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1. Treatment of elderly patients with non-ST-elevation myocardial infarction: the nationwide POPular age registry

Author

Gimbel, Marieke E., Chan Pin Yin, Dean R. P. P., van den Broek, Wout W. A., Hermanides, Renicus S., Kauer, Floris, Tavenier, Annerieke H., Schellings, Dirk, Brinckman, Stijn L., The, Salem H. K., Stoel, Martin G., Heestermans, Ton A. C. M., Rasoul, Saman, Emans, Mireille E., van de Wetering, Machiel, van Bergen, Paul F. M. M., Walhout, Ronald, Nicastia, Debby, Aksoy, Ismail, van ’t Hof, Arnoud, Knaapen, Paul, Botman, Cees-Joost, Liem, Anho, de Nooijer, Cornelis, Peper, Joyce, Kelder, Johannes C., and ten Berg, Jurriën M.

Published
2024
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3. Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study

Author

Auer, Johann, Hubauer, Martin, Pandzic, Sead, Preishuber, Eva, Primus-Grabscheit, Carina, Reitgruber, Dietmar, Schmalzer, Florian, Adlbrecht, Christopher, Schober, Andreas, Hajos, Johannes, Keil, Christoph, Schratter, Alexandra, Frick, Matthias, Benda, Magdalena Anna, Mächler, Maximilian, Mutschlechner, Beatrix, Saely, Christoph, Sprenger, Lukas, Lichtenauer, Michael, Eber, Miriam, Hoppe, Uta, Kolbitsch, Tobias, Jirak, Peter Michael, Mirna, Moritz, Schönbauer, Robert, Bergler-Klein, Jutta, Hengstenberg, Christian, Stojkovic, Stefan, Scherr, Daniel, Manninger-Wünscher, Martin, Rohrer, Ursula, Stühlinger, Markus, Schgoer, Wilfried, Schwarzl, Jana, Pürerfellner, Helmut, Derndorfer, Michael, Ebner, Christian, Eder, Veronika, Kollias, Georgios, Sturmberger, Thomas, Sieghartsleitner, Stefan, Vijgen, Johan, Koopman, Peter, Dujardin, Karl, Anné, Wim, De Ceuninck, Michel, Tavernier, Rene, Duytschaever, Mattias, Knecht, Sébastien, Missault, Luc, Vandekerckhove, Yves, Rossenbacker, Tom, Ector, Bavo, Charlier, Filip, Debruyne, Philippe, Dewilde, Willem, Janssens, Luc, Roosen, John, Vankelecom, Bart, Heidbuchel, Hein, Delesie, Michiel, Vervoort, Gert, Rombouts, Hans, Vanassche, Thomas, Engelen, Matthias, Verhamme, Peter, Willems, Rik, Constance, Christian, Pranno, Nicolas, Cox, Jafna, Bata, Iqbal, Macle, Laurent, Aguilar, Martin, Tourigny, Julia Cadrin, Dubuc, Marc, Dyrda, Katia, Guerra, Peter, Khairy, Paul, Mondésert, Blandine, Rivard, Léna, Roy, Denis, Tadros, Rafik, Talajic, Mario, Thibault, Bernard, Nault, Isabelle, Blier, Louis, Champagne, Jean, Molin, Franck, O'Hara, Gilles, Philippon, François, Plourde, Benoit, Sarrazin, Jean-François, Steinberg, Christian, Coufal, Zdenek, Balazsik, David, Mikulica, Michal, Zapeca, Jakub, Cermak, Ondrej, Drasnar, Tomas, Falc, Matej, Hornof, Josef, Racz, Blazej, Weissova, Danica, Linkova, Hana, Paskova, Eva, Petr, Robert, Sirakova, Andrea, Kettner, Jiri, Benak, Ales, Holek, Martin, Podpera, Ivo, Podperova, Monika, Vancura, Vlastimil, Jandik, Tomas, Smid, Jiri, Dedek, Vratislav, Banik, Jan, Durdil, Vaclav, Hnat, Tomas, Lellouche, Nicolas, Rouffiac, Ségolène, Taldir, Guillaume, Bridonneau, Valentin, Couffon, Philippe, Daudin, Magalie, Hamon, Cécile, Lacaze, Jonathan, Quentin, Anne, Thebault, Christophe, Boiffard, Emmanuel, Billon, Olivier, Miette, Fabien, Pouliquen, Hervé, Turlotte, Guillaume, Gorka, Hervé, Albert, Franck, Bayle, Sandrine, Bensaid, Reda, Dasoveanu, Madalina, Demichili, Thibaud, Dutoiu, Teodora, Khalil, Cliff, Loghin, Caterina, Range, Grégoire, Roussel, Laurent, Socié, Pierre, Thuaire, Christophe, Extramiana, Fabrice, Algalarrondo, Vincent, Boughanmi, Haten, El Mansour, Noreddine, Mohammad, Usman, Sellier, Romain, Elbaz, Meyer, Laperche, Clémence, Maury, Philippe, Kiss, Robert, Borsanyi, Tunde, Gingl, Zoltan, Polgar, Balaza, Benczur, Bela, Bodor, Alexandra, Hepp, Tamas, Malati, Eva, Nagy, Laszlo, Erdei, Norbert, Kapus, Jozsef, Kapus, Katalin, Toth, Brigitta, Matoltsy, Andras, Kiss, Tunde, Merkely, Bela, Herczeg, Szilvia, Kiss, Orsolya, Sallo, Zoltan, Toth, Kalman, Habon, Tamas, Rabai, Miklos, Totsimon, Kinga, Zilahi, Zsolt, Bencze, Gabriella, Santa, Janos, Aradi, Daniel, Kelemen, Barbara, Bolognese, Leonardo, Nesti, Martina, Notarstefano, Pasquale Giovanni, D'Orazio, Simona, Cosmi, Franco, Becattini, Cecilia, Agnelli, Giancarlo, Broccatelli, Belinda, Mosconi, Maria Giulia, Paciaroni, Maurizio, Urbini, Chiara, Parato, Vito Maurizio, Notaristefani, Camilla, Scarano, Michele, Ameri, Pietro, Ghigliotti, Giorgio, Guglielmi, Giulia, Lotti, Roberta, Merlo, Andrea Carlo, Muiesan, Maria Lorenza, Abondio, Andrea, Berasi, Caterina, Mattiuzzo, Elena, Mutti, Claudio, Salvetti, Massimo, Pignatelli, Pasquale, Menichelli, Danilo, Pastori, Daniele, Tamiya, Eiji, Matsumoto, Takahiro, Takabe, Tomosato, Yamamoto, Shoichi, Yamashita, Haruyo, Higashiue, Shinichi, Furuya, Onichi, Hiramatsu, Norihiko, Kasuga, Kensuke, Kojima, Saburo, Komooka, Masatoshi, Kuroyanagi, Satoshi, Matsuura, Makoto, Takemoto, Tetsushi, Yamamoto, Shuji, Saito, Katusmi, Abe, Takuro, Ishida, Issei, Iwanami, Yuji, Kataoka, Shohei, Moriyama, Tetsu, Murohashi, Akira, Sasaki, Akihito, Nakamura, Yuichiro, Ueno, Tetsuya, Shimane, Akira, Hamana, Tomoyo, Ichibori, Hirotoshi, Inoue, Tomohiro, Itoh, Mitsuaki, Iwane, Seigo, Kawai, Hiroya, Kokawa, Tatsuya, Masumoto, Akiko, Matsuo, Koki, Miyata, Taishi, Nakano, Shinsuke, Oishi, Shogo, Onishi, Tetsuari, Sawada, Takahiro, Saito, Takayuki, Shoda, Mitsuhiko, Takahashi, Nobuyuki, Takaya, Tomofumi, Taniguchi, Yasuyo, Tsukamoto, Shota, Tsukishiro, Yasue, Tsukiyama, Yoshiro, Tsunamoto, Hiroshi, Uzu, Kenzo, Yamamoto, Hiroyuki, Yamamoto, Tetsuya, Yokoi, Kiminobu, Yoshida, Chiaki, Watanabe, Nobuhiro, Betsuyaku, Tetsuo, Adachi, Kumiko, Awane, Kouichi, Goto, Daisuke, Sakakibara, Mamoru, Watanabe, Masashi, Ueno, Hideki, Hiroe, Yoshitaka, Matsuo, Koshi, Ayata, Kenji, Fukuda, Ko, Hata, Yoshiki, Hashimoto, Katsushi, Matsumi, Hiroaki, Nikaido, Akira, Okamoto, Shuichi, Sime, Iveta, Stirna, Valters, Reinholde, Ilze, Hansone, Silvija, Kozlovska, Anita, Romanova, Janina, Klincare, Dace, Pontaga, Natalja, Dirmans, Igors, Kalnins, Artis, Upite, Dana, Gersamija, Arcils, Teleznikovs, Arturs, Rozkova, Nadezda, Safro, Jelena, Anguera Camós, Ignasi, Domenico Dallaglio, Paolo, Salguero Bodes, Rafael, Arnbas, Fernando, Borrego, Luis, Marco, Alvaro, Jimenez, Javier Ramos, Gómez-Doblas, Juan José, Pérez Cabeza, Alejandro, Ferreira Gonzålez, Ignacio, Limeres Freire, Javier, Lopez Grau, Merce, Viñolas Prat, Xavier, Moreno Weidmann, Zoraida, Guerra Ramos, Jose Maria, Alonso Martin, Maria Concepcion, Campos Garcia, Bieito, Mogro Carranza, Javier Mauricio, Mendez Zurita, Francisco Javier, Rodriguez Font, Enrique, Gonzales Matos, Carlos Eduardo, García Hernando, Víctor, Lindholm, Carl-Johan, Thulin, Jörgen, Wallén, Håkan, Hagwall, Kristina, Eliasson, Ken, Lundvall, Martin, Olsson, Jens, Kjellman, Björn, Lind, Markus, Johansson, Lars, Svedberg, Niclas, Berglund, Stefan, Söderberg, Julia, Zedigh, Christer, Mooe, Thomas, Axelsson, Mattias, Binsell, Emil, Huber, Daniel, Müller, Christian, Danier, Isabelle, Kühne, Michael, Okamura, Bernhard, Schoepfer, Hadrien, Simmen, Cornelia, Reichlin, Tobias, Chollet, Laurève, Lam, Anna, Wittmer, Severin, Rickli, Hans, Gall, Christian, Hametner, Greta, Intorp, Stephanie, Luescher, Daniel, Haegeli, Laurent, Berg, Jan Christopher, Ebrahimi, Ramin, Auricchio, Angelo, Crljenica, Carmela, Moccetti, Tizziano, Monti, Cristina, Pasotti, Elena, Petrova, Iveta, Rossi, Mariagrazia, Mach, François, Namdar, Mehdi, de Groot, Joris, Proost, Virginnio, Neefs, Joline, Linz, Dominik, van Stipdonk, Twan, den Uijl, Dennis, Alings, Marco, Schaap, Jeroen, Segers, Dolf, Wouters, Noemi, Bartels, Louis, Tieleman, Robert, Pisters, Ron, de Vries, Tim, Selig, Jaap, Kuijper, Aaf, Bot, Pieter, Keijzers, Mitran, Verdel, Gerardus, Tukkie, Raymond, van den Bos, Ewout, Kauer, Floris, Oemrawsingh, Rohit, Stevenhagen, Jeroen, van Es, Jan, Lip, Gregory, Gupta, Dhiraj, Kotalczyk, Agnieszka, Gunstone, Anthony, Brixey, Richard David, Gorog, Diana, Dinarvand, Danial, Gue, Ying, Kanji, Rahim, Memtsas, Vassilios, Senior, Roxy, Bioh, Gabriel, Wong, Yuk-Ki, Child, Nick, Piccini, Jonathan P, Caso, Valeria, Connolly, Stuart J, Fox, Keith A A, Oldgren, Jonas, Jones, W Schuyler, Gorog, Diana A, Durdil, Václav, Viethen, Thomas, Neumann, Christoph, Mundl, Hardi, and Patel, Manesh R

