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Cancer is a complex disease characterized by the unrestrained proliferation and dissemination of abnormal cells. The issue continues to be a notable public health concern on a global scale, with millions of new cases and fatalities being reported annually. Despite significant advances in cancer treatment, it remains a major challenge due to the high cost and toxicity of current therapies. Phytochemicals naturally found in plants are crucial resources for developing novel drugs and potential cancer therapies. The clinical efficacy of these anti-cancer agents has been demonstrated against diverse neoplastic cell lines. Additional investigation in this field can result in improved cancer therapies. Among many other plants effective against cancer, this literature review explores the anti-cancer properties of Annona muricata, a plant commonly known as soursop, which is a tropical plant species native to Central and South America, the Caribbean, and West Africa known for its edible fruit which has some medicinal merits, but also some toxicological effects. Annona muricata has been traditionally used for medicinal purposes, including cancer treatment. Acetogenins, alkaloids, phenolic compounds, and other active compounds are only a few of the phytochemicals that this review cites as being present in A. muricata. The review also looks into A. muricata’s biological abilities to fight lung, liver, prostate, colon, pancreas, and breast cancers. The toxicity of A. muricata and possible adverse effects are also covered in the review. The review also looks at the usage of nanoparticles with A. muricata as a cancer treatment. Overall, this literature review provides valuable insights into the potential anti-cancer properties of A. muricata and its potential as a therapeutic agent in cancer treatment. [ABSTRACT FROM AUTHOR]

Malaria remains a major global public health issue, demanding significant resources from governments, health organizations, and international organizations toward its elimination as an endemic disease. In 2016, Sri Lanka achieved the remarkable feat of being declared "malaria free" by the World Health Organisation (WHO), after over a century of indigenous disease. To identify significant lessons of global importance in eliminating endemic malaria by reviewing literature on Sri Lanka's successful elimination campaign. The history of malaria in Sri Lanka highlights the nation's journey from widespread malaria prevalence to achieving malaria-free status in 2016. Key interventions, such as the establishment of the Anti-Malaria Campaign in 1911, the introduction of Dichloro-Diphenyl-Trichloroethane (DDT) in 1946, and the launch of a malaria eradication program in 1958, played crucial roles in controlling the disease. However, challenges such as insecticide resistance, environmental changes, and civil war periodically caused resurgences. The 21st century saw intensified efforts in surveillance, vector control, and community engagement, culminating in the elimination of indigenous malaria cases in 2012. Despite this success, the risk of reintroduction from imported cases remains, necessitating ongoing vigilance and preventive measures. The case study of Sri Lanka is remarkable, and can provide valuable insight for stakeholders involved in eradicating malaria, with the caveat that this case is further evidence of the differential nature of malaria transmission worldwide., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.