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Introduction: Multiple systems are available for chemo-mechanical preparation during pulpectomy, but an evolution of the exclusive paediatric rotary single file system has opened new doors in paediatric endodontics. The aim was primarily to compare the quality of obturation and instrumentation time and secondarily to report pain perception between manual files and rotary file systems in deciduous molars. Materials and Methods: Pulpectomy was performed in 60 carious mandibular primary molars indicated for pulpectomy in children aged 4–8 years after considering the selection criteria. These teeth were divided randomly into three groups of 20 each, wherein canals were prepared using Hand K files in Group 1, HeroShaper Rotary File System in Group 2 and Kedo S Square single paediatric rotary file in Group 3. The quality of obturation was assessed using intraoral radiographs, and instrumentation time was recorded in seconds using a stopwatch. Pain during instrumentation was assessed using Wong Baker's FACES Pain Scale. Collected data were subjected to analysis using the Chi-square test, one-way ANOVA and Honestly Significant Difference post hoc test. Results: Mean instrumentation time was least for the Kedo-S Square file system (57.47 ± 9.26), followed by the HeroShaper group (99.6 ± 23.62), and maximum time was recorded for Hand files (255.99 ± 46.20), and this difference was statistically significant (P = 0.00), whereas there was no significant difference regarding the quality of obturation and pain perception between the three groups. Conclusion: As the Kedo S Square system showed the fastest canal preparation, it can be recommended for pulpectomy procedures in primary teeth because the length of appointment is directly proportional to the behaviour of the child.

BACKGROUND: Mangifera indica L. (mango), a medicinal plant rich in biologically active compounds, has potential to be used in disease‐preventing and health‐promoting products. The present investigation reveals and uncovers bioactive metabolites with remarkable therapeutic efficiency from mango (family: Anacardiaceae) seeds. RESULTS: Biological activity was determined by antimicrobial, antioxidant and anticancer assays, and metabolite profiling was performed on gas chromatography coupled to quadrupole time‐of‐flight mass spectrometry (GC‐QTOF‐MS) and liquid chromatography coupled to quadrupole time‐of‐flight mass spectrometry (LC‐QTOF‐MS) platforms. Validation of active metabolites was carried out by in silico molecular docking (Molinspiration Cheminformatics Server and PASS). Extracted and identified metabolites were screened; 54 compounds associated with various groups were selected for the in silico interaction study. CONCLUSIONS: Molecular docking revealed lead molecules with a potential binding energy score, efficacy and stable modulation with a selected protein domain. Investigation, directed by in vitro and in silico analysis, confirms mango seeds as an excellent source of potential metabolites as a therapeutic agent. © 2024 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

Background: Irrigation plays a pivotal role in pulp therapy owing to its flushing action and removal of the smear layer which if present prevents penetration of medicaments and sealers into the dentinal tubules. Aim: This study aims to evaluate and compare the smear layer removal potency of three commercial Irrigating agents. Materials and Methods: Single rooted 30 teeth were selected, decoronated, and randomly divided into three groups according to the irrigation regime to be used (Group I − 5% sodium hypochlorite [NaOCl] + ethylenediaminetetraacetic acid [EDTA], Group II – Chloraxid Gel + EDTA, Group III – Tween Kleen + 3% NaOCl). After recommended biomechanical preparation and irrigation, teeth were stained with 1% methylene blue dye for 24 h and sectioned in 2 halves. Stereomicroscopy was used to assess dye penetration and scanning electron microscope (SEM) analysis was done to detect dentinal surface changes. Data were analyzed using one-way ANOVA test and Tukey honestly significant difference test by statistical software SPSS version 20.0. Results: The highest dye penetration exhibiting smear layer removal for the apical third was seen in Group II (44.78) and for the middle third in Group I (64.73) which was statistically significant. SEM analysis showed maximum dentinal tubules visibility and patency in Group I and minimum in Group III. Conclusion: Newer irrigating materials (1-hydroxyethylidene-1, 1-bisphosphonate) exhibited weak potency for smear layer removal. The sequential use of gold standard NaOCl + EDTA gave satisfactory results, however, in apical third NaOCl Gel + EDTA was found to be more effective. Therefore, it can be prudent to use NaOCl Gels as a safer alternative to conventional means.

Background: Minimally invasive techniques should be employed to maintain pulp vitality without affecting physiological tooth resorption for pediatric patients. This study aims to evaluate clinical and radiographic success of light cure calcium silicate and resin-modified glass ionomer (RMGI) as indirect pulp-capping agent in primary molars in children between 5 and 9 years. Materials and Methods: In this randomized clinical trial study, 40 primary molars with the International Caries Detection and Assessment System criteria 4–6 score were divided randomly into two groups after computerized randomization method. After caries excavation by minimally invasive dentistry principle, affected dentin was lined by either light cure calcium silicate (Group I) or RMGI (Group II) liner followed by composite restoration. Clinical success was determined with the absence of symptoms and bitewing radiographs were taken at baseline, 3, and 6 months' interval to measure increase in dentin increment using ImageJ software. Statistical analysis for intergroup comparison was done using Paired t-test, and Independent t-test was used for intragroup comparison. The level of statistical significance was set at P < 0.05. Results: Change in dentin increment seen from baseline to 6 months in Group I was 0.19 mm and in Group II was 0.20 mm (P = 0.924). Intragroup increment was statistically significant during all follow-up intervals for both the groups (Group I – P ≤ 0.001, Group II – P = 0.009). For baseline remaining dentin thickness >1.5 mm, statistically significant increase was observed in the dentin increment at 3 months' interval between both the groups. Conclusion: Both TheraCal LC and Vitrebond show acceptable clinical and radiographic results when used in primary molars as indirect pulp treatment agents. Both the liners are equivalent to each other in terms of feasibility and cost-effectiveness but TheraCal LC can be preferred due to better handling and avoiding the manipulation step thereby reducing treatment time.