Published
2022
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5. One-year performance of thin-strut cobalt chromium sirolimus-eluting stent versus thicker strut stainless steel biolimus-eluting coronary stent: a propensity-matched analysis of two international all-comers registries

Author

Vlieger, Selina, Danzi, Gian B., Kauer, Floris, Oemrawsingh, Rohit M., Stojkovic, Sinisa, IJsselmuiden, Alexander J.J., Routledge, Helen, Laanmets, Peep, Roffi, Marco, Fröbert, Ole, Baello, Pascual, Wlodarczak, Adrian, Puentes, Angel, Polad, Jawed, and Hildick-Smith, David

Published
2020
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6. Treatment of elderly patients with non-ST-elevation myocardial infarction: the nationwide POPular age registry

Author

Gimbel, Marieke E., primary, Chan Pin Yin, Dean R. P. P., additional, van den Broek, Wout W. A., additional, Hermanides, Renicus S., additional, Kauer, Floris, additional, Tavenier, Annerieke H., additional, Schellings, Dirk, additional, Brinckman, Stijn L., additional, The, Salem H. K., additional, Stoel, Martin G., additional, Heestermans, Ton A. C. M., additional, Rasoul, Saman, additional, Emans, Mireille E., additional, van de Wetering, Machiel, additional, van Bergen, Paul F. M. M., additional, Walhout, Ronald, additional, Nicastia, Debby, additional, Aksoy, Ismail, additional, van ’t Hof, Arnoud, additional, Knaapen, Paul, additional, Botman, Cees-Joost, additional, Liem, Anho, additional, de Nooijer, Cornelis, additional, Peper, Joyce, additional, Kelder, Johannes C., additional, and ten Berg, Jurriën M., additional

Published
2023
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8. Rotation, Velocity and Deformation Imaging in Hypertrophic Cardiomyopathy

