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5. Peat swamp hydrological connectivity and runoff vary by hydrogeomorphic setting: Implications for carbon storage.

Author

McCarter, Colin, Kaufman, Stephen, Branfireun, Brian, and Waddington, James

Subjects
RUNOFF, PEAT, SWAMPS, WATER table, WATER quality, WETLANDS, RIVER channels, WATERSHEDS
Abstract

Despite their importance in carbon cycling and catchment runoff dynamics, the hydrology of temperate peat swamps in response to changing hydrometeorological conditions is largely understudied. We examined the importance of hydrogeomorphic settings in controlling hydrological connectivity and runoff in a temperate peat swamp in southern Ontario, Canada over two consecutive growing seasons with contrasting conditions (dry and wet years). We chose two different small‐scale hydrogeomorphic settings to investigate: (i) a site with strong wetland‐stream interactions (i.e., an unconfined stream channel; unconfined) and (ii) a site with limited wetland‐stream interactions (confined). During the wet year, the confined site exhibited a consistently gaining stream, maintaining lateral hydrological connectivity and yielding high runoff ratios, while during the dry year, the confined site lost water and experienced low runoff ratios during storm events. Overland flow at the unconfined site maintained a longitudinal hydrological connectivity delivering water to its sub‐catchment outflow, as reinforced by hydrochemical observations. This connectivity was maintained in the wet year but ceased in the dry year despite consistent upstream sub‐catchment water inflow due to high depression storage. Runoff ratios were reduced because of this hydrological disconnection. We highlight the importance of small‐scale hydrogeomorphic setting on peat swamp carbon storage as facilitated by the variation of within‐site hydrological connectivity and runoff, which also has important implications for downstream water quality. The unconfined site maintained a higher water table position in both years and has much greater peat carbon stocks. We suggest peat swamp channelization either naturally or through drainage decreases carbon stocks. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Integrins protect cardiomyocytes from ischemia/reperfusion injury

Author

Okada, Hideshi, Lai, N Chin, Kawaraguchi, Yoshitaka, Liao, Peter, Copps, Jeffrey, Sugano, Yasuo, Okada-Maeda, Sunaho, Banerjee, Indroneal, Schilling, Jan M, Gingras, Alexandre R, Asfaw, Elizabeth K, Suarez, Jorge, Kang, Seok-Min, Perkins, Guy A, Au, Carol G, Israeli-Rosenberg, Sharon, Manso, Ana Maria, Liu, Zheng, Milner, Derek J, Kaufman, Stephen J, Patel, Hemal H, Roth, David M, Hammond, H Kirk, Taylor, Susan S, Dillmann, Wolfgang H, Goldhaber, Joshua I, and Ross, Robert S

Subjects
Biochemistry and Cell Biology, Medical Physiology, Biomedical and Clinical Sciences, Biological Sciences, Heart Disease, Cardiovascular, Heart Disease - Coronary Heart Disease, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Aetiology, 2.1 Biological and endogenous factors, Amino Acid Sequence, Animals, Calcium, Cell Hypoxia, Cells, Cultured, Humans, Integrins, Male, Membrane Potential, Mitochondrial, Mice, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, Myocardial Ischemia, Myocardial Reperfusion Injury, Myocytes, Cardiac, Peptide Fragments, Phosphorylation, Protein Binding, Protein Interaction Domains and Motifs, Protein Processing, Post-Translational, Protein Stability, Protein Subunits, Rats, Rats, Sprague-Dawley, Ryanodine Receptor Calcium Release Channel, Medical and Health Sciences, Immunology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Ischemic damage is recognized to cause cardiomyocyte (CM) death and myocardial dysfunction, but the role of cell-matrix interactions and integrins in this process has not been extensively studied. Expression of α7β1D integrin, the dominant integrin in normal adult CMs, increases during ischemia/reperfusion (I/R), while deficiency of β1 integrins increases ischemic damage. We hypothesized that the forced overexpression of integrins on the CM would offer protection from I/R injury. Tg mice with CM-specific overexpression of integrin α7β1D exposed to I/R had a substantial reduction in infarct size compared with that of α5β1D-overexpressing mice and WT littermate controls. Using isolated CMs, we found that α7β1D preserved mitochondrial membrane potential during hypoxia/reoxygenation (H/R) injury via inhibition of mitochondrial Ca2+ overload but did not alter H/R effects on oxidative stress. Therefore, we assessed Ca2+ handling proteins in the CM and found that β1D integrin colocalized with ryanodine receptor 2 (RyR2) in CM T-tubules, complexed with RyR2 in human and rat heart, and specifically bound to RyR2 amino acids 165-175. Integrins stabilized the RyR2 interdomain interaction, and this stabilization required integrin receptor binding to its ECM ligand. These data suggest that α7β1D integrin modifies Ca2+ regulatory pathways and offers a means to protect the myocardium from ischemic injury.

