differs between the two populations.

Published
2003
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12. Lack of minority K65R-resistant viral populations detected after repeated treatment interruptions of tenofovir/zidovudine and lamivudine in a resource-limited setting.

Author

McCormick AL, Goodall RL, Joyce A, Ndembi N, Chirara M, Katundu P, Walker S, Yirrell D, Gilks CF, and Pillay D

Subjects
CD4 Lymphocyte Count, Drug Combinations, Drug Resistance, Viral drug effects, Drug Resistance, Viral genetics, HIV Infections virology, HIV-1 genetics, Humans, Lamivudine administration & dosage, Mutation drug effects, Mutation genetics, Viral Load drug effects, Zidovudine administration & dosage, Anti-HIV Agents therapeutic use, HIV Infections drug therapy, HIV-1 drug effects, Lamivudine therapeutic use, Zidovudine therapeutic use
Published
2010
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