Author

Kauer, Floris, Zijlstra, Felix, Geleijnse, Marcel, and Cardiology

Abstract

Hypertrophic cardiomyopathy (HCM) is regarded as one of the most common inherited cardiac diseases. In a number of population studies the prevalence of HCM is estimated in the general population to be at least 1 in 500. HCM is inherited with an autosomal dominant Mendelian pattern, variable expressivity, and age-related (and incomplete) penetrance. Clinical diagnosis of HCM requires confirmation of phenotypic expression, that is an unexplained increase in left ventricular (LV) wall thickness (≥15 mm in adults) associated with a nondilated LV chamber with cardiac imaging (usually echocardiography). Phenotype positive patients may show different patterns of LV hypertrophy: reverse septal curvature, sigmoidal and apical forms have been described. Relatives identified with pathogenic mutations (gene carriers) but without evidence of the disease phenotype comprise a new HCM subgroup, designated as genotype positive-phenotype negative individuals. The risk of eventually developing LV hypertrophy in this group is currently uncertain. In this thesis we investigated the value of speckle tracking echocardiographically (STE)-derived global and regional LV rotation and strain in HCM mutation gene carriers and patients, both in systole and diastole. In the first part of this thesis STE analysis of myocardial velocity, rotation and strain in systole and diastole is introduced. In Chapter 2 a literature review of LV twist mechanics in cardiomyopathies is presented. Analysis of LV twist mechanics may provide substantial pathophysiological understanding in a variety of cardiomyopathies. In the second part of this thesis the feasibility of STE is studied. In Chapter 3 it is shown with a moving phantom model that mitral annular velocities can be accurately determined by STE in an angle independent way. In Chapter 4 the feasibility, observer variability and test-retest variability of LV twist measurements by STE is described. The method appeared to be feasible in approximately two thirds of the subjects with good observer variability and temporal reproducibility, potentially allowing to study changes in LV twist over time in an individual patient. The third part of this thesis is dedicated to the value of STE in HCM carriers and patients. In Chapter 5 it is shown that in HCM patients, LV basal rotation is increased, whereas apical rotation was normal, resulting in increased LV twist. The increased basal rotation may be explained by loss of counteraction of the subendocardial fibre helix, caused by endocardial ischemia due to microvascular dysfunction. LV apical rotation and twist were dependent on the pattern of LV hypertrophy. In patients with a sigmoidal septal curvature, LV apical rotation and twist are increased as compared to patients with a reverse septal curvature. This may be partly explained by the degree of subendocardial ischemia since patients with a sigmoidal septal curvature more often had LV outflow tract obstruction. The extravascular compressive forces caused by gradients due to the outflow obstruction may lead to more extensive microvascular dysfunction and subendocardial ischemia. In Chapter 6 differences in regional basal rotation in HCM patient with a typical reverse septal curvature are described. Basal septal and anterior segments, the segments mostly involved in the hypertrophic process, showed increased rotation compared to other segments where re-rotation rate, the diastolic LV back rotation velocity, is decreased in the septal segment of the basal LV. In Chapter 7 it is shown that although systolic twist is increased in HCM patients LV untwist is delayed, impairing diastolic filling. In a pilot study described in Chapter 8 we tried to investigate the feasibility and value of LV systolic and diastolic strain and rotation (twist) parameters during exercise in patients with HCM, with emphasize on the reserve as clinical exercise-related symptoms in patients with HCM but without LV outflow-tract obstruction are presumed to be related to diastolic dysfunction. Although in this study a blunted diastolic longitudinal functional reserve as assessed by tissue Doppler and STE analysis in HCM patients during exercise is shown, the principal finding of this study is that the feasibility of STE during upright bicycle testing is very limited. In Chapter 9 the relation between resting diastolic deformation indices and subjective (NYHA Class) and objective (ergometry) exercise tolerance in HCM patients is studied. Although the conventional early diastolic myocardial lengthening velocity parameter (e’) is the strongest predictor for exercise workload in HCM patients also STE deformation parameters like strain, unstrain and untwist showed independent correlations to exercise workload. In the final two chapters we investigated the possibilities of STE in detecting preclinical HCM in family members of HCM patients as an alternative for genetic testing, comparable to prior studies using TDI in which conflicting results were reported, potentially caused by the angle-dependency of TDI. In Chapter 10 increased peak late diastolic annular velocities in HCM genetically affected subjects without LV hypertrophy were shown with STE analysis. In contrast, peak early diastolic values could not differentiate genotype (+) from genotype (-) individuals. Finally, in Chapter 11 it is shown that in HCM mutation carriers untwist and unstrain rates are also decreased and delayed indicating early diastolic abnormalities.

Published
2022

9. Morphological characteristics of lesions with thin cap fibroatheroma—a substudy from the COMBINE (OCT-FFR) trial

Author

Roleder-Dylewska, Magda, primary, Gasior, Pawel, additional, Hommels, Tobias M, additional, Roleder, Tomasz, additional, Berta, Balasz, additional, Ang, Hui Ying, additional, Ng, Jaryl Chen Koon, additional, Hermanides, Renicus S, additional, Fabris, Enrico, additional, IJsselmuiden, Alexander J J, additional, Kauer, Floris, additional, Alfonso, Fernando, additional, von Birgelen, Clemens, additional, Escaned, Javier, additional, Camaro, Cyril, additional, Kennedy, Mark W, additional, Pereira, Bruno, additional, Magro, Michael, additional, Nef, Holger, additional, Reith, Sebastian, additional, Malinowski, Krzysztof, additional, De Luca, Giuseppe, additional, Garcia Garcia, Hector M, additional, Granada, Juan F, additional, Wojakowski, Wojciech, additional, and Kedhi, Elvin, additional

Published
2022
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10. TCT-311 Complicated Plaques Prevail in Longer Lesions of DM Patients, but Lesions’ Length Does Not Impact DM Patients’ Prognosis: Data From COMBINE OCT-FFR Trial

Author

Roleder, Tomasz, primary, Berta, Balazs, additional, Ijsselmuiden, Alexander, additional, Alfonso, Fernando, additional, García-Guimaraes, Marcos, additional, Kauer, Floris, additional, Hermanides, Rik, additional, De Luca, Giuseppe, additional, Kennedy, Mark, additional, Malinowski, Krzysztof, additional, Wojakowski, Wojtek, additional, and Kedhi, Elvin, additional

Published
2022
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11. Morphological characteristics of lesions with thin cap fibroatheroma—a substudy from the COMBINE (OCT-FFR) trial.

Author

Roleder-Dylewska, Magda, Gasior, Pawel, Hommels, Tobias M, Roleder, Tomasz, Berta, Balasz, Ang, Hui Ying, Ng, Jaryl Chen Koon, Hermanides, Renicus S, Fabris, Enrico, IJsselmuiden, Alexander J J, Kauer, Floris, Alfonso, Fernando, Birgelen, Clemens von, Escaned, Javier, Camaro, Cyril, Kennedy, Mark W, Pereira, Bruno, Magro, Michael, Nef, Holger, and Reith, Sebastian

Subjects
ATHEROSCLEROSIS complications, MAJOR adverse cardiovascular events, RESEARCH methodology, DIABETES, ATHEROSCLEROSIS, RISK assessment, CORONARY circulation, COMPARATIVE studies, CORONARY artery disease, OPTICAL coherence tomography, DESCRIPTIVE statistics, DISEASE risk factors
Abstract

Aims To study if any qualitative or quantitative optical coherence tomography (OCT) variables in combination with thin cap fibroatheroma (TCFA) patients could improve the identification of lesions at risk for future major adverse cardiac events (MACEs). Methods and results From the combined optical coherence tomography morphologic and fractional flow reserve hemodynamic assessment of non- culprit lesions to better predict adverse event outcomes in diabetes mellitus patients: COMBINE (OCT-FFR) trial database (NCT02989740), we performed a detailed assessment OCT qualitative and quantitative variables in TCFA carrying diabetes mellitus (DM) patients with vs. without MACE during follow-up. MACEs were defined as a composite of cardiac death, target vessel myocardial infarction, clinically driven target lesion revascularization, and hospitalization for unstable angina. From the 390 fractional flow reserve (FFR)-negative DM patients, 98 (25.2%) had ≥1 OCT-detected TCFA, of which 13 (13.3%) had MACE and 85 (86.7%) were event-free (non-MACE). The baseline characteristics were similar between both groups; however, a smaller minimal lumen area (MLA) and lower mean FFR value were observed in MACE group (1.80 vs. 2.50 mm2, P = 0.01, and 0.85 vs. 0.89, P = 0.02, respectively). Prevalence of healed plaque (HP) was higher in the MACE group (53.85 vs. 21.18%, P = 0.01). TCFA were predominantly located proximal to the MLA. TCFA area was smaller in the MACE group, while no difference was observed regarding the lesion area. Conclusion Within TCFA carrying patients, a smaller MLA, lower FFR values, and TCFA location adjacent to a HP were associated with future MACE. Carpet-like measured lesion area surface was similar, while the TCFA area was smaller in the MACE arm, and predominantly located proximal to the MLA. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Thin-Cap Fibroatheroma Rather Than Any Lipid Plaques Increases the Risk of Cardiovascular Events in Diabetic Patients: Insights From the COMBINE OCT–FFR Trial