Published
2013

9. Data from The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents

Author

Canon, Jude, primary, Osgood, Tao, primary, Olson, Steven H., primary, Saiki, Anne Y., primary, Robertson, Rebecca, primary, Yu, Dongyin, primary, Eksterowicz, John, primary, Ye, Qiuping, primary, Jin, Lixia, primary, Chen, Ada, primary, Zhou, Jing, primary, Cordover, David, primary, Kaufman, Stephen, primary, Kendall, Richard, primary, Oliner, Jonathan D., primary, Coxon, Angela, primary, and Radinsky, Robert, primary

Published
2023
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10. Supplemental Figure 3 from The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents

Author

Canon, Jude, primary, Osgood, Tao, primary, Olson, Steven H., primary, Saiki, Anne Y., primary, Robertson, Rebecca, primary, Yu, Dongyin, primary, Eksterowicz, John, primary, Ye, Qiuping, primary, Jin, Lixia, primary, Chen, Ada, primary, Zhou, Jing, primary, Cordover, David, primary, Kaufman, Stephen, primary, Kendall, Richard, primary, Oliner, Jonathan D., primary, Coxon, Angela, primary, and Radinsky, Robert, primary

Published
2023
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11. Supplemental Figure 2 from The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents

Author

Canon, Jude, primary, Osgood, Tao, primary, Olson, Steven H., primary, Saiki, Anne Y., primary, Robertson, Rebecca, primary, Yu, Dongyin, primary, Eksterowicz, John, primary, Ye, Qiuping, primary, Jin, Lixia, primary, Chen, Ada, primary, Zhou, Jing, primary, Cordover, David, primary, Kaufman, Stephen, primary, Kendall, Richard, primary, Oliner, Jonathan D., primary, Coxon, Angela, primary, and Radinsky, Robert, primary

Published
2023
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12. Supplemental Figure 1 from The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents

Author

Canon, Jude, primary, Osgood, Tao, primary, Olson, Steven H., primary, Saiki, Anne Y., primary, Robertson, Rebecca, primary, Yu, Dongyin, primary, Eksterowicz, John, primary, Ye, Qiuping, primary, Jin, Lixia, primary, Chen, Ada, primary, Zhou, Jing, primary, Cordover, David, primary, Kaufman, Stephen, primary, Kendall, Richard, primary, Oliner, Jonathan D., primary, Coxon, Angela, primary, and Radinsky, Robert, primary

Published
2023
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15. RANK Is the Intrinsic Hematopoietic Cell Surface Receptor That Controls Osteoclastogenesis and Regulation of Bone Mass and Calcium Metabolism

Author

Li, Ji, Sarosi, Ildiko, Yan, Xiao-Qiang, Morony, Sean, Capparelli, Casey, Tan, Hong-Lin, McCabe, Susan, Elliott, Robin, Scully, Sheila, Van, Gwyneth, Kaufman, Stephen, Juan, Shao-Chieh, Sun, Yu, Tarpley, John, Martin, Laura, Christensen, Kathleen, McCabe, James, Kostenuik, Paul, Hsu, Hailing, Fletcher, Frederick, Dunstan, Colin R., Lacey, David L., and Boyle, William J.

Published
2000

21. Data from Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody

Author

Coxon, Angela, primary, Bready, James, primary, Min, Hosung, primary, Kaufman, Stephen, primary, Leal, Juan, primary, Yu, Dongyin, primary, Lee, Tani Ann, primary, Sun, Ji-Rong, primary, Estrada, Juan, primary, Bolon, Brad, primary, McCabe, James, primary, Wang, Ling, primary, Rex, Karen, primary, Caenepeel, Sean, primary, Hughes, Paul, primary, Cordover, David, primary, Kim, Haejin, primary, Han, Seog Joon, primary, Michaels, Mark L., primary, Hsu, Eric, primary, Shimamoto, Grant, primary, Cattley, Russell, primary, Hurh, Eunju, primary, Nguyen, Linh, primary, Wang, Shao Xiong, primary, Ndifor, Anthony, primary, Hayward, Isaac J., primary, Falcón, Beverly L., primary, McDonald, Donald M., primary, Li, Luke, primary, Boone, Tom, primary, Kendall, Richard, primary, Radinsky, Robert, primary, and Oliner, Jonathan D., primary

Published
2023
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22. Supplementary Figure 1 from Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody

Author

Coxon, Angela, primary, Bready, James, primary, Min, Hosung, primary, Kaufman, Stephen, primary, Leal, Juan, primary, Yu, Dongyin, primary, Lee, Tani Ann, primary, Sun, Ji-Rong, primary, Estrada, Juan, primary, Bolon, Brad, primary, McCabe, James, primary, Wang, Ling, primary, Rex, Karen, primary, Caenepeel, Sean, primary, Hughes, Paul, primary, Cordover, David, primary, Kim, Haejin, primary, Han, Seog Joon, primary, Michaels, Mark L., primary, Hsu, Eric, primary, Shimamoto, Grant, primary, Cattley, Russell, primary, Hurh, Eunju, primary, Nguyen, Linh, primary, Wang, Shao Xiong, primary, Ndifor, Anthony, primary, Hayward, Isaac J., primary, Falcón, Beverly L., primary, McDonald, Donald M., primary, Li, Luke, primary, Boone, Tom, primary, Kendall, Richard, primary, Radinsky, Robert, primary, and Oliner, Jonathan D., primary