In this work, we have demonstrated agar and oxidized bacterial cellulose cryogels as a potential hemostatic dressing material. TEMPO-oxidized bacterial cellulose (OBC) was incorporated into the agar matrix, improving its mechanical and hemostatic properties. The oxidation of bacterial cellulose (BC) was evidenced by chemical characterization studies, confirming the presence of carboxyl groups. The in vitro blood clotting test conducted on agar/OBC composite cryogels demonstrated complete blood clotting within 90 seconds, indicating their excellent hemostatic efficacy. The cryogels exhibited superabsorbent properties with a swelling degree of 4200%, enabling them to absorb large amounts of blood. Moreover, the compressive strength of the composite cryogels was appreciably improved compared to pure agar, resulting in a more stable physical structure. The platelet adhesion test proved the significant ability of the composite cryogels to adhere to and aggregate platelets. Hemocompatibility and cytocompatibility tests have verified the safety of these cryogels for hemostatic applications. Finally, the material exhibited remarkable in vivo hemostatic performance, achieving clotting times of 64 seconds and 35 seconds when tested in the rat tail amputation model and the liver puncture model, respectively. The experiment results were compared with those of commercial hemostat, Axiostat, and Surgispon, affirming the potential of agar/OBC composite cryogel as a hemostatic dressing material. [ABSTRACT FROM AUTHOR]

An approximate bound state solution of the Klein–Gordon equation is derived analytically for the 3-dimensional space with a combination framework of linear plus modified Yukawa Potential (LIMYP) using the Nikiforov–Uvarov (N–U) method for obtaining the energy eigenvalues and corresponding wave function. A detailed study of mass spectra of all combination sets of heavy-light flavor mesons vis-a-vis (K s / K q ; K = C , B) is investigated by treating both heavy-light flavor mesons non-relativistic with an effective quark–antiquark interaction potential for different quantum states. Along with that, an elucidated graphical representation is scrutinized with the calculated mass spectra obtained from the energy eigenvalue against the corresponding variables for all the combination sets of heavy-light flavors mesons. Therefore, the current framework potential provides excellent reconciliation with the experimental data of states known to date and minuscule % difference in lower quantum states, which increases with higher quantum states that can be correlated with the higher screening factor coming into the account. [ABSTRACT FROM AUTHOR]

Background: Inguinal hernioplasty is one of the most commonly performed surgical procedures associated with moderate to severe postoperative pain. Optimal postoperative analgesia is important to prevent negative outcomes. The Ultrasound guided transversus abdominis plane (TAP) block is a peripheral nerve block that involves innervations of the anterolateral abdominal wall derived from T6-L1 which increases duration of analgesia & prolongs the time to first analgesic request, reduces postoperative analgesic consumption and reduces opioids related side effects. Various adjuvants to bupivacaine have been used to extend the analgesic effect. Most commonly used are dexmedetomidine, clonidine, dexamethasone and fentanyl. In this study we used clonidine and fentanyl. Primary objective was to assess the duration of postoperative analgesia while secondary objectives were to compare the quality of analgesia as measured by VAS score, the total amount of rescue analgesics consumed in 24 hours, side effects, and complications if any between the adjuvants. Aims and Objectives: To assess the duration of postoperative analgesia with clonidine v/s fentanyl as adjuvant to bupivacaine (p). To compare the quality of analgesia as measured by Visual Analogue pain scale (VAS) score, the total amount of rescue analgesics consumed in 24 hours and side effects and complications if any between the adjuvants Materials and methods: An observational hospital based study was conducted at Gandhi Medical College, Bhopal comprising of 60 patients between age group 18-60 years, male, belonging to ASA grade I to II, scheduled for elective bilateral inguinal hernioplasty under the subarachnoid block (SAB) after informed consent. GROUP C (B+C) - 30 patients received bilateral TAP block using 22 ml solution--consisting of 20 ml 0.25% bupivacaine and 1 mcg/kg clonidine dissolved in 2 ml normal saline. GROUP F (B+F) - 30 patients received bilateral TAP block using 22 ml solution--consisting of 20 ml 0.25% bupivacaine and 1 mcg/kg fentanyl dissolved in 2 ml normal saline. Diclofenac 75mg was used as rescue analgesia. Post operative pain is evaluated by VAS score for pain at 0,2,4,8,12 and 24 hrs postoperatively, time to 1st analgesia, total analgesia and any complications were noted. Result: There was no statistical significant difference between the two groups in demographic characteristics (age and ASA), The overall p value of mean heart rate, mean systolic bp, mean diastolic bp between 2 group is less than 0.001, the difference was statistically significant which means the average hemodynamic parameter values of group F (B+F) were greater than group C (B+C), The VAS score of group C Was significantly lower than VAS score of group F during all the intervals of time (p<0.001), Significant difference was seen in post-operative Ramsay sedation score at 2 hour, at 4 hours, at 8 hours, between GROUP F and GROUP C (p value <0.05). GROUP F has higher Ramsay sedation score, No significant difference was seen at 12 and 24 hours (p value > 0.05), between GROUP F and GROUP C, time to 1st rescue analgesia is longer in group clonidine, Total analgesic consumption in the group C was lower compared to that of group F which was significant statistically(p < 0.05). The incidence of hypotension and bradycardia more in group C. Other adverse effects were comparable. Conclusion: Addition of clonidine to Bupivacaine in TAP Block prolongs the post-operative analgesia than fentanyl. It provides longer first analgesia request time and less total analgesia consumption with minimal side effects. Addition of fentanyl to Bupivacaine in TAP Block gives more hemodynamic stability. [ABSTRACT FROM AUTHOR]