Author

Fabris, Enrico, primary, Berta, Balasz, additional, Roleder, Tomasz, additional, Hermanides, Renicus S., additional, IJsselmuiden, Alexander J.J., additional, Kauer, Floris, additional, Alfonso, Fernando, additional, von Birgelen, Clemens, additional, Escaned, Javier, additional, Camaro, Cyril, additional, Kennedy, Mark W., additional, Pereira, Bruno, additional, Magro, Michael, additional, Nef, Holger, additional, Reith, Sebastian, additional, Roleder-Dylewska, Magda, additional, Gasior, Pawel, additional, Malinowski, Krzysztof, additional, De Luca, Giuseppe, additional, Garcia-Garcia, Hector M., additional, Granada, Juan F., additional, Wojakowski, Wojciech, additional, and Kedhi, Elvin, additional

Published
2022
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13. Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study

Author

Piccini, Jonathan P, primary, Caso, Valeria, additional, Connolly, Stuart J, additional, Fox, Keith A A, additional, Oldgren, Jonas, additional, Jones, W Schuyler, additional, Gorog, Diana A, additional, Durdil, Václav, additional, Viethen, Thomas, additional, Neumann, Christoph, additional, Mundl, Hardi, additional, Patel, Manesh R, additional, Auer, Johann, additional, Hubauer, Martin, additional, Pandzic, Sead, additional, Preishuber, Eva, additional, Primus-Grabscheit, Carina, additional, Reitgruber, Dietmar, additional, Schmalzer, Florian, additional, Adlbrecht, Christopher, additional, Schober, Andreas, additional, Hajos, Johannes, additional, Keil, Christoph, additional, Schratter, Alexandra, additional, Frick, Matthias, additional, Benda, Magdalena Anna, additional, Mächler, Maximilian, additional, Mutschlechner, Beatrix, additional, Saely, Christoph, additional, Sprenger, Lukas, additional, Lichtenauer, Michael, additional, Eber, Miriam, additional, Hoppe, Uta, additional, Kolbitsch, Tobias, additional, Jirak, Peter Michael, additional, Mirna, Moritz, additional, Schönbauer, Robert, additional, Bergler-Klein, Jutta, additional, Hengstenberg, Christian, additional, Stojkovic, Stefan, additional, Scherr, Daniel, additional, Manninger-Wünscher, Martin, additional, Rohrer, Ursula, additional, Stühlinger, Markus, additional, Schgoer, Wilfried, additional, Schwarzl, Jana, additional, Pürerfellner, Helmut, additional, Derndorfer, Michael, additional, Ebner, Christian, additional, Eder, Veronika, additional, Kollias, Georgios, additional, Sturmberger, Thomas, additional, Sieghartsleitner, Stefan, additional, Vijgen, Johan, additional, Koopman, Peter, additional, Dujardin, Karl, additional, Anné, Wim, additional, De Ceuninck, Michel, additional, Tavernier, Rene, additional, Duytschaever, Mattias, additional, Knecht, Sébastien, additional, Missault, Luc, additional, Vandekerckhove, Yves, additional, Rossenbacker, Tom, additional, Ector, Bavo, additional, Charlier, Filip, additional, Debruyne, Philippe, additional, Dewilde, Willem, additional, Janssens, Luc, additional, Roosen, John, additional, Vankelecom, Bart, additional, Heidbuchel, Hein, additional, Delesie, Michiel, additional, Vervoort, Gert, additional, Rombouts, Hans, additional, Vanassche, Thomas, additional, Engelen, Matthias, additional, Verhamme, Peter, additional, Willems, Rik, additional, Constance, Christian, additional, Pranno, Nicolas, additional, Cox, Jafna, additional, Bata, Iqbal, additional, Macle, Laurent, additional, Aguilar, Martin, additional, Tourigny, Julia Cadrin, additional, Dubuc, Marc, additional, Dyrda, Katia, additional, Guerra, Peter, additional, Khairy, Paul, additional, Mondésert, Blandine, additional, Rivard, Léna, additional, Roy, Denis, additional, Tadros, Rafik, additional, Talajic, Mario, additional, Thibault, Bernard, additional, Nault, Isabelle, additional, Blier, Louis, additional, Champagne, Jean, additional, Molin, Franck, additional, O'Hara, Gilles, additional, Philippon, François, additional, Plourde, Benoit, additional, Sarrazin, Jean-François, additional, Steinberg, Christian, additional, Coufal, Zdenek, additional, Balazsik, David, additional, Mikulica, Michal, additional, Zapeca, Jakub, additional, Cermak, Ondrej, additional, Drasnar, Tomas, additional, Falc, Matej, additional, Hornof, Josef, additional, Racz, Blazej, additional, Weissova, Danica, additional, Linkova, Hana, additional, Paskova, Eva, additional, Petr, Robert, additional, Sirakova, Andrea, additional, Kettner, Jiri, additional, Benak, Ales, additional, Holek, Martin, additional, Podpera, Ivo, additional, Podperova, Monika, additional, Vancura, Vlastimil, additional, Jandik, Tomas, additional, Smid, Jiri, additional, Dedek, Vratislav, additional, Banik, Jan, additional, Durdil, Vaclav, additional, Hnat, Tomas, additional, Lellouche, Nicolas, additional, Rouffiac, Ségolène, additional, Taldir, Guillaume, additional, Bridonneau, Valentin, additional, Couffon, Philippe, additional, Daudin, Magalie, additional, Hamon, Cécile, additional, Lacaze, Jonathan, additional, Quentin, Anne, additional, Thebault, Christophe, additional, Boiffard, Emmanuel, additional, Billon, Olivier, additional, Miette, Fabien, additional, Pouliquen, Hervé, additional, Turlotte, Guillaume, additional, Gorka, Hervé, additional, Albert, Franck, additional, Bayle, Sandrine, additional, Bensaid, Reda, additional, Dasoveanu, Madalina, additional, Demichili, Thibaud, additional, Dutoiu, Teodora, additional, Khalil, Cliff, additional, Loghin, Caterina, additional, Range, Grégoire, additional, Roussel, Laurent, additional, Socié, Pierre, additional, Thuaire, Christophe, additional, Extramiana, Fabrice, additional, Algalarrondo, Vincent, additional, Boughanmi, Haten, additional, El Mansour, Noreddine, additional, Mohammad, Usman, additional, Sellier, Romain, additional, Elbaz, Meyer, additional, Laperche, Clémence, additional, Maury, Philippe, additional, Kiss, Robert, additional, Borsanyi, Tunde, additional, Gingl, Zoltan, additional, Polgar, Balaza, additional, Benczur, Bela, additional, Bodor, Alexandra, additional, Hepp, Tamas, additional, Malati, Eva, additional, Nagy, Laszlo, additional, Erdei, Norbert, additional, Kapus, Jozsef, additional, Kapus, Katalin, additional, Toth, Brigitta, additional, Matoltsy, Andras, additional, Kiss, Tunde, additional, Merkely, Bela, additional, Herczeg, Szilvia, additional, Kiss, Orsolya, additional, Sallo, Zoltan, additional, Toth, Kalman, additional, Habon, Tamas, additional, Rabai, Miklos, additional, Totsimon, Kinga, additional, Zilahi, Zsolt, additional, Bencze, Gabriella, additional, Santa, Janos, additional, Aradi, Daniel, additional, Kelemen, Barbara, additional, Bolognese, Leonardo, additional, Nesti, Martina, additional, Notarstefano, Pasquale