1. Brief Report: Ritonavir Concentrations in Hair Predict Virologic Outcomes in HIV-Infected Adolescents With Virologic Failure on Atazanavir-Based or Ritonavir-Based Second-Line Treatment
- Author
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Chawana, Tariro D, Nhachi, Charles FB, Nathoo, Kusum, Ngara, Bernard, Okochi, Hideaki, Louie, Alexander, Kuncze, Karen, Katzenstein, David, Metcalfe, John, Gandhi, Monica, and Team, Adolescent Treatment Failure Study
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Sexually Transmitted Infections ,Clinical Research ,Clinical Trials and Supportive Activities ,Infectious Diseases ,Pediatric ,HIV/AIDS ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Infection ,Adolescent ,Anti-HIV Agents ,Atazanavir Sulfate ,Female ,HIV Infections ,Hair ,Humans ,Male ,Ritonavir ,Treatment Failure ,Treatment Outcome ,Viral Load ,Zimbabwe ,adolescents ,virologic treatment failure ,ritonavir concentrations in hair ,adherence ,Adolescent Treatment Failure (ATF) Study Team ,Clinical Sciences ,Public Health and Health Services ,Virology ,Clinical sciences ,Epidemiology ,Public health - Abstract
BackgroundSuboptimal adherence to antiretroviral therapy (ART) is responsible for most virologic failure among adolescents with HIV. Methods for objectively measuring adherence to ART are limited. This study assessed the association between ritonavir concentrations in hair and self-reported adherence and modified directly administered ART on virologic outcomes among HIV-infected adolescents who were virologically failing second-line ART in Harare, Zimbabwe.MethodsHIV-infected adolescents on atazanavir-based or ritonavir-based second-line treatment for >6 months with viral load ≥1000 copies/mL were randomized to either modified directly administered ART (mDAART) plus standard of care (intervention) or standard of care alone (control). Questionnaires were administered; viral load and hair samples were collected at baseline and after 90 days. Virological suppression was defned as
- Published
- 2021