Published
2023
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23. Supplementary Methods, Figure Legends, and References from Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody

Author

Coxon, Angela, primary, Bready, James, primary, Min, Hosung, primary, Kaufman, Stephen, primary, Leal, Juan, primary, Yu, Dongyin, primary, Lee, Tani Ann, primary, Sun, Ji-Rong, primary, Estrada, Juan, primary, Bolon, Brad, primary, McCabe, James, primary, Wang, Ling, primary, Rex, Karen, primary, Caenepeel, Sean, primary, Hughes, Paul, primary, Cordover, David, primary, Kim, Haejin, primary, Han, Seog Joon, primary, Michaels, Mark L., primary, Hsu, Eric, primary, Shimamoto, Grant, primary, Cattley, Russell, primary, Hurh, Eunju, primary, Nguyen, Linh, primary, Wang, Shao Xiong, primary, Ndifor, Anthony, primary, Hayward, Isaac J., primary, Falcón, Beverly L., primary, McDonald, Donald M., primary, Li, Luke, primary, Boone, Tom, primary, Kendall, Richard, primary, Radinsky, Robert, primary, and Oliner, Jonathan D., primary

Published
2023
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24. Supplementary Figure 4 from Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody

Author

Coxon, Angela, primary, Bready, James, primary, Min, Hosung, primary, Kaufman, Stephen, primary, Leal, Juan, primary, Yu, Dongyin, primary, Lee, Tani Ann, primary, Sun, Ji-Rong, primary, Estrada, Juan, primary, Bolon, Brad, primary, McCabe, James, primary, Wang, Ling, primary, Rex, Karen, primary, Caenepeel, Sean, primary, Hughes, Paul, primary, Cordover, David, primary, Kim, Haejin, primary, Han, Seog Joon, primary, Michaels, Mark L., primary, Hsu, Eric, primary, Shimamoto, Grant, primary, Cattley, Russell, primary, Hurh, Eunju, primary, Nguyen, Linh, primary, Wang, Shao Xiong, primary, Ndifor, Anthony, primary, Hayward, Isaac J., primary, Falcón, Beverly L., primary, McDonald, Donald M., primary, Li, Luke, primary, Boone, Tom, primary, Kendall, Richard, primary, Radinsky, Robert, primary, and Oliner, Jonathan D., primary

Published
2023
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25. Supplementary Figure 2 from Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody

Author

Coxon, Angela, primary, Bready, James, primary, Min, Hosung, primary, Kaufman, Stephen, primary, Leal, Juan, primary, Yu, Dongyin, primary, Lee, Tani Ann, primary, Sun, Ji-Rong, primary, Estrada, Juan, primary, Bolon, Brad, primary, McCabe, James, primary, Wang, Ling, primary, Rex, Karen, primary, Caenepeel, Sean, primary, Hughes, Paul, primary, Cordover, David, primary, Kim, Haejin, primary, Han, Seog Joon, primary, Michaels, Mark L., primary, Hsu, Eric, primary, Shimamoto, Grant, primary, Cattley, Russell, primary, Hurh, Eunju, primary, Nguyen, Linh, primary, Wang, Shao Xiong, primary, Ndifor, Anthony, primary, Hayward, Isaac J., primary, Falcón, Beverly L., primary, McDonald, Donald M., primary, Li, Luke, primary, Boone, Tom, primary, Kendall, Richard, primary, Radinsky, Robert, primary, and Oliner, Jonathan D., primary

Published
2023
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26. Supplementary Figure 3 from Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody

Author

Coxon, Angela, primary, Bready, James, primary, Min, Hosung, primary, Kaufman, Stephen, primary, Leal, Juan, primary, Yu, Dongyin, primary, Lee, Tani Ann, primary, Sun, Ji-Rong, primary, Estrada, Juan, primary, Bolon, Brad, primary, McCabe, James, primary, Wang, Ling, primary, Rex, Karen, primary, Caenepeel, Sean, primary, Hughes, Paul, primary, Cordover, David, primary, Kim, Haejin, primary, Han, Seog Joon, primary, Michaels, Mark L., primary, Hsu, Eric, primary, Shimamoto, Grant, primary, Cattley, Russell, primary, Hurh, Eunju, primary, Nguyen, Linh, primary, Wang, Shao Xiong, primary, Ndifor, Anthony, primary, Hayward, Isaac J., primary, Falcón, Beverly L., primary, McDonald, Donald M., primary, Li, Luke, primary, Boone, Tom, primary, Kendall, Richard, primary, Radinsky, Robert, primary, and Oliner, Jonathan D., primary

Published
2023
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