Giovanni, additional, D'Orazio, Simona, additional, Cosmi, Franco, additional, Becattini, Cecilia, additional, Agnelli, Giancarlo, additional, Broccatelli, Belinda, additional, Mosconi, Maria Giulia, additional, Paciaroni, Maurizio, additional, Urbini, Chiara, additional, Parato, Vito Maurizio, additional, Notaristefani, Camilla, additional, Scarano, Michele, additional, Ameri, Pietro, additional, Ghigliotti, Giorgio, additional, Guglielmi, Giulia, additional, Lotti, Roberta, additional, Merlo, Andrea Carlo, additional, Muiesan, Maria Lorenza, additional, Abondio, Andrea, additional, Berasi, Caterina, additional, Mattiuzzo, Elena, additional, Mutti, Claudio, additional, Salvetti, Massimo, additional, Pignatelli, Pasquale, additional, Menichelli, Danilo, additional, Pastori, Daniele, additional, Tamiya, Eiji, additional, Matsumoto, Takahiro, additional, Takabe, Tomosato, additional, Yamamoto, Shoichi, additional, Yamashita, Haruyo, additional, Higashiue, Shinichi, additional, Furuya, Onichi, additional, Hiramatsu, Norihiko, additional, Kasuga, Kensuke, additional, Kojima, Saburo, additional, Komooka, Masatoshi, additional, Kuroyanagi, Satoshi, additional, Matsuura, Makoto, additional, Takemoto, Tetsushi, additional, Yamamoto, Shuji, additional, Saito, Katusmi, additional, Abe, Takuro, additional, Ishida, Issei, additional, Iwanami, Yuji, additional, Kataoka, Shohei, additional, Moriyama, Tetsu, additional, Murohashi, Akira, additional, Sasaki, Akihito, additional, Nakamura, Yuichiro, additional, Ueno, Tetsuya, additional, Shimane, Akira, additional, Hamana, Tomoyo, additional, Ichibori, Hirotoshi, additional, Inoue, Tomohiro, additional, Itoh, Mitsuaki, additional, Iwane, Seigo, additional, Kawai, Hiroya, additional, Kokawa, Tatsuya, additional, Masumoto, Akiko, additional, Matsuo, Koki, additional, Miyata, Taishi, additional, Nakano, Shinsuke, additional, Oishi, Shogo, additional, Onishi, Tetsuari, additional, Sawada, Takahiro, additional, Saito, Takayuki, additional, Shoda, Mitsuhiko, additional, Takahashi, Nobuyuki, additional, Takaya, Tomofumi, additional, Taniguchi, Yasuyo, additional, Tsukamoto, Shota, additional, Tsukishiro, Yasue, additional, Tsukiyama, Yoshiro, additional, Tsunamoto, Hiroshi, additional, Uzu, Kenzo, additional, Yamamoto, Hiroyuki, additional, Yamamoto, Tetsuya, additional, Yokoi, Kiminobu, additional, Yoshida, Chiaki, additional, Watanabe, Nobuhiro, additional, Betsuyaku, Tetsuo, additional, Adachi, Kumiko, additional, Awane, Kouichi, additional, Goto, Daisuke, additional, Sakakibara, Mamoru, additional, Watanabe, Masashi, additional, Ueno, Hideki, additional, Hiroe, Yoshitaka, additional, Matsuo, Koshi, additional, Ayata, Kenji, additional, Fukuda, Ko, additional, Hata, Yoshiki, additional, Hashimoto, Katsushi, additional, Matsumi, Hiroaki, additional, Nikaido, Akira, additional, Okamoto, Shuichi, additional, Sime, Iveta, additional, Stirna, Valters, additional, Reinholde, Ilze, additional, Hansone, Silvija, additional, Kozlovska, Anita, additional, Romanova, Janina, additional, Klincare, Dace, additional, Pontaga, Natalja, additional, Dirmans, Igors, additional, Kalnins, Artis, additional, Upite, Dana, additional, Gersamija, Arcils, additional, Teleznikovs, Arturs, additional, Rozkova, Nadezda, additional, Safro, Jelena, additional, Anguera Camós, Ignasi, additional, Domenico Dallaglio, Paolo, additional, Salguero Bodes, Rafael, additional, Arnbas, Fernando, additional, Borrego, Luis, additional, Marco, Alvaro, additional, Jimenez, Javier Ramos, additional, Gómez-Doblas, Juan José, additional, Pérez Cabeza, Alejandro, additional, Ferreira Gonzålez, Ignacio, additional, Limeres Freire, Javier, additional, Lopez Grau, Merce, additional, Viñolas Prat, Xavier, additional, Moreno Weidmann, Zoraida, additional, Guerra Ramos, Jose Maria, additional, Alonso Martin, Maria Concepcion, additional, Campos Garcia, Bieito, additional, Mogro Carranza, Javier Mauricio, additional, Mendez Zurita, Francisco Javier, additional, Rodriguez Font, Enrique, additional, Gonzales Matos, Carlos Eduardo, additional, García Hernando, Víctor, additional, Lindholm, Carl-Johan, additional, Thulin, Jörgen, additional, Wallén, Håkan, additional, Hagwall, Kristina, additional, Eliasson, Ken, additional, Lundvall, Martin, additional, Olsson, Jens, additional, Kjellman, Björn, additional, Lind, Markus, additional, Johansson, Lars, additional, Svedberg, Niclas, additional, Berglund, Stefan, additional, Söderberg, Julia, additional, Zedigh, Christer, additional, Mooe, Thomas, additional, Axelsson, Mattias, additional, Binsell, Emil, additional, Huber, Daniel, additional, Müller, Christian, additional, Danier, Isabelle, additional, Kühne, Michael, additional, Okamura, Bernhard, additional, Schoepfer, Hadrien, additional, Simmen, Cornelia, additional, Reichlin, Tobias, additional, Chollet, Laurève, additional, Lam, Anna, additional, Wittmer, Severin, additional, Rickli, Hans, additional, Gall, Christian, additional, Hametner, Greta, additional, Intorp, Stephanie, additional, Luescher, Daniel, additional, Haegeli, Laurent, additional, Berg, Jan Christopher, additional, Ebrahimi, Ramin, additional, Auricchio, Angelo, additional, Crljenica, Carmela, additional, Moccetti, Tizziano, additional, Monti, Cristina, additional, Pasotti, Elena, additional, Petrova, Iveta, additional, Rossi, Mariagrazia, additional, Mach, François, additional, Namdar, Mehdi, additional, de Groot, Joris, additional, Proost, Virginnio, additional, Neefs, Joline, additional, Linz, Dominik, additional, van Stipdonk, Twan, additional, den Uijl, Dennis, additional, Alings, Marco, additional, Schaap, Jeroen, additional, Segers, Dolf, additional, Wouters, Noemi, additional, Bartels, Louis, additional, Tieleman, Robert, additional, Pisters, Ron, additional, de Vries, Tim, additional, Selig, Jaap, additional, Kuijper, Aaf, additional, Bot, Pieter, additional, Keijzers, Mitran, additional, Verdel, Gerardus, additional, Tukkie, Raymond, additional, van den Bos, Ewout, additional, Kauer, Floris, additional, Oemrawsingh, Rohit, additional, Stevenhagen, Jeroen, additional, van Es, Jan, additional, Lip, Gregory, additional, Gupta, Dhiraj, additional, Kotalczyk, Agnieszka, additional, Gunstone, Anthony, additional, Brixey, Richard David, additional, Gorog, Diana, additional, Dinarvand, Danial, additional, Gue, Ying, additional, Kanji, Rahim, additional, Memtsas, Vassilios, additional, Senior, Roxy, additional, Bioh, Gabriel, additional, Wong, Yuk-Ki, additional, and Child, Nick, additional

Published
2022
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18. TCT-82 Thin-Cap Fibroatheroma Rather Than Any Lipid Plaques Increases the Risk of Cardiovascular Events: Insights From the COMBINE FFR-OCT Trial

Author

Fabris, Enrico, primary, Berta, Balazs, additional, Roleder-Dylewska, Magda, additional, Roleder, Tomasz, additional, Gasior, Pawel, additional, Hermanides, Rik, additional, Ijsselmuiden, Alexander, additional, Kauer, Floris, additional, Alfonso, Fernando, additional, von Birgelen, Clemens, additional, Escaned, Javier, additional, Camaro, Cyril, additional, Kennedy, Mark, additional, Magro, Michael, additional, Nef, Holger, additional, Malinowski, Krzysztof, additional, De Luca, Giuseppe, additional, Garcia-Garcia, Hector, additional, Granada, Juan, additional, Wojakowski, Wojciech, additional, and Kedhi, Elvin, additional

Published
2021
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19. TCT-89 Morphological Characteristics of Thin-Cap Fibroatheroma Lesions in Patients With and Without Future Adverse Events: Insights From the COMBINE (OCT-FFR) Study

Author

Roleder-Dylewska, Magda, primary, Gasior, Pawel, additional, Roleder, Tomasz, additional, Ng, Jaryl, additional, Huiying, Ang, additional, Hermanides, Rik, additional, Fabris, Enrico, additional, Ijsselmuiden, Alexander, additional, Kauer, Floris, additional, Alfonso, Fernando, additional, von Birgelen, Clemens, additional, Escaned, Javier, additional, Camaro, Cyril, additional, Pereira, Bruno, additional, Magro, Michael, additional, Nef, Holger, additional, Malinowski, Krzysztof, additional, Garcia-Garcia, Hector, additional, Granada, Juan, additional, De Luca, Giuseppe, additional, Kennedy, Mark, additional, Wojakowski, Wojciech, additional, and Kedhi, Elvin, additional

Published
2021
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22. Thin-cap fibroatheroma predicts clinical events in diabetic patients with normal fractional flow reserve: the COMBINE OCT–FFR trial

Author

Kedhi, Elvin, primary, Berta, Balazs, additional, Roleder, Tomasz, additional, Hermanides, Renicus S, additional, Fabris, Enrico, additional, IJsselmuiden, Alexander J J, additional, Kauer, Floris, additional, Alfonso, Fernando, additional, von Birgelen, Clemens, additional, Escaned, Javier, additional, Camaro, Cyril, additional, Kennedy, Mark W, additional, Pereira, Bruno, additional, Magro, Michael, additional, Nef, Holger, additional, Reith, Sebastian, additional, Al Nooryani, Arif, additional, Rivero, Fernando, additional, Malinowski, Krzysztof, additional, De Luca, Giuseppe, additional, Garcia Garcia, Hector, additional, Granada, Juan F, additional, and Wojakowski, Wojciech, additional

Published
2021
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23. One-year performance of thin-strut cobalt chromium sirolimus-eluting stent versus thicker strut stainless steel biolimus-eluting coronary stent : a propensity-matched analysis of two international all-comers registries

Author

Vlieger, Selina, Danzi, Gian B., Kauer, Floris, Oemrawsingh, Rohit M., Stojkovic, Sinisa, IJsselmuiden, Alexander J. J., Routledge, Helen, Laanmets, Peep, Roffi, Marco, Fröbert, Ole, Baello, Pascual, Wlodarczak, Adrian, Puentes, Angel, Polad, Jawed, Hildick-Smith, David, Vlieger, Selina, Danzi, Gian B., Kauer, Floris, Oemrawsingh, Rohit M., Stojkovic, Sinisa, IJsselmuiden, Alexander J. J., Routledge, Helen, Laanmets, Peep, Roffi, Marco, Fröbert, Ole, Baello, Pascual, Wlodarczak, Adrian, Puentes, Angel, Polad, Jawed, and Hildick-Smith, David

Abstract

OBJECTIVES: Recent improvements in coronary stent design have focussed on thinner struts, different alloys and architecture, more biocompatible polymers, and shorter drug absorption times. This study evaluates safety and efficacy of a newer generation thin-strut cobalt chromium sirolimus-eluting coronary stent (SES, Ultimaster) in comparison with a second-generation thicker strut stainless steel biolimus-eluting stent (BES, Nobori) in percutaneous coronary intervention (PCI) practice. METHODS: A propensity score analysis was performed to adjust for differences in baseline characteristics of 8137 SES patients and 2738 BES patients of two PCI registries (e-Ultimaster and NOBORI 2). An independent clinical event committee adjudicated all endpoint-related adverse events. RESULTS: The use of SES, as compared with BES was associated with a significantly lower rate of myocardial infarction (MI) (1.2% vs 2.2%; P = 0.0006) and target vessel-related MI (1.1% vs 1.8%; P = 0.002) at 1 year. One-year composite endpoints of all predefined endpoints were lower in patients undergoing SES implantation (target lesion failure: 3.2% vs 4.1%; P = 0.03, target vessel failure: 3.7% vs 5.0%; P = 0.003, patient-oriented composite endpoint 5.7% vs 6.8%; P = 0.03). No significant differences between SES and BES were observed in all-cause death (2.0% vs 1.6%; P = 0.19), cardiac death (1.2% vs 1.2%; P = 0.76) or stent thrombosis (0.6% vs 0.8%; P = 0.43). CONCLUSIONS: These findings suggest an improved clinical safety and efficacy of a newer generation thin-strut SES as compared with a second-generation thicker strut BES., Funding Agency:Terumo Europe

Published
2021
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24. One-year clinical outcomes in patients with renal insufficiency after contemporary PCI: data from a multicenter registry

Author

Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Scholz, Sean S., Lauder, Lucas, Ewen, Sebastian, Kulenthiran, Saarraaken, Marx, Nikolaus, Sakhov, Orazbek, Kauer, Floris, Witkowski, Adam, Vaglimigli, Marco, Wijns, William, Scheller, Bruno, Böhm, Michael, Mahfoud, Felix, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Scholz, Sean S., Lauder, Lucas, Ewen, Sebastian, Kulenthiran, Saarraaken, Marx, Nikolaus, Sakhov, Orazbek, Kauer, Floris, Witkowski, Adam, Vaglimigli, Marco, Wijns, William, Scheller, Bruno, Böhm, Michael, and Mahfoud, Felix

Abstract

Background Chronic kidney disease (CKD) is highly prevalent in patients with coronary artery disease (CAD). Objective The outcome following revascularization using contemporary technologies (new-generation abluminal sirolimus-eluting stents with thin struts) in patients with CKD (i.e., glomerular filtration rate of < 60 mL/min/1.73m2) and in patients with hemodialysis (HD) is unknown. Methods e-Ultimaster is a prospective, single-arm, multi-center registry with clinical follow-up at 3 months and 1 year. Results A total of 19,475 patients were enrolled, including 1466 patients with CKD, with 167 undergoing HD. Patients with CKD had a higher prevalence of overall comorbidities, multiple/small vessel disease (≤ 2.75 mm), bifurcation lesions, and more often left main artery treatments (all p < 0.0001) when compared with patients with normal renal function (reference). CKD patients had a higher risk of target lesion failure (unadjusted OR, 2.51 [95% CI 2.04–3.08]), target vessel failure (OR, 2.44 [95% CI 2.01–2.96]), patient-oriented composite end point (OR, 2.19 [95% CI 1.87–2.56]), and major adverse cardiovascular events (OR, 2.34 [95% CI 1.93–2.83, p for all < 0.0001]) as reference. The rates of target lesion revascularization (OR, 1.17 [95% CI 0.79–1.73], p = 0.44) were not different. Bleeding complications were more frequently observed in CKD than in the reference (all p < 0.0001). Conclusion In this worldwide registry, CKD patients presented with more comorbidities and more complex lesions when compared with the reference population. They experienced higher rate of adverse events at 1-year follow-up. Graphic abstract One-year summary outcomes of contemporary PCI in renal insufficiency. CKD chronic kidney disease, POCE patient oriented composite endpoint, MACE major adverse cardiovascular events, TLF target lesion failure, TLR target lesion revascularization, ST stent thrombosis

Published
2020

28. TCT CONNECT-279 Transradial PCI Outcomes in the OPTIMIZE IDE Trial: Exploring a Transradial PCI Indication for the Slender IDS and DIRECT RX Sirolimus-Eluting Coronary Stents

Author

Rao, Sunil, primary, IJsselmuiden, A.J.J., additional, Kauer, Floris, additional, Amoroso, Giovanni, additional, Zidar, James, additional, Tonino, Pim, additional, Caputo, Ronald, additional, Yakubov, Steven, additional, Saito, Shigeru, additional, and Kereiakes, Dean, additional

Published
2020
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29. TCT CONNECT-281 Clinical Outcomes of Optical Coherence Tomography Detected High-Risk Versus Low-Risk Coronary Atherosclerotic Lesions in Medically Treated Fractional Flow Reserve Negative Lesions in Diabetes Mellitus Patients: The COMBINE Trial

Author

Kedhi, Elvin, primary, Roleder, Tomasz, additional, Hermanides, Rik, additional, Ijsselmuiden, Alexander, additional, Alfonso, Fernando, additional, Kauer, Floris, additional, Escaned, Javier, additional, Camaro, Cyril, additional, Kennedy, Mark, additional, von Birgelen, Clemens, additional, Magro, Michael, additional, Nef, Holger, additional, De Luca, Giuseppe, additional, and van Royen, Niels, additional

Published
2020
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31. One-year clinical outcomes in patients with renal insufficiency after contemporary PCI: data from a multicenter registry

Author

Scholz, Sean S., primary, Lauder, Lucas, additional, Ewen, Sebastian, additional, Kulenthiran, Saarraaken, additional, Marx, Nikolaus, additional, Sakhov, Orazbek, additional, Kauer, Floris, additional, Witkowski, Adam, additional, Vaglimigli, Marco, additional, Wijns, William, additional, Scheller, Bruno, additional, Böhm, Michael, additional, and Mahfoud, Felix, additional

Published
2019
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32. TCT-284 Latest Update of the Worldwide Everyday Practice Registry Assessing the Xposition S Self-Apposing Stent in Challenging Lesions With Vessel Diameter Variance (SIZING Registry)

Author

Schnupp, Steffen, primary, Siry, Marcus, additional, Sukiennik, Adam, additional, Weilenmann, Daniel, additional, Somi, Samer, additional, Liew, HoungBang, additional, Jessurun, Gillian A., additional, Ajmi, Issameddine, additional, Ijsselmuiden, Alexander, additional, Kauer, Floris, additional, and Huynh, Vi-Phong, additional

Published
2019
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33. Comparison of an everolimus-eluting bioresorbable scaffold with an everolimus-eluting metallic stent in routine PCI: three-year clinical outcomes from the AIDA trial

Author

Kerkmeijer, Laura S.M., primary, Tijssen, Ruben Yannick G., additional, Hofma, Sjoerd H., additional, van der Schaaf, Rene J., additional, Arkenbout, Karin E., additional, Kraak, Robin P., additional, Weevers, Auke, additional, Piek, Jan J., additional, de Winter, Robbert J., additional, Tijssen, Jan G.P., additional, Henriques, Jose P.S., additional, Wykrzykowska, Joanna J., additional, Ijsselmuiden, Alexander, additional, Kauer, Floris, additional, Beijk, Marcel A., additional, Vis, Marije, additional, and Koch, Karel, additional

Published
2019
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36. TCT-329 Prospective Evaluation of Drug Eluting Self Apposing Stent for the Treatment of Unprotected Left Main Coronary Artery Disease: 1-Year Results of the TRUNC Study

Author

Tamburino, Corrado, primary, Briguori, Carlo, additional, Jessurun, Gillian A., additional, Reczuch, Krzysztof, additional, Cortese, Bernardo, additional, Maillard, Luc, additional, Ochala, Andrzej, additional, Kauer, Floris, additional, Siry, Marcus, additional, Sardella, Gennaro, additional, Sukiennik, Adam, additional, Ijsselmuiden, Alexander, additional, Bouchez, David, additional, and Baumbach, Andreas, additional

Published
2018
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37. TCT-470 Worldwide Everyday Practice Registry Assessing the Xposition S Self-apposing Stent in Challenging Lesions with Vessel Diameter Variance (SIZING Registry)

Author

Siry, Marcus, primary, Sukiennik, Adam, additional, Weilenmann, Daniel, additional, Somi, Samer, additional, Schnupp, Steffen, additional, Jessurun, Gillian A., additional, Ijsselmuiden, Alexander, additional, Geuns, Robert-Jan van, additional, Balland, Anais, additional, and Kauer, Floris, additional

Published
2018
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40. Angiographic and Optical Coherence Tomography Insights Into Bioresorbable Scaffold Thrombosis

Author

Karanasos, Antonios, Van Mieghem, Nicolas, van Ditzhuijzen, Nienke, Felix, Cordula, Daemen, Joost, Autar, Anouchska, Onuma, Yoshinobu, Kurata, Mie, Diletti, Roberto, Valgimigli, Marco, Kauer, Floris, van Beusekom, Heleen, de Jaegere, Peter, Zijlstra, Felix, van Geuns, Robert-Jan, and Regar, Evelyn

Subjects
Male, Tissue Scaffolds, Coronary Thrombosis, drug-eluting stents, Original Articles, bioabsorbable implants, Coronary Artery Disease, Middle Aged, Coronary Angiography, Coronary Vessels, Coronary Interventions, Absorbable Implants, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, tomography, optical coherence, Humans, Female, Everolimus, Immunosuppressive Agents, Aged
Abstract

Supplemental Digital Content is available in the text., Background— As bioresorbable vascular scaffolds (BVSs) are being increasingly used in complex real-world lesions and populations, BVS thrombosis cases have been reported. We present angiographic and optical coherence tomography (OCT) findings in a series of patients treated in our center for definite bioresorbable scaffold thrombosis. Methods and Results— Up to June 2014, 14 patients presented with definite BVS thrombosis in our center. OCT was performed in 9 patients at the operator’s discretion. Angiographic and OCT findings were compared with a control group comprising 15 patients with definite metallic stent thrombosis. In the BVS group, time interval from index procedure to scaffold thrombosis ranged from 0 to 675 days. Incomplete lesion coverage by angiography was identified in 4 of 14 cases, malapposition by OCT in 5 of 9 cases, strut discontinuity in 2 of 9 cases, and underexpansion in 2 of 9 cases. Five patients had discontinued dual antiplatelet therapy, and in 3 of them discontinued dual antiplatelet therapy discontinuation had occurred the week preceding the event. There were no significant differences in angiographic or OCT findings between BVS and metallic stent thrombosis. Conclusions— Suboptimal implantation with incomplete lesion coverage, underexpansion, and malapposition comprises the main pathomechanism for both early and late BVS thrombosis, similar to metallic stent thrombosis. Dual antiplatelet therapy discontinuation seems to also be a secondary contributor in several late events. Our observations suggest that several potential triggers for BVS thrombosis could be avoided.

Published
2015

45. Response by Costa et al to Letter Regarding Article, “The Rotterdam Radial Access Research: Ultrasound-Based Radial Artery Evaluation for Diagnostic and Therapeutic Coronary Procedures”

Author

Costa, Francesco, primary, Daemen, Joost, additional, Diletti, Roberto, additional, Kauer, Floris, additional, Geuns, Robert-Jan van, additional, Ligthart, Jurgen, additional, Witberg, Karen, additional, Zijlstra, Felix, additional, Valgimigli, Marco, additional, Van Mieghem, Nicolas M., additional, and van Leeuwen, Maarten A.H., additional

Published
2016
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46. The Rotterdam Radial Access Research

Author

Costa, Francesco, primary, van Leeuwen, Maarten A.H., additional, Daemen, Joost, additional, Diletti, Roberto, additional, Kauer, Floris, additional, van Geuns, Robert-Jan, additional, Ligthart, Jurgen, additional, Witberg, Karen, additional, Zijlstra, Felix, additional, Valgimigli, Marco, additional, and Van Mieghem, Nicolas M., additional

Published
2016
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47. Angiographic and Optical Coherence Tomography Insights Into Bioresorbable Scaffold Thrombosis Single-Center Experience

Author

Karanasos, Antonios, van Mieghem, Nicolas, Ditzhuijzen, Nienke, Felix, Cordula, Daemen, Joost, Autar, A, Onuma, Yoshinobu, Kurata, Mie, Diletti, Roberto, Valgimigli, Marco, Kauer, Floris, van Beusekom, H.M.M., de Jaegere, Peter, Zijlstra, Felix, van Geuns, Robert Jan, Regar, Evelyn, Karanasos, Antonios, van Mieghem, Nicolas, Ditzhuijzen, Nienke, Felix, Cordula, Daemen, Joost, Autar, A, Onuma, Yoshinobu, Kurata, Mie, Diletti, Roberto, Valgimigli, Marco, Kauer, Floris, van Beusekom, H.M.M., de Jaegere, Peter, Zijlstra, Felix, van Geuns, Robert Jan, and Regar, Evelyn

Abstract

Background-As bioresorbable vascular scaffolds (BVSs) are being increasingly used in complex real-world lesions and populations, BVS thrombosis cases have been reported. We present angiographic and optical coherence tomography (OCT) findings in a series of patients treated in our center for definite bioresorbable scaffold thrombosis. Methods and Results-Up to June 2014, 14 patients presented with definite BVS thrombosis in our center. OCT was performed in 9 patients at the operator's discretion. Angiographic and OCT findings were compared with a control group comprising 15 patients with definite metallic stent thrombosis. In the BVS group, time interval from index procedure to scaffold thrombosis ranged from 0 to 675 days. Incomplete lesion coverage by angiography was identified in 4 of 14 cases, malapposition by OCT in 5 of 9 cases, strut discontinuity in 2 of 9 cases, and underexpansion in 2 of 9 cases. Five patients had discontinued dual antiplatelet therapy, and in 3 of them discontinued dual antiplatelet therapy discontinuation had occurred the week preceding the event. There were no significant differences in angiographic or OCT findings between BVS and metallic stent thrombosis. Conclusions-Suboptimal implantation with incomplete lesion coverage, underexpansion, and malapposition comprises the main pathomechanism for both early and late BVS thrombosis, similar to metallic stent thrombosis. Dual antiplatelet therapy discontinuation seems to also be a secondary contributor in several late events. Our observations suggest that several potential triggers for BVS thrombosis could be avoided.

Published
2015

49. Delayed and decreased LV untwist and unstrain rate in mutation carriers for hypertrophic cardiomyopathy.

Author

Kauer, Floris, van Dalen, Bas M., Michels, Michelle, Schinkel, Arend F. L., Vletter, Wim B., van Slegtenhorst, Marjon, Soliman, Osama I. I., and Geleijnse, Marcel L.

Subjects
HEART physiology, LEFT heart ventricle, BLOOD circulation, BLOOD pressure, DIASTOLE (Cardiac cycle), DISEASE susceptibility, CARDIAC hypertrophy, MITRAL valve, GENETIC mutation, LEFT ventricular hypertrophy
Abstract

Background The echocardiographic focus to detect abnormalities in genetically hypertrophic cardiomyopathy (HCM) affected subjects without left ventricular (LV) hypertrophy (G+/LVH-) has been on diastolic abnormalities in transmitral flow and longitudinal myocardial function with tissue Doppler imaging. The aim of this study was to assess diastolic LV unstrain and untwist. Methods and results Forty-one consecutive genotyped family members of HCM patients (mean age 37 ± 11 years, 16 men) and 41 age-and gender-matched healthy volunteers underwent speckle-tracking echocardiography to measure untwist and unstrain. No significant differences between G+/LVH - and control subjects were seen in maximal systolic twist and global longitudinal strain. In diastole, the early peak untwist rate was significantly lower in G+/LVH- subjects compared with control subjects (62 ± 19°s -1 vs. 76 ± 30°s -1, P <0.05), whereas the late peak untwist rate tended to be higher. Untwist from maximal twist until the first 20% of diastole was delayed in G+/LVH - subjects (39.3 ± 12.9% vs. 51.3 ± 15.6%, P <0.005). Late diastolic unstrain rate was significantly higher in G+/LVH- subjects in the inferoseptal wall (111 ± 33 s -1 vs. 94 ± 32 s -1, P = 0.024), the inferolateral wall (105 ± 42 vs. 75 ± 35 s -1, P = 0.007) and the anteroseptal wall (97 ± 26 vs. 80 ± 23s -1, P - 0.010). Unstrain from maximal twist until the first 20% of diastole was delayed in G+/LVH- subjects in the inferoseptal (18.9 ± 14.0% vs. 30.1 ± 17.7%, P = 0.005), inferolateral (27.1 ± 16.3% vs. 39.2 ± 18.0%, P = 0.015) and anteroseptal (19.1 ± 14.7% vs. 35.8 ± 18.5%, P = 0.0003) segments. Conclusions In mutation carriers, for HCM LV, untwist and unstrain are delayed and untwist rate and unstrain rate are decreased. [ABSTRACT FROM AUTHOR]

Published
